CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Wanqiu Yang,Zhicheng Wang,Xudong Hu,Yingjun Chai,Gaoyu Liu,Shengli Zhang,Haibo Zeng,Xiaoming Li
Scintillator films with high light output and low cross-talk are essential for highly sensitive and high-resolution X-ray imaging applications. However, only specific scintillators prepared with high-cost method or pixelated template meet these demands. Solution processed strategies possess the merit of low-cost while scintillator particles are usually in chaos with severe light scattering, especially for thick films up to hundreds of microns, resulting in poor imaging sensitivity and resolution. Herein, we demonstrate that low-symmetrical zero-dimensional Cs 3 Cu 2 I 5 scintillator can grow longitudinally with spray-coating strategy with the assistance of crystal facet inhibitor. The additive, triallyl isocyanurate, exhibits preferred crystal face binding ability, inducing oriented growth and well-defined columnar structure with large thickness more than one hundred microns. The final scintillator films show higher luminescence polarity and light output, contributing to remarkable improvement in light yield and imaging resolution of 71% and 81% compared with the control sample, respectively. Besides, the added monomer crosslinks under annealing and provide robust protection, leading to excellent radiation hardness and storage stability under ambient environment. By virtue of the negligible afterglow, artifact-free X-ray imaging at a frame rate of 3840 fps is fulfilled, indicating the promising prospects of this strategy for application in low-cost, high-performance fast X-ray imaging.
研究领域:
材料科学
·
医学影像
·
光学
✓ 已验证
产品关联
DOI
高影响因子
Laser & Photonics Reviews
·
2025
·
IF 10
Wei Liao,Kai Han,Yuzhen Wang,Zhiguo Xia
X-ray imaging based on scintillators with visible-light emission primarily reveals structural information, but the integrated detection of complex targets, especially biological systems, remains challenging. Here, a dual-mode collaborative imaging strategy is proposed based on the design of perovskite-type halide scintillators (Cs 2 HfCl 6 :Mo 4+ ), which present efficient near-infrared (NIR) emission above 900 nm upon the excitations of 808 nm laser and X-ray sources. Dual-mode indirect imaging with simple excitation source switching has been performed to visualize bone and blood vessels in biological targets. The light yield and detection limit are estimated to be 44500 Ph MeV −1 and 87.4 nGy s −1 , respectively, and a dual-mode imaging screen with spatial resolution of 14 lp mm −1 for NIR imaging and 12 lp mm −1 for X-ray imaging is successfully obtained. This work may stimulate research into the NIR scintillators for the development of multi-mode imaging with mitigating light crosstalk.
研究领域:
材料科学
·
医学影像
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
Science Advances
·
2023
·Vol. 9
·期 35
·
IF 13.6
Depeng Chu,Binxia Jia,Naiming Liu,Yunxia Zhang,Xiaotong Li,Jiangshan Feng,Jiacheng Pi,Zhou Yang,Guangtao Zhao,Yucheng Liu,Shengzhong (Frank) Liu,Nam-Gyu Park
Preliminary theoretical analyses indicate that lattice relaxation may be used to release lattice strain in the FAPbI3 perovskite to warrant both high x-ray detection performance and improved stability. Herein, we demonstrate stable black α-phase FAPbI3 single crystals (SCs) realized by lattice engineering via annealing in the ambient atmosphere. The engineered α-FAPbI3 SC detector shows almost all the best figures of merit including a high sensitivity of 4.15 × 105 μC Gyair−1 cm−2, a low detection limit of 1.1 nGyair s−1, a high resolution of 15.9 lp mm−1, and a short response time of 214 μs. We further demonstrate high-definition x-ray imaging at a dose rate below 10 nGyair s−1 on the FAPbI3 SC, indicating a minimal dose-area product of 0.048 mGyair cm2 to the patient for one-time posteroanterior chest diagnosis, which is more than 3000 times lower than the international reference level of 150 mGyair cm2. In addition, the robust long-term stability enables the FAPbI3 SC x-ray detector to work steadily for more than 40 years.
研究领域:
材料科学
·
医学影像
·
辐射探测
✓ 已验证
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2024
·
IF 3.2
Jingkun Chen,Xue Yang,Yucheng Li,Minghui Xu,Xuechun Yang,Jian Tang,Pu Zheng,Jie Yan,Jingtai Zhao,Qianli Li
The development of high-speed imaging technology requires ultrafast scintillators. ZnO is an excellent scintillator whose near-band-edge (NBE) radiation attenuation can reach subnanosecond levels. Homogeneous and unique double-layered ZnO:Sc microcrystals (1% doping) were prepared by adding polyvinylpyrrolidone during a hydrothermal reaction. The growth process of double-layer ZnO:Sc microcrystals and the effects of Sc doping concentration on the morphology of ZnO:Sc microcrystals were studied. ZnO:Sc tended to nucleate into twins in weakly basic hexamethylenetetramine. The c-axis growth of ZnO was inhibited by Sc doping, and the growth pyramid of ZnO:Sc was in accordance with the Burton–Cabrera–Frank growth model in the (002) plane, according to the spiral dislocation. Sheet ZnO:Sc microcrystals were obtained under high-concentration Sc doping. After hydrogen annealing, the NBE intensity of 0.5%-doped ZnO:Sc microcrystals was higher than that of ZnO, mainly owing to inhibition of defect luminescence and sheet morphology, which reduced the self-absorption of ZnO:Sc. The decay time of the ZnO:Sc microcrystals after hydrogen annealing under ultraviolet excitation was less than 1 ns. Combining the annealed microcrystals with polydimethylsiloxane to form a flexible composite film enables the scintillation screen to be used for ultrafast X-ray detection with a spatial resolution of up to 16 lp/mm.
研究领域:
材料科学
·
光学
✓ 已验证
DOI
高影响因子
Nanoscale
·
2022
·Vol. 15
·期 4
·1835-1848
·
IF 8.307
Wenjing Xie,Han Li,Houqiang Yu,Hongfu Zhou,Anran Guo,Qing Yao,Ling Zhang,Yongsheng Zhao,Hongan Tian,Ling Li
Iodized oil has an excellent X-ray imaging effect, but it shows poor embolization performance. When used as an embolic agent, it is easily washed off by the blood flow and eliminated from the body. Therefore, it is essential to use iodized oil in combination with solid embolic agents such as gelatin sponge or to perform multiple embolization procedures to achieve the therapeutic effect. In the present study, a poly(N-isopropyl acrylamide)-co-acrylic acid (PNCAA) temperature-sensitive nanogel was synthesized by emulsion polymerization; the nanogel was then emulsified with iodized oil to prepare a thermosensitive iodized oil Pickering gel emulsion (TIPE). The oil–water (O/W) ratio of an O/W emulsion system can reach 4 : 6. When injected into the body, TIPE transforms into a nonflowing coagulated state at physiological temperature; the iodized oil is locked in the emulsion structure, thereby achieving local embolization and continuous imaging effects, which not only retain the X-ray imaging effect of the iodized oil but also improve its embolization effect. Subsequently, we further evaluated renal artery embolization in a normal rabbit renal artery model, and the results showed that TIPE shows a long-term conformal embolization performance and excellent long-term X-ray imaging ability.
研究领域:
医学材料学
·
介入放射学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Laser & Photonics Reviews
·
2023
·
IF 11
Peng Ran,Xinya Chen,Zeng Chen,Yirong Su,Juan Hui,Lurong Yang,Tianyu Liu,Xiangyang Tang,Haiming Zhu,Xiao-Jian She,Yang (Michael) Yang
Copper-based halides have emerged as promising scintillator materials for X-ray imaging due to their favorable photophysical characteristics, such as negligible self-absorption, high light output, and fast decay. Among these materials, Cs 3 Cu 2 I 5 , a blue emitter, currently delivers the highest scintillation light output under steady-state X-rays. However, there is a significant spectral mismatch between its emission band and the spectral responsivity of regular flat-panel photodiode arrays. In this study, a comprehensive analysis of the physical properties of the CsCu 2 I 3 scintillator is conducted, and its perfect spectral compatibility is discovered, which results in a higher photodiode signal despite its relatively lower light output compared to typical Cs 3 Cu 2 I 5 scintillators. Furthermore, CsCu 2 I 3 exhibits faster light decay properties, making it especially suitable for Computed Tomography (CT) X-ray imaging. High-quality X-ray cone beam computed tomography (CBCT) imaging is successfully demonstrated using the fast-decaying CsCu 2 I 3 scintillator screen. Additionally, the flexibility of the scintillator allows for non-planar imaging, showcasing advantages not available with traditional rigid scintillators. These results not only highlight the significant promise of the CsCu 2 I 3 scintillator but also emphasize the necessity of considering spectral compatibility when designing novel scintillator materials.
研究领域:
医学影像学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2023
·Vol. 15
·期 33
·13628-13634
·
IF 6.7
Sijian Wu,Lifang Yuan,Geng Chen,Chaoyue Peng,Yahong Jin
All-inorganic metal halide perovskite (MHP) materials have been widely studied because of their unique optoelectronic properties, whereas there has been little research reported on their X-ray afterglow imaging properties. Herein, we report the design and synthesis of Mn2+-doped hexagonal CsCdCl3 MHP crystals with excellent X-ray scintillation and X-ray induced afterglow. The orange emission from Mn2+ shows a red shift due to the strong interaction of the Mn2+–Mn2+ dimers formed at higher doping concentrations. The high-energy X-rays with higher electron filling capacity to feed the shallow (0.71 eV) and deep (0.90–1.08 eV) traps enable a long orange afterglow for more than 300 min. The afterglow emission can be rejuvenated effectively by 870 nm stimulus or heating even after 72 h of decay. Finally, we demonstrate the proof-of-concept applications of the fabricated flexible scintillator films for real-time online X-ray imaging with a spatial resolution of 12.2 lp mm−1, as well as time-lapse X-ray imaging recorded by a cell phone, which shows promise for being able to do offline late-time detection of X-ray afterglow imaging in the future.
研究领域:
材料科学
·
光电学
·
放射学
·
成像科学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Zihan Wang,Yuanbo Ma,Changmao Wan,Hui Zhang,Xu Pan,Jiajiu Ye
Halide perovskites exhibit substantial potential for use in X-ray imaging applications. However, significant challenges persist in seamlessly integrating these materials with pixelated array readout circuits and in ensuring sufficient attenuation for direct X-ray detection imaging. In this study, we propose a reliable approach involving the manipulation of crystallization dynamics, rheological engineering, and an inter-grain cross-linking strategy to prepare robust and tunable perovskite-polymer composite (PPC) films on the scale of hundreds of microns. The PPC film was reinforced with multifunctional additives possessing bonding and stress-buffering capabilities, which effectively alleviated residual tensile stress, leading to a significant enhancement of mechanical strength. The obtained perovskite-polymer composite detector exhibits a high sensitivity of 2.51 × 10 4 μC Gy air −1 cm −2 , excellent pixel-level uniformity with a low photo-response non-uniformity (PRNU) value of 1.85 % and a high spatial resolution of 0.57 line pairs per pixel (lp pix −1 ). This approach provides valuable guidance for perovskite-based X-ray imaging.
研究领域:
材料科学
·
医学影像学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yucheng Li,Xuechun Yang,Kuan Ren,Yulin Liu,Zhan Xu,He Feng,Keli Deng,Bo Deng,Wanli Shang,Jianjun Dong,Feng Wang,Qianli Li,Xuyong Yang
X-ray imaging has garnered widespread interest in biomedical diagnosis and nondestructive detection. The exploration of radio-photoluminescence has hastened the advancement of X-ray information storage. However, significant challenges persist in achieving the prolonged imaging of curved objects without attenuation. Here, europium-doped strontium fluoride (SrF2:Eu) is meticulously created to exhibit a linear response to an extensive range of X-ray doses (maximum dose > 5000 Gy), showcasing excellent X-ray information reading/erasing reusability properties (10 cycles). This is accompanied by a red-to-blue emission transition under UV excitation, sustaining for 150 days without attenuation. To elucidate the phenomena of irradiated photoluminescent discoloration and the reversible X-ray storage of SrF2:Eu, we propose an electron-vacancy trap (valence conversion) mechanism, information stably retained by the SrF2:Eu-based device under ambient conditions due to high energy barriers. The time-lapse readout capability is further demonstrated for three-dimensional imaging of curved objects (10 lp mm–1) based on SrF2:Eu embedded within a polydimethylsiloxane (SrF2:Eu@PDMS). The SrF2:Eu demonstrates time-lapse imaging, reversible radio-photoluminescence, and recoverable X-ray storage, offering a promising avenue for optical information encryption and anticounterfeiting applications.
研究领域:
材料科学
·
医学影像
·
光学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2024
·
IF 13
Hanqi Wei,Qihua Yang,Guihua Li,Xuan Liu,Junben Huang,Chujie Wang,Xiaoming Li,Gemei Cai
As one type of recent emerging lead-free perovskites, Cs 2 ZrCl 6 nanocrystals are widely concerned, benefiting from the eminent designability, high X-ray cutoff efficiency, and favorable stability. Improving the luminescence performance of Cs 2 ZrCl 6 nanocrystals has great importance to cater for practical applications. In view of the surface defects frequently formed by the liquid phase method, the particle morphology and surface quality of this material are expected to be regulated if certain intervention is made in the synthesis process. In the work, differing from normal cell lattice modulation based on the ion doping, the grain size and surface morphology of Cs 2 ZrCl 6 nanocrystals are optimized via adding a certain amount of InCl 3 to the synthetic solution. The surface defects are restored to inhibit the defect-induced non-radiative transition, resulting in the improvement of the luminescence properties. Moreover, a flexible Cs 2 ZrCl 6 @polydimethylsiloxane film with excellent heat, water, and bending resistance and a light-emitting diode (LED) device are fabricated, exhibiting excellent application potential for X-ray imaging and blue LED.
研究领域:
材料科学
·
光学工程
·
医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Tianshuai Lyu,Pieter Dorenbos,Canhua Li,Silei Li,Jian Xu,Zhanhua Wei
It is challenging to rational design persistent luminescence and storage phosphors with high storage capacity of electrons and holes after X-ray charging. Such phosphors have potential applications in anti-counterfeiting and X-ray imaging. Here we have combined vacuum referred binding energy diagram (VRBE) construction, photoluminescence spectroscopy, and thermoluminescence to study the trapping processes of charge carriers in NaYGeO 4 . In NaYGeO 4 :0.004Bi 3+ and NaYGeO 4 :0.004Bi 3+ ,0.005Ln 3+ (Ln = Tb or Pr), Bi 3+ appears to act as a shallow electron trap, while Bi 3+ and Ln 3+ act as deep hole trapping and recombination centres. We will show how to experimentally determine the VRBE in the Bi 2+ 2 P 1/2 ground state in NaYGeO 4 and NaLuGeO 4 by thermoluminescence study. The electron trap depth produced by Bi 3+ codopant in NaLu 1-x Y x GeO 4 :0.003Bi 3+ ,0.008 Tb 3+ can be adjusted, by increasing x, resulting in conduction band engineering. By combining Bi 3+ as an electron trap and Bi 3+ and Tb 3+ as the hole traps, excellent X-ray charged afterglow phosphors were developed. The integrated TL intensity of the optimized NaYGeO 4 :0.004Bi 3+ and NaYGeO 4 :0.003Bi 3+ ,0.008Tb 3+ after exposure to X-rays is about 4.5 and 1.1 times higher than that of the state-of-the-art BaFBr(I):Eu 2+ storage phosphor. Intense initial Tb 3+ 4f → 4f afterglow appears in NaYGeO 4 :0.003Bi 3+ ,0.008Tb 3+ and more than 40 h afterglow is measurable in NaYGeO 4 :0.004Bi 3+ and NaYGeO 4 :0.003Bi 3+ , 0.008 Tb 3+ after X-ray charging. We will show proof-of-concept anti-counterfeiting and X-ray imaging applications by using the developed afterglow phosphors and CsPbI 3 quantum dots. This work not only provides experimental evidence on the VRBE in the Bi 2+ 2 P 1/2 ground state in NaYGeO 4 , but also shows how to design and develop good afterglow phosphors for anti-counterfeiting and X-ray imaging by deeply studying and controlling the trapping processes of charge carriers in bismuth and/or lanthanides doped inorganic compounds.
研究领域:
材料科学
·
光学工程
✓ 已验证
DOI
高影响因子
Computational and Structural Biotechnology Journal
·
2019
·
IF 4.72
Shu-Ting Lu,Dan Xu,Ru-Fang Liao,Jia-Zhen Luo,Yu-Hang Liu,Zhen-Hua Qi,Cai-Ju Zhang,Nai-Li Ye,Bo Wu,Hai-Bo Xu
Single-component nanomaterials such as bismuth (Bi) based on nanoparticles (NPs) intrinsically having both diagnostic and therapeutic capabilities are widely needed in biomedical fields. However, their design and fabrication still face enormous challenges. Here, a kind of pure Bi NPs with ultrahigh X-ray attenuation coeffcient was developed and evaluated as a simple but powerful theranostic nanomaterals and potent light-to-heat conversion efficiency for photoacuostic imaging (PAI)/photothermal therapy (PTT) in this study. The prepared pure Bi NPs showed excellent photothermal performance and the temperature of NPs solution (1 mg/mL) increased to 70 °C under near-infrared light irradiation within 4 min. The pure Bi NPs showed obvious enhancement effect both in X-ray computed tomography (CT) and PA imaging modalities in vivo . In addition, the glioma growth was efficiently suppressed by the pure Bi NPs after 808 nm laser irradiation, while maintained the biosafety and low toxicity. Thus, it is notable that this type of Bi nanomaterial has great potential in multi-imaging guided cancer treatment.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）