TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2025
·
IF 3.4
Xing-Jie Zhang,Peng-Yun Yang,Ling Ding,Jun Wang,Xiao-Li Li,Wei-Lie Xiao
Photodamage, a type of skin inflammation caused by excessive exposure to solar radiation, leads to skin redness, inflammation, and even the development of skin cancer, posing a severe threat to individuals living at high altitudes. UVB radiation is considered the primary factor contributing to photodamage. It stimulates macrophages within the epidermis, triggers inflammasome activation, and increases the inflammatory cytokine interleukin-1β (IL-1β) production. This study examined the protective effects of the compound isolicoflavonol (ILF) and its mechanism against UVB-induced photodamage. We irradiated UVB to create a photodamage model in mice and macrophages. Next, we assessed ILF's ability to protect the skin and cells from UVB photodamage and its inhibitory effects on UVB-mediated NLRP3 inflammasome. Our findings indicated that ILF reduced UVB-induced skin injury and inflammation in mouse skin, decreased cell death, NLRP3 inflammasome activation, ROS production, and mitochondrial dysfunction. These results suggest that ILF may be a potent agent for protecting the skin against UVB-induced photodamage.
研究领域:
皮肤病学
·
药理学
·
免疫学
·
放射生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Kai Tang,Tong Xu,Chengzhou Zhang,Wenjie Li,Yuheng Chen,Caixia Kan,Daning Shi,Xiaosheng Fang,Mingming Jiang
Perovskite ferroelectrics with switchable spontaneous polarization have aroused widespread attention due to their potential applications in nonvolatile memory, optoelectronic detection, and so forth, yet they face challenges like insufficient thermal stability, structural brittleness, lead toxicity concerns, and other aspects. This paper presents the first well-defined synthesis of one-dimensional (1D) lead-free ferroelectric CsCu 2 Br 3 single-crystals (SCs), which possess a wide bandgap (≈4.1 eV), high Curie temperature, in-plane ferroelectric self-polarization, prominent optical anisotropy, and other notable properties. These characteristics enable the samples to sensitively detect weak ultraviolet-B (UVB) signals and precisely discriminate linear polarization states. A prototype polarization-sensitive UVB photodetector based on 1D CsCu 2 Br 3 SCs is successfully fabricated, demonstrating exceptional photoresponse performance with a photoresponsivity of 400 mA W − 1 , a specific detectivity of 1.12 × 10 12 Jones, a rapid response characteristic with rise/fall times of 1.2/1.6 ms, and a high polarization ratio of 4.3 under 320 nm linearly polarized light illumination. By leveraging a dual-parameter optoelectronic signal-polarization encoding technology, the detector realizes encryption communication, with the channel capacity being augmented by 1.45 times. This work establishes CsCu 2 Br 3 SCs as eco-benign perovskite platforms for probing ferroelectricity and multi-physical coupling phenomena, demonstrating their critical role in advancing cross-disciplinary functional material research.
研究领域:
材料科学
·
光电子学
·
铁电材料研究
✓ 已验证
DOI
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
·
2026
·
IF 3.7
Chenqi Guo,Wenwen Zhang,Mingxi Li,Chunjing Song,Xiujun Zhang,Peng Wang,Yan Wang
Overexposure to ultraviolet B (UVB) radiation induces oxidative stress, inflammation, and apoptosis, which accelerates collagen degradation and skin aging. Current strategies for managing photodamage mainly focus on sun protection and skin repair; however, comprehensive therapeutic approaches are urgently needed. Herbal medicine-derived materials have shown great promise in combating photodamage. Modified Qing'e Formula (MQEF) has demonstrated the ability to treat photodamage by restoring redox homeostasis and is considered an effective anti-photodamage herbal remedy. However, the traditional oral decoction limits its application in topical treatments. In this study, we synthesized novel multifunctional carbon quantum dots (CQDs) using MQEF as a precursor (MQEF-CQDs). These CQDs exhibit superior antioxidant capacity compared to traditional herbal extracts and show no significant toxicity to HaCaT cells, indicating good biocompatibility and potential for skin drug delivery. Furthermore, MQEF-CQDs were incorporated into a thermosensitive hydrogel to form a MQEF-CQDs-hydrogel (MQEF-CQDs-gel) dressing, which is better suited for external use. This hydrogel displays temperature, pH, and rheological properties that align with the skin's physiological environment, along with dual functions of antimicrobial and restorative actions. Both in vitro and in vivo experiments demonstrate that MQEF-CQDs and MQEF-CQDs-gel mitigate UVB-induced photodamage through antioxidant, anti-inflammatory, anti-apoptotic, and collagen degradation-inhibition pathways. Additionally, MQEF-CQDs-gel significantly reduces skin damage, promotes the reconstruction of the epidermal structure, and restores damaged collagen fibers. These findings indicate that MQEF-CQDs represent a promising pathway for the green and sustainable production of herbal-based medicines, with broad industrial applications and as a potent candidate for photodamage treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2025
·
IF 3.5
Yan-Xia Li,He Ma,Le Shi,Zhong-Fei Zhang,Yu-Meng Wu,Chao Yan,Yan Chen,Yong-Ming Lu
BACKGROUND Polysaccharides from Pleurotus citrinopileatus exhibit diverse bioactivities, yet their efficacy against ultraviolet B (UVB)-induced photoaging remains unexplored. This study aimed to purify and characterize a specific PCP and assess its protective effects using a UVB-induced zebrafish model. RESULTS A polysaccharide, designated as PCP-2, was isolated from P. citrinopileatus through hot-water extraction, ultrafiltration and chromatography. PCP-2 is a galactoglucan with a molecular weight of 1.52 × 10 6 Da, predominantly composed of 1,4-linked glucopyranosyl and 1,4,6-linked galactopyranosyl residues. In UVB-exposed zebrafish, PCP-2 administration resulted in a significant reduction of reactive oxygen species and malondialdehyde levels, alongside enhanced activities of antioxidant enzymes, including superoxide dismutase, catalase and glutathione peroxidase. Additionally, PCP-2 inhibited apoptosis by upregulating Bcl-2 expression and downregulating caspase-3. It also attenuated cellular senescence, as indicated by decreased β -galactosidase activity and increased telomerase activity. Moreover, PCP-2 promoted the synthesis of type I and III collagen by suppressing matrix metalloproteinases MMP-1 and MMP-3 and reduced melanin production through the downregulation of tyrosinase expression. Mechanistic studies suggested that these protective effects are mediated via activation of the Nrf2/HO-1 signaling pathway. CONCLUSION PCP-2 from P. citrinopileatus effectively mitigates UVB-induced photoaging, primarily by activating the Nrf2/HO-1 pathway. These findings suggest PCP-2's potential as an anti-photoaging agent in both food and pharmaceutical industries. © 2025 Society of Chemical Industry.
研究领域:
生物化学
·
药理学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Cosmetic Dermatology
·
2024
·
IF 2.3
Lu Hu,Jiyu Weng,Ziqin Wang,Chujie Huang,Lanyue Zhang
Background Aging is a physiological phenomenon in the process of life, and skin aging has a significant impact on human appearance. Therefore, the search for methods to delay skin aging is of great significance for improving the quality of human life. Materials and Methods This study investigated the anti-photoaging effect of Tricholoma matsutake (T) extract composition combined with bakuchiol (B) and ergothioneine (E), and explored its potential mechanism through transcriptome, metabolomics, and network pharmacology. Results 57 main chemical components are identified from the ethanol extract of T. matsutake (T), including D-carnitine (24.55%), α,α-trehalose (15.56%), DL malic acid (8.99%), D-(−)-quinic acid (7.46%), erucamide (7.04%) and so on. After TBE treatment, inflammation of the mice dorsal skin is significantly minimized. Hematoxylin and eosin (H&E) staining and toluidine blue staining reveal that TBE has an anti-inflammatory effect on the back skin tissue of mice. Masson staining shows that TBE has a repair effect on mice dorsal skin tissue. In addition, the inflammatory factors (IL-1β, IL-6, TNF-α) in the mice dorsal skin tissues are significantly reduced but collagen (COL-1) is significantly increased. By cellular immunofluorescence assay, TBE is shown to promote PPAR-α expression in cells. Transcriptomics, metabolomics, and network pharmacology have revealed that TBE can regulate exogenous stimuli and cancer-related signaling pathways to prevent skin aging. Conclusion The results suggest that TBE can be a beneficial supplement to natural anti-aging.
研究领域:
药理学
·
皮肤科学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
Coatings
·
2023
·Vol. 13
·期 6
·985
·
IF 3.4
Enguo Zhou,Yuan Liu,Huajin Yuan,Xiaoling Cheng,Yuanhong Zhong,Jiebing He,Xi Lu
This content introduces a novel Ultraviolet (UV)-shielding material, Zn2Al-MADS-LDH (MADS-LDH), which was synthesized through co-precipitation method to insert sodium dodecyl diphenyl ether disulfonate (MADS) into the interlayer of Zn2Al-LDH layered double hydroxide (LDH), to improve the photoaging resistance of polyvinyl chloride (PVC). The characterization results indicated that MADS-LDH had a host-guest interaction between the LDH host layer and MADS guest anion, and it exhibited superior UV absorption capabilities than Zn2Al-CO3-LDH (CO3-LDH) and a broader absorption spectrum compared to MADS. A series of LDHs/PVC film composite materials containing LDHs nanosheets were prepared by incorporating the prepared LDHs into a PVC matrix via a solvent casting method. As expected, the MADS-LDH/PVC film composite materials exhibited enhanced photoaging resistance. The results of photoaging tests indicated that MADS-LDH inhibits the rate of carbonyl generation during photoaging of MADS-LDH/PVC film composite materials, resulting in a decrease in the carbonyl index (ΔCl) and relative degradation rate (RDR) compared to pristine PVC film and CO3-LDH/PVC film composite materials. Furthermore, the study evaluated the influence of different UV light wavelength ranges, such as UVB (280~315 nm), UVC (200~280 nm), and UV (200~400 nm), on the aging performance of PVC film and LDHs/PVC film composite materials. The results demonstrated that UV had the highest aging effect on PVC composite films, followed by UVC and UVB. Therefore, the MADS-LDH is a highly efficient and promising UV-shielding material with excellent potential for wide applications in the field of PVC.Keywords:hydrotalcite;polyvinyl chloride;intercalation;UV-shielding materials;film composite materials
研究领域:
材料科学
·
高分子化学
·
光化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Advanced Optical Materials
·
2025
·Vol. 13
·期 26
·e01335
·
IF 7.2
Xihui Shan,Xulong Lv,Dongxun Chen,Yi Zhang,Lipeng Huang,Yanjie Liang
Multifunctional phosphors combining persistent luminescent and photochromic properties have garnered increasing attention, given their capability of absorbing the photon energy and trapping the light-generated charge carriers by defects. To date, extensive efforts have been devoted to achieving reversible photochromism in visible/infrared afterglow materials. However, research on integrating ultraviolet (UV) persistent luminescence and photochromic behavior into a single material is relatively lacking. Herein, multimode luminescence in a Gd 3+ single-doped Sr 3 (PO 4 ) 2 phosphor is demonstrated, featuring narrowband ultraviolet-B (NB-UVB) photoluminescence, NB-UVB afterglow, and multicolor photochromism. The temperature-dependent NB-UVB photoluminescence of the Sr 3 (PO 4 ) 2 :Gd 3+ phosphor reveals its potential as a ratiometric optical thermometer with high relative sensitivity (2.5% K −1 at 110 K). Meanwhile, this phosphor exhibits robust NB-UVB persistent luminescence lasting >24 h upon X-ray irradiation. Besides, the material also displays exceptional concentration-dependent multicolor photochromism (white-to-blue and white-to-brown) under bright-field conditions only in response to X-ray irradiation, coupled with excellent bleaching and recovery capability under thermal treatment or 254 nm UV light stimulation. The synergistic integration of NB-UVB persistent luminescence and concentration-dependent multicolor photochromism positions this phosphor as a promising candidate for versatile applications, including covert optical tagging, optical information storage, and advanced anti-counterfeiting.
研究领域:
材料科学
·
发光材料
·
光学功能材料
·
光致变色材料
·
持久发光
·
光学测温
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Wen Ji,Cuiyin Qian,Xiaopeng Su,Xiang Li,Zhenqing Zhang,Yonggui Ma,Mingjin Zhang,Duxin Li
Gentiana dahurica Fisch. ( G. dahurica ) is one of the legitimate sources of Qinjiao in Traditional Chinese Medicine (TCM) and grows on high-altitude plateaus. Plants develop unique biochemical accumulations to resist plateau conditions, especially the strong UV irradiation. Thus, this study aimed to investigate the polysaccharide of G. dahurica (GDP), its structure and its activity against UVB irradiation. Four GDPs were isolated and two of them were subjected to structural elucidation. The results suggested that GDP-1 has 53.5 % Ara and 30.8 % GalA as its main monosaccharides, with a molecular weight (Mw) of 23 kDa; the GDP-2 has 33.9 % Ara and 48.5 % GalA, with a Mw of 82 kDa. Methylation and NMR spectroscopy analysis revealed that GDP-1 contains →5)-α-Ara f -(1 → 5)-α-Ara f -(1 → 3,5)-α-Ara f -(1 → 3,4)-α-Gal p A-(6-OMe)-(1→ as the main chain, the branches of GalA (with esterification), and the terminal Ara; the GDP-2 contains →4)-α-Gal p A-(1 → 4)-α-Gal p A-(6-OMe)-(1 → 5)-α-Ara f -(1 → 3,5)-α-Ara f -(1→ as the main chain, the branches of →5)-α-Ara f -(1–5)-α-Ara f , and the terminal GalA. Both GDP-1 and GDP-2 exhibited concentration-dependent antioxidant activity against DPPH, ABTS and hydroxyl radicals. Moreover, GDPs significantly attenuated the decreases in viability and proliferation of HaCaT cells after UVB irradiation. They can scavenge reactive oxygen species (ROS) and improve the activities of endogenous antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH). The potential mechanism explored by flow cytometry assays of cell apoptosis and cell cycle distribution suggested that GDPs exert protective effects against UVB irradiation by reducing ROS and attenuating S phase cell arrest. In brief, the GDP-1 and GDP-2 are α-1,3- and α-1,4- arabinogalacturonan, respectively. The high content of Ara could be attributed to biochemical accumulation in resisting to the plateau environment and to prevent UVB irradiation-related damage in cells. These findings provide insight into authentic medicinal herbs and the development of GDPs in the modern pharmaceutical and cosmetics industry.
研究领域:
药理学
·
生物化学
·
植物科学
·
化妆品
·
传统中药
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Functional Foods
·
2020
·
IF 3.701
Zhenbang Xiao,Shengtao Yang,Jiali Chen,Chengyong Li,Chunxia Zhou,Pengzhi Hong,Shengli Sun,Zhong-Ji Qian
Ultraviolet radiation B cause photoaging of the skin by enhancing the high expression of matrix metalloproteinases (MMPs) to degrade collagen and inhibit the synthesis of procollagen. Trehalose (TRE), a widely occurring natural disaccharide, has been shown to play a cytoprotective role in many pathological processes. However, few studies have evaluated whether it has anti-photoaging potential. In this study, we investigated the anti-photoaging and mechanism of action of TRE using Human immortalized keratinocytes (HaCaT) cells. The results indicated that TRE pretreatment effectively scavenges reactive oxygen species (ROS) accumulation induced by UVB and increases the content of certain endogenous antioxidant factors in HaCaT cells. TRE suppressed UVB-induced MMP expression by blocking mitogen-activated protein kinases (MAPKs), activator protein 1 (AP-1) and NF-κB signaling. TRE treatment increased procollagen I synthesis via activating transforming growth factor-β (TGF-β)/Smad pathway and demonstrated that TRE may be a potential natural disaccharide for photoaging therapy in the future.
研究领域:
皮肤科
·
细胞生物学
·
药理学
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
·
2023
·Vol. 125
·期 9
·2300009
·
IF 2.7
Zhiming Liu,Ying Zheng,Bowen Yue,Yali Luo,Zhaoxin Cao,Jingyi Su,Xinyu Wang,Yan Zhang,Yifei Zhang,Bingxue Wang,Xiaoliang Cheng,Zhiyong Zhou,Xuemei Ge
Jujube peel pigment (JP), an ideal natural water-soluble pigment extracted from jujube peel, mainly consists of flavonoids and possesses a wide range of physiological activities. In this study, JP-loaded multivesicular liposomes (JP-MVL) were prepared using the double emulsification method. JP-MVL was characterized, and its encapsulation efficiency was determined using the UV-Vis method. Furthermore, the release behavior and antioxidant capacity of JP-MVL were evaluated in vitro. The results displayed in the structure of JP-MVL were spherical with internal vesicles; the average particle size of JP-MVL was 5.63 μm, and the zeta potential was −69.50 mV. Analysis of the release results indicated that the best-fitting models in PBS (Phosphate buffered saline pH 7.4) and 0.9% NaCl were the Higuchi and first-order kinetic models, respectively. The cytotoxicity of JP-MVL at the appropriate concentrations was negligible and had a good protective effect against UVB-induced photodamage.
研究领域:
药剂学
·
生物化学
·
皮肤科学
✓ 已验证
产品关联
DOI
高影响因子
Materials Horizons
·
2025
·
IF 10.7
Yi Wang,Jiaren Du,Hengwei Lin,Dirk Poelman,Eugeniusz Zych
Materials that emit ultraviolet C (UVC) or ultraviolet B (UVB) radiation are essential in domains such as environmental surveillance, public health, and optoelectronic technologies, owing to their elevated photon energy and distinct optical characteristics. However, the development of innovative persistent luminescent phosphors exhibiting emission within the UVC or UVB spectral range continues to pose a considerable challenge. Herein we present a novel Pr3+-doped Na2SrSi2O6 phosphor featuring a cyclosilicate framework, which exhibits sustained photon emission in the UVC and UVB regions, alongside luminescence in the red spectral range. The Na2SrSi2O6:Pr3+ phosphor demonstrates pronounced and long-lasting UVC, UVB and red persistent luminescence following X-ray excitation, underscoring its effectiveness for utilization in both dark and bright environments. Moreover, the incorporation of smaller ionic radius co-dopants such as Mg2+ or Ca2+ effectively enhances the red emission intensity of the phosphor. In contrast, the introduction of the larger ionic radius co-dopant Ba2+ not only enhances the content of UVC emission but also improves the overall luminescent efficacy. As the content of Ba2+ increases, the phosphor exhibits a spectral transition from UVC to UVB within the ultraviolet region. Notably, the applications of this phosphor were assessed in bright-field and dark-field imaging, showcasing its considerable potential for high-contrast monitoring in bright daylight, and advanced optical marking technologies. This work advances the development of visible-to-invisible persistent luminescent materials and offers a good example of engineering the cyclosilicate matrices for luminescence spectrum tuning.
研究领域:
材料科学
·
发光材料
·
光电子学
·
固态化学
·
环境监测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Marine Drugs
·
2025
·Vol. 23
·期 11
·445
·
IF 5.4
Junming Zhang,Jiangming Zhong,Yi Li,Qi Zhou,Zhiyun Du,Li Lin,Peng Shu,Ling Jiang,Wei Zhou
Background: Ultraviolet B (UVB) radiation induces oxidative stress, inflammation, and collagen degradation in skin, leading to photodamage. Ergosterol (ERG)—a sterol widely distributed in fungi and algae, including numerous marine species—possesses antioxidant and anti-inflammatory activities, but its photoprotective mechanisms remain unclear. Methods: Using integratedin vitro(UVB-irradiated human keratinocytes) andin vivo(topical ERG in a murine UVB model) approaches, combined with transcriptomic and network pharmacology analyses, we evaluated ERG’s effects on oxidative stress, inflammation, and extracellular matrix integrity. Results: ERG treatment preserved keratinocyte viability, reduced reactive oxygen species, and suppressed pro-inflammatory mediators after UVB exposure. In mice, topical ERG significantly attenuated epidermal hyperplasia, maintained tight-junction integrity, and inhibited collagen matrix degradation. Mechanistically, ERG exerted dual inhibition of the nuclear factor kappa B (NF-κB) pathway, which mediates inflammation, and the mitogen-activated protein kinase (MAPK) pathway, which regulates collagen degradation. Conclusions: These findings identify ERG as a marine-derived sterol with potent photoprotective activity that simultaneously targets oxidative stress, inflammation, and extracellular matrix damage, highlighting its promise as a natural compound for dermatological applications and aligning with ongoing efforts to explore marine-derived agents against skin oxidative stress and inflammation.
研究领域:
皮肤病学
·
海洋天然产物
·
药理学
·
分子生物学
·
氧化应激与炎症
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）