POLYMER
·
2026
·
IF 5.1
Wei Luo,Hongyan An,Chao Tan,Liang Wang,Daozhu Dong,Qing Liu,Qiao Cheng,Xiangzhi Song
Sustained-release technologies for fragrance hold significant application value in the daily chemical, agricultural, and tobacco industries. However, conventional carrier systems such as nanoparticles, microcapsules, micelles, and inclusion complexes suffer from complicated preparation processes, poor scalability, and high costs. To address these challenges, we designed a facile and green fragrance sustained-release film system based on a hydrogen-bond-mediated cellulose–menthol network, which features simplified processing and a tunable structural architecture. The resulting composite films (HPMC@M and HEC@M) exhibited excellent film-forming ability, high menthol encapsulation efficiency (up to 90%) and a fivefold extension of the release period compared to free menthol. GC-MS and thermogravimetric analysis (TGA) revealed that the cellulose network effectively suppresses menthol volatilization, while SEM observations and XRD analysis confirmed a homogeneous porous structure that enables gradual diffusion. DFT calculations and FTIR analysis revealed that intermolecular hydrogen bonding between menthol and cellulose chains is the dominant retention mechanism, with HPMC exhibiting a stronger interaction energy (−25.27 kcal mol −1 ) than HEC (−22.18 kcal mol −1 ), which accounts for its superior release control. This environmentally benign, scalable, and low-cost approach provides a promising platform for the sustained release of lipophilic fragrances and functional volatiles in diverse industrial applications.
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DOI
高影响因子
BIOMATERIALS
·
2025
·
IF 12.9
Chunxue Dai,Yingjiao He,Hongyan Lu,Xiaotong Feng,Naling Long,Qile Song,Yuwei Li,Yifan Wang,Lisandra L. Martin,Cundong Fan,Dongdong Sun
Hydrogen therapy as an emerging strategy for anticancer medicine is attracting attention. However, the limitations of effective hydrogen storage and release have hindered its development and application for hydrogen therapy. Herein, a high hydrogen storage nanoquadruplex (PdH 0.2 ) 4 Se based on a palladium-selenium core has been designed and shows enhanced intratumoral accumulation via an enhanced permeability and retention (EPR) effect. High-efficiency hydrogen can be released from (PdH 0.2 ) 4 Se, activated by near infrared irradiation (NIR), and combines with available selenium (Se) to produce highly toxic hydrogen selenide (H 2 Se), which in turn unbalances the GSH/GSSG ratio and induces ROS overproduction. The effect demonstrates that (PdH 0.2 ) 4 Se irradiated by NIR significantly inhibits cancer cell proliferation, migration, invasion and angiogenesis in vitro . Furthermore, irradiation of (PdH 0.2 ) 4 Se by NIR can induce significant ferroptosis of cancer cells by triggering mitochondrial dysfunction, ROS generation and lipid peroxidation-mediated oxidative damage in vitro . Finally, NIR irradiated (PdH 0.2 ) 4 Se also exhibits tumor-targeted photothermal imaging, and inhibition of tumor growth in vivo activating cancer ferroptosis. Importantly, (PdH 0.2 ) 4 Se demonstrates excellent safety and biocompatibility in vitro and in vivo . Thus together, our findings support the rational design of an effective hydrogen storage (PdH 0.2 ) 4 Se nanoquadruplex with NIR-controlled release causing an unbalance of cellular GSH/GSSG and inducing cancer ferroptosis could be a highly efficient strategy for hydrogen-mediated cancer therapy.
研究领域:
纳米医学
·
癌症生物学
·
光疗
·
药物输送
·
生物无机化学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Zhanhu Xu,Ya Liu,Dongfang Wang,Shujie Yan,Yiyang Xu,Xiaofeng Wang,Qian Li
Metal-organic frameworks (MOFs) are considered highly promising nanomedicine carriers due to their well-defined structures, high specific surface area and porosity, adjustable pore size, and ease of chemical functionalization. However, traditional MOFs face limitations in lattice size and strong non-covalent interactions between the host and guest, posing significant challenges for high and responsive drug loading. In this study, defect-engineered MOFs (UiO-66-NH 2 ) with uniform mesopores were successfully prepared by reducing ligands and adding modulators. Compared to perfect UiO-66-NH 2 , the loading capacity of the defective UiO-66-NH 2 increased more than twofold. Utilizing phase change material as a trigger for drug release, precise temperature-responsive drug release was accomplished. This offers a novel strategy for MOFs materials in drug delivery and controlled release . This study will aid future efforts in using MOFs for selective drug delivery to cells, particularly in cancer treatment and related fields.
研究领域:
纳米医学
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHARMACEUTICAL SCIENCES
·
2017
·
IF 2.713
Yao Lv,Qixia Pan,S.W. Annie Bligh,Heyu Li,Huanling Wu,Qingqing Sang,Li-Min Zhu
In this work, a smart drug delivery system of core-sheath nanofiber is reported. The core-sheath nanofibers were prepared with thermoresponsive poly-(N-isopropylacrylamide) (as core) and hydrophobic ethyl cellulose (as sheath) by coaxial electrospinning. Analogous medicated fibers were prepared by loading with a model drug ketoprofen (KET). The fibers were cylindrical without phase separation and have visible core-sheath structure as shown by scanning and transmission electron microscopy . X-ray diffraction patterns demonstrated the drug with the amorphous physical form was present in the fiber matrix. Fourier transform infrared spectroscopy analysis was conducted, finding that there were significant intermolecular interactions between KET and the polymers. Water contact angle measurements proved that the core-sheath fibers from hydrophilic transformed into hydrophobic when the temperature reached the lower critical solution temperature. In vitro drug-release study of nanofibers with KET displayed that the coaxial nanofibers were able to synergistically combine the characteristics of the 2 polymers producing a temperature-sensitive drug delivery system with sustained-release properties. In addition, they were established to be nontoxic and suitable for cell growth. These findings show that the core-sheath nanofiber is a potential candidate for controlling drug delivery system.
研究领域:
材料科学
·
药学
·
纳米技术
·
药物递送系统
✓ 已验证
DOI
PubMed
高影响因子
POLYMER TESTING
·
2021
·
IF 4.282
Yanping Huang,Ye Dan,Nianhua Dan,Yining Chen
An inflammatory-responsive intelligent controlled-release drug-loaded membrane (polycaprolactone/poly (hydroxyethyl methacrylate hydroxyethyl-methacrylate -2-(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol -3-yl) acetoxy) ethyl meth acylate) PCL/P(HEMA-HEIn) was prepared. Drug precursors HEIn was synthesized by the esterification reaction between indomethacin (Indo) and hydroxyethyl methacrylate (HEMA) and the structure of HEIn was confirmed by 13 C NMR and ESI-MS. Through in-situ crosslinking polymerization and solvent evaporation, the drug-loaded membranes were fabricated. Furthermore, the morphology, chemical and physical properties demonstrated that HEIn and HEMA were copolymerized and well dispersed in the film. The drug released from PCL/P(HEME-HEIn) could be triggered by inflammation environment and the release amount increased along with the degree of inflammation. Results of in vivo evaluation proved that the PCL/P(HEME-HEIn) film had the capacity of inhibiting inflammation, which was beneficial to wound healing. The proposed strategy towards PCL/P(HEME-HEIn) opened new window for drug controlled-releasing via inflammatory response.
研究领域:
药学
·
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
·
IF 3.764
Dan-Na Hu,Xiao-Jie Ju,Xing-Qun Pu,Rui Xie,Wei Wang,Zhuang Liu,Liang-Yin Chu
Self-regulating insulin controlled-release systems have gained more attention due to their advantages of timely response to blood glucose change and avoiding side effects caused by the high-frequency injection. In this paper, the temperature-responsive monomer N-isopropylacrylamide (NIPAM) and glucose-responsive monomer 3-acrylamidophenylboronic acid (AAPBA) are copolymerized and then grafted with alginate to prepare temperature/glucose dual-responsive copolymers alginate-g-P(NIPAM-co-AAPBA) (Alg-g-PNA). The temperature and glucose responsiveness under different conditions, rheological characteristics, glucose-mediated insulin release, and biotoxicity of the Alg-g-PNA copolymers are studied. The results show that the copolymer solution is in the sol state at 10 °C and insulin can be dispersed uniformly, while it turns into the gel state when the temperature rises to physiological 37 °C for in situ delivery of insulin. Due to the sensitivity to blood glucose levels, the hydrogels can quickly respond to the increase in blood glucose and undergo the gel-to-sol transition and release insulin to reduce blood glucose when the environmental blood glucose rises. Moreover, the hydrogels have good sol–gel transition reversibility in response to changes between normoglycemic and hyperglycemic levels. The cell cytotoxicity results show that the hydrogels have good biocompatibility to be a safe carrier for insulin delivery. The proposed injectable temperature/glucose dual-responsive hydrogels in this study provide a novel type of self-regulating insulin delivery systems for diabetes therapy.
研究领域:
生物材料
·
糖尿病治疗
·
高分子化学
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2018
·
IF 5.08
Yanze Bi,Xinyun Zhu,Jianliang Zhao,Hanrui Cui,Zhenguo Wang,Yan Li,Cai-qi Wang
Magnesium has a very promising adhibition in biomedical field for its excellent mechanical and biodegradable properties, however, the intelligent applications of biomedical magnesium developed difficultly due to its characteristic degradation. A intelligent biomedical magnesium was constructed on magnesium (Mg) surface by incorporating polydopamine (PD) and mechanized hollow mesoporous silica nanoparticles (HMSs) as smart delivery platform nanocontainers. The supramolecular nanovalves of mechanized HMSs consisted of alginate/chitosan multilayers by self-assembly, which are capable of entrapping rhodamine 6G in the mesopores and can release the cargo under the chemical environment of alkali or Mg iron stimuli that correspond to the degradation of biomedical Mg. The alkali/Mg 2+ dual stimuli-responsive release property of the HMSs endows the biodegradable Mg with controlled release potential. The well-designed smart delivery nanocontainers were combined with polydopamine deposited on Mg for excellent adhesion properties and positively charged amino group of PD. Furthermore, when the biomedical Mg with these mechanized HMSs was degraded in the simulated body environment, the alkali/Mg 2+ -triggered release of cargos from this smart delivery platform could bring a more functional application.
研究领域:
生物医学工程
·
材料科学
·
纳米技术
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
Advanced Materials Interfaces
·
2019
·Vol. 6
·期 4
·1801965
·
IF 4.713
Yunyu Sun,Ye Liu,Bo Song,Hui Zhang,Ruomeng Duan,Dafeng Zhang,Bin Dong
Micromotor that exhibits various movement behaviors has attracted more attention in recent years. However, most researchers focus on its motion behavior and few have studied the fluid flow surrounding it. In this work, a novel micromotor with both controlled motion behavior and surrounding fluid flow, which is driven by near-infrared (NIR) light based on the unique Marangoni effect caused by the light irradiation of its constituent, i.e., polypyrrole (PPy), is reported. Interestingly, these motion behaviors and the surrounding fluid flow can be easily switched by adjusting the incident angle of the NIR laser. This unique property may have potentials in different fields. Among others, its application in remotely controlled targeted delivery and release is demonstrated.
研究领域:
材料科学
·
生物医学工程
·
流体力学
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产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2016
·
IF 0.62
Xu Zhang,Yanbao Zhao,Songqiang Xie,Lei Sun
Thiol and amine difunctionalized porous silica (pSiO 2 -SH/NH 2 ) nanoparticles (NPs) were prepared by condensation. The obtained pSiO 2 -SH/NH 2 NPs present uniform spheres with size of 55 nm . Folic acid (FA) as a tumor targeting agent was conjugated on the surface of pSiO 2 NPs by amide linkage (pSiO 2 -SH/FA NPs), and captopril (Cap) as test drug was used to evaluate the releasing behavior. Results indicated that Cap is easily encapsulated into the pores of pSiO 2 -SH/FA NPs, which can further react with the inner thiols to form disulfide bonds . The Cap release from pSiO 2 -Cap/FA nanocarriers can be controlled by dithiothreitol (DTT) or reduced glutathione (GSH). The pSiO 2 -SH/FA nanocarriers showed low cytotoxicity and redox-responsive drug release.
研究领域:
纳米医学
·
药物递送系统
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2019
·Vol. 10
·期 26
·3585-3596
·
IF 4.76
Xiaoying Xu,Qian Zhang,Kang Liu,Nailiang Liu,Ying Han,Weixing Chen,Chao Xie,Pengfei Li,Jie He
Photo-controlled release that shows a quick response and high spatial/temporal accuracy has become attractive given its potential applications for biomedicines. A few metal complexes are known for their uses in detoxification, sterilization, and diagnosis and treatment of diseases, but, the encapsulation and controlled release of those metal ions using polymer micelles are challenging. We report an interesting photo-controlled release of metal ions via photo-responsive triazoline-containing amphiphilic polymers. Amphiphilic random copolymers of glycidyl methacrylate and oligo(ethylene oxide) methyl ether methacrylate were prepared through free radical copolymerization. The glycidyl pendants were converted to azide, followed by a 1,3-dipolar cycloaddition reaction to form triazoline with norbornene. The resulting random copolymers containing triazoline formed micelles with a critical micellar concentration (CMC) of 7.68 × 10−3 mg mL−1. The triazoline moieties could coordinate to transition metal ions, e.g. Co2+, and thus encapsulate the metal ions to the core of micelles. Photo-induced denitrogenation of triazoline was able to disrupt the coordination of Co2+ and triazoline, therefore leading to the release of Co2+. Solution viscosity, UV-vis/NMR spectroscopy and TEM were used to show that the coordination and release of Co2+ ions were successful upon exposure to light. The photo-controlled release profile was found to be linearly dependent on the irradiation time, which is potentially useful for the delivery of essential ions in vivo.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Xuan Huang,Xuezhong Du
The synthesis and host–guest chemistry of pillararene (PA) derivatives are a hot research topic, and the applications of PAs in relevant research fields are essential to explore. Carboxylate-substituted pillar[6]arene (CPA[6])-valved mesoporous silica nanoparticles (MSNs) functionalized with dimethylbenzimidazolium (DMBI) and bipyridinium (BP) stalks were constructed, respectively, for multiresponsive controlled release. CPA[6] encircled the DMBI or BP stalks to develop supramolecular nanovalves for encapsulation of cargo within the MSN pores. The release of cargo was triggered by acidic pH or competitive binding for the dethreading of CPA[6] and the opening of the nanovalves; moreover, coordination chemistry is the first strategy to activate CPA nanovalves by metal chelating with the carboxylate groups of CPA for cargo release. The controlled release of the CPA[6]-valved MSN delivery systems can meet diverse requirements and has promising biological applications in targeted drug therapy.
研究领域:
材料科学
·
药物化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2017
·
IF 2.714
Kai-di Cui,Bei-xing Li,Xue-ping Huang,Lei-ming He,Da-xia Zhang,Wei Mu,Feng Liu
Sustained-release profile is an important component in the quality control of microcapsules. In the current study, we propose a reliable, convenient, and versatile strategy to assess the controlled-release performance of MCs under artificial, simulated conditions. Dissolution tests were performed using an experimental device equipped with syringe filters. The optimum experimental conditions utilized 80% v/v methanol (3 ml) as a release medium at each sampling point, Nylon 6 filters (13 mm diameter, 0.22 μm pore size) as diffusion barriers, and a sampling regime based on predetermined changed intervals. Validation tests demonstrated that this strategy possessed favorable universality for three wall materials (polyurea, polyurethane and urea-formaldehyde) and three core materials (phoxim, pyraclostrobin and clomazone), as all sampling points had standard errors below 3.4%. Our proposed method also showed apparent advantages in experimental precision and the demand for a release medium compared with dynamic dialysis.
研究领域:
药剂学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）