METABOLIC BRAIN DISEASE
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2018
·Vol. 34
·期 1
·93-101
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IF 2.441
Zhu Ji-Xiao,Shan Jia-Ling,Hu Wei-Qiong,Zeng Jin-Xiang,Shu Ji-Cheng
Gallic acid (3,4,5-trihydroxybenzoic acid) is a naturally occurring polyphenolic compound. Previous study has shown that gallic acid possessed significant antidepressant-like activity in mice, which was partly mediated by increasing serotonin and catecholamine levels. The main aim of the present study is to investigate the possible effects of gallic acid on brain-derived neurotrophic factor (BDNF) signaling activation. Mice were exposed to chronic mild stress (CMS) and orally administrated with gallic acid for four weeks. The behavioral results showed that gallic acid not only reversed the decreased sucrose preference, but also attenuated the increased immobility time. In addition, gallic acid promoted both the BDNF and p-TrkB levels in the hippocampus induced by CMS. Moreover, the results also demonstrated that the inactivated Akt-mTOR signaling pathway, as well as its downstream effectors induced by CMS was activated again by gallic acid. Last, immunofluorescence detection indicated that gallic acid reversed the newborn neurons inhibition in the dentate gyrus by CMS. In conclusion, these results show that the activation of the hippocampal BDNF-Akt-mTOR signaling is involved in the antidepressant-like effects of gallic acid.
研究领域:
神经科学
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药理学
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压力研究
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分子生物学
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DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
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2018
·
IF 3.741
Yechang Feng,Yang Hu,Limin Man,Teng Yuan,Chaoqun Zhang,Zhuohong Yang
Shape memory polymers play an increasingly significant role in the fields of electronics, aerospace and medical science. However, the most of shape memory polymers are derived from petroleum resource nowadays. Herein, biobased thiol-epoxy shape memory network was obtained from gallic acid-based thiol and diglycidyl ether of bisphenol A (DGEBA). The resulting network shows good shape memory performance with the shape-fixity ratio of 98.7%, shape-recovery ratio of 97.7% and excellent cycle stability, which is comparable to the petroleum counterparts. Further, epoxidized vegetable oils were incorporated into the above thiol-epoxy network to investigate the effect of epoxidized vegetable oils on the properties of the resulting networks. After introducing the vegetable oils, shape-fixity ratios show irrelevance with the network structures and keep above 96%. Shape-recovery ratio declines with the increase of epoxidized linseed oil (ELO) contents, but when ELO content equals to 20 wt% of DGEBA, shape-recovery speed enhances compared to the network without epoxidized vegetable oils. This is the first attempt to fabricate the thiol-epoxy shape memory networks from renewable biomasses.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
POLYMER
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2020
·
IF 4.231
Longfang Ren,Xiangdong Ma,Jian Zhang,Taotao Qiang
WPU was prepared by a simple and bio-based method using poly(1,3-propylene glycol-adipic acid) (PPA) and isophorone diisocyanate (IPDI) as raw materials. Intriguingly, PPA can be synthesized using 1,3-propanediol which was extracted from plant stalk. Then a non-toxic, environmental-friendly gallic acid modified bio-based waterborne polyurethane (GWPU) was successfully prepared utilizing the prepolymer method with gallic acid (GA) was as a modifier. The structures, morphologies and thermostability of GWPU were confirmed by FTIR, TEM, TG , DSC and AFM . Furthermore. Its mechanical properties and water resistance were evaluated as well. The results demonstrated that self-prepared PPA has no influence on the properties of polyurethane. However, when the content of GA was increased from 0% to 3.3%, the tensile strength of GWPU film increased by 155.3% compared with that of unmodified PU film, the elongation at break decreased by 86%, and the decomposition temperature of the film increased by 23.8 °C, the surface roughness decreased by 41.0%. In addition, through the crosslinking of GA, the water resistance of GWPU is improved.
研究领域:
材料科学
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高分子化学
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环境科学
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DOI
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 24
·15150-15157
·
IF 4.036
Di Huo,Gongge Lin,Mengfan Lv
In this work, a simple and reproducible hydrothermal synthesis was employed to synthesize two-dimensional Bi2Se3 nanosheets by using gallic acid as a reductant. Meanwhile, the effects of the amounts of gallic acid and sodium hydroxide and the surfactant Triton X-100 on phase composition and morphology of the obtained Bi2Se3 were also studied. The results reveal that gallic acid could effectively reduce Se4+ to Se2− and gave rise to the formation of Bi2Se3. Additionally, keeping the reaction conditions of molar ratio of gallic acid to the precursor elements (Bi + Se) at 1 to 1 (or higher) and using strong alkaline solutions were the key factors to synthesize high purity crystalline Bi2Se3 nanosheets. Furthermore, flower-like Bi2Se3 composed of nanosheets with a dozen nanometer thickness could be easily fabricated by adding appropriate amounts of Triton X-100. This work provides a novel approach for synthesis of ultra-thin Bi2Se3 nanosheets in a controllable manner.
研究领域:
材料科学
·
化学
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DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Mengge Feng,Xuelian Zeng,Quan Lin,Yunxiao Wang,Hongjiang Wei,Shanyi Yang,Guangwei Wang,Xingyu Chen,Mengqin Guo,Xin Yang,Jun Hu,Yangge Du,Yanbing Zhao,Yufeng Zhang,Xiangliang Yang
The postoperative periodontal wound is in a complex physiological environment, the bacteria accumulation, the saliva stimulation, and the food residues retention will aggravate the wound deterioration. Commercial periodontal dressings have been widely used for postoperative periodontal treatment, and there still exists some problems, such as poor biocompatibility, weak adhesion, insufficient antibacterial and anti-inflammatory properties. In this study, a chitosan-gallic acid graft copolymer (CS-GA) is synthesized as a potential periodontal dressing hydrogel. CS-GA possesses high swelling rate, adjustable degradability, self-healing ability, biocompatibility, strong adhesion ability, high mechanical properties and toughness. Furthermore, CS-GA has good scavenging ability for ·OH, O 2 − , and 1 O 2. And CS-GA has good inhibition effect on different bacterial through bacterial membranes damage. CS-GA can stop bleeding in a short time and adsorb erythrocytes to form physical blood clots to enhance the hemostatic performance. In addition, CS-GA can reduce inflammatory factors expressions, increase collagen fibers deposition and neovascularization to promote wounds healing, which makes it as a potential periodontal dressing for postoperative tissue restoration. This article is protected by copyright. All rights reserved
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DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2025
·
IF 6.4
QiHang Bu,ZeiFeng Yue,ZiHan Wang,Ning Jiang,Haibo Luo,RongXue Sun,QianYuan Liu,JianHua Xu,Cheng Wang,JiaJun Fu
Given the environmental problems caused by petroleum-based packaging materials, there is an urgent requirement for the development of sustainable bio-based green active packaging materials. Despite this need, the practical application of bio-based polymers, such as chitosan and cellulose, is limited due to their poor mechanical properties and barrier properties. Here, we prepared a novel chitosan-based green active composite film, employing chitosan nanoparticles encapsulating gallic acid as nanofillers. The interfacial interactions between the nanoparticles and chitosan matrix were found to significantly enhance the mechanical properties and barrier properties of the composite film. Moreover, the integration of gallic acid-loaded nanoparticles substantially improved the antimicrobial and antioxidant activities of the composite film. These improvements are crucial for inhibiting the proliferation of food-borne microorganisms and the oxidation of lipids, thereby preserving the quality and safety of foods. Freshness preservation experiments have demonstrated that this composite film could effectively mitigate the quality degradation of crayfish meat during storage, thereby verifying its potential application in the field of food packaging. Consequently, this sustainable bio-based green active packaging film has the potential to replace the traditional petroleum-based packaging film and inspires the development of new sustainable bio-based active packaging films.
研究领域:
食品科学
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材料科学
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DOI
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 21
·15021-15030
·
IF 3.9
Jingxuan Liu,Hongyu Zhao,Mengyue Wang,Wenzheng Ban,Xi Lu,Bin Yan
In this work, gallic acid was successfully grafted onto quaternary aminated chitosan to prepare a high efficiency cationic flocculant. The mechanism of flocculation and different influencing factors were studied in detail. The prepared flocculant only needs 60 mg L−1 to achieve a 98.7% and 94.5% removal rate on methyl blue (MB) and Congo red (CR), respectively. The high removal rate (93.2%) of a CR-MB mixed dye also confirms the universality of flocculation. In addition, kaolin as a simulated suspended solid was removed at a rate of 97% in the experiment at a dosage of 3 mg L−1. A zeta potential test showed that it worked best when the potential of the flocculation system was zero; this was because an electrostatic balance was reached between the flocculant and pollutant. Importantly, the three-functional molecules can provide more possibilities to form hydrogen bonds with water molecules, which is conducive to the stretching of flocculant molecular chains in salt water. The flocculant maintained a high stability in four different salt environments and has a positive industrial application significance. Furthermore, the flocculation experiment of the actual wastewater of the printing and dyeing plant found that the dye wastewater changed obviously from turbidity to clarification, which proved the practical application potential of the flocculant. This work provides a feasible idea for the preparation of bio-based flocculants.
研究领域:
环境科学
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材料科学
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DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
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2021
·
IF 5.03
Pingping Tang,Tingting Zheng,Lirui Shen,Guoying Li
Collagen hydrogels with a three-dimensional network structure were prepared through self-assembly of collagen molecules, and incubated in laccase-catalyzed gallic acid solutions (L-GA) with different concentrations (0.5–10%, w/v, calculated from the L-GA mother solution). UV-visible spectroscopy and Fourier transform infrared spectrometry suggested that quinones and cross-links between the quinones and the collagen molecules had formed. With an increase in L-GA concentration from 0.5 to 5%, the degree of cross-linking increased from 8.78% to 19.13%; when the L-GA concentration exceeded 5%, the degree of cross-linking increased slightly. At L-GA concentrations ≤ 5%, the thermal denaturation temperature (from 67.4to 74.7°C), the storage modulus (from 90 to 251.42 Pa) and the ABTS• + free radical scavenging activity (from 4.89 to 98.92%) significantly increased, and a distinct decrease was observed in the degree of enzymatic degradation (from 81.48 to 49.34%). At L-GA concentrations >5%, only a slight improvement in these properties was observed. The gel strength of the modified collagen hydrogels reached a maximum value of 1346 g, which was more than twice that of the native collagen hydrogel (656 g) at 5%L-GA. Furthermore, afterthe concentration of L-GA exceeded 1%, the pore sizes observed by scanning electron microscopy began to diminish and showed denser network structures. These data indicated that the properties of collagen hydrogels can be substantially improved by modification with an appropriate concentration of L-GA.
研究领域:
生物材料
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材料科学
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生物化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Xueyan Li,Changlong Bi,Yuanfei Wang,Chong Peng,Yun Li,Shuyi Yang,E. Tao
To address the pH limitations of traditional Cr(VI) adsorbents, converting Cr(VI) anions into the more stable Cr(III) cations through a reduction reaction is an effective strategy. Therefore, in this study, gallic acid (GA), with a high redox potential, was selected as the reducing agent, together with chitosan (CS) as the substrate, and sodium alginate (SA) as the gelling agent. A novel SCG composite material was successfully prepared using the sol-gel crosslinking method, which efficiently captured and reduced Cr(VI) while immobilizing Cr(III). At pH = 4, t = 150 min, and T = 30 °C, 1 g/L of SCG can remove 94.7 % of Cr(VI), with a reduction rate of 67.5 %, achieving efficient and stable Cr(VI) removal over a wide pH range. Furthermore, the SCG material demonstrated good pH adaptability (It can still remove 84 % of Cr(VI) at pH = 7) and practical applicability. Comparative experiments and DFT calculation results showed that the introduction of GA not only helped form a more compact network structure but also interacted synergistically with CS, significantly promoting the removal of Cr(VI). In conclusion, the SCG composite material provides a new approach for the treatment of Cr(VI)-contaminated wastewater.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Kun Lin,Yu-zhang Zhu,Hua-wei Ma,Jincheng Wu,Chao-nan Kong,Yang Xiao,Hong-cun Liu,Li-lan Zhao,Xiao-lin Qin,Li-fang Yang
In this study, an active film composed of gallic acid (GA), chitosan (CS), and cellulose nanocrystals (CNC) was prepared using a solution casting method and synergistic photodynamic inactivation (PDI) technology. Characterization of the film showed that the CS-CNC-GA composite film had high transparency and UV-blocking ability. The addition of GA (0.2 %–1.0 %) significantly enhanced the mechanical properties, water resistance, and thermal stability of the film. The tensile strength increased up to 46.30 MPa, and the lowest water vapor permeability was 1.16 × e −12 g/(cm·s·Pa). The PDI-treated CS-CNC-GA1.0 composite film exhibited significantly enhanced antibacterial activity, with inhibition zone diameters of 31.83 mm against Staphylococcus aureus and 21.82 mm against Escherichia coli. The CS-CNC-GA composite film also showed good antioxidant activity. Additionally, the CS-CNC-GA 1.0 composite film generated a large amount of singlet oxygen under UV-C light irradiation. It was found that using the CS-CNC-GA 1.0 composite film for packaging and storage of oysters at 4 °C effectively delayed the increase in pH, total colony count, and lipid oxidation in oysters. In conclusion, the CS-CNC-GA composite film based on PDI technology has great potential for applications in the preservation of aquatic products.
研究领域:
食品科学
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材料科学
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生物技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2025
·
IF 3.5
Wen Zhang,Yue Zhang,Qian-yu Zhang,Xue-ning Ren,Ji-xiang Ge
BACKGROUND Gallic acid (GA) is recognized for its significant antioxidative and anti-inflammatory properties. The processing and consumption of GA-rich foods influence the interaction with cell wall polysaccharides, thereby impacting the bioavailability and bioaccessibility of GA. This study aimed to develop a biomimetic dietary fiber (BDF) model composed of bacterial cellulose, pectin, and GA to investigate the interactions, digestive behavior, and antioxidant synergism between polysaccharides and GA within the BDF. RESULTS The microstructural, compositional, and crystalline characteristics of the synthesized BDF were found to be comparable to those of natural dietary fibers. During simulated digestion in the stomach and small intestine, a total of 38.02% of GA was released from the BDF, while 61.98% remained in a polysaccharide–GA conjugated form post-digestion. In free radical scavenging assays, the GA bound within the BDF exhibited a greater antioxidant capacity than free GA. CONCLUSION The interactions between polysaccharides and GA are mediated by hydrogen bonding, hydrophobic interactions, van der Waals forces, and other non-covalent interactions. The release mechanism of GA involves its escape and diffusion from the BDF network structure, the disintegration of the BDF, and the dissolution of pectin. Polysaccharides provide a protective effect on the bioactivity of GA and enhance its synergistic role in antioxidative stress, thereby improving its bioaccessibility. These findings lay the groundwork for further exploration of the interaction mechanisms between polysaccharides and GA in dietary fibers and hold significant implications for the development of dietary intervention strategies aimed at mitigating oxidative damage. © 2025 Society of Chemical Industry.
研究领域:
食品科学
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营养学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Jian Chen,Huili Liu,Jing Zhang,Mengmeng Hou,Haojie Cheng,Jiaman Wu,Shouren Zhang,Baocheng Yang
Excessive ultraviolet (UV) exposure from sunlight has brought serious threats to human health. Due to their excellent UV absorption and antioxidant properties, natural polyphenols have emerged as green UV filters to replace commercial sunscreens which have alarming biosafety and serious damage to marine environments. However, the commercial application of polyphenols is greatly limited by their narrow wavelength absorption, long-term instability, and deep skin penetration. Herein, broadband UV filters with good antioxidant ability and high security were developed by coordination assembly of gallic acid and Zn2+ with combination of polyvinylpyrrolidone (PVP) (Zn-GA-PVP NPs). Owing to the π–π stacking interaction, ligand-to-metal charge transfer, and the carambola-like morphology, the UV shielding range of Zn-GA-PVP NPs is broadened to entire UVA and UVB region through both absorption and reflection of UV rays. The antioxidant ability of Zn-GA-PVP NPs is protected by PVP, which guarantees that they will negatively generate but effectively scavenge reactive oxygen species upon UV exposure. The abundant phenolic hydroxyl groups and proper particle size allow Zn-GA-PVP NPs to have strong skin adhesion but not to penetrate into the deep skin. Meanwhile, Zn-GA-PVP NPs also show good water resistance and easy mechanical removal because of the amphipathy of PVP. Zn-GA-PVP NPs exhibit a high UV protection effect and good biosafety in a photodamage mouse model. This study provides a promising approach for modifying natural polyphenols to better suit their use in commercial sunscreens.
研究领域:
材料科学
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生物学
·
皮肤病学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）