POLYMERS FOR ADVANCED TECHNOLOGIES
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2018
·Vol. 29
·期 11
·2838-2847
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IF 2.137
Shuchen Shi,Dongyi Li,Chunxiao Chai,Yufeng Wu,Ying Xu
A novel modified polyaspartic acid polymer, polyaspartic acid/4-(2-aminoethyl) morpholine graft copolymer (PASP/AEM), was prepared through a ring-opening reaction of polysuccinimide and 4-(2-aminoethyl) morpholine and characterized by 1 H NMR. The scale inhibition performance of this copolymer and its ability to disperse Fe 2 O 3 were investigated in static tests. Scanning electron microscopy and X-ray powder diffraction were used to analyze the effects of PASP/AEM on scale formation. The performance and mechanism of corrosion inhibition by the synthesized copolymer were studied via weight loss measurements and electrochemical measurements. The results showed that PASP/AEM possessed outstanding scale and corrosion inhibition efficiencies and had potential for use as a green scale and pickling inhibitor.
研究领域:
材料科学
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化学工程
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高影响因子
COLORATION TECHNOLOGY
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2026
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IF 2.6
Fei Yuan,Jiahui Wang,Shufen Zhang
Azo-pyridone dyes are attractive candidates for high-performance color filters owing to their rigid conjugated frameworks and high thermal stability. However, their practical application is often limited by strong intermolecular interactions that promote aggregation, resulting in broadened absorption profiles and compromised optical quality in thin films. Herein, we demonstrate that introducing N-heterocyclic substituents, morpholine and pyridine, onto the azo-pyridone core effectively disrupts π–π stacking and suppresses aggregation, enabling uniform dye dispersion in poly(methyl methacrylate) (PMMA) matrices. The resulting dye-PMMA composite films exhibit high optical transmittance (>90%), significantly improved yellow color purity and excellent thermal and photostability (Δ E < 3). Combined experimental and density functional theory (DFT) analyses reveal that the heterocyclic substituents modulate the molecular electrostatic potential distribution and reduce intermolecular interaction strength, accounting for the suppressed aggregation behaviour. Both morpholine and pyridine proved effective, confirming the generality of this substitution strategy. This work provides a practical molecular design approach based on N-heterocyclic modification for developing high-performance azo-pyridone dyes for advanced color filter applications.
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高影响因子
ACS Applied Polymer Materials
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2024
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IF 4.4
Mengyao He,Rui Liu,Xiaoli Li,Gan Zhang,Guanxing Lao,Song Guo,Yuanli Liu
Compared with traditional luminescent materials, nonconventional luminogens have been extensively studied due to their unique properties and wide range of applications. However, the study of nonconventional luminescent polymers is rare because most luminescent polymeric materials can only emit light at high concentrations and require noble metal catalysts for synthesis. Particularly, their application in the field of metal ion detection and biological imaging is still restricted. To expand its application scope, this work designed a series of luminescent polymeric materials only containing carboxyl and amide groups, which were synthesized from poly(methyl vinyl ether maleic anhydride) and 4-(2-aminoethyl)morpholine at different molar ratios (PMVEMA/AML are 1:1, 1:2, and 1:3). The synthesized luminogens exhibited controllable luminescence colors and excellent solubility in various commonly used solvents. Additionally, the polymers can achieve luminescence in dilute solutions, and the maximal luminescence efficiencies can be up to 5.55%. At last, polymer M3 with good biocompatibility and low cytotoxicity can be used to sensitively detect Mg2+ ions in vivo and in vitro. Notably, polymer M3 possesses the ability to target the organelle lysosome in cell imaging.
研究领域:
材料科学
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生物医学工程
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化学
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高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2019
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IF 4.833
Zhang Li,Zhong-Chang Wang,Xin Li,Muhammad Abbas,Song-Yu Wu,Shen-Zhen Ren,Qi-Xing Liu,Yi Liu,Peng-Wen Chen,Yong-Tao Duan,Peng-Cheng Lv,Hai-Liang Zhu
In this paper, 41 hybrid compounds containing diaryl-1,5-diazole and morpholine structures acting as dual COX-2/5-LOX inhibitors have been designed, synthesized and biologically evaluated. Most of them showed potent antiproliferative activities and COX-2/5-LOX inhibitory in vitro. Among them, compound A33 displayed the most potency against cancer cell lines (IC 50 = 6.43–10.97 μ M for F10, HeLa, A549 and MCF-7 cells), lower toxicity to non-cancer cells than celecoxib ( A33 : IC 50 = 194.01 μ M vs. celecoxib : IC 50 = 97.87 μ M for 293T cells), and excellent inhibitory activities on COX-2 (IC 50 = 0.17 μ M) and 5-LOX (IC 50 = 0.68 μ M). Meanwhile, the molecular modeling study was performed to position compound A33 into COX-2 and 5-LOX active sites to determine the probable binding models. Mechanistic studies demonstrated that compound A33 could block cell cycle in G2 phase and subsequently induced apoptosis of F10 cells. Furthermore, compound A33 could significantly inhibit tumor growth in F10-xenograft mouse model, and pharmacokinetic study of compound A33 indicated that it showed better stability in vivo . In general, compound A33 could be a promising candidate for cancer therapy.
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DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2020
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IF 7.183
Qi Chen,Yang He,Yiping Zhao,Li Chen
Oxidative stress is a compelling risk factor during hemodialysis in patients with renal failure to elevated mortality risk. Intervening the effect of oxidative stress in the pathogenesis of dialysis-associated complications requires developing a more direct hemodialysis membrane route to prevent and relieve oxidative stress in the dialysis process. In this work, combining the anti-oxidative property of tannic acid (TA) and high biocompatibility of poly (N-acryloyl morpholine) (PACMO), the TA-PACMO functionalized poly (ether sulfone) (PES) hemodialysis membranes have been fabricated using the hydrogen-bonded layer-by-layer (HB-LbL) assembly technology. The functionalized membranes directly quenched excess reactive oxygen species, improved the serum total antioxidant capacity, and suppressed lipid peroxidation and protein glycosylation. More interestingly, the TA-PACMO functionalized hemodialysis membranes effectively protected cardiomyocytes (H9C2), and vascular endothelial cells (HUVEC) from oxidative damage the improvement of antioxidant enzymes activities such as superoxide dismutase and catalase. The introduction of PACMO indicated in considerable improvement of blood compatibility and reduction of complement activation compared to a single TA modified hemodialysis membrane. The typical toxins, including urea and lysozyme, were efficiently removed from the dialysis simulant experiment, confirming the feasibility of the TA-PACMO HB-LbL functionalized strategy. The results revealed that, with the TA-PACMO content increasing, the functionalized membranes with superior comprehensive performances had stronger anti-oxidative stress, better biocompatibility, and more efficient dialysis performance. The present work provided a promising candidate in the development and application of hemodialysis membrane against oxidative stress, which alleviated patients' complications to address the long-term hemodialysis.
研究领域:
生物医学工程
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材料科学
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肾病学
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生物材料
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高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2024
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IF 4
Youzhi Su,Jianjiang Lu,Xuwei Guo,Jun Liu,Haibin Fu,Li Yu
A modified QuEChERS purification–liquid chromatography-tandem mass spectrometry method was developed to simultaneously detect six morpholine pesticide residues in plant-derived foods. The samples were extracted using acetonitrile and purified using three adsorbents, namely, graphitized carboxyl MWCNTs , C 18 , and SAX. The limit of quantitation was 0.07–0.75 µg/kg, and the average recoveries ranged from 71.3 % to 113.8 %. The precision ranged from 1.2 % to 13.8 % at four spiked concentrations of 0.5, 1, 5, and 10 µg/kg. The method was applied to analyze 540 samples obtained from 17 types of plant-derived foods collected in Yining, China. Dimethomorph and flumorph were detected in nine types of matrices, and the residue levels did not exceed the maximum residue limits (MRLs) set by the national standard GB 2763–2021. Furthermore, we assessed the risk of acute and chronic exposure to the tested pesticides. The pesticide residue levels were acceptable in all the samples.
研究领域:
食品安全
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分析化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）