FOOD CHEMISTRY
·
2026
·
IF 10.4
Ji-min Lv,Wang-ting Zhou,Chong-de Sun,Yan Cao,Qi-le Xia,Zeng-qun Zhou,Sen-miao Liang,Meng-ting Wang,Xing-jiang Qi
An ultrasonic-assisted natural deep eutectic solvent (UAE-NaDES) method was developed to extract flavonoids from Chinese bayberry leaves. The extraction conditions were optimized by response surface methodology using a Box-Behnken design. The choline chloride and lactic acid (1:3, 20% water) NaDES exhibited superior flavonoid extraction efficiency (135.12 mg myricitrin equivalent/g dry weight) compared with 80% ethanol under optimized ultrasonication conditions (485 W, 25 min, 50 °C). Fifteen flavonoids were identified, among which myricitrin was the most abundant, followed by myricetin deoxyhexoside gallate and epigallocatechin gallate. Molecular dynamics simulations indicated that UAE-NaDES improved extraction efficiency by forming more stable hydrogen bonds and increasing the solvent-accessible surface area. Electron spin resonance spectroscopy confirmed that the extracts obtained by UAE-NaDES exhibited stronger DPPH and •OH radical-scavenging activities than those obtained using conventional organic solvent extracts. This study provides a sustainable and efficient green strategy for high-value utilization of Chinese bayberry leaves through flavonoid extraction.
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PubMed
高影响因子
Frontiers in Pharmacology
·
2024
·
IF 4.4
Wang Mengting,Mao Haiguang,Ke Zhijian,Wang Jinbo
Background: The hypoglycemic effects of Chinese bayberry leaves proanthocyanidins (BLPs) have been demonstrated. It is unclear, nevertheless, whether BLPs reduced postprandial blood glucose levels by regulating glucose uptake and glucose transport.
Method: This study investigated the effect of BLPs (25, 50 and 100 μg/mL) on glucose uptake and glucose transport in human intestinal epithelial cells (Caco-2 cells). The uptake of 2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl) amino]-D-glucose (2-NBDG) and disaccharidases activity in Caco-2 cells were measured. The glucose transport ability across the cell membrane was determined using the established Caco-2 monolayer model. The transcript and protein levels of key glucose transporters were analyzed using real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting, respectively.
Results: The results showed that BLPs significantly decreased glucose uptake and disaccharidases activity (p<0.05). Otherwise, BLPs treatment obviously inhibited glucose transport across the Caco-2 monolayer in both simulated-fast (5 mM glucose) and simulated-fed (25 mM glucose) conditions. It was attributed to the suppression of glucose transporter2 (GLUT2) and sodium-dependent glucose cotransporter 1 (SGLT1) by BLPs. BLPs were found to significantly downregulated the transcript level and protein expression of glucose transporters (p<0.05). Meanwhile, the mRNA expression of phospholipase C (PLC) and protein kinase C (PKC) involved in the signaling pathway associated with glucose transport were decreased by BLPs.
Conclusion: These results suggested that BLPs inhibited intestinal glucose transport via inhibiting the expression of glucose transporters. It indicated that BLPs could be potentially used as a functional food in the diet to modulate postprandial hyperglycemia.
研究领域:
药理学
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营养学
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细胞生物学
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PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2023
·
IF 6.2
Tong Wu,Fang Ren,Zhengzheng Guo,Jiale Zhang,Xin Hou,Zhengyan Chen,Yanling Jin,Penggang Ren
The flourishing development of electronic devices and radar detection technologies necessitates the urgent creation of high-efficiency electromagnetic wave (EMW) absorption materials with expansive absorption bandwidths. Although MXene has garnered significant interest in the domain of EMW absorption due to its tunable dielectric properties and structural designability, its high permittivity often results in poor impedance matching and a single loss mechanism, which makes it difficult to realize optimal EMW absorption capabilities. In this work, CoNi bimetallic metal–organic frameworks (MOFs) derived bayberry-like magnetic porous carbon (CoNiMPC)@carbon nanotubes (CNTs)/MXene (CNCM) hybrids were initially synthesized via simple solution precipitation, thermal treatment, and electrostatic self-assembly strategy. As anticipated, excellent EMW absorption characteristics were achieved by adjusting the ratio of CoNiMPC@CNTs and MXene. Multi-heterointerfaces consisting of zero-dimensional porous carbon , one-dimensional carbon nanotubes, and two-dimensional (2D) MXene, electrical/magnetic coupling effects, and polarization loss induced by abundant heterointerfaces endow the prepared CNCM hybrids with high-performance EMW absorption. Notably, the CNCM-7 hybrid material exhibits a minimum reflection loss (RL min ) of − 65.3 dB at 6.8 GHz with a mere 2.7 mm thickness and an effective absorption bandwidth (EAB, RL < −10 dB) of 5.0 GHz at a thickness of 1.27 mm. This study proposes a unique viewpoint and approach towards the design and preparing high-performance MXene-based EMW absorption materials.
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FOOD CHEMISTRY
·
2021
·
IF 7.514
Qiaozhi Zhang,Zhijie Huang,Yong Wang,Yanbo Wang,Linglin Fu,Laijin Su
Protein glycation and formation of advanced glycation end-products (AGEs) impose threats to the human health. This study firstly investigated the inhibition of Chinese bayberry ( Myrica rubra ) phenolics on AGEs formation through mechanistic analysis. Four common Chinese bayberry cultivars were selected to prepare phenolic-rich extracts (CBEs) and characterized for phenolic composition, and their anti-AGE properties were evaluated in multiple in vitro systems. Total sixteen phenolics were quantified in CBEs by UPLC-ESI-MS/MS. CBEs reduced total and specific fluorescent AGEs formation in various simulating models, and protected the protein from structural modification, oxidation, and cross-linking. Mechanistic analysis unveiled that scavenging of free radicals, inactivation of transition metals, interaction with protein to form complexes, and trapping of reactive α-dicarbonyls to form adducts underlain the mechanisms of the anti-glycative actions of CBEs. Chinese bayberry fruits, especially the cultivars Biqi and Wuzi, may be a promising dietary strategy to mitigate AGEs load in the human body.
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高影响因子
Journal of Functional Foods
·
2019
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IF 3.197
Mengting Wang,Jing Jiang,Jinhu Tian,Shiguo Chen,Xingqian Ye,Yaqin Hu,Jianchu Chen
α-Glucosidase is a key enzyme related to starch digestion and type-2 diabetes. In the present study, the inhibition effect and the underlying mechanism of Chinese bayberry leaves proanthocyanidins (BLPs) on α-glucosidase were investigated by enzyme kinetic analysis, multi-spectroscopy and molecular docking simulation. The results revealed that BLPs was a high potential noncompetitive-type inhibitor of α-glucosidase with the half maximal inhibitory concertation (IC50) value of 0.037 ± 0.001 mg mL −1 and acarbose equivalent (AE) of 517.01 mmol AE g −1 . What’s more, BLPs may interact with some amino acids surrounded in the allosteric site of α-glucosidase to form a complex driven by hydrogen bonding and hydrophobic interaction, and thus change the structure and microenvironment of α-glucosidase, leading to the decrease of activity of α-glucosidase. The present study suggested that BLPs as epigallocatechin-3-O-gallate (EGCG) polymers could be a novel α-glucosidase inhibitor and had potential to be further used in functional food or anti-diabetic drug.
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Food & Function
·
2017
·Vol. 8
·期 9
·3259-3270
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IF 3.247
Xiaozhou Zhou,Shiguo Chen,Xingqian Ye
The anti-obesity effects of different proanthocyanidin extracts (PE) from Chinese bayberry (Myrica rubra Sieb.et Zucc.) leaves were evaluated in a high-fat (HF) diet-induced obese rat model. The leaves of Chinese bayberry (LCB), a non-desaccharified proanthocyanidin extract (NDPE), and a desaccharified proanthocyanidin extract (DPE) were compared with orlistat, a conventional anti-obesity drug used as a positive control. The rats from all of the PE-treated groups showed obvious weight loss, with the greatest weight loss in the DPE group (P < 0.05). Compared to the HF group, almost all of the PE-treated groups showed significantly reduced levels of serum TC, TG, AST, ALT, ALP, LDL-C, ADP and a LEP/ADP ratio, and increased levels of HDL-C and LEP. Furthermore, the expression levels of SIRT1, PPAR-γ, C/EBP-α, BMP4 and UCP1 were investigated in the liver, kidney, epididymis and abdominal adipose tissue. Compared to the HF group, PPAR-γ and C/EBP-α levels were significantly reduced and SIRT1, BMP4 and UCP1 levels were significantly upregulated in the DPE-treated group. Our results suggested that PE exerted its anti-obesity effects by upregulating the expression of SIRT1, thus inducing the deacetylation of PPAR-γ and downregulating the expression of C/EBP-α, and also upregulating the expression of BMP4 to boost the levels of brown fat.
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Food Packaging and Shelf Life
·
2025
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IF 10.6
Yifan Xue,Ben Niu,Yanchao Han,Weijie Wu,Guannan Wang,Ming Yin,Xiangjun Fang,Ruiling Liu,Hangjun Chen,Haiyan Gao,Honglei Mu
In this study, dual-functional cellulose-based cushioning packaging materials containing cinnamaldehyde essential oil (CEO) were developed to reduce vibrations and provide antibacterial activity during fruit transportation. Cellulose was extracted from Zizania latifolia byproduct, and the cellulose cushioning materials containing CEO (CEO@CCM) were prepared using the mechanical foaming and polyvinyl alcohol (PVA) blend reinforcement method. Compared with traditional corrugated cardboard, CEO@CCM exhibited optimal static compression performance. The incorporation of PVA improved its mechanical properties, resulting in a porosity of 95.42 %, cushioning coefficient of 5.14, and rebound rate of 85.31 %. Cinnamaldehyde was incorporated into the cushioning material to impart antibacterial properties, effectively inhibiting the growth of Penicillium citrinum and Escherichia coli in vitro. Additionally, the application of CEO@CCM in reducing vibrations during simulated transportation of bayberry was investigated. The packaging technique could maintain fruit quality by minimizing mechanical damage and inhibiting microbial growth. The dual-functional cushioning packaging demonstrates significant application potential for enhancing food self-life.
研究领域:
食品科学
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材料科学
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Jiarui Tong,Xiangrong Zhu,Xiumei Chen,Nengguo Tao
Chinese bayberry is a highly fragile and perishable fruit that requires protective and functional packaging to maintain its postharvest quality. In this study, a novel bio-based aerogel was developed using a gelatin/dialdehyde starch matrix reinforced with cellulose nanofibrils (CNF) via Schiff-base crosslinking and freeze-drying. The as-prepared aerogel exhibited superior compressibility, elasticity, and biodegradability. This aerogel was further functionalized by loading trans-2-hexenal (E2H) and combined with 1-methylcyclopropene (1-MCP) treatment, thereby constructing a postharvest preservation system for Chinese bayberry with the triple functionality of ethylene inhibition, antifungal activity, and cushioning performance. The optimal aerogel formulation (30% CNF content) demonstrated robust mechanical performance and sustained E2H release behavior, which followed first-order kinetics. In vitro and in vivo assays confirmed its significant inhibitory effect against Penicillium citrinum , the primary postharvest pathogen of bayberry. Storage experiments at 4 °C revealed that the synergistic effect of E2H-loaded aerogel pads and 1-MCP treatment effectively reduced decay, preserved firmness and nutritional quality, and extended the shelf life of bayberries to 18 d, significantly surpassing the control group which lost commercial value after 8 d. Furthermore, the aerogel completely degraded in soil within two weeks, confirming its potential as an eco-friendly packaging material. This work, integrating both protective and active preservation functionalities, provides a sustainable and efficient packaging approach for fragile fruit.
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Food Frontiers
·
2025
·
IF 6.9
Ji-Min Lv,Wei Quan,Xiao-Hua Cheng,Jing Zhu,Aliyu Idris Muhammad,Wang-Ting Zhou,Xing-Jiang Qi,Chong-De Sun
Polyphenols have been widely recognized for their ability to modulate the host inflammatory response and orchestrate the intestinal microenvironment. In this study, epigallocatechin gallate (EGCG), dihydromyricetin-3′-O-sulfate (DMS), and myricitrin were identified as the major bioactive polyphenols in bayberry leaves and subsequently isolated with high purity (≥98%) by preparative liquid chromatography. Among them, myricitrin exhibited strong anti-inflammatory effects without cytotoxicity in Caco-2 cells by suppressing NF-κB activation and downstream inflammatory cytokines. In a DSS-induced colitis model, myricitrin effectively alleviated disease symptoms, preserved colonic tissue integrity, promoted goblet cell activity, and reduced inflammation-related cytokines. It also reshaped gut microbiota composition by enriching beneficial genera such as Akkermansia and Ligilactobacillus . Molecular dynamics simulations further revealed stable hydrogen bonding between myricitrin and NF-κB at key residues, providing mechanistic support for its anti-inflammatory activity. Together, these findings highlight high-purity myricitrin as a promising functional food ingredient for intestinal inflammation intervention and microbiota-targeted modulation.
研究领域:
植物化学
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炎症研究
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胃肠病学
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营养科学
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微生物组研究
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分子生物学
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计算生物学
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DOI
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Huijia Song,Haipin Zhang,Yulian He,Ruixia Gao,Yue Wang,Wenting Wang,Lisa D. Pfefferle,Xiaoshuang Tang,Yuhai Tang
Rutin (RT), a widely distributed natural flavonoid compound, has been generally utilized as an important active ingredient owing to its considerable biomedical and economic value. Inspired by the structure features of densely-packed bayberry and well-orientated honeycomb, a novel type of magnetic molecularly imprinted polymers (HB-TI-MMIPs) with abundant high-affinity and uniformly-distributed binding sites was rationally constructed for the selective enrichment of RT from Sophora japonica. The polymerization conditions, physicochemical properties, and adsorption performance of the imprinted nanomaterials were systematically investigated. The optimized HB-TI-MMIPs display a high adsorption capacity, fast adsorption rate, and satisfactory selectivity towards RT. Meanwhile, the proposed analytical methodology using HPLC, with HB-TI-MMIPs as adsorbents, successfully applied to enrich and detect RT from Sophora japonica with high recoveries (87.2–94.6%) and good RSDs (lower than 4.3%). Therefore, the fabricated HB-TI-MMIPs with a fast magnetic responsivity and desirable adsorption performance would be attractive in plant active ingredients extraction fields.
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ACS Omega
·
2020
·
IF 2.87
Yilong Liu,Xianan Zhang,Liuhuan Zhan,Chang Xu,Linxiao Sun,Huamin Jiang,Chongde Sun,Xian Li
The present study is to investigate the polyphenolic composition and in vivo antidiabetic effect of white-fleshed Chinese bayberry cultivar “Shui Jing”. By liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS), 38 polyphenols were identified in the Shui Jing fruit extract (SJE), where proanthocyanidins (PAs), including epigallocatechin gallate (EGCG), as well as flavonols, including myricitrin and quercetrin, were the predominant ingredients. After a 5-week experiment, the SJE (200 mg/kg bodyweight) significantly reduced fasting blood glucose, elevated glucose tolerance, and insulin sensitivity in diabetic KK-Ay mice. It markedly attenuated bodyweight gain and decreased glycolipid metabolism-related markers including insulin, leptin, glucagon, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and alanine aminotransferase (ALT) levels in mice. Liver weight and hepatic lipid accumulation were also significantly reduced by the SJE. Gene expressions of insulin 1 (INS1) and glycogen synthase kinase 3 β (GSK3b) were markedly inhibited while the hepatic phosphorylation of AMPKα was significantly increased in the liver of SJE-treated mice, indicating that the SJE may exert an antidiabetic effect through an AMPK-dependent pathway. In conclusion, white bayberry rich in PAs and flavonols may have great potential in the regulation of diabetes mellitus.
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Food Bioscience
·
2024
·
IF 4.8
Lijun Jiang,Chenyu Wang,Fan Zhao,Shuangdie Li,Di Sun,Qingbao Ma,Zhongjie Yu,Bin Zhang,Yu Liu,Wei Jiang
Aquatic products were susceptible to spoilage during storage due to microorganisms and enzymes , which could cause food safety problems. The electrospun nanofiber films, based on pullulan (PUL) and polyvinyl alcohol (PVA) incorporating bayberry pomace anthocyanin extract (BAE), were developed to monitor the freshness states of aquatic products in this study. The SEM results revealed that the electrospun nanofiber films exhibited a smooth surface, and the average diameter decreased from 481.56 nm to 237.68 nm as anthocyanin content increased from 0 to 20%. The FTIR and XRD results showed that there were no new characteristic peaks, confirming the successful loading of BAE. The incorporation of BAE decreased the water content (from 13.58% to 7.84%), swelling ratio (from 146.75% to 114.24%), water vapor permeability (from 3.38 g·mm·m −2 ·Pa −1 ·s −1 ·10 −5 to 2.00 g·mm·m −2 ·Pa −1 ·s −1 ·10 −5 ), and elongation at break (from 24.67% to 14.90%), but increased water solubility (from 74.99% to 85.74%) and water contact angle (from 51.84° to 63.73°). The electrospun nanofiber films presented obvious color changes in buffer solutions (pH 2.0 to 12.0) or volatile ammonia and showed good reversibility. Besides, the electrospun nanofiber films were stable during storage at 4 °C or 25 °C for 20 days. Furthermore, PUL-PVA-A15 effectively distinguished the freshness states (fresh, sub-fresh and spoiled) of Penaeus vannamei during storage at 4 °C by showing different colors (from pink to grayish purple to green). Therefore, the electrospun nanofiber films showed great potential to real-time monitor the quality of aquatic foods as intelligent packaging.
研究领域:
食品科学
·
材料科学
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高影响因子
危险品化学品经营许可证（带存储）