JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Turong Shi,Jiachun Feng,Beibei Tang
Amphiphilic block copolymers are widely used as additives in ultrafiltration membranes preparation by nonsolvent-induced phase separation. During membrane-forming process, an increase in coagulation bath temperature (CBT) will accelerate the kinetics of phase inversion and also promote the micellization of amphiphilic block copolymers. Herein, polyethylene oxide-polypropylene oxide-polyethylene oxide, marketed as Pluronic, is utilized as an additive for preparing asymmetric ultrafiltration membranes. Influence of temperature-induced micelle transition behavior of Pluronic on membrane formation and performance is investigated in detail. It is found that when the CBT increases, temperature-induced micelle transition of Pluronic will lead to a dual effect: (1) The decrease in Pluronic diffusion rate results in a reduced diffusion of the solvent interacting with it, thereby slowing down the precipitation kinetics during phase inversion. (2) The decrease in particle size of Pluronic micelles brings about a reduction in the region left by Pluronic micelles extracted from the casting solution, thus decreasing the membrane pore size. The intrinsic characters of Pluronic, including molecular weight, hydrophilic and hydrophobic block ratio and concentration, determine the dual effect of micelle transition. This work provides an in-depth understanding and practical guidance for the preparation of asymmetric membranes with amphiphilic block copolymers as additive systems.
研究领域:
材料科学
·
膜技术
·
高分子化学
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Yujuan Chen,Abdur Rauf Khan,Dexin Yu,Yujia Zhai,Jianbo Ji,Yikang Shi,Guangxi Zhai
Traditional cancer therapies carry a risk of serious side effects and toxicity. Developing an alternative treatment modality that is highly effective, has low toxicity and is noninvasive is urgently required. Here, we exploited molybdenum oxide (MoOx) nanosheets as a drug carrier and degradable photothermal agent to provide a chemo-photothermal combination cancer therapy. The MoOx nanosheets were synthesized by a one-pot hydrothermal method and then modified with pluronic F127 to improve physiological stability and biocompatibility. The F127-modified nanosheets (MoOX@F127) showed ultrahigh drug loading efficiency (DLE) of doxorubicin (DOX) (DLE%; 65%, W (load DOX) /[W (load DOX) + W MoOx@F127 ]), strong near-infrared (NIR) absorption and desirable pH-dependent degradability. After intravenous injection, MoOx@F127 nanosheets were degraded at physiological pH and were rapidly excreted from normal organs, while they were effectively accumulated and retained long-term in the more acidic tumor tissue. This simultaneously ensured effective tumor ablation after NIR irradiation and avoided long-term retention and toxicity in vivo . Compared to chemotherapy or photothermal therapy alone, in vitro and in vivo tumor ablation studies have shown a notably improved synergistic effect of the combination therapy. Our study presents a multifunctional nanosystem with a desirable degradability for chemo-photothermal combination cancer therapy that has great potential in biomedical applications.
研究领域:
肿瘤学
·
纳米医学
·
生物材料学
✓ 已验证
DOI
PubMed
高影响因子
FUEL
·
2022
·
IF 8.035
You Zhao,Wenkai Zhao,Yonghou Xiao,Qidong Zhao,Chengbin Li,Xiaoying Dong,Shengnan Lu
As an efficient fuel purification technique, adsorption desulphurization has attracted wide attention. Silicon oxide has been verified as a promising candidate for adsorption desulfurization reagent due to the advantages of stable structure, inexpensiveness and accessibility. However, its adsorption desulfurization performance is always weakened by the limited pore channel size leading to pore diffusion resistance over the traditional microporous silicon oxide, and it suffers from the poor shape selectivity of mesoporous silicon oxide as well. In this work, we successfully prepared a novel super microporous silica material (SMS) with a unique bimodal micro-mesoporous pore size distribution mainly around 1.2 nm, 1.6 nm and 1.8 ∼ 3.5 nm, using a pluronic triblock copolymer with approximately an average molecular weight of 3858 as template by hydrothermal synthesis. The SMS possessed the characteristics of Ia3d cubic phase and super microporous as well as mesoporous silica structure, according to the X-ray diffraction characterization as well as nitrogen adsorption isotherms. The SMS could effectively reduce the diffusion resistance and exhibit improved shape selectivity compared to microporous or mesoporous silicon oxide, respectively, by virtue of its bimodal micro-mesoporous pore size distribution. Under an optimized crystallization temperature of 100 °C for 24 h, the as-synthesized SMS displayed a notable desulfurization performance with a breakthrough capacity of 0.122 mmol S/g benzothiophene, which was significantly superior to that of traditional mesoporous silica KIT-6 (0.04 mmol S/g). Furthermore, the desulfurization performance of SMS adsorbent was not significantly reduced after three cycles of regeneration. The SMS exhibited high desulfurization capacity, easy regeneration and satisfactory regeneration performance, and it could be applied in adsorptive desulfurization technology.
研究领域:
材料科学
·
能源化学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Jinsong Tao,Zhengjie Wei,Yaxin Cheng,Meng Xu,Qiuxia Li,Simon Ming-Yuen Lee,Wei Ge,Kathy Qian Luo,Xueqing Wang,Ying Zheng
A suitable animal model for preclinical screening and evaluation in vivo could vastly increase the efficiency and success rate of nanomedicine development. Compared with rodents, the transparency of the zebrafish model offers unique advantages of real-time and high-resolution imaging of the whole body and cellular levels in vivo. In this research, we established an apoptosis-sensing xenograft zebrafish tumor model to evaluate the anti-cancer effects of redox-responsive cross-linked Pluronic polymeric micelles (CPPMs) visually and accurately. First, doxorubicin (Dox)-loaded CPPMs were fabricated and characterized with glutathione (GSH)-responsive drug release. Then, the B16F10 xenograft zebrafish tumor model was established to mimic the tumor microenvironment with angiogenesis and high GSH generation for redox-responsive tumor-targeting evaluation in vivo. The high GSH generation was first verified in the xenograft zebrafish tumor model. Compared with ordinary Pluronic polymeric micelles, Dox CPPMs had a much higher accumulation in zebrafish tumor sites. Finally, the apoptosis-sensing B16F10-C3 xenograft zebrafish tumor model was established for visual, rapid, effective, and noninvasive assessment of anti-cancer effects at the cellular level in vivo. The Dox CPPMs significantly inhibited the proliferation of cancer cells and induced apoptosis in the B16F10-C3 xenograft zebrafish tumor model. Therefore, the redox-responsive cross-linked Pluronic micelles showed effective anti-cancer therapy in the xenograft zebrafish tumor model. This xenograft zebrafish tumor model is available for rapid screening and assessment of anti-cancer effects in preclinical studies.
研究领域:
药理学
·
肿瘤学
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纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2012
·
IF 3.212
Fatima Zohra Dahmani,Hui Yang,Jianping Zhou,Jing Yao,Ting Zhang,Qiang Zhang
In order to enhance paclitaxel oral bioavailability, mixed polymeric micelles that comprised of pluronic copolymers and low molecular weight heparin-all-trans-retinoid acid (LHR) conjugate were developed. PTX-loaded mixed polymeric micelles (MPMs) were prepared by dialysis method with high drug loading 26.92 ± 2.08% and 25.82 ± 1.9% for F127/LHR and P188/LHR MPMs respectively, and were found to be spherical in shape with an average size of around 140 nm and a narrow size distribution. In vitro release study showed that pluronic/LHR MPMs exhibited delayed release characteristics compared to Taxol and faster drug release profile compared to LHR plain polymeric micelles (PPMs). The cytotoxic activity of PTX-loaded pluronic/LHR MPMs was slightly higher than LHR PPMs in MCF-7 cells ( p < 0.01). In situ effective permeability of PTX through rat small intestine was 5- to 6-fold higher with mixed micelles than that of Taxol. Moreover, pluronic/LHR MPMs achieved significantly higher AUC and C max level than both of LHR PPMs and Taxol. This enhancement might be due to the inhibition of both P-glycoprotein efflux system and cytochrome P450 metabolism by pluronic copolymers. The current results encourage further development of paclitaxel mixed polymeric micelles as an oral drug delivery system .
研究领域:
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2021
·
IF 9.078
Ting-Ting Li,Mengfan Xing,Bo Gao,Hai-Tao Ren,Hao-Kai Peng,Xiayun Zhang,Jia-Horng Lin,Ching-Wen Lou
In order to solve the recycling of the puncture-resistant soft composites, this study constructs a multiscale self-healing gel-fabric soft composite synergistically toughened by Pluronic/PMEA hydrogel, hydroxyapatite nanoparticles (HAP NPs) and aramid fabric. Results show that the gel matrix has a self-healing efficiency of 85% after puncture damage, and the stab resistances are highly positively associated with the toughness of the hydrogel matrix. When toughened by 4% HAP NPs, the spike and knife resistances of soft composites are improved by 132% and 130%, respectively. After being laminated, the composite exhibits a self-repairing efficiency of 52% and still has excellent performance after multiple punctures. At lamination angle of 45° and the gel volume fraction of 45%, the composite has the best puncture resistance properties, and the 37 layers can resist against the E1 stab resistance energy. The synergistic toughened mechanism is due to the interfacial shear strength between the fiber and the gel matrix. Overall, this research provides a novel structural design for the recycling of high-performance puncture-resistant composites.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF DRUG TARGETING
·
2025
·
IF 3.9
Jiaying Li,Tingyuan Li,Mingjie Gong,Xiaowen Wang,Qinyang Hua,Xia Jiang,Qilong Wang,Elmurat Toreniyazov,Jiangnan Yu,Xia Cao,Michael Adu-Frimpong,Ximing Xu
Phloretin exhibits strong antioxidant and anti-ageing properties by inhibiting mitochondrial oxidation of glutamate, succinic acid, and ascorbic acid. However, its clinical application is limited by poor aqueous solubility and low oral bioavailability. To enhance its bioavailability and efficacy, we incorporated phloretin into nano-micelles (phloretin-MM) using the thin film dispersion method. Characterisation revealed that the optimal formulation had TPGS and Pluronic F68 in a 4:1 ratio as the excipients, which resulted in spherical micelles with an average particle size of 33.28 nm and an encapsulation efficiency of 71.2 ± 0.48%. The in vitro release profile showed that the phloretin-MM showed significantly higher cumulative release rates than free phloretin across various pH conditions, while the pharmaceutical analysis in rats indicated that phloretin-MM significantly improved the oral bioavailability of phloretin (about 5 folds) in circulation. Additionally, through the analysis of the staining of zebrafish under light microscopy and the average gray value, it can be concluded that phloretin has anti-ageing drug effect, and phloretin-MM is better than free phloretin. These findings suggest that TPGS/Pluronic F68-modified phloretin-MM could serve as an excellent nano-drug carrier system, potentially enhancing the solubility, bioavailability, and anti-ageing effects of phloretin for broader clinical applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2015
·
IF 2.729
Miaomiao Tian,Yongcun Zou,Shaoyan Zhou,Tianpeng Wang,Xueju Lv,Qiong Jia
Novel magnetic adsorbents based on Fe 3 O 4 /SiO 2 /poly(acrylamide- N , N' -methylene bisacrylamide) magnetic microspheres modified with non-ionic triblock copolymer surfactant were successfully prepared as a magnetic solid phase extraction adsorbent for the determination of trace natamycin in jam samples. The adsorbent was characterized by scanning electron microscopy, transmission electron microscopy, Fourier transformed infrared spectroscopy, vibrating sample magnetometer, and X-ray diffractometer analysis, confirming that Pluronic L64 was effectively functionalized on the magnetic materials. Various experimental parameters affecting the extraction capacity were investigated including adsorbent amount, extraction time, desorption time, sample pH, and ionic strength. For recovery evaluations, the jam samples were spiked at two concentration levels of 100 and 200 μg kg −1 of natamycin and the recovery values were in the range of 78.8–93.4%. The relative standard deviations (RSD) for the recoveries were less than 3.5%. The novel magnetic solid phase extraction method provided several advantages, such as simplicity, low environmental impact, convenient extraction procedure, and short analysis time when used for natamycin analysis.
研究领域:
分析化学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2022
·Vol. 62
·期 6
·1811-1822
·
IF 2.573
Jian Chen,Chuang Zhou,Wei Cai,Fuxiang Huang,Chunyan Zhang,Liangliang Cao,Fancheng Meng
Ceramic/polymer nanocomposites have been extensively explored for dielectric capacitor application due to their high energy storage performance and ease of processing, flexibility, and low cost. However, improving compatibility between inorganic and organic materials is of great significance and has been a long-standing challenge. In this work, the polymer surfactant Pluronic™ F127 was employed to perform surface modification of BaTiO 3 through a facile solution process. The compatibility between BaTiO 3 nanoparticles and P (VDF-HFP) can be remarkably strengthened by the affinity between F127 polymer chains and the organic matrix. Structural defects such as pores, cracks, and agglomeration of inorganic particles were obviously reduced, and interfacial polarization has been significantly enhanced. The discharged energy density U d and charge–discharge efficiency η reach up to 5.0 J/cm 3 and 58.1% under the breakdown strength of 3740 kV/cm for the nanocomposite containing 1 vol% BT@F127. These dielectric properties are clearly better than the nanocomposite using unmodified BT, as well as similar hybrids reported previously.
研究领域:
材料科学
·
电气工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Jinchao Chen,Chunmei Gao,Shuangquan Zhao,Shenghui Liu,Shifeng Ji,Yunqing Xing,Tianyang Wu,Jinjian Wu,Hongyu Chen,Peng Zou,Jiaonan Cai
In this work, the NH 2 -MIL-125/F127/PES membranes with superior ultrafiltration , anti-fouling and self-cleaning were constructed via the RTIPS method. Characterizations showed the successful fabrication of NH 2 -MIL-125 with good photocatalysis activities, together with its stable anchoring in PES membrane. The loss of NH 2 -MIL-125 was suppressed by hydrogen bond between F127 and NH 2 -MIL-125, where hydrophilic F127 significantly boosted permeability and anti-fouling property. The permeability-selectivity trade-off effect was alleviated by NH 2 -MIL-125 with a regular size window. It was observed that the membranes prepared by the RTIPS method occurred a spongy-like cross-section and a porous surface, which imparted the membrane with improved ultrafiltration and mechanical properties over the finger-like cross-section and dense skin caused by the NIPS method. The optimal membranes exhibited decent permeability (1511 L/m 2 h), BSA rejection rate (85.3%) and high COD removal rate over the commercial membranes, whose flux recovery rate was up to 76.91% after two cycles under light irradiation by the synergistic effect of F127 and NH 2 -MIL-125. The membrane fouled with RhB exhibited excellent regeneration properties benefiting from the holes (h + ) and superoxide free radicals ( • O 2 − ), as well as reactive •OH. Overall, the membrane with F127 and NH 2 -MIL-125 presented a highly promising in improving ultrafiltration and self-cleaning via the RTIPS method.
研究领域:
材料科学
·
环境工程
·
化学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2017
·Vol. 295
·期 4
·703-707
·
IF 1.723
Lu Wangting,Zhang Geng,Wei Feng,Li Wenhui,Cheng Kun,Ding Fei,Zhang Jiying,Zheng Wanquan
Palladium nanocrystals (NCs) are highly useful functional materials in many applications, and the performances of Pd NCs were strongly depended on the crystalline facet exposed on their surface. In this work, Pd NCs were synthesized in aqueous solutions by using Na 2 PdCl 4 as the precursor, citric acid as the capping agent, and Pluronic F127 as both stabilizer and reductant. By adjusting the reaction parameters, Pd cuboctahedrons, octahedrons, and triangular nanoplates with well-defined facets can be produced. This study provides a new pathway for the shape-controlled preparation of noble metal NCs.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2024
·Vol. 16
·期 24
·3485
·
IF 4.7
Meizhen Yin,Xinying Zhang,Tongguang Zhang,Zhiqiang Bao,Zhihui He
The present study aimed to explore an ideal delivery system for triptolide (TPL) by utilizing the thin-film hydration method to prepare drug-loaded, folate-modified mixed pluronic micelles (FA–F-127/F-68–TPL). Scanning electron microscopy and atomic force microscopy showed that the drug-loaded micelles had a spherical shape with a small particle size, with an average of 30.7 nm. Cell viability experiments showed that FA–F-127/F-68–TPL significantly reduced HepG2 cell viability, exhibiting strong cytotoxicity. Its cytotoxicity was markedly enhanced compared with bare TPL. Nile red (Nr) was used as a model drug to prepare FA–F-127/F-68–Nr to further validate its tumor-targeting and cellular uptake capability. After coincubation with HepG2 cells, a multifunctional microplate reader showed that intracellular fluorescence intensity significantly increased, indicating that FA–F-127/F-68–Nr could more effectively enter the cells. A nude mouse model of subcutaneous hepatocellular carcinoma was constructed. Following tail vein injection of FA–F-127/F-68–Nr, the fluorescence imaging system showed that FA–F127/F-68–Nr could significantly target tumor tissue, and even if entering the small-sized tumor was challenging, it could be excreted through urine. Nude mice with subcutaneous hepatocellular carcinoma were treated with tail vein injections of FA–F-127/F-68–TPL (45 µg/kg) every other day for 21 days. The results showed that the growth of the transplanted tumors was significantly slowed, with no significant difference compared with bare TPL. In summary, the FA–F-127/F-68–TPL exhibits the advantages of low cost, excellent biological properties, active/passive targeting capabilities, notable cytotoxicity against liver cancer cells, and significant inhibition of transplanted hepatocellular carcinoma growth. Significantly, the FA–F-127/F-68–TPL, despite challenges in targeting tumors with an insignificant EPR effect, can be efficiently excreted via the kidneys, thereby preventing the release of the drug during prolonged circulation and potential damage to normal tissues. Therefore, FA–F-127/F-68–TPL represents a promising antitumor drug delivery system.
研究领域:
药剂学
·
肿瘤学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）