DYES AND PIGMENTS
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2023
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IF 4.5
Zixuan Zhao,Qinghua Hu,Wenjuan Liu,Xuerui Xiong,Zhiyong Wang,Hongqing Wang
In this work, we aimed to construct a sensitive and convenient sensor for trace amounts of water detection in highly polar organic solvents . We designed and synthesized four D-π-A structure sensors DTA-2QA-OH, TPA-2QA, TPA-2QA-OH, and TPA-4QA-OH by adjusting the electron donor and the linking site of the electron acceptor . The TPA-2QA-OH synthesized by connecting hydroxylated triphenylamine and quinolinium at position 2C can be used as a sensitivity sensor for trace amounts of water detection in highly polar organic solvents by using Na 2 HPO 4 as a deprotonation reagent. TPA-2QA-OH can detect trace amounts of water in DMSO, MeOH, and EtOH in both colorimetric and near-infrared fluorescence modes. The significant color change of the sensing systems was captured by a smartphone and analyzed by using the PhotoMetrix APP to construct a standard curve between RGB values and water content in solvents. The detection limit of the sensor TPA-2QA-OH for trace amounts of water by using colorimetric, fluorescent, or smartphone methods were calculated as low as 0.0009% vol in DMSO, 0.0064% vol in MeOH, and 0.0014% vol in EtOH, respectively. For the first time, the influence of the connection site of quinolinium on the photophysical properties and detection performance of the sensor was found. The conjugation of the electron donor groups as well as the introduction of hydroxyl groups on the electron donor are important for the construction of D-π-A structure colorimetric and fluorescence ICT sensors for trace water detection in highly polar organic solvents.
研究领域:
分析化学
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材料科学
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高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2023
·Vol. 41
·期 23
·3245-3252
·
IF 5.4
Yuehua Zhao,Hongbo Chen,Shaojie Geng,Shunjie Liu,Dapeng Wang
Comprehensive Summary Here, we combined the photon antibunching analysis, fluorescence correlation spectroscopy, and time-domain fluorescence lifetime imaging microscopy (TD-FLIM) to study the emission properties of a representative AIE-luminogen—4,4’-(benzo[ c ][1,2,5] thiadiazole-4,7-diyl)bis( N , N -diphenylaniline) (TPA-BT) at the single emitter level in a tetrahydrofuran (THF)/water solution where water is a non-solvent for TPA-BT. Our findings suggest that, at a constant water fraction in the solution, the size of TPA-BT aggregates increases with the TPA-BT concentration; TPA-BT aggregates are not a quantum emitter at room temperature in the solution. Moreover, utilizing TD-FLIM and a gel trapping technique allowed us to study the fluorescence lifetime of individual TPA-BT aggregates. Adding a polar solvent like water does not result in an overall decrease in fluorescence lifetime. Rather, it causes the fluorescence lifetime distribution to become wider, and only some molecules experience a decrease in their fluorescence lifetime. These results could represent a step forward in further understanding the photophysics of AIE-luminogens.
研究领域:
光学
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化学
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高影响因子
Catalysis Science & Technology
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2026
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IF 4
Qiao Zeng,Jinshan Chen,Chi Wang,Kai Li,Yi Mei
Photocatalytic reduction of CO2 into CH4 represents a sustainable strategy for carbon recycling, yet achieving efficient multi-electron transfer and selective C–H bond formation remains challenging. Herein, we construct a cooperative multi-interfacial photocatalytic system by integrating copper phthalocyanine (CuPc) and photodeposited Pt nanoparticles onto a TiO2@TPA hybrid. The TiO2@TPA framework, derived from MIL-125 hydrolysis, provides robust Ti–O–C linkages and intrinsic ligand-to-metal charge transfer (LMCT) channels, while CuPc extends visible-light absorption and facilitates interfacial electron delocalization and migration through its π-conjugated macrocycle. Pt nanoparticles exhibit dual functionality—as electron sinks on TiO2 for multi-electron CO2 reduction and as interfacial bridges promoting charge transfer between TiO2 and CuPc. Comprehensive spectroscopic and photoelectrochemical analyses confirm efficient carrier separation, accelerated interfacial charge transfer, and strong electronic coupling at the heterointerfaces. The optimized TiO2@TPA(15Pt,5Cu) catalyst achieves a CH4 evolution rate of 199.2 μmol·g-1·h-1 with 99.9% selectivity, markedly outperforming single-component or monometallic counterparts. In-situ FTIR spectroscopy reveals successive *COOH, *CO, *CHO, and *CH intermediates, validating the multi-step hydrogenation mechanism. This work extends LMCT-based interface engineering toward deep CO2 methanation, offering new insights for the rational design of highly efficient and selective multi-electron photocatalysts.
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JOURNAL OF FLUORESCENCE
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2025
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IF 3.1
Wei Siyi,Xu Yanqing,Long Qian,Xie Haotian,Wu Wenqi,Chen Xueke,Lin Yan,Cui Hanfeng F.
Cysteine (Cys) plays a critical role in both physiological and food domains, with abnormal levels being closely linked to various diseases. Therefore, the development of highly selective and sensitive detection methods is essential. In this study, a “On-off” fluorescent probe, TPA-DNBS, based on a triphenylamine (TPA) derivative, was designed. Compared to traditional probes, TPA-OH offers greater rigidity, stronger conjugation, and a larger Stokes shift, demonstrating superior signal-to-noise ratio and detection stability in complex biological and environmental samples. The probe exhibits specific response to Cys via a photo-induced electron transfer (PET) mechanism: in the presence of Cys, the DNBS quencher group is cleaved, leading to a significant increase in fluorescence. The probe shows excellent detection performance, with a linear range from 1 × 10⁻³ M to 1 × 10⁻⁹ M and a detection limit as low as 1.05 nM, along with good selectivity, interference resistance, stability, and reproducibility. In practical sample analysis, the recovery rates of spiked Cys in milk and mineral water were 99.7%–106.6% and 102.1%–103.3%, respectively, with relative standard deviations below 2.5%. These results indicate the broad applicability of the probe in complex samples.
研究领域:
分析化学
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生物成像
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传感器与探针
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食品分析
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环境监测
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DOI
PubMed
高影响因子
Journal of Physical Chemistry C
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2022
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IF 4.177
Hui Peng,Ye Tian,Xinxin Wang,Tiantian Dong,Zongmian Yu,Yonghao Xiao,Zhenheng Zhang,Jianping Wang,Bingsuo Zou
Recently, low-dimensional metal halides (LDMHs) have attracted tremendous attention due to their fascinating optoelectronic properties. Here, we report an organic–inorganic hybrid Cu(I)-based metal halide of (TPA)CuCl2 (TPA+ = tetrapropylammonium cation), where the isolated [CuCl2]− units are surrounded by TPA+, thus forming a zero-dimensional block. Moreover, the as-synthesized compound shows a broad green emission with a photoluminescence (PL) quantum efficiency of 91.8% and a large Stokes shift of 230 nm, stemming from the self-trapped exciton (STE) transition. Variable-temperature Raman spectra reveal that there is a strong anharmonic electron–phonon coupling in (TPA)CuCl2, which provides clear evidence for the formation of STEs, and this is also supported by the temperature-dependent PL spectra of (TPA)CuCl2. Moreover, it was found that TPA+ not only works as a ligand but also participates in the STE emission. Our results provide a clear statement that the formation of the STE is related not only to the low-frequency phonon of [CuCl2]− clusters but also to the mid-infra vibration of organic molecules, which promotes the understanding of the emission mechanism of LDMHs.
研究领域:
材料科学
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光学
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物理化学
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高影响因子
MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Xiaoyong Tian,Yu Zhang,Kezhen Zhang,Nan Wang,Huaping Wang,Hongyao Xu,Shanyi Guang
A new fluorescent probe TPA-DAP with aggregation-induced emission ( AIE ) characteristic based on 2,6-pyridinedicarboxylic acid was synthesized for the detection of paramagnetic ions (Cu 2+ , Co 2+ , Ni 2+ ). In the DMF/PBS (5:95, v/v, pH = 7.40) solvent mixture, the fluorescence intensity exhibited a notable enhancement of over 3-fold when compared to DMF alone. Concurrently, fluorescence quenching phenomena were observed in the presence of Cu 2+ , Co 2+ , and Ni 2+ , with corresponding detection limits measured at 56.4 nM, 22.4 nM, and 26.5 nM, respectively. These detection limits were found to be lower than the prescribed thresholds for Cu 2+ in Class I groundwater and Co 2+ , Ni 2+ in Class III groundwater, multi-functional detection was possible. The coordination constants were 9.07 × 10 5 , 3.63 × 10 5 and 5.69 × 10 5 , respectively. However, in the DMSO system, the probe will be highly selective in the presence of solvent shielding effects. The probe showed more than 10-fold enhancement of fluorescence intensity in DMSO/Tris-HCl (5:95, v/v, pH = 7.00) compared to DMSO and specific detection of Cu 2+ with a detection limit of 36.7 nM and a coordination constant of 4.35 × 10 5 , and was cyclically detectable in the presence of EDTA. TPA-DAP was applied for the detection of Cu 2+ in actual water samples and showed good biocompatibility and recyclability, making it suitable for water testing and test paper experiments, and also for a wide range of applications in the identification of Cu 2+ , Co 2+ , Ni 2+ and other bioassays in cells and zebrafish. Solvents could be selected according to actual test requirements.
研究领域:
分析化学
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生物医学
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环境科学
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高影响因子
Biomed Research International
·
2021
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IF 3.411
Si Wen,Mengke Sun,Li Ye,Bin Yang,Lizhi Hu,Mao-Qiang Man
The benefits of emollients for eczematous dermatitis and psoriasis have been thought to be due to the improvements in epidermal function, including epidermal permeability barrier, stratum corneum hydration, and stratum corneum pH. We determined here whether emollient can direct inhibit cutaneous inflammation. Ear inflammation was induced by topical application of either 12-O-tetradecanoylphorbol-13-acetate (TPA) or 1-fluoro-2,4-dinitrofluorobenzene (DNFB). Either 1% hydrocortisone cream or the novel emollient was applied to the right ear of the mice 45 min and 2 hours after TPA or DNFB application. The untreated left ear served as untreated controls. Both ear weight and ear thickness were measured 24 hours after TPA and DNFB application. Topical applications of either hydrocortisone cream or emollient significantly decreased both ear thickness and ear weight in comparison to untreated controls. In DNFB model, hydrocortisone significantly lowered expression levels of mRNA for IL-1α, IL-1β, and TNFα, while the emollient markedly decreased expression levels of IL-1α and TNFα mRNA. In TPA model, both hydrocortisone and emollient significantly decreased expression levels of IL-1α, IL-1β, IL-6, and TNFα mRNA. In parallel, inflammatory infiltration was also reduced by topical applications of either hydrocortisone or emollient. These results demonstrate that this novel emollient can directly inhibit cutaneous inflammation in murine models of both acute irritant contact dermatitis and acute allergic contact dermatitis. However, whether this emollient could also alleviate eczematous dermatitis in humans remains to be explored.
研究领域:
皮肤病学
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免疫学
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药理学
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DOI
PubMed
高影响因子
Journal of Functional Foods
·
2019
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IF 3.197
Junlei Liu,Huarong Huang,Zebin Huang,Yuran Ma,Lanyue Zhang,Yan He,Dongli Li,Wenfeng Liu,Susan Goodin,Kun Zhang,Xi Zheng
Eriocitrin is a flavonoid that is isolated from orange peel. Resveratrol is a polyphenol compound, which is present in various fruits, such as grapes. The aim of the present study was to investigate both in vitro and in vivo anti-inflammatory effects of eriocitrin combined with resveratrol using lipopolysaccharide (LPS)-induced RAW264.7 cells and a mouse model of ear edema. The results showed that eriocitrin combined with resveratrol strongly inhibited LPS-induced secretion of nitric oxide (NO), tumor necrosis factor-α (TNF-α), and Interleukin-1β (IL-1β). Moreover, Eriocitrin combined with resveratrol potently inhibited nuclear factor-κB (NF-κB), phosphor-STAT3, and phosphor-AKT, which was accompanied by inhibition of phosphorylation in mitogen-activated protein kinase (MAPK) signaling pathways . Treatment with eriocitrin combined with resveratrol alleviated edema and subcutaneous tissue inflammation caused by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vivo . This study also demonstrated that treatment with eriocitrin and resveratrol decreased the levels of the pro-inflammatory cytokines TNF-α and IL-1β. The results of the present study indicate that eriocitrin combined with resveratrol effectively inhibits inflammatory responses both in vitro and in vivo .
研究领域:
药理学
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免疫学
·
细胞生物学
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DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
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2024
·
IF 3.9
Dandan Li,Wenrong Zhao,Gang Li,Yan Xu,Liang Xu,Bo Tang
Graphical Two novel star-shaped fluorophores named PDI−S and PDI−Se are constructed by S/Se-fused perylene diimides (PDIs) connected with bicarbazole core. Particularly, PDI−S presents excellent two-photon absorption cross-action (δ TPA ) of 3775 GM excited with 800 nm light, which is the highest value based on PDIs motif in the NIR−I region (700–900 nm). Two-photon absorption (TPA) has attracted growing attention over recent years owing to the wide range of applications in organic nonlinear optical (NLO) materials. The quantitative sensitivity of a two-photon molecular entity is determined by its TPA cross-section (δ TPA ). Perylene diimides (PDIs) are excellent n-type organic semiconductor materials demonstrating distinguished thermal, optical, and chemical stability. Nonetheless, PDIs-based scaffolds exhibit poor δ TPA in the NIR−I region (700–900 nm) due to the lack of suitable molecular design. Here, two novel star-shaped PDIs fluorophores, namely PDI−S and PDI−Se, were constructed by four periphery S/Se-fused PDIs connected with bicarbazole core. PDI−S manifested excellent δ TPA of 3775 GM, which are among the highest values reported for PDIs excited in the NIR−I region.
研究领域:
有机化学
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材料科学
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DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
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2020
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IF 6.182
Bin Shang,Yuan Zhan,Min Chen,Limin Wu
Although quite some self-healing coatings have been reported to date, underwater healable coatings were involved very limited. Here, we report a novel underwater healable superoleophobic coating through depositing functional SiO 2 @ [email protected] particles on the TPA/EVA-70% film. The obtained coating not only possess excellent underwater superoleophobic and antifouling properties, but also quick healable performance by remote NIR irradiation. Thus, it may provide stable and long-lasting underwater antifouling properties against marine growth and oil contamination.
研究领域:
材料科学
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表面化学
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海洋技术
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高影响因子
CARBOHYDRATE POLYMERS
·
2023
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IF 11.2
Shengchang Tao,Yuchen Song,Shaobo Ding,Ruirong He,Qiankun Shi,Fang Hu
Photodynamic therapy (PDT) eradicates tumors via the generation of toxic reactive oxygen species (ROS) by activation of a photosensitizer (PS) with appropriate light. Local PDT toward tumors can trigger the immune response to inhibit distant tumors, but the immune response is usually insufficient. Herein, we used a biocompatible herb polysaccharide with immunomodulatory activity as the carrier of PS to enhance the immune inhibition of tumors after PDT. The Dendrobium officinale polysaccharide (DOP) is modified with hydrophobic cholesterol to serve as an amphiphilic carrier. The DOP itself can promote dendritic cell (DC) maturation. Meanwhile, TPA-3BCP are designed to be cationic aggregation-induced emission PS. The structure of one electron-donor linking to three electron-acceptors endows TPA-3BCP with high efficiency to produce ROS upon light irradiation . And the nanoparticles are designed with positively charged surfaces to capture antigens released after PDT, which can protect the antigens from degradation and improve the antigen-uptake efficiency by DCs. The combination of DOP-induced DC maturation and antigen capture-increased antigen-uptake efficiency by DCs significantly improves the immune response after DOP-based carrier-mediated PDT. Since DOP is extracted from the medicinal and edible Dendrobium officinale , the DOP-based carrier we designed is promising to be developed for enhanced photodynamic immunotherapy in clinic.
研究领域:
癌症治疗
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免疫学
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药学
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生物技术
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DOI
PubMed
高影响因子
ChemistrySelect
·
2026
·Vol. 11
·期 25
·e73786
·
IF 2.3
Han Li,Ziqiang Wan,Zhaojiang Yin,Qian Long,Yanqing Xu,Xueke Chen,Hanfeng Cui,Fusheng Liao
Sulfur dioxide (SO 2 ) and its derivative bisulfite (HSO 3 − ) are widely utilized in food processing but pose potential health hazards at excessive concentrations, highlighting the critical need for rapid and sensitive detection methods for sulfite/bisulfite species. Herein, we report the synthesis of a novel fluorescent probe TPA-OH featuring a donor–π–acceptor (D–π–A) architecture, with triphenylamine (TPA) as the electron-donating unit and 7-hydroxy-1-indanone as the electron-withdrawing moiety. The conjugated C═C double bond enables intramolecular charge transfer (ICT) within the probe. Upon interaction with sulfite/bisulfite species, presumably through nucleophilic addition to the C═C bond, the π-conjugated system is disrupted, resulting in a pronounced fluorescence enhancement accompanied by a distinct blue shift. Under optimized conditions, TPA-OH exhibited a low detection limit of 0.053 µM based on repeated calibration experiments and a broad linear range of 5.0 × 10 − 8 ∼1.0 × 10 − 5 M, along with good stability and strong anti-interference capability toward sulfite/bisulfite detection. This probe was successfully applied for HSO 3 − quantification in real samples and fluorescence imaging of exogenously added HSO 3 − in HepG-2 cells under controlled experimental conditions. Its favorable cytocompatibility supports its use for fluorescence imaging of exogenous sulfite/bisulfite species in living cells under the current experimental conditions. Graphical A novel D–π–A fluorescent probe (TPA-OH) was designed using a triphenylamine donor. The probe detects HSO 3 − via a specific nucleophilic addition disrupting π-conjugation. TPA-OH exhibits an ultralow detection limit of 0.05 nM and broad linear range. Successfully applied for HSO 3 − detection in foods and fluorescence imaging in living cells.
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