DYES AND PIGMENTS
·
2018
·
IF 3.767
Xiran Yang,Simin Liu
The host−guest interactions between Auramine O ( AuO ) dye and cucurbit[ n ]uril (CB[ n ], n = 7, 8) were investigated in aqueous solution by 1 H NMR, UV/Vis, fluorescence spectroscopic techniques and single crystal diffraction. The results indicate the simultaneous formation of 1:1 and 2:1 inclusion complexes between CB[7] and AuO with two binding constants as 1.17 × 10 5 M −1 and 3.99 × 10 2 M −1 by UV/Vis spectroscopy titration (1.20 × 10 5 M −1 and 5.26 × 10 3 M −1 by fluorescence spectroscopy) in phosphate buffer (pH 7.4). And a 1:2 homoternary inclusion complex CB[8]· AuO 2 with binding constant as 2.95 × 10 9 M −2 (by fluorescence spectroscopy titration) is detected. Interestingly, the appearance of intense new broad emission band with big red-shift (100 nm) with respect to that of AuO proves the formation of excimer upon encapsulation of AuO molecules in CB[8]. Determination of single crystal structure of CB[8]· AuO 2 further discloses the existence of J-type dimer with intermolecular CH···π interactions between two included phenyl groups on AuO molecules. Upon host−guest complexation of AuO with CB[7] or CB[8], the p K a shifts of AuO were measured.
研究领域:
化学
·
分子科学
·
超分子化学
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产品关联
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2026
·
IF 3.6
Shengke Li,Yiyun Gao,Miao Cheng,Hao Zhou,Kehan Zhang,Ruibing Wang,Aihua Zou
Controllable and on-demand delivery of nanopesticides have great potential to enhance pesticide utilization and facilitate sustainable agriculture. Photo-responsive supramolecular host–guest systems capped on mesoporous nanomaterials are deemed as competitive nanovalves for efficient and straightforward control of pesticide release. Herein, azobenzene-modified mesoporous silica nanoparticles (Azo-MSNs) were fabricated for loading the pesticide imidacloprid (IMI) and subsequent construction of photo-responsive nanopesticides by taking advantage of the ternary host–guest complexes of cucurbit[8]uril(CB[8])/ trans -Azo/paraquat (PQ) as nanovalves. UV-irradiation will open the nanovalves due to attenuated binding affinity of CB[8]/PQ/ trans -Azo complexes, thus triggering the release of trapped IMI inside Azo-MSNs. In detail, MSNs-as (∼160 nm) were synthesized with a template agent and directly used to produce surface-modified Azo-MSNs-as. After template removal, the obtained Azo-MSNs were loaded with IMI to produce IMI@Azo-MSNs (35.60% pesticide loading), which were treated with CB[8]/PQ complexes to construct photo-responsive supramolecular nanopesticides IMI@CB[8]/PQ/Azo-MSNs. The supramolecular nanopesticides can achieve controllable and on-demand release of IMI upon 6 h of UV irradiation (total 51.20% vs. 87.95% during 11 h). This work offers an efficient and straightforward approach to constructing photo-responsive nanopesticides and holds significant importance for the sustainable development of modern agriculture. Graphical Cucurbit[8]uril-based ternary complexes with paraquat and azobenzene are employed as photo-responsive nanovalves for the facile and efficient construction of smart nanopesticides, enabling controllable and on-demand pesticide release. This strategy holds great promise for promoting the sustainable development of modern agriculture.
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DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Yuan-Fu Ding,Tianlei Sun,Shengke Li,Qiaoxian Huang,Ludan Yue,Liangkui Zhu,Ruibing Wang
Orally administered colon-targeted formulations of drugs are of great importance in managing diseases in the colon. However, it is often challenging to maintain the integrity of such formulations during delivery, particularly in the gastric environment, which may lead to premature drug release before reaching the targeted colon. Herein, an oral colon-targeted drug delivery hydrogel (OCDDH) was developed through cucurbit[8]uril (CB[8])-mediated noncovalent cross-linking of phenylalanine (Phe)-modified Konjac glucomannan (KGM), in which berberine (BBR), a natural anti-inflammatory product originating from Chinese medicine, was loaded into the hydrogel matrix. With the strong host–guest complexation mediated cross-linking and the inherent reversibility of such interactions, KGM-Phe@CB[8] hydrogel exhibited a readily tunable degree of cross-linking and an excellent self-healing capability, and therefore the hydrogel retained ultrahigh stability in the gastric environment, which is important for orally administered formulations to target the colon. In the colon, KGM may get degraded by colon-specific enzymes, β-mannanase or β-glucosidase, resulting in burst release of the loaded cargoes on site. The structure and specific payload release of the hydrogel, with and without BBR, have been fully characterized in vitro, and the therapeutic effect of BBR-loaded KGM-Phe@CB[8] hydrogel was evaluated against dextran sulfate sodium (DSS) induced ulcerative colitis (UC) in a mouse model. Very interestingly, the BBR-loaded KGM-Phe@CB[8] hydrogel exhibited significantly improved therapeutic efficacy in treating colitis, without causing any systemic toxicity, when compared with free BBR. This strategy may pave a new way in the development of advanced supramolecular OCDDH.
研究领域:
药学
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药物递送系统
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结直肠疾病
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超分子化学
✓ 已验证
产品关联
DOI
PubMed
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2023
·
IF 6.1
Kai-Ni Wei,Ru-Pei Yang,Shu-Zhen Huang,Zhu Tao,Qing Tang,Ying Huang
The simultaneous detection of multiple quaternary ammonium pesticides (QAPs) in water is a challenge due to their high solubility in water and similar structures. In this paper, we have developed a quadruple-channel supramolecular fluorescence sensor array for the simultaneous analysis of five QAPs, including paraquat (PQ), diquat (DQ), difenzoquat (DFQ), mepiquat (MQ), and chlormequat (CQ). Not only were QAP samples of different concentrations (10, 50, and 300 μM) in water distinguished with 100% accuracy but also single QAP and binary QAP mixed samples (DFQ-DQ) were sensitively quantified. Our experimental interference study confirmed that the developed array has good anti-interference ability. The array can quickly identify five QAPs in river and tap water samples. In addition, it also qualitatively detected QAP residues in Chinese cabbage and wheat seedlings extract. This array has rich output signals, low cost, easy preparation, and simple technology, demonstrating great potential in environmental analysis.
研究领域:
分析化学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Haotian Jiang,Shenghui Liu
In this work, the self-healing polyethersulfone ultrafiltration membrane constructed by host-guest chemistry between cucurbit [8]uril (CB [8] is a family of macrocyclic compounds comprising 8 glycoluril units) and two guest molecules based on reverse thermally induced phase separation (RTIPS) method was developed, which had excellent self-healing performance, better mechanical properties, and high permeation flux and BSA rejection rate. The membrane autonomously restored it BSA rejection rate up to about 89% from rejection rate levels as low as 21% after damage. The observed self-healing performance were attributed to the swelling of pore-filled CB [8] hydrogel into the damage position, the molecular interdiffusion of the hydrogel chains, the strong hydrogen bond of the hydrogel chains and the host-guest interaction between CB [8] and two guest molecules (HEC-Np and PVA-MV). SEM morphologies illustrated that the prepared pore-filled membrane via the RTIPS method had homogeneous and porous skin surface and sponge-like cross-section, which imparted the prepared membranes with improved permeability and better mechanical properties. Properties of MR-CB [8] membranes, which varied with increased content of CB [8], were evaluated by permeability, water contact angle, thermogravimetric analysis (TGA), mechanical properties, FRR, scanning electron microscope (SEM) and atomic force microscopy (AFM). The contact angle water showed that CB [8] hydrogel enhanced the surface hydrophilicity of the prepared membrane. TGA illustrated that the thermal stability improved with the increased content of CB [8]. The optimal pore-filled CB [8] hydrogel membrane (MR-CB [8] 2 ) exhibited that the pure water flux reached 2100.5 L/m 2 h, while the BSA rejection rate remained at 86.0%. The results of this work suggested pore-filled CB [8] hydrogel membrane was a more promising way to develop polyethersulfone ultrafiltration membranes with self-healing performance.
研究领域:
材料科学
·
膜技术
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Lancheng Wang,Mingjie Xu,Huimin Zhou,Kun Yan,Shiqi Duan,Dandan Xue,Youmei Wang,Bin Di,Chi Hu
The target of typical PCR analysis is restricted to nucleic acids. To this end, we report here a novel strategy to simultaneously detect genetic and metabolic markers using commercial PCR kits with cucurbit[8]urils (CB[8]) implemented to manipulate the activity of Taq DNA polymerase. CB[8] binds with the nonionic surfactants and displaces them from the polymerase surface, resulting in decreased enzyme activity. Meanwhile, the inhibited enzyme can be reversibly activated when spermine, the downstream metabolite of ornithine decarboxylase (ODC), is present in the sample, which competitively binds to CB[8] and recovers polymerase activity. CB[8] was implemented in conventional PCR kits not only to reduce false-positive results but also to extend the detection range of PCR technology. With this novel method to detect ODC in cell lysates containing both the nucleotides and intracellular metabolites, positive results were only observed in highly active HEK 293T cells, whereas silent cells treated with ODC inhibitor showed negative readouts, therefore providing a simple but elegant dual-modality PCR method for precision diagnosis.
研究领域:
分子生物学
·
生物技术
·
分析化学
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 9.8
Qinghong Bai,Yu Xia,Yukun Kang,Ying Yang,Yahui Yang,Li Zeng,Chun Liu,Xin Xiao
Gentamicin (GEN), an aminoglycoside antibiotic, is widely used in treating infections within the livestock industry but readily causes food residues and environmental pollution. This study developed a novel water-soluble supramolecular fluorescent probe DBTPy 2+ @Q[8], through host–guest interactions between the methylpyridine-modified benzothiophene cationic fluorophore (DBTPy 2+ ) and cucurbit[8]uril (Q[8]). This enabled specific GEN recognition and detection via the fluorescence indicator displacement (FID) mechanism. The DBTPy 2+ -Q[8] assembly induced significant fluorescence quenching, while GEN addition rapidly restored fluorescence. The restored intensity exhibited a good linear relationship with GEN concentration in the range of 0.1–10 μM (R 2 = 0.996), with a limit of detection (LOD) of 0.206 μM. The probe exhibited good selectivity and anti-interference capability, achieving 92.0%–104.1% spiked recoveries in water and food samples, and enabled specific GEN fluorescence imaging in living cells. This work establishes a novel supramolecular host–guest strategy for fluorescent probes enabling rapid, quantitative, specific GEN detection.
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产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2019
·Vol. 8
·期 13
·1900174
·
IF 6.27
Haishi Qiao,Jing Jia,Haowen Shen,Sibo Zhao,Enping Chen,Wei Chen,Bin Di,Chi Hu
Nanosystems responsive to tumor-specific enzymes are considered as a highly attractive approach to intracellular drug release for targeted cancer therapy. Mesoporous silica nanoparticles are capped with tryptophan-mediated cucurbit[8]uril complex with Fe 3 O 4 to minimize the premature drug leakage while being able to deliver the payload on demand at the target tissue. The supramolecular interaction between tryptophan and cucurbit[8]uril is disrupted in the presence of indoleamine 2,3-dioxygenase 1 (IDO1) enzyme (abundant in the tumor intracellular microenvironment), which catalyzes the metabolism of tryptophan into N -formylkynurenine, resulting in the disassembly of the “gate-keeper” of the nanocarriers and intracellular release of therapeutics exclusively in tumor cells. The drug release from the nanocarrier with high selectivity to overexpressed IDO1 enzyme induces significant cytotoxicity against HepG2 cells in vitro, as well as the superior antitumor effects in vivo. This robust supramolecular nanosystem with sophisticated structure and property provides a promising platform for intracellular drug release targeting the intrinsic microenvironmental enzyme inside the tumor cells.
研究领域:
纳米技术
·
药物递送系统
·
癌症治疗
·
酶响应纳米载体
·
超分子化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2023
·
IF 6
Dan Yang,Yang Luo,Shang Wei Yuan,Li Xia Chen,Pei Hua Ma,Zhu Tao,Xin Xiao
In recent years, most of the constructions on cucurbit[ n ]uril-based supramolecular polymers have been based on host–guest chemistry, however, this limits the choice of host and guest. Herein, we present a newly designed supramolecular polymer, namely Q[8]@PEG-HPTS formed by utilizing outer surface Q[8] interactions. In aqueous solution, the supramolecular polymer Q[8]@PEG-HPTS was obtained quickly and simply by mixing Q[8] with PEG-HPTS, where after, a variety of characterization techniques were employed to confirm the structure of the Q[8]@PEG-HPTS. The ability of this system to selectively recognize metal ions as well as pesticide molecules was also investigated; selectivity was observed for Fe 3+ and paraquat. The biocompatibility and excellent fluorescence properties associated with the constituents of the supramolecular polymer allowed for the imaging of HeLa cells. This system could image and trace the nucleus through the cytoplasm, indicating that it could enter and internalize HeLa cells. Finally, by continuously adjusting the ratio between Q[8] and PEG-HPTS, a Q[8]@PEG-HPTS hydrogel was obtained. This hydrogel exhibited a stimulated temperature response, and opens up further possibilities for exploring the applications of such supramolecular polymers.
研究领域:
化学
·
材料科学
·
生物医学
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Nanhang Zhu,Yujia Zhang,Jia Cheng,Yanchao Mao,Ke Kang,Guohao Li,Qiangying Yi,Yao Wu
Enriching small extracellular vesicles (sEVs) with undamaged structure and function is a pivotal step for further applications in biological and clinical fields. It has prompted researchers to explore a carrier material that can efficiently capture sEVs while also gently release the captured sEVs. Here, 1-adamantylamine (1-ADA) responsive immuno-affinitive supramolecular magnetic nanoparticles (ISM-NPs) incorporating ternary host-guest complexation structures mediated by CB[8] were proposed to achieved the goal. In particular, the ternary host-guest complexation was constructed by the host molecule (cucurbit[8]uril, CB[8]) mediated assembly of two guest molecules (naphthol and bipyridine), and served as a cleavable bridge to connect the magnetic core and peripheral antibody. These constructed ISM-NPs performed well in the applications of capturing sEVs with a high capture efficiency of 85.5%. Further, the CB[8]-mediated ternary host-guest complexation structures can be disassembled with addition of the 1-ADA. Thus, the sEVs recognized by the anti-CD63 were released competitively, with a decent release efficiency more than 82%. The released sEVs kept intact morphology and exhibited appropriate size distribution and concentration. This supramolecular magnetic system, with 1-ADA responsive ternary host-guest complexation structures, may contribute to efficient enrichment of any other biomarkers, likely cells, proteins, peptides, etc.
研究领域:
纳米技术
·
生物材料
·
生物医学工程
·
细胞生物学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2023
·
IF 4.5
Haifeng Yao,Yahui Zhang,Yongping Dong,Mingfu Ye
Graphdiyne (GDY) is considered as another promising carbon material in biosensing field. However, the application of GDY in ECL sensing is in its infancy stage, and different roles of GDY are urgent to be discovered. In this work, strong anodic Ru(bpy) 3 2+ electrochemiluminescence (ECL) was obtained at a cucurbit[8]uril (Q[8]) modified electrode. Although GDY exhibited electrocatalytic effect on the oxidation of Ru(bpy) 3 2+ , an apparent inhibiting effect of GDY on the ECL signal was observed due to the energy transfer. An “on-off-on” mode ECL sensor was fabricated to detect pancuronium (PMD) based on the competitive host–guest interaction between ferrocene (Fc), PMD and Q[8]. Fc modified single-stranded DNA was immobilized onto the surface of GDY, which could be attached onto the electrode through the interaction between Fc and Q[8]. The quenching effect of GDY could apparently decrease ECL signal. PMD exhibited stronger combining ability with Q[8] than Fc, and could replace Fc from the cavity of Q[8], leading to the recovery of ECL signal. The variation of ECL intensity changed linearly with the PMD concentration in the range of 10 nM to 50 μM with a detection limit of 5 nM (3σ). The proposed sensor has high sensitivity, outstanding specificity and accuracy, indicating that GDY has promising potential application in ECL sensing field based on its inhibiting effect.
研究领域:
分析化学
·
生物传感
·
材料科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）