Heliyon
·
2018
·
IF 0
Ningning Cheng,Jingjing Zhang,Jingmei Yin,Shenmin Li
The harm of trans-fatty acids to health has aroused public concern. It is believed that the main source of trans-fatty acids in diets is the isomerization of unsaturated fatty acids in edible oils during cooking. However, the information on the isomerization mechanism is very limited. In this paper, we used oleic acid, an unsaturated fatty acid, as a simplified model for edible oil and investigated the mechanism of cis/trans isomerization by computation and experiments. The computational results show that R c -O-O-H is a very important intermediate, and the cleavage of O-O bond in R c -O-O-H is the rate-controlling step during the cis/trans isomerization. Using the ATR-FTIR measurements, the contents of elaidic acid were measured quantitatively in sites. The experimental results indicate that the cis/trans isomerization of oleic acid can occur obviously only under oxidizing condition when the temperature is higher than 120 °C.
研究领域:
食品化学
·
计算化学
·
物理有机化学
·
营养科学
✓ 已验证
DOI
PubMed
RENEWABLE ENERGY
·
2019
·
IF 5.439
Nisakorn Saengprachum,Dongren Cai,Mantian Li,Ling Li,Xiaocheng Lin,Ting Qiu
Via the crosslinking of chitosan and sulfosuccinic acid (SSA), the acidic chitosan membrane (ACM) was prepared for biodiesel production from esterification of oleic acid and methanol. ATR-FTIR, TGA, XRD, SEM and EDX were applied to characterize the prepared ACM. The acidic site density and swelling capacity of the prepared ACM were investigated. The ACM possessed the 4.62 mmol/g of acidic site density, which was just a little less than 4.76 mmol/g of Amberlyst-15, meanwhile, ACM was proven to be much higher than Amberlyst-15 in swelling capacity. Under the same reaction, the 98.76% of conversion can be obtained while the Amberlyst-15 only reached 44.30%. The optimization of process variables was conducted by the combination of single factor experiment and Box-Behnken design (BBD) response surface methodology . The catalytic activity of ACM in different esterification of fatty acids and alcohols was also investigated. And the catalytic mechanism of esterification catalyzed by ACM was clarified. Based on the catalytic mechanism, the kinetic model was established to describe the esterification and obtain relevant kinetic parameters ( E a + , E a − , A + and A - ), meanwhile, the kinetic results were compared to the same reaction with different catalysts in detail. Besides, the reusability of the prepared ACM was studied.
研究领域:
化学工程
·
能源科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS TODAY
·
2018
·
IF 4.667
Yi-Tong Wang,Zhen Fang,Fan Zhang
Carbonaceous catalyst, with a variety of acid sites, was successfully synthesized by a two-step method at low temperature. The synthesized catalyst (Zr-SO 3 H@CMC) was characterized by elemental analysis, XRD, ICP-OES, FT-IR, BET, SEM-EDX and Boehm titration. It had high total acid content (8.45 mmol/g) for oleic acid esterification with high biodiesel yields (> 99%) at 40–90 °C. Under conditions of 90 °C, 20/1 methanol/oleic acid molar ratio, 5 wt% catalyst and 2 h reaction time, biodiesel yield of > 87% was achieved after 10 cycles of use. At lower temperatures (40, 50 and 60 °C), biodiesel yield still reached 82%, 93% and 90% after 3 cycles, respectively. The high activity of Zr-SO 3 H@CMC benefited from low activation energy of 24.7 KJ/mol. It shows potential application for esterification of free fatty acids or pretreatment of oils with high acid value for the green production of biodiesel.
研究领域:
化学工程
·
可再生能源
·
催化科学
✓ 已验证
产品关联
DOI
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2022
·
IF 3.322
Weigang Yuan,Fenglei Jian,Yueguang Rong
Some traditional Chinese medicines exert roles in the therapy of liver diseases by modulating autophagy. Bifendate (DDB), a synthetic intermediate of Schisandrin C extracted from Schisandrae chinensis , is clinically used to treat hepatitis in China. While DDB is a positive control to research some potential hepatoprotective agents, its related molecular mechanisms are unknown. In this study, we show that DDB inhibited autophagosome−lysosome fusion, lysosome acidification and autophagic lysosome reformation. Moreover, DDB attenuated oleic acid-induced lipid droplet accumulation. These findings reveal the effects of DDB on the autophagy-related processes and lysosomal function, and also provide a possibility to understand the bioactivity mechanism of DDB in the future.
研究领域:
药理学
·
肝病学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 22
·4899-4907
·
IF 5.344
Ping Zhu,Liuzhu Zhou,Yiyan Song,Ling Cai,Minghui Ji,Jun Wang,Gang Ruan,Jin Chen
Recently, with increasing medical practices, including organ transplantation and tumor chemotherapy, fungal infections, particularly the occurrence of drug-resistant fungal strains, remain a severe problem for the public health, which cause worse complications in the immunocompromised patients. The search for efficacious yet safe antifungal agents is in high demand in precision medicine. However, fungicides are often poorly water soluble for oral absorption, which is difficult for pharmaceutical efficacy evaluation. In this study, lipophilic oleic acid (OA)-grafted mesoporous silica (SBA-15) was facilely modified by cetyltrimethylammonium bromide (CTAB), which acts as an efficient antifungal drug matrix of itraconazole (ITZ). Characterized by physicochemical methods, the rod-like SBA-15-OA–CTAB/ITZ composite with retained mesostructural regularity shows that the loading amount of ITZ in the mesopore is ∼18%, contributing to the enhanced antifungal activity against Aspergillus fumigatus (A. fumigatus) and Candida albicans (C. albicans). The antimicrobial mechanism study suggests that the reactive oxygen species (ROS) were formed when fungal cells were incubated with the formulated ITZ, while there was no ROS formation in the presence of pure ITZ, which may result from the quaternary ammonium moieties of CTAB in the nanocomposites. Due to the potential toxicity of CTAB on mammalian cells, the as-synthesized mesoporous SBA-15-OA–CTAB/ITZ provides an alternative molecular design for the formulation improvement of a lipophilic antifungal drug applicable for external uses such as topical therapy.
研究领域:
医学
·
药学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 54
·48810-48815
·
IF 3.289
Ge Yang,Jianxi Zhao
A reverse aggregate system composed of oleic acid and diethylenetriamine in cyclohexane has been studied. Small angle X-ray scattering (SAXS) measurements and polarising microscopy (POM) observations suggested the formation of reverse vesicles. FT-IR measurements showed simple attraction between DETA and OA, which increased the size of the head of the forming unit and resulted in reverse vesicle formation. Therefore, the viscosity of solutions depended on the mole ratios of DETA to OA,β, and reached a maximum of 122 Pa s at β = 1 for 1 mol L−1 OA. Dynamic oscillatory sweeps were carried out for this system of equi-mole mixed OA (1 mol L−1) and DETA. Strong elasticity was observed, where the elastic modulus (G′) always dominated over the viscous modulus (G′′) over the range of examined frequencies. The elastic plateau modulus G′P was 127.4 Pa and G′P was found to decrease exponentially with temperature. Strain sweeps exhibited a strain-softening response at high strains. The effect of trace amounts of water was also examined for equi-mole mixed OA (1 mol L−1) and DETA, where the reverse vesicles remained. The water was found to improve the association of DETA with OA and increase the visco-elasticity of the solution. The maximum viscosity was as high as 6005 Pa s at W0 = 6, and G′P also reached 530 Pa. The solution became gelatinous in appearance.
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Huijing Chen,Shanliang Zhong,Guoxiang Chi,Huiying Li,Kewei Chen,Zhirong Wang,Jianquan Kan
Starch–lipid complexes with functional properties have gained extensive attention; however, little attention has been paid to how oleic acid-based lipid types and thermomechanical treatment affect the functional characteristics of starch. This study investigated the effects of five oleic acid-based lipids (oleic acid, monoolein, diolein, triolein, and rapeseed oil) and thermomechanical treatment on the structural and physicochemical properties of wheat starch. The crystal patterns and complexing indices showed that thermomechanical treatment promoted the formation of oleic acid, monoolein, and diolein V -type starch–lipid complexes with an intact granular structure, whereas triolein and rapeseed oil formed complexes with starch. Moreover, oleic acid, monoolein, and diolein significantly altered starch gelatinisation, retrogradation behaviour, more resistant starch formed in their complexes and thus decreased its digestibility. Rheological analyses indicated that the formation of lipid complexes increased the viscoelastic modulus of starch. Our results deepen understanding of the key role of oleic acid-rich lipids in starch-based foods.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Ruiping Wei,Mingzhu Yao,Ziqi Wang,Huijun Liu,Rongying Xia,Lei Yang,Guanghui Ma,Lijing Gao,Xiaomei Pan,Guomin Xiao
The properties of support have significant effects on the catalytic performance of supported catalysts. The present study involves the synthesis of a series of Mo-modified NbOPO4 supports, which were subsequently utilized for the preparation of supported NiCu bimetallic catalysts via a hydrothermal method. All catalysts were evaluated in the HDO of oleic acid to long-chain alkanes without carbon loss, an essential procedure for contemporary industrial applications. The effects of acidity and porosity on the dispersity and valence states of the metal components were systematically investigated via BET, XRD, SEM, XPS, NH3-TPD, and H2-TPR. Catalytic performance of the materials for HDO of oleic acid was assessed and it revealed that NiCu supported on Mo-modified NbOPO4 exhibited significantly enhanced selectivity for C18 compared to those supported on NbOPO4 (53.10% VS 84.16%) under the mild reaction condition of 250 °C reaction temperature, 3 MPa initial H2 pressure and 7 h reaction time. The resluts demonstrated the significant potential of Mo-modified NbOPO4 as a support for NiCu bimetallic catalysts, enabling efficient conversion of oleic acid into C18 and highlighted the crucial role of support modification in enhancing catalytic performance.
研究领域:
催化化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2024
·
IF 15.8
Yang Li,Qianqian Zhang,Zhen Sun,Mingjie Rong,Chunhuan Jiang,Lehui Lu
The utilization of alkyl radicals (•R) for hypoxic tumor therapy has great prospects due to its O2-independence and high reactivity. However, correlational initiators for in vivo activation remain scarce. Here, we report that ultrasound excitation of oleic acid-capped BaTiO3 (OA@BaTiO3) can result in an •R cascade and hence a means to conquer hypoxic tumors. Mechanistic studies find that the •R signal disappears when OA@BaTiO3 undergoes acid washing post-treatment, which is a common procedure for removing the unwanted byproduct BaCO3. Combined with the infrared spectrum analysis, acid treatment was proven to weaken the peaks at 2840–2970 cm–1 characteristic of -CH2- and terminal -CH3 stretching vibration of OA. There is compelling evidence that high temperature thermal oxidation of OA involves the generation of •R. Thus, acid washing is considered to remove the loosely bound yet catalytically active OA. And piezoelectric BaTiO3, a potential electron–hole redox catalyst, can sensitize these OA molecules and disintegrate them to •R. This unexpected discovery provides us with a distinctive mentality to seek diverse •R initiators for tumor ablation, as well as an additional perspective on the postprocessing of synthetic materials.
研究领域:
材料科学
·
肿瘤学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2023
·
IF 5.9
Nan Li,Sufeng Zhang,Yali Liu,Valentin Nica,Sergiu Coseri
Cellulose-based materials are currently considered prime candidates for replacing petrochemical plastics because they are biodegradable and cost-effective, while the insufficient hydrophobicity makes them fail to meet application demands, which is a primary issue to be addressed. This work developed a green, catalyst-free approach to prepare high-hydrophobicity amidated cellulose (ADC) by anchoring the COOH-containing oleic acid (OLA) onto NH 2 -containing aminated cellulose (AMC) via amide bonds. The unsaturated fatty acid tail provides a hydrophobic barrier in ADC films . The surface water contact angle of the ADC film reached 133° and remained above 110° for at least one hour. Subsequently, the ADC suspension was applied on the surface of paper from old corrugated container (P-OCC) by an impregnation approach to investigate the improvement of hydrophobic properties. The results showed that the hydrophobicity of P-OCC was increased by ADC, with the water contact angle reached to 132° from 0°. Noticeably, the tensile strength of the ADC impregnated P-OCC (A-POCC) also increased by 2 times. This indicates that with excellent hydrophobicity and mechanical strength , the ADC has great potential application in green functional coating materials.
研究领域:
高分子材料科学
·
表面与界面化学
·
生物质功能材料
·
绿色化学
·
包装材料工程
✓ 已验证
DOI
高影响因子
JOURNAL OF POROUS MATERIALS
·
2026
·
IF 3.2
Guo Hanxu,Fu Sen,Yuan Hong
Hierarchical zeolites can provide multidimensional spatial networks, thereby holding significant potential as catalysts for BTX production from biomass pyrolysis. In this study, nano-ZSM-5 zeolite (Z X-X ) with a hierarchical pore structure was synthesized using glycine as a growth inhibitor. Due to the exceptional ability of Ni to cleave C–C and C–H bonds, Ni modification was performed on the Z 30-0.2 catalyst. The effects of glycine and Ni loading on the morphology and pore structure of the zeolites were systematically investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and N 2 adsorption–desorption. The results demonstrated that the particle size of 10 wt% Ni-Z 30-0.2 zeolite ranged from 200 to 300 nm, with a BET surface area of 314 m 2 /g and abundant mesopores. The NH 3 -TPD results showed that the acid amount of 10 wt% Ni-Z 30-0.2 was 0.72 mmol/g. The prepared zeolite was employed in a fixed-bed reactor to catalyze the pyrolysis of oleic acid for the production of benzene, toluene, and xylene (BTX). The introduction of metal Ni significantly enhanced the BTX yield. At 500 ℃, the average BTX yield achieved with the 10 wt% Ni-Z 30-0.2 catalyst was 19.4 wt%, which was higher than that of the zeolite without Ni loading.
✓ 已验证
产品关联
DOI
高影响因子
Water
·
2025
·Vol. 17
·期 17
·2561
·
IF 3
Xiaojia Huang,Yuanyuan Hu,Xiaowei Cheng,Weibin Pan
Cylindrospermopsis raciborskiiis a toxin-producing cyanobacterium that is easy to overlook. It has strong environmental adaptability and is currently spreading around the world and gradually dominating to form a persistent bloom, causing ecological and environmental risks and drinking water safety issues. In this study, we systematically investigated the inhibitory effects of oleic acid onC. raciborskiiand elucidated the underlying mechanisms through morphological observation, physiological assays, and bioinformatics analysis. Our results demonstrated that oleic acid strongly inhibits the growth ofC. raciborskii, with a 72 h half-maximal effective concentration (EC50) of 0.903 mg·L−1. At 1.6 mg·L−1, oleic acid achieved an inhibition rate of 99.5% within 48 h, indicating rapid suppression of cyanobacterial growth. Physiological analyses revealed that oleic acid severely impaired photosynthetic activity, as evidenced by significant reductions in key parameters (rETRmax, α, Fv/Fm, and Fv/Fo) and altered photosynthetic pigment composition, suggesting structural and functional damage to the photosynthetic apparatus. Morphological observations further showed that oleic acid disrupted filament integrity, inducing cell shrinkage, cytoplasmic vacuolation, cell wall detachment, membrane rupture, and eventual cellular disintegration. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis indicated that oleic acid interferes with multiple metabolic processes, including nutrient and cofactor synthesis, membrane transport, and signal transduction, ultimately triggering algal cell death. This study highlights oleic acid as a promising eco-friendly agent for mitigatingC. raciborskiiblooms, offering potential applications in ecological prevention and emergency bloom control.
研究领域:
环境微生物学
·
水生生态学
·
毒理学
·
分子生理学
·
藻类生物学
·
生态毒理学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）