Journal of Functional Biomaterials
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2025
·Vol. 16
·期 9
·346
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IF 5.2
Zexing Deng,Litong Shen,Qiwei Cheng,Ying Li,Tianming Du,Xin Zhao
The development of high-performance sensing materials is critical for advancing bioelectronics. Conductive hydrogels, with their unique flexibility, are promising candidates for biomedical sensors. However, traditional conductive hydrogels often suffer from excessive swelling and undesirable antibacterial activity, limiting their practical use. To overcome these challenges, anti-swelling, antibacterial, and ionically conductive hydrogels were built through free radical polymerization. The preparation was conducted using a monomer mixture comprising acrylic acid (AA), the antibacterial zwitterionic compound [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA), and the hydrophobic monomer lauryl methacrylate (LMA). The protonation of SBMA by AA enables electrostatic repulsion, thereby imparting anti-swelling properties to the hydrogel. The introduction of hydrophobic LMA components further enhances the anti-swelling and mechanical performance of hydrogel. The resulting hydrogel exhibits excellent anti-swelling property with a swelling ratio of 59.36% after 120 h and good mechanical performance with a tensile strength of 158 kPa, an elongation at break of 176%, and a compressive strength of 0.37 MPa at 80% strain. In addition, hydrogels possess superior sensing performance for strain sensing with a gauge factor of 1.315 within 40–60% of strain, 330 ms of response time, and 177 ms of recovery time. Furthermore, the hydrogel is capable of monitoring human motion and physiological signals. These attributes make it highly suitable for wearable sensors and biomedical monitoring applications.
研究领域:
材料科学
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生物医学工程
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传感器与执行器
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高分子化学
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可穿戴电子
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产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 9
·期 3
·882-891
·
IF 6.183
Zecong Xiao,Xinyao Zheng,Ying An,Kangning Wang,Junwen Zhang,Huacheng He,Jiang Wu
Growth factors (GFs) have been well known for their therapeutic effects on wound healing. Due to their vulnerable biostability, biomaterial carriers are usually used to deliver GFs to maintain their bioactivity. Among the carriers, PEG hydrogels are the most widely applied. But the uncontrolled release of GFs and their immunogenicity dramatically retard the application of PEG hydrogels as carriers of GFs. Herein, FGF2 loaded zwitterionic sulfobetaine methacrylate (SBMA) hydrogels were developed, and it was revealed that these hydrogels were more effective in delivering FGF2 for wound healing than were PEG hydrogels. In vitro studies demonstrated that SBMA hydrogels could successfully prolong the release of FGF2, which effectively maintained the bioactivity of FGF2. Further in vivo investigation showed that SBMA hydrogels could efficiently accelerate wound regeneration by promoting granulation tissue formation, collagen deposition, cell proliferation and migration, reepithelialization and angiogenesis. All results validated that SBMA hydrogels were promising substituents of PEG hydrogels for delivering FGF2 for wound regeneration.
研究领域:
生物材料
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组织工程
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伤口愈合
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Chang Sun,Yanchao Zhang,Fengmei Dong,Jianyi Zhao,Peipei Zhang,Shaohai Li,Yang Gao,Yuanrui Wang,Guanghui Gao
Medical catheters are highly susceptible to friction and infection when intervening or implanting in the body, and to thrombosis when in contact with blood. Coating medical catheters with lubricant and antibacterial hydrogel is an effective strategy but struggle to achieve. Here, hydrogel coating on the catheter surface with lubrication and antibacterial properties was constructed by the rapid polymerization of acrylamide (AAM) and sulfobetaine methacrylate (SBMA) in the presence of quaternary ammonium chitosan (QCS) based on the redox-based cross-linking method. First, the medical catheter surface was decorated with a polyethyleneimine (PEI) adhesive layer. The pre-gel solution was then applied to the catheter surface, followed by immersion in an aqueous FeSO 4 ·7H 2 O solution, where a large amount of SO 4 -• was generated by a redox reaction between ammonium persulfate (APS) and Fe 2+ , which rapidly triggered the monomer to cross-link to form the coating. Polyelectrolyte PEI as the adhesive layer could bind the coating to the substrate through hydrogen bonding interactions and confer antimicrobial properties to the coating with the assistance of QCS (antibacterial rate of 95.88 % against E. coli and 97.11 % against B. subtilis). The hydrogel coatings exhibited outstanding lubricity with a low coefficient of friction (COF ≈ 0.053) and excellent antifouling properties (resists non-specific protein adsorption, inhibits platelet adhesion and prevents thrombosis (The clotting time was extended from 25.6 s to 74.7 s)) based on the integration of SBMA. This work shed new light on the design of hydrogel coatings to achieve modification of the substrate surface.
研究领域:
生物材料
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生物医学工程
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材料科学
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表面化学
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产品关联
DOI
高影响因子
Biomaterials Advances
·
2024
·
IF 5.5
Lingtao Wang,Ruiting Xu,Lingjie Meng,Qiuyang Zhang,Zheng Qian,Jie Chen,Changjiang Pan
Although magnesium alloy has received tremendous attention in biodegradable cardiovascular stents , the poor in vivo corrosion resistance and limited endothelialization are still the bottlenecks for its application in cardiovascular stents. Fabrication of the multifunctional bioactive coating with excellent anti-corrosion on the surface is beneficial for rapid re-endothelialization and the normal physiological function recovery of blood vessels. In the present study, a bioactive hydrogel coating was established on the surface of magnesium alloy by copolymerization of sulfobetaine methacrylate (SBMA) and acrylamide (AM) via ultraviolet (UV) polymerization, followed by the immobilization of fucoidan (Fu). The results showed that the as-prepared multifunctional hydrogel coating could enhance the corrosion resistance and the surface wettability of the magnesium alloy surface, endowing it with the ability of selective albumin adsorption; meanwhile, it could augment biocompatibility. The following introduction of fucoidan on the surface could further improve the hemocompatibility characterized by reducing protein adsorption , minimizing hemolysis, and preventing platelet aggregation and activation. Additionally, the immobilized fucoidan promoted endothelial cell (EC) growth, as well as up-regulated the expression of vascular endothelial growth factor (VEGF) and nitric oxide (NO) in endothelial cells (ECs). Consequently, this research paves a novel approach to developing a versatile bioactive coating for magnesium alloy surfaces and lays a foundation in cardiovascular biomaterials .
研究领域:
材料科学
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生物医学工程
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心血管材料
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表面工程
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产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
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2023
·
IF 5
Yongming Zeng,Tianchi Xu,Xiao-Fang Hou,Jiang Liu,Changqing Liu,Zhaosen Chang,Jianglin Fang,Dongzhong Chen
To achieve convenient storage of bioactive materials such as protein enzymes (proteases) at ambient temperature, with both their spatial structure and biocatalytic activity well retained, is highly appealing but challenging. Herein, a variety of amphiphilic random copolymers have been well synthesized via reversible addition–fragmentation chain transfer (RAFT) copolymerization of sulfobetaine methacrylate (SBMA) and various length fluoroalkyl methacrylate monomers. By simultaneously introducing fluoroalkyl and zwitterionic segments in random copolymerization, such kinds of amphiphilic random copolymers combined the advantages of both polyzwitterionic and fluoropolymers, which were capable of constructing uniform tiny single-chain nanoparticles (SCNPs) of around 10 nm in a wide range of compositions and fabrication conditions from aqueous solutions. Through intramolecular self-folding of the fluorinated alkyl segments to constitute the compact inner cores and the superhydrophilic zwitterionic SBMA polymer segments forming the outer passivated layer, the thus obtained SCNPs exhibited remarkable enzyme stabilizing capability through morphological adjustment, hydration, and heterocoagulation mechanisms for the investigated glucose oxidase (GOx) and horse radish peroxidase (HRP), acting like artificial molecular chaperones. Moreover, enzyme catalytic activity enhancement in the HRP@SCNPs system was well demonstrated with a representative enzyme-catalyzed cascade oxidization reaction for the synthesis of an azobenzene chromophore. Therefore, this work provides a facile fabricating strategy for SCNPs from well-synthesized amphiphilic random copolymers via RAFT, which may serve as promising stabilizers for ambient temperature storage and activity preservation of proteases.
研究领域:
聚合物化学
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生物化学
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材料科学
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纳米技术
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产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Feng Guo,Yunen Liu,Kai Jiao,Rui Yang,Mingxiao Hou,Xing Zhang
Currently, the only treatment for moderate and severe aortic valve calcification disease is valve replacement. The clinical use of bioprosthetic heart valves (BHVs) is limited because of device failure caused by structural degeneration, such as the calcification of BHV leaflets. In the present study, poly(ethylene glycol) diacrylate (PEGDA) was incorporated with zwitterion (2-[methacryloyloxy]ethyl)dimethyl-(3-sulfopropyl) ammonium hydroxide (SBMA) forming a balanced charged network, which was further used to modify decellularized heart valves (DHV) and improve anticalcification properties. Valvular prostheses were designed and manufactured to comply with the requirements of ISO-5840 for valve fluid dynamics (i.e., effective orifice area = 1.9 cm2, regurgitant fraction = 1.5% for Φ25 mm surgical valve at heart stroke of 80 mL). Weight loss of artificial heart valves (PEGDA-SBMA-DHV) was less than 5.5% after enzymatic hydrolysis for 12 h. No obvious calcification was observed in artificial heart valves that were modified with PEGDA-SBMA, whereas calcification was found in decellularized heart valves and the PEGDA-modified group. Furthermore, histological staining results indicated that artificial heart valves (PEGDA-SBMA-DHV) with a balanced charged network elicited negligible inflammation. Thus, balanced charged networks of PEGDA-SBMA with cationic and anionic groups can prevent the transportation of Ca2+ ions and enzyme molecules, conferring efficient anticalcification properties to artificial heart valves.
研究领域:
生物医学工程
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材料科学
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心血管医学
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产品关联
DOI
PubMed
LANGMUIR
·
2021
·
IF 3.882
Chong Liu,Fang Cheng,Bo Liu,Dongdong Gao,Gang Cheng,Chunmei Li,Huanan Wang,Wei He
Surface-initiated polymerization is an attractive approach to achieve desired interfacial compositions and properties on a wide range of substrates and surfaces. Due to mild reaction conditions, multiple surface-initiated polymerization methods, such as atom-transfer radical polymerization (ATRP), reversible addition–fragmentation chain-transfer polymerization, and so forth, have been developed and studied in academia and industry. However, the current methods require the combination of metal catalysts, special initiators, and oxygen removal. Herein, we developed a surface-initiated carbanion-mediated anionic polymerization (SI-CMAP), which can be conducted in aqueous solutions in the presence of oxygen without the need for metal catalysts. Zwitterionic 2-(N-3-sulfopropyl-N,N-dimethyl ammonium)ethyl methacrylate (SBMA) was selected as a model monomer to develop and demonstrate this strategy. The vinyl sulfone (VS) groups displayed on substrate surfaces reacted with N-methylimidazole (NMIM), which was used as the in situ initiator. The polymerization mechanism was extensively studied from many aspects at room temperature, including the changes in reaction conditions, factors affecting the polymerization extent, and substrate surfaces. We also demonstrated the compatibility of this method with a broad spectrum of monomers ranging from SBMA to other acrylates and acrylamides by using glycine betaine as a reaction additive. This method was also evaluated for the preparation of polymer-coated nanoparticles. For polymer-coated silica nanoparticles, their hydrodynamic diameter, copper contamination, and effects of salt and protein concentrations were compared with SI-ATRP in parallel. SI-CMAP in aqueous solutions in air and the absence of metal catalysts make this method sustainable and cost-effective. We believe that SI-CMAP can be readily adapted to the industrial surface coating and large-scale nanoparticle preparation under mild conditions.
研究领域:
聚合物化学
·
材料科学
·
表面科学
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Meijun Chen,Kun Lei,Pengshan Guo,Xin Liu,Pengchao Zhao,Meng Han,Bianyun Cai,Guangda Li,Jinghua Li,Jingqiang Cui,Xinling Wang
Construction of highly stretchable and sensitive flexible strain sensors is of great significance for wide applications in human–computer interaction, wearable devices, and electronic skins. However, it turned out to be not effortless to integrate the two seemingly contrary features of high stretchability and sensitivity into a system. Herein, we designed a nanocomposite conductive hydrogel (NCCH) composed of zwitterionic poly(HEAA-co-SBMA) polymers and lithium magnesium silicate (XLG) by means of multi-reversible molecular interactions (MRMIs) including borate ester bonds between polyHEAA and borax, hydrogen bonds , and polySBMA-XLG-based electrostatic interaction, endowing the NCCH with enhanced mechanical, self-healing, adhesive, biocompatible, and sensing performances. The MRMI method enabled NCCHs to obtain an excellent stretchability (∼1080 %)/compressibility (∼98.5 %), a tensile strength of ∼ 0.06 MPa, a good self-healing with a fracture strain recovery of 90.5 %, and a strong adhesion on various hard and soft substrates (e.g. a adhesive shear force of 60 kPa to pigskin tissues). Besides, the integration of zwitterionic polySBMA and conductive XLG promoted charge transfer. by optimal ioinic channels. Based on these outstanding strengths, the NCCHs were farther rationally fabricated as multifunctional strain sensors with remarkable sensing stability for fast and accurately detecting strain/pressure-induced deformation, joint motions, and animal heartbeats. Notably, the excellent self-healing property of NCCH sensors can facilitate their long-period usage and complete recyclability for avoiding wastes. The new MRMI-based NCCH sensor without any conductive additives is deemed to provide a new strategy for broadening their multifunctional strain sensor and healthcare monitoring applications.
研究领域:
材料科学
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纳米技术
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传感器
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生物医学工程
·
可穿戴设备
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）