ADVANCED ENGINEERING MATERIALS
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2026
·
IF 3.6
Zexin Liu,Danfeng Du,Xinfeng Nie,Chaowei Sun,Lulu Qiao,Zewei Hao,Xiurong Guo
The energy-absorbing box plays an important role in energy absorption and buffering during the collision of automobiles, but traditional energy-absorbing boxes rely on their aluminum alloy shells for energy dissipation. In this study, TaC-reinforced aluminum foam composite (AT-FC) was filled into an aluminum alloy square tube to design a new type of structure for an energy-absorbing box. The effects of TaC particle content, Ti powder content, and wood fiber content on the yield stress and plateau stress of the composites were optimized using response surface methodology. The optimized composite containing 10.52% TaC exhibited a more uniform pore structure and improved energy absorption behavior. Through a combination of finite element simulation and actual testing, the stress changes and energy absorption state of energy-absorbing boxes under quasi-static compression and dynamic impact are explored. The energy absorption performance of the AT-FC-filled energy-absorbing box is better than that of Al foam-filled energy-absorbing boxes and unfilled energy-absorbing boxes. In low-speed impact, the energy absorption capacity of the AT-FC-filled energy-absorbing box can reach 35 MJ/m 3 , which is 34.6% higher than the unfilled energy-absorbing box and 20.7% higher than the Al foam-filled energy-absorbing box. These findings demonstrate that AT-FC is a promising lightweight energy-absorbing material for crash-box applications.
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DOI
高影响因子
MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Xinya Ma,Yingqi Ou,Zequn Jiang,Junqiang Qiu,Dan Zhou,Dan Xu
Antioxidants are effective in scavenging free radicals in the human body and the intake of antioxidant-rich foods in the daily diet can help prevent diseases. In order to classify antioxidant-containing beverages and control food quality, our project develops a rapid, widely applicable, and accurate method to determine the total antioxidant capacity (TAC) in beverages. 3D honeycomb-like nitrogen-doping carbon nanozymes were successfully prepared by the template-free and pyrolysis methods. A series of instruments were employed to investigate the morphology, composition and pore structure information of carbon nanozymes. Among them, NC-900 with its rich mesoporous structure was capable of rapidly transferring electrons to catalyze the oxidation of TMB by H 2 O 2 . NC-900 exhibited the best peroxidase-like activity at pH 4, reaction time of 10 min, and enzyme concentration of 26 µg/mL. The maximal reaction rate of NC-900 towards substrates TMB and its affinity for H 2 O 2 were higher than that reported carbon nanozymes. Using reductants such as AA as antioxidant models, the NC-900-based sensor was characterized by wide detection range, low detection limit and high selectivity. The successful use of this approach to assess TAC in commercial beverages broadened the conceivable applications of carbon nanozymes. The present method shows a broad application prospect of carbon nanozyme in food analysis and human health.
研究领域:
食品科学
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生物化学
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材料科学
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DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
XianYue Jiang,CaiXia Huo,HongFei Chen,NingKun Liu,KaiJiao Li,JianCheng Wang,Na Zhu,Shuo Yu,AiJun Li,Qixian Zhang,Suxuan Du
Three kinds of spraying powders with different mole ratio: #3 (TaC:ZrC:SiC = 0.6:1.2:3), #2 (TaC:ZrC:SiC = 0.6:1.2:2), #1 (TaC:ZrC:SiC = 0.6:1.2:1) were prepared by spray granulation. TaC-ZrC-SiC (TZS) multicomponent composite coatings were prepared on C/C composites with SiC coating by atmospheric plasma spraying. The ablation behavior and anti-ablation mechanism of TZS multi-component composite coating were investigated by using 4.2 MW/m 2 oxyacetylene flame. After ablation, the TZS coating presents three different ablated morphologies: ablated center region, ablated transition region and ablated edge region. In the ablation edge region, a protective SiO 2 -encapsulated TaC/ZrC core-shell structure formed, while the transition region was dominated by Ta 2 Zr 6 O 17 composite oxide generated through solid-phase reaction between Ta 2 O 5 and ZrO 2 . Notably, the TZS-#3 coating exhibited no peeling in its ablation center, demonstrated the lowest mass ablation rate among the three coatings, and ultimately showed superior ablation resistance.
研究领域:
材料科学
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陶瓷涂层
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高温材料
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烧蚀防护
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DOI
高影响因子
CARDIOVASCULAR DRUGS AND THERAPY
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2026
·
IF 3.5
Sha Lei,Du Anning,Xu Xiaoying,Li Zhu,Xu Biao,Kang Lina
Purpose Mitochondrial dysfunction and cardiomyocyte death drive pressure overload-induced heart failure (HF). N-lactylphenylalanine (N-Lac-Phe) plays an important role in the myocardial metabolic network after infarction. However, its role in chronic pressure overload heart failure remains unclear. This study examines N-Lac-Phe’s effects on cardiac function in transverse aortic constriction (TAC)-induced heart failure and mitochondrial function in Angiotensin II (Ang II)-injured H9c2 cardiomyoblasts. Methods Human plasma Lac‑Phe levels were measured by liquid chromatography-mass spectrometry (LC-MS) and correlated with heart failure. In mice, echocardiography and other methods assessed the impact of Lac‑Phe on cardiac function, H9c2 cardiomyoblasts, and mitochondria. In vitro, H9c2 cells were treated with Ang II and Lac‑Phe, followed by analysis of apoptosis and mitochondrial dysfunction using immunoblotting and fluorescent staining. Results Plasma Lac‑Phe levels were negatively correlated with cardiac function. In TAC‑induced heart failure mice, Lac‑Phe administration improved cardiac function, attenuated myocardial injury including fibrosis, hypertrophy, apoptosis and ferroptosis, and alleviated the downregulation of MFN2. In Ang II‑injured H9c2 cardiomyoblasts, Lac‑Phe reduced apoptosis, restored mitochondrial function, and upregulated p‑AMPK, PGC‑1α and MFN2 expression. Conclusion N-Lac-Phe correlates with cardiac function and improves TAC-induced heart failure by reducing apoptosis, ferroptosis, and mitochondrial damage. It may attenuate Ang II-induced apoptosis and mitochondrial dysfunction via the AMPK/PGC-1α/MFN2 axis.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Ximing Duan,Jiale Zheng,Pengfei He,Shujun Hu,Chuan Sun,Zhenfeng Hu,Fengchun Jiang,Zenghua Liu,Xiubing Liang
Enhancing the ablation resistance of ultra-high temperature ceramics based on the solid-liquid theory has become a research hotspot in the field of thermal protection. In this study, HfC-TaC micron composite powders were prepared using spray granulation, and a solid-solution (Hf, Ta)C coating was deposited on the Ta10W substrate through the dual solid-solution effect of radio frequency inductively coupled plasma spheroidization and supersonic atmospheric plasma spraying. The phase composition, microstructure, ablation resistance, and underlying mechanisms of the coating were investigated. The results indicate that after ablation for 200 s at 2200 °C and 2300 °C, the high melting point solid-phase products, HfO 2 and Hf 6 Ta 2 O 17 , serve as structural skeletons, while the liquid-phase Ta 2 O 5 acts as a filler, collectively protecting the Ta10W substrate from oxidation and ablation.
研究领域:
材料科学
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陶瓷
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热防护系统
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等离子喷涂
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高温材料
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产品关联
DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
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2021
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IF 7.664
Hongtao Guo,Feng Wang,Heng Luo,Yang Li,Zhichao Lou,Yuan Ji,Xueyu Liu,Bin Shen,Yuhui Peng,Kunming Liu,Shaohua Jiang
Efficient, flexible, thin, and easy processing electromagnetic interference (EMI) performance materials attract attention to prevent increasingly electromagnetic pollution. Herein, we fabricated multiple spatial-scale conductive frameworks containing tantalum carbide (TaC) nanoparticles by electrospinning and high-temperature pyrolysis. The electrospun composite fabrics possess outstanding properties such as an excellent tensile strength of 9.5 MPa and excellent flexibility. Furthermore, the TaC nanoparticles with appropriate concentration can interconnect with each other endowing the composite fabrics with high electrical conductivity of 10.4 S cm −1 . It also has great EMI SE of up to 37.7 dB in X band with only 0.2 mm thickness, and the SSE/t values of 4290.1 dB cm 2 g −1 . Owing to its pore structure, the shielding mechanism is mainly based on reflection and the finite element simulation further visually confirmed the excellent shielding capabilities. This novel electrospun composite fabrics have a great potential to be applied in fields of aerospace, and electronic devices.
研究领域:
材料科学
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电子工程
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DOI
高影响因子
PHARMACEUTICAL BIOLOGY
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2021
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IF 3.503
Yue Cui,Yongqiang Wang,Gang Liu
Context Epigallocatechin gallate (EGCG) is the most abundant catechin from tea. Previous studies have indicated EGCG has a cardioprotective effect.Objective This manuscript mainly explores the role of EGCG in pressure-overload cardiac hypertrophy and its mechanism related to the Akt/mTOR pathway.Methods and methods Transverse aortic constriction (TAC) was utilized to establish the cardiac hypertrophy mice model. C57BL/6 mice were assigned into 6 groups. Starting from the first day after surgery, mice received different doses of EGCG (20, 40, 80 mg/kg) or vehicle orally for four weeks. Heart weight to body weight (HW/BW) ratio and heart weight to tibia length (HW/TL) ratio as well as hematoxylin-eosin staining were utilized to evaluate cardiac hypertrophy. Masson’s trichrome and Sirius red staining were used to depict cardiac fibrosis. The expressions of fibrosis and hypertrophy-related markers and Akt/mTOR pathway were quantified by western blot and qRT-PCR.Results EGCG significantly attenuated cardiac function shown by decreased HW/BW (TAC, 6.82 ± 0.44 vs. 20 mg/kg EGCG, 5.53 ± 0.45; 40 mg/kg EGCG, 4.79 ± 0.32; 80 mg/kg EGCG, 4.81 ± 0.38) and HW/TL (TAC, 11.94 ± 0.69 vs. 20 mg/kg EGCG, 11.44 ± 0.49; 40 mg/kg EGCG, 8.83 ± 0.58; 80 mg/kg EGCG, 8.98 ± 0.63) ratios as well as alleviated cardiac histology. After treatment, hemodynamics was improved, cardiac fibrosis was attenuated. The activated Akt/mTOR pathway was inhibited by EGCG.Discussion and conclusions EGCG plays a protective role in the TAC model by regulating the Akt/mTOR pathway, which provides a theoretical basis for its clinical treatment.
研究领域:
心脏病学
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药理学
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分子生物学
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS CHEMISTRY
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2011
·Vol. 21
·期 25
·9095-9102
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IF 5.101
Xinyong Tao,Yiping Li,Jun Du,Yang Xia,Yingchao Yang,Hui Huang,Yongping Gan,Wenkui Zhang,Xiaodong Li
Finding a general procedure to produce a whole class of materials in a similar way is a desired goal of materials chemistry. In this work, we report a new bamboo-based carbothermal method to prepare nanowires of covalent carbides (SiC and B4C) and interstitial carbides (TiC, TaC, NbC, TixNb1−xC, and TaxNb1−xC). The use of natural nanoporous bamboo as both the renewable carbon source and the template for the formation of catalyst particles greatly simplifies the synthesis process. Based on the structural, morphological and elemental analysis, volatile oxides or halides assisted vapour–liquid–solid growth mechanism was proposed. This bamboo based carbothermal method can be generalized to other carbide systems, providing a general, one-pot, convenient, low-cost, nontoxic, mass production, and innovative strategy for the synthesis of carbide nanostructures.
研究领域:
材料化学
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纳米材料科学
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高影响因子
Advanced Science
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2024
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IF 14.3
Zhenming Tian,Han-Jian Hu,Chun Cheung Chan,Tian Hu,Chaoyang Cai,Hong Li,Limin Rong,Gang-Biao Jiang,Bin Liu
In the realm of neural regeneration post-spinal cord injury, hydrogel scaffolds carrying induced neural stem cells (iNSCs) have demonstrated significant potential. However, challenges such as graft rejection and dysfunction caused by mitochondrial damage persist after transplantation, presenting formidable barriers. Tacrolimus, known for its dual role as an immunosuppressant and promoter of neural regeneration, holds the potential for enhancing iNSC transplantation. However, systemic administration of tacrolimus often comes with severe side effects. This study pioneers the development of a self-healing hydrogel with sustained-release tacrolimus (COCu-Tac), tailored specifically for iNSC transplantation after spinal cord injury. This research reveals that the sustained release of tacrolimus enhances axonal growth and improves mitochondrial quality control in iNSCs and neurons. Further analysis shows that tacrolimus targets FKBP52 rather than FKBP51, enhancing mitophagy via the FKBP52/AKT pathway. This advanced system demonstrates significant efficacy in promoting neural regeneration and restoring motor function following spinal cord injury.
研究领域:
神经科学
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再生医学
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药理学
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2024
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IF 8
Chen Sun,Yutong Ye,Xueting Luo,Wentao Xiang,Cao Li,Bingbing Jiang,Xiaoying Wang,Ziqiang Xu
Total antioxidant capacity (TAC) is a significant indicator for evaluating nutritional value of fruit and beverage industries, in the aspects of their reactive oxygen species (ROS) scavenging activity. The sensitivity and selectivity of the TAC assay based on the peroxidase (POD) assay is restricted by their poor catalytic activity. Herein, a simple and sensitive strategy for assessing TAC in fruits based on light (808 nm) boosted POD like activity of Au 25 nanoclusters (NCs) have been reported. The absorption bands of mercaptohexanoic acid (MHA)-protected Au 25 NCs could be extended into the near-infrared region (∼770 nm) by introducing neutrally charged ligands or 2,2’(ethylene dioxy) diethyl thiol (EDT)) as bi-thiol ligands, which may contribute to more obvious light enhanced POD activity. The most intense absorption at 770 nm can be obtained by the ratio of MHA/EDT=1.7:0.3 (denoted as MEA-17). Since we have confirmed that ROS is involved in the light enhanced POD like activity, the concentration of various antioxidants AA, GSH and L-Cys, can be analyzed by their inhibitory effect to the oxidation of TMB. More importantly, light enhanced POD like activity of MEA-17 have been successfully utilized to analysis TAC value in various fresh fruits. This work not only provide novel direction for the rational development of near-infrared light-enhanced POD-like nanozyme, but also further expands the prospect of the application of Au 25 NCs protected with thiols for TAC analysis.
研究领域:
纳米技术
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分析化学
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生物技术
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DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
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2023
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IF 4.7
Xiaoda Wang,Yuqing Zhao,Lumin Han,Ling Li,Anton A. Kiss
Cylcohexanol is an essential bulk chemical that can be produced via cyclohexene hydration, a liquid-liquid two-phase reaction that is limited by the low reaction rate and the equilibrium conversion. Adding an appropriate solvent is the most promising method to break through these limitations. However, in previous works the solvent was almost blindly selected without a global consideration. In this work, a rational multiscale method is proposed for the effective selection of an economical and sustainable solvent for the direct hydration of cyclohexene. At the molecular scale, liquid-liquid phase equilibrium was estimated using group contribution methods to rapidly screen the potential solvent candidates from a range of organics, based on the partition coefficient. At the reactor scale, the candidates were experimentally investigated to pick out the solvents that could significantly improve the conversion, without introducing side reactions or deactivating the catalyst. At the process scale, the total annual cost (TAC), CO 2 emission, and other metrics were calculated to evaluate the eco-efficiency of all solvents. Using this multi-scale method, acetophenone was selected as an eco-efficient solvent from over 100 organics, resulting in the reduction of TAC by 8 % and CO 2 emission by 17 % in the production process. Using acetophenone also led to the increase of cyclohexanol yield from 12.3 % to 27.6 % without the occurrence of side reactions and catalyst deactivation.
研究领域:
化学工程
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可持续化学
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过程系统工程
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DOI
高影响因子
Journal of Cardiovascular Translational Research
·
2025
·
IF 2.5
Hou Xiaolu,Hu Guoling,Wang Heling,Yang Ying,Sun Qi,Bai Xiuping
Heart failure (HF) is a clinical syndrome caused by structural or functional abnormalities in heart. Egr2 has been reported to be protective for multiple diseases, but its effect on HF remains unknown. The present study intended to investigate the potential role of Egr2 in HF and its possible downstream effectors. High Egr2 expression in heart was observed in HF mice. Egr2 knockdown alleviated cardiac damage and function in HF mice. Egr2 knockdown inhibited myocardial inflammation and apoptosis both in vivo and in vitro. Egr2 inhibited Acot1 transcription expression via directly binding to its promoter. Acot1 overexpression reduced Lipopolysaccharide (LPS)-induced cardiomyocyte inflammation and apoptosis. Functional rescue experiments revealed that Acot1 reversed the effects of Egr2 on LPS-induced cell apoptosis and inflammation. Overall, Egr2 knockdown might ameliorate HF by inhibiting inflammation and apoptosis in cardiomyocytes by targeting Acot1. This study might provide evidence to better understand the molecular mechanisms of HF pathogenesis. Graphical Egr2 knockdown might ameliorate HF by inhibiting inflammation and apoptosis in cardiomyocytes, possibly through Acot1.
研究领域:
心血管生物学
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分子医学
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DOI
PubMed
高影响因子
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