PLANTA MEDICA
·
2018
·Vol. 84
·期 11
·759-767
·
IF 2.494
Zhen Zhang,Shuai Zhao,Xiaolei Li,Xiaoqi Zhuo,Wu Zhang,Qian Nie,Shuguang Wang,Lianqi Yan,Yu Sun
Wear debris-induced osteolysis is one of the major reasons for subsequent aseptic loosening after cementless hip arthroplasty. Increasing evidence suggests that receptor activator of nuclear factor kappa-B (NF-κB) ligand-mediated osteoclastogenesis and osteolysis are responsible for wear debris-induced aseptic loosening. In the present study, we explored the effect of amentoflavone (AMF) on inhibiting osteoclast generation and wear debris-induced osteolysis in vitro and in vivo. Twenty-four male C57BL/J6 mice were randomly divided into four groups: a sham group and groups with titanium wear debris treatment followed by intraperitoneal injection of various concentrations of AMF (0, 20, and 40 mg/kg/day). The micro computed tomography scanning and histological analysis were performed. Bone marrow-derived macrophages were cultured to investigate the effect of AMF on osteoclast generation and function. The results showed that AMF suppressed osteoclastogenesis, F-actin ring formation, and bone absorption without cytotoxicity. AMF prevented titanium wear debris-induced osteolysis in mice. AMF suppressed the relative proteins of NF-κB and mitogen-activated protein kinase (MAPKs) signaling pathways. Thus, the present study suggests that AMF derived from plants could inhibit osteoclastogenesis and titanium wear debris-induced osteolysis via suppressing NF-κB and MAPKs signaling pathways.
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高影响因子
SYNTHESIS-STUTTGART
·
2013
·Vol. 45
·期 16
·2234-2240
·
IF 2.5
Wenbin Lu,Zhuye Liang,Yuwei Zhang,Fan Wu,Qun Qian,Hegui Gong
Alkyl aryl ketones were prepared on a gram scale by the nickel-catalyzed reductive coupling of alkyl iodides with aroyl chlorides. When scaled up 30-fold, this reaction shows a comparable coupling efficiency to the previously reported reaction performed under small-scale conditions. The mild and convenient reaction conditions show excellent tolerance to a range of functional groups and provide the ketones in good to excellent yields.
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高影响因子
SYNTHESIS-STUTTGART
·
2015
·Vol. 48
·期 02
·231-237
·
IF 2.689
Yongbo Zhou,Zhongwen Li,Xiao Yang,Xiulin Chen,Mei Li,Tieqiao Chen,Shuang-Feng Yin
A simple and environmentally benign method was developed for the synthesis of chalcones in high to excellent yields by a phosphorous acid promoted alkyne–aldehyde hydration–condensation in an oil/water two-phase system. The method is the first efficient protocol for the preparation of chalcones that is mediated by a simple Brønsted acid in a two-phase system.
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高影响因子
SYNTHESIS-STUTTGART
·
2013
·Vol. 45
·期 24
·3349-3354
·
IF 2.5
Haidong Wei,Tianbin Li,Yue Zhou,Lihong Zhou,Qingle Zeng
Alkyl halides, including heteroarylmethyl and arylmethyl halides, bromoacetate, and cinnamyl bromide, are readily prepared via halogenation from basic raw materials, even using green processes. It is essential to replace their downstream products with them to prepare medicinally important heterocycles quinazolin-4(3H)-ones. Copper(I) bromide catalyzed domino reaction of alkyl halides and anthranilamides under air affords 2-substituted quinazolin-4(3H)-ones in good to excellent yields and with wide functional group tolerance. A mechanism for a copper(I) bromide involved organometal-catalyzed reaction via a four-step domino reaction is proposed.
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高影响因子
SEMINARS IN NEUROLOGY
·
2017
·Vol. 37
·期 05
·589-596
·
IF 1.891
Jörg Dietrich,Sebastian F. Winter,Joshua P. Klein
Management of patients with brain cancer critically depends on an accurate interpretation of imaging findings that will guide treatment decisions. Treatment with chemotherapy and radiation can affect the imaging characteristics of a tumor and therefore cause misinterpretation of treatment response. Specifically, radiotherapy or chemotherapy may result in distinctive imaging abnormalities that can be challenging to differentiate from tumor itself. Moreover, cancer therapy can be associated with unique adverse effects on the brain, which need to be appropriately recognized by the treating physician to guide patient management. Specific imaging findings, such as radiation-induced tissue necrosis, leukoencephalopathy, pseudoprogression, and pseudoresponse represent treatment-related phenomena that can complicate interpretation of imaging studies and clinical decision making. The aim of this review is to describe these phenomena and improve clinician familiarity as to how these appear on structural (MRI) and functional (perfusion, spectroscopy, PET) imaging studies.
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高影响因子
SEMINARS IN NEUROLOGY
·
2017
·Vol. 37
·期 05
·481-482
·
IF 1.891
David M. Greer
The Guest Editor of this issue of Seminars in Neurology is Dr Joshua P. Klein. Dr Klein is the Associate Professor of Neurology and Radiology at the Harvard Medical School (HMS) and the founding Chief of the Division of Hospital Neurology in the Department of Neurology at the Brigham and Women's Hospital (BWH). Dr Klein is from New York and graduated with honors from the University of Pennsylvania in 1997 and then from the Medical Scientist Training Program at the Yale University School of Medicine in 2005. He is a 2009 graduate of the Harvard (BWH/MGH) Neurology Residency Program where he served as the Chief Resident in his final year. He then completed a fellowship in Diagnostic Neuroimaging at the BWH and is board certified in both Neurology and Neuroimaging. He serves as the Chair of the Membership Committee, member of the Board of Directors, and Secretary of the Executive Committee of the American Society of Neuroimaging . He served as the Chair of the Neurohospitalist Section of the American Academy of Neurology from 2015 to 2017 and is the Section Leader of the RITE Advisory Panel for Neuroimaging. He is a member of the Board of Directors of the Neurohospitalist Society . In addition, he is a member of the Editorial Board of Access Medicine Neurology (McGraw Hill) and Scientific Chair of the Audio Digest Foundation Neurology Board Review Course. At the BWH, he serves as the Clinical Service Director for Inpatient Neurology and Chair of the Neurology Finance Committee. Here, he also served for several years as the Director of Performance Improvement for Neurology. He previously served as the Associate Director of the Neurology Medical Student Clerkship and is the Society Head of the HMS Neuroanatomy Laboratory, where he taught for 10 years. He additionally serves as an Advisor for Best Doctors Inc., Advance Medical Inc., and DocFlight Inc., and is on the Scientific Advisory Board for Aladdin Inc. Dr Klein has participated in neuroimaging research across many areas of clinical neurology, including neuroinflammatory diseases, traumatic brain injury, and neurotoxicity related to cancer therapy. He has published over 70 journal articles, as well as chapters in major textbooks of neurology, hospital medicine, neurosurgery, and psychiatry. He is a frequent lecturer at national and international conferences and has directed or participated in medical education courses in Havana, Pune, Paris, Dubai, and Manila. With Drs Allan H. Ropper and Martin A. Samuels, he coauthored the 10th edition of the textbook “Adams and Victor's Principles of Neurology,” and is also coauthoring the upcoming 11th edition of the same title. Among many clinical and teaching awards, Dr Klein received the HMS Miyawaki Faculty Teaching Award in 2009, the BWH/MGH Neurology Faculty Teacher of the Year Award in 2012, and was selected as a Distinguished Clinician at the BWH in 2017. He is a Fellow of the American Neurological Association , the American Society of Neuroimaging , and the American Academy of Neurology . I greatly appreciate the efforts of Dr Klein, as well as of all the contributing authors, for their superb and insightful work in this issue of Seminars in Neurology , which provides a stellar update of the ever-changing field of neuroimaging. The issue provides not only practical advice to the practicing clinicians, but also deep insights into the cutting-edge research that is taking place rapidly in this field. On a personal note, I express warm thanks to my friend and colleague, Josh, who has been a leader in the field and a mentor to many. We hope you enjoy this marvelous issue!
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高影响因子
SYNTHESIS-STUTTGART
·
2020
·Vol. 53
·期 07
·1341-1348
·
IF 2.675
Xinxin Zhao,Lin Guo,Chao Yang,Wujiong Xia
A highly regioselective [3+2] cyclization of alkenes with 2-iodoanilines under the irradiation of UV light is described. This general, metal-free strategy facilitates the direct preparation of 2-mono-/disubstituted indolines as well as spiroindolines through alkene carboamination in one step. Mechanistic studies suggested that the photochemical protocol proceeded via a radical pathway.
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高影响因子
SYNTHESIS-STUTTGART
·
2018
·Vol. 51
·期 03
·739-746
·
IF 2.722
Qing-Wen Song,Qing-Ning Zhao,Jing-Yuan Li,Kan Zhang,Ping Liu
It is promising and challenging to achieve the effective construction of carbonates using CO2 and a non-noble metal catalyst. Herein, selective catalytic conversion of CO2 and switchable alcohol candidates to produce linear or cyclic carbonates and α-hydroxy ketones via effective zinc catalyst was developed. A series of primary alcohols and cyclohexanol, 1,2-diols, and water can serve as nucleophiles to give alkyl or aryl 2-substituted-3-oxobutan-2-yl carbonates, substituted 1,3-dioxolan-2-ones, 3-substituted 3-hydroxybutan-2-ones, respectively with excellent selectivity and high yields.
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高影响因子
SYNLETT
·
2021
·Vol. 32
·期 14
·1437-1446
·
IF 2.454
Haifei Wang,Chuliang Gong,Chen Zhang,Xiaojun Zheng,Qinglin Hou,Qingxia Zhou,Guiyin Zhou,Yao Chen
In this work, we introduced a multifunctional Ag(I)/CAAA-amidphos complex catalyzed asymmetric 1,3-dipolar cycloaddition of acrylates with α-imino esters, affording a series of 2,4,5-trisubstituted endo-pyrrolidines in good yields (up to 97%) with high enantioselectivities (up to 98% ee). Meanwhile, the catalytic system was also applied in the three-component one-pot reaction of α-imino esters formed in situ under the action of N,N′-diisopropylcarbodiimide. In addition, the gram-scale reaction was realized for the formal synthesis of (+)-ibophyllidine in eight steps.
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高影响因子
SYNTHESIS-STUTTGART
·
2019
·Vol. 51
·期 21
·4048-4065
·
IF 2.867
Rui-Xiang Wang,Zhuang Fang,Guanyinsheng Qiu,Wenlin Xie,Jin-Biao Liu
The copper-catalyzed synthesis of 3-vinylisocoumarin-1-imine is reported. The transformation proceeds smoothly with good yields in THF and the regioselectivity was determined by a O-nucleophilic 6-endo cyclization. Studies on the mechanism indicate that copper trifluoroacetate serves as a Lewis acid, and the use of vinyl-connected 2-alkynylbenzamide is important for this O-nucleophilic 6-endo cyclization.
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高影响因子
SYNTHESIS-STUTTGART
·
2019
·Vol. 51
·期 15
·2923-2935
·
IF 2.867
Qinghe Wang,Dulin Kong,Tiao Huang,Mingshu Wu
An efficient synthetic strategy for anti-3,4-disubstituted phosphadihydrocoumarin compounds has been established by tandem aza-Michael–aldol-like annulations of tetrahydroisoquinolines with O-vinylphosphonylated salicylaldehydes as an aldo-vinyl bifunctional building block. This conversion was characterized by ‘green’ properties such as a step- and atom-economy, catalyst-free conditions, highly anti-selectivity, and readily available starting materials.
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高影响因子
SYNTHESIS-STUTTGART
·
2015
·Vol. 47
·期 23
·3751-3757
·
IF 2.689
Zhijie Li,Quan Wen,Lihong Zhou,Xingmei Deng,Qingle Zeng
The synthesis of highly important α-hydroxycarboxylic acid anilides via copper-catalyzed chemoselective C–N coupling reactions of α-hydroxyamides and aryl halides is described. This highly selective N-arylation process demonstrates wide substrate scope, cost savings and easy operation. In addition, the chirality of l-3-phenyllactamide is preserved during the reaction.
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高影响因子
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