OPTICAL MATERIALS
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2023
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IF 3.9
Xiandi Yu,Qianshu Xia,Peng Liu,Yan Xu
Lanthanide-doped upconversion (UC) nanomaterials with zero background auto-fluorescence are of extensive interest in optical fields. Here, a NaYF 4 :Yb 3+ /Er 3+ @Zr-UiO-66 nanostructure was prepared by simultaneously encapsulating NaYF 4 :Yb 3+ /Er 3+ nanoparticles (NPs) and promoting the nucleation of UiO-66 under solvothermal condition. Traditional nanosize-surface induced defects and grain boundaries of NaYF 4 :Yb 3+ /Er 3+ upconversion nanoparticles (UCNPs) were greatly minimized; enabling a highly efficient energy transfer confirmed by the prolonged fluorescence lifetime and enhanced UC emission of NaYF 4 :Yb 3+ /Er 3+ @Zr-UiO-66 nanocomposite. The optical thermometry property of nanocomposite was investigated based on the fluorescence intensity ratio (FIR) technique in the temperature range of 303–393 K. The maximum relative temperature sensitivities (S r ) were calculated to be 1.02 and 0.73% K −1 based on a pair of thermally coupled energy levels (TCLs) of ( 2 H 11/2 → 4 I 15/2 , 4 S 3/2 → 4 I 15/2 ) and another pair of non-thermally coupled energy levels (NTCLs) of ( 2 H 11/2 → 4 I 15/2 , 4 F 9/2 → 4 I 15/2 ), respectively. Besides, it exhibited effective internal optical heating property due to the thermal excitation between the two adjacent TCLs of 2 H 11/2 and 4 S 3/2 in NaYF 4 :Yb 3+ /Er 3+ UCNPs as heated by increasing the laser power. This work demonstrates a feasible confined synthesis of NaYF 4 :Yb 3+ /Er 3+ @Zr-UiO-66 nanocomposite with extreme UC emitting performance, and it holds great potential acting as both ratiometric thermometer and optical heater for multifunctional applications.
研究领域:
材料科学
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光学工程
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纳米技术
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-10
·
IF 10.6
Hu Yulin,Xu Baoqi,Li Wei,Liang Lin,Fei Fan,Lin Quankui
The human cannot detect light with a wavelength exceeding 700 nm, primarily due to limitations in the physiological structure of the human eye. However, in certain specific scenarios, the ability to detect near-infrared (NIR) light proves to be extremely valuable. To attain this desired capability, NIR up conversion nanoparticles (UCNPs) were prepared and doped in the optical lens materials, aiming to obtain a NIR light “visible” optical lens. It is demonstrated that the doping of UCNPs in the optical lens materials does not significantly impact on their mechanical properties, optical properties, surface properties and it exhibits excellent biocompatibility in cell and animal experiments. More importantly, the UCNPs doping can convert NIR light into visible light within the material effectively and stably. The eyes can “see” the NIR light after wearing such UCNPs doped optical lens. Such NIR light visible optical lens could have great potential in actual applications.Graphical Abstract
研究领域:
光学
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纳米技术
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生物医学工程
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Meihua Bao,Xiaopeng Yang,Xiumei Yin,Yanfu Wang,Nan Ma,Wei Yang,Jianduo Chen,Qinyao Li,ChengYue Wang
Dental caries is regarded as the most widespread non - infectious disease in humans, primarily induced by acidogenic bacterial biofilms, which results in the demineralization and dissolution of dental hard tissues. In this study, a socket sealant was designed to prevent dental caries and promote tooth remineralization. The sealant can function under the acidic conditions (pH < 5.5) of biofilm infection. Under near - infrared light (980 nm) irradiation, graphene oxide (GO) is excited to generate resonance energy transfer (FRET). It then intelligently responds to green fluorescence (NaYF 4 ) to signal the onset of caries. Simultaneously, it releases MgO and mineralized ions (Mg 2+ ) to regulate the cariogenic acidic environment. Moreover, owing to the outstanding photothermal and photodynamic effects of GO, this material can further strengthen the destructive impact on bacterial biofilm by inhibiting bacterial adhesion under 980 - nm near - infrared light irradiation. Most significantly, the material can not only reverse the caries microenvironment at the pH and microbial levels but also facilitate the self - healing of demineralized teeth in terms of microstructure and mechanical properties.
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ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Xia Xu,Zhuo Wang,Pengpeng Lei,Yingning Yu,Shuang Yao,Shuyan Song,Xiuling Liu,Yue Su,Lile Dong,Jing Feng,Hongjie Zhang
Novel flower-like α-NaYb(Mn)F4:Er3+/Tm3+@NaYF4 upconversion nanoparticles (UCNPs) as luminescent nanothermometers have been developed by combining liquid–solid solution hydrothermal strategy with thermal decomposition strategy. Under 980 nm excitation, they exhibit intense upconversion luminescence and temperature-dependent upconversion luminescence over a wide temperature range. The influence of temperature on “band-shape” upconversion luminescence (UCL) spectra and the intensity of emission bands are analyzed and discussed in detail. We further successfully test and verify that intensity ratios REr of 2H11/2 → 4I15/2 and 4S3/2 → 4I15/2 and RTm of 1G4 → 3H5 and 3H4 → 3H6 are sensitive to temperature, and the population of active ions follows Boltzmann-type population distribution very well. These luminescent nanothermometers could be applied over a wide temperature range from 123 to 423 K with high sensitivity, which enable them to be excellent candidates for temperature sensors.
研究领域:
材料科学
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光学
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纳米技术
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DOI
PubMed
高影响因子
JOURNAL OF RARE EARTHS
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2022
·
IF 4.632
Haining Song,Haifeng Zhou,Qianqian Zhuang,Zexin Li,Fenglei Sun,Zhenlei Yuan,Youxin Lou,Guangjun Zhou,Yujun Zhao
Oxidizing ClO − and IO 4 − exist widely in environment and are closely related to the health of organisms. Accordingly, fast, sensitive, and direct detection of the two species is significant. Using IFE in UCNPs @PAA and Fe(II)-phenanthroline system, an elegant ratiometric fluorescent nanosensor , without noble metal nanoparticle , was designed for the detection of ClO − and IO 4 − . Fe(II)-phenanthroline complex is used as fluorescent absorber, which can quench green light of UCNPs with gradually varied extent depending on the concentration of Fe(II). The linear zone extends to 800 and 120 μmol/L while the detection limit is 1.30 and 0.58 μmol/L for NaClO and NaIO 4 , respectively. Finally, the nanosensor was successfully applied to detect NaClO and NaIO 4 spiked in milk, spring water, and tap water with good recoveries.
研究领域:
分析化学
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环境科学
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生物医学
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DOI
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2023
·
IF 4.3
Huanhuan Li,Qiyi Bei,Bingshan Li,Suleiman A. Haruna,Murugavelu Marimuthu,Mehedi Hassan,Zhen Ding,Quansheng Chen
A novel enzymatic biosensor was developed for the determination of ciprofloxacin (CIP) using upconversion nanoparticles (UCNPs) and the color development strategy of potassium titanium oxalate (PTO). The presence of CIP triggers the specific recognition of CIP by the aptamer, which leads to the dissociation of PDA-encapsulated magnetic nanoparticles (Fe 3 O 4 @PDA-Apt) from the horseradish peroxidase-functionalized UCNPs (cDNA-UCNPs-HOR) and facilitates fluorescence recovery. Accordingly, CIP demonstrated the ability to indirectly alter the quantity of H 2 O 2 , where PTO could selectively interact with H 2 O 2 , leading to the formation of yellow peroxo-titanic acid, which enabled the colorimetric detection of CIP. Under ideal conditions, the linear ranges for fluorescence and colorimetry were 10–1000 µg L −1 and 100–1000 µg L −1 , respectively, with detection limits (LOD) of 2.1 and 16.7 µg L −1 . Finally, the precision and accuracy of the method were validated with HPLC and achieved satisfactory results ( P > 0.05).
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CHEMISTRY-A EUROPEAN JOURNAL
·
2014
·Vol. 20
·期 10
·2888-2894
·
IF 5.696
Fei Yuan,Hongqi Chen,Juan Xu,Yiyan Zhang,Yong Wu,Lun Wang
Graphical LET there be luminescence! A new luminescence energy transfer (LET) system has been designed for the detection of thrombin in the near-infrared (NIR) region by utilizing NIR-to-NIR upconversion lanthanide nanophosphors (UCNPs) as the donor and gold nanorods (Au NRs) as the acceptor (see figure). The LET system was used to monitor thrombin concentrations in aqueous buffer and human blood samples. The method was also successfully applied to thrombin detection in blood samples. A new luminescence energy transfer (LET) system has been designed for the detection of thrombin in the near-infrared (NIR) region by utilizing NIR-to-NIR upconversion lanthanide nanophosphors (UCNPs) as the donor and gold nanorods (Au NRs) as the acceptor. The use of upconverting NaYF 4 :Yb 3+ ,Tm 3+ nanoparticles with sharp NIR emission peaks upon NIR excitation by an inexpensive infrared continuous wave laser diode provided large spectral overlap between the donor and the acceptor. Both the Au NRs and carboxyl-terminated NaYF 4 :Yb 3+ ,Tm 3+ UCNPs were first modified with different thrombin aptamers. When thrombin was added, a LET system was then formed because of the specific recognition between the thrombin aptamers and thrombin. The LET system was used to monitor thrombin concentrations in aqueous buffer and human blood samples. The limits of detection for thrombin are as low as 0.118 n M in buffer solution and 0.129 n M in human serum. The method was also successfully applied to thrombin detection in blood samples.
研究领域:
生物化学
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纳米技术
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分析化学
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生物医学工程
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Yu Wu,Arul Murugesan,Yaru Han,Juan Han,Yiping Chen,Huanhuan Li
An injectable BZUCNPs-PACMSNs/PGB sensor was proposed to detect AFB 1 . • BPEI was coated on ZUCNPs to improve the water-soluble ability of ZUCNPs • A dual-gated strategy was presented to improve the stability of UCNPs sensor. • BPEI@Cu 2+ can effectively quench the fluorescence of ZUCNPs due to IFE. • Injectable PGB hydrogel was utilized for stable and on-site AFB 1 detection. An expanding presence of aflatoxin B 1 (AFB 1 ) contamination across the global food supply represents a serious threat to public health. This work developed a portable sensor using Zn 2+ -doped upconversion nanoparticles (ZUCNPs) that Cu 2+ -induced fluorescence quenching with an injectable polyvinyl alcohol/gelatin/borax (PGB) hydrogel. First, ZUCNPs exhibiting enhanced fluorescence were modified with branched polyethylenimine (BPEI) to form signal probes known as BZUCNPs. Additionally, mesoporous silica nanoparticles (MSNs) were fabricated via sol-gel methods, loaded with Cu 2+ and coated with aptamer (Apt) and polydopamine (PDA) to create dual-gated capture probes (PACMSNs). Afterwards, BZUCNPs and PACMSNs were mixed to form sensing probes and then integrated into the PGB hydrogel, forming the final sensor (BZUCNPs-PACMSNs/PGB). In the presence of AFB 1 at pH 5.5, the AFB 1 diffused into the PGB hydrogel, disrupting the PDA and Apt layer due to acid environment and changing the structure of Apt as AFB 1 specifically bound to it. Then, Cu 2+ released and facilitated the formation of BPEI@Cu 2+ complex on the surface of ZUCNPs, which produced inner filter effect (IFE) that quenched fluorescence. When experimental conditions were optimized, a pronounced linear calibration curve ( R 2 = 0.994) was observed, linking fluorescence to the logarithm of AFB 1 levels across a 0.1–100 μg/kg AFB 1 range. And its sensitivity was characterized with a detection limit of 0.03 μg/kg. Furthermore, the sensor's applicability was confirmed through analysis of food matrices, including wheat, corn, peanuts, and water, yielding high analytical accuracy with relative standard deviations below 6.08% and recovery rates ranging from 93.77% to 107.67%.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Lu Han,Min Chen,Qian Huang,Weijie Lan,Chong Wang,Leiqing Pan,Kang Tu
Foodborne illnesses caused by Salmonella rank first among bacterial foodborne diseases, representing a significant risk to public health and food safety, which necessitates the development of rapid and sensitive detection technologies. This study developed an upconversion‑tungsten disulfide PCR fluorescence sensor based on a “dual quenching-dual recovery” mechanism for the detection of Salmonella typhimurium ( S. typhimurium ). By utilizing the dual properties of tungsten disulfide, which include peroxidase-like activity and high fluorescence quenching efficiency, the sensor establishes a quantitative correlation between the upconversion fluorescence signal and S. typhimurium concentration, following target-specific signal amplification via PCR. The constructed method demonstrated good specificity and repeatability, with a detection limit as low as 22.5 CFU/mL. Furthermore, by reducing the number of PCR cycles by approximately 12 (from 34 to 22), the detection time was shortened by about 24 min while achieving a detection limit comparable to that of qPCR. The sensor performed excellently in real food matrices (chicken, eggs, fish), showing spike recovery rates of 92.0%–106.3% and relative standard deviations below 10%. In summary, the upconversion fluorescence biosensing strategy integrated with PCR amplification presented in this study provides a highly sensitive, rapid, and reliable solution for the pathogen detection, significantly enhancing the capacity for prevention and control of foodborne diseases.
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PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Yunlian Zhang,Md Mehedi Hassan,Yawen Rong,Rui Liu,Huanhuan Li,Qin Ouyang,Quansheng Chen
Tetracycline, a broad-spectrum antibiotic, has been widely used in disease treatment and other fields. However, due to the unreasonable use, its residue remains in food which eventually harms human health. Here described an upconversion nanosensor for tetracycline detection based on magnetic separation and electrostatic adsorption. To identify tetracycline, tetracycline aptamer, and europium ions (Eu 3+ ) were introduced in the system. According to the electrostatic adsorption principle, Eu 3+ exposed core–shell UCNPs were bound to negative complex of magnetic nanoparticles (MNPs) and aptamer. In the presence of tetracycline, UCNPs separated with MNPs-aptamer and remained in the supernatant by an external magnetic field. Under optimal conditions, the linear detection range of tetracycline was 0.5–1000 ng·mL −1 , and the detection limit was 0.17 ng·mL −1 . It has been successfully applied to detect tetracycline in food samples. The constructed method provided broad prospects for tetracycline detection with the merits of simple operation, high sensitivity, excellent repeatability, and selectivity.
研究领域:
分析化学
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纳米技术
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食品安全
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DOI
PubMed
高影响因子
Materials Horizons
·
2018
·Vol. 6
·期 2
·375-384
·
IF 13.183
Daoqing Fan,Erkang Wang,Shaojun Dong
DNA computing has shown impressive developments and exhibited amazing power over the past few decades. However, most current DNA logic devices can only produce single-modal output that is monochromic or even invisible, which greatly limits their reliability and practicality, integration capability and computing complexity. Emission-tunable upconversion nanoparticles (UCNPs) are ideal multicolor outputs for DNA computing, however UC luminescent (UCL) DNA logic systems have rarely been reported. Here, for the first time, we report “DNA-Unlocked Inner-Filter-Effect” (DU-IFE) between oxidized 3,3′,5,5′-tetramethylbenzidine (OxTMB) and upconversion nanoparticles (UCNPs) that subtly matches a “lock–key” strategy. Based on the DU-IFE, we construct the first ever UCL DNA logic library. Superior to previous DNA logic systems, this logic library can generate dual-modal (visual and UCL) multicolor label-free outputs, in which RGB (red, green, blue) colorful UCL ones are also visual under harmless NIR-laser. By selectively unlocking the IFE “lock” with different DNA “keys”, diverse basic, advanced and concatenated logic circuits, a logic-controlled molecular RGB-signal-light, triple-parallel-arrays are successfully constructed. All of the above logic operations demonstrate the strengthened reliability and practicality, powerful integration capability and improved computing complexity of this UCL logic library. Moreover, we fabricate an inspiring and useful biosensor with RGB colorful results based on the DU-IFE (a DNA caliper), providing a vivid prototype for potential biological applications.
研究领域:
生物化学
·
分子生物学
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纳米技术
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生物医学工程
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DOI
高影响因子
ANALYST
·
2022
·Vol. 147
·期 17
·3917-3923
·
IF 5.227
Feiyan Tang,Qing Hua,Xiaobin Wang,Feng Luan,Li Wang,Yanhong Li,Xuming Zhuang,Chunyuan Tian
As an efficient and easily available pesticide, imidacloprid (IM) has been widely used in agriculture to kill pests. However, threats to the ecological environment are becoming increasingly prominent, caused by abuse and pesticide residues. This paper reports a sensitive electrochemiluminescence (ECL) sensor based on upconverting nanoparticle functional zeolite imidazolate framework (UCNPs@ZIF-8) nanocomposites combined with molecularly imprinted polymers (MIPs) to successfully achieve the quantitative detection of IM. The composites exhibited a certain multi-faceted prismatic structure and the effective binding of UCNPs was demonstrated by characterization technology. In addition, a sensor with MIPs/UCNPs@ZIF-8/GCE as the working electrode exhibited outstanding ECL performance, including a strong and stable signal and excellent selectivity under optimal conditions. This sensor showed a good linear response to IM over a wide concentration range (0.1 ng L−1–1 mg L−1), with a limit of detection as low as 0.01 ng L−1. More significantly, it was successfully applied to the determination of IM concentration levels in food, which provides broad application prospects for the construction of pesticide ECL sensors.
研究领域:
分析化学
·
环境科学
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材料科学
·
食品安全
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DOI
PubMed
高影响因子
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