POLYHEDRON
·
2025
·
IF 2.6
Kuiyu Yi,Congyin Zhang
A meticulously crafted nanoscale fluorescence sensor, featuring Eu 3+ -functionalized ZIF-8 (Eu 3+ @ZIF-8), has been triumphantly synthesized utilizing a streamlined and effective process. This fluorescence sensor ingeniously harnesses the robust complexation between oxytetracycline (OTC) and Eu 3+ ions within Eu 3+ @ZIF-8, markedly augmenting the characteristic fluorescence of Eu 3+ via an exquisite antenna effect. This enhancement facilitates ultrasensitive fluorescence-based sensing of OTC. This groundbreaking application introduces a novel paradigm for OTC detection, accompanied by an exhaustive elaboration on the potential mechanism underlying OTC testing. The Eu 3+ @ZIF-8 fluorescence sensor stands as an exemplary advanced tool for OTC detection, evidenced by its remarkable attributes: swift response, unparalleled selectivity, and exquisite sensitivity. Its application in detecting spiked OTC in environmental samples, such as lake water and tap water, has demonstrated impeccable performance, validating its reliability and presenting a versatile platform technology with vast potential for environmental monitoring.
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Nanoscience and Nanotechnology Letters
·
2018
·Vol. 10
·期 8
·1095-1100
·
IF 2.917
Du Jingjing,Song Ya,Xie Shaowen,Feng Yahui,Jiang Jianbing,Xu Lijian
A facile and sensitive electrochemical sensor based on hierarchical nanoporous Pd-HSiO1.5/Ni–Co composite electrode for detecting oxytetracycline (OTC) was prepared in this study through the composite electrodeposition method. Electrodeposition conditions and detecting
parameters, such as concentration of hierarchical nanoporous Pd-HSiO1.5 particles, detection temperature and scanning rate were also studied. Moreover, the repeatability, accuracy and anti-interference performance of electrochemical biosensor were investigated. Results showed that
the hierarchical nanoporous composite electrode had the optimum electrocatalytic activity for OTC when the concentration of hierarchical nanoporous Pd-HSiO1.5 particles was 2 g/L and detection temperature was 25 °C. In addition, the electrochemical biosensor showed good electrocatalytic
activity for OTC detection, with a linear relationship between oxidation peak current and concentration of OTC detection from 4.0 × 10–4 to 1.0 × 10–8 M. The limit of detection was as low as 1.0 × 10–8 M. Moreover, practical
operations showed that the biosensor had good reproducibility, accuracy, and good anti-interference performance for other antibiotics such as ampicillin sodium and rifampicin.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Caixia Deng,Shuang Li,JiaYu Wang,Yingying Li,Jian Chen,Fenglin Tang,Xiupei Yang
Type II heterojunction photocatalysts were fabricated by compositing BiOBr with TiO 2 , with samples labeled BiOBr/TiO 2 -1 to BiOBr/TiO 2 -5 (the number denotes the mass of TiO 2 in mg used during synthesis). Among these, BiOBr/TiO 2 -2 (containing 100 mg TiO 2 ) exhibited optimal visible-light photocatalytic performance for oxytetracycline hydrochloride (OTC) degradation, achieving 94.38 % removal within 60 min. High-resolution transmission electron microscopy (HRTEM) confirmed successful composite formation through the observation of dual lattice spacings (0.28 nm for BiOBr (1 1 0) and 0.35 nm for TiO 2 ). This composite displayed a superior degradation rate constant of 0.04757 min −1 , exceeding those of pristine BiOBr and TiO 2 by factors of 2 and 14, respectively. The enhanced activity was attributed to effective charge separation enabled by the Type II heterojunction structure. Radical trapping experiments combined with electron paramagnetic resonance (EPR) analysis identified photogenerated holes (h + ) and superoxide radicals (•O 2 − ) as the dominant reactive species. HPLC–MS analysis revealed degradation intermediates, and toxicity assessment predicted progressive detoxification during the process. This study demonstrated that BiOBr/TiO 2 -2 is a stable and efficient photocatalyst with significant potential for antibiotic wastewater treatment.
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Journal of Water Process Engineering
·
2025
·
IF 6.7
Hui Li,Long Zhou,Zuliang Chen
Aquaculture wastewater is contaminated with antibiotics such as oxytetracycline (OTC), which presents a serious threat to the environment and public health. In this study, Fe Co MOF@MIP combining 2D bimetallic metal organic framework (MOF) with molecular imprinting technique was prepared for removing typical antibiotic-OTC from mariculture wastewater. Batch experiments indicated that the maximal capacity of adsorption of Fe Co MOF@MIP to OTC was 36.9836 mg/g at 303 K, higher than that of Fe Co MOF@NIP. The large number of spatial recognition sites in the blotting layer provides specific selectivity, and adsorption mechanism might be associated with the electrostatic adsorption process, hydrogen bonding and complexation among OTC and Fe Co MOF@MIP. The adsorption process fits a quasi-secondary kinetic model with R 2 = 0.9966, suggesting that the rate of adsorption is dominated by a physical adsorption mechanism involving the sharing of electrons among the Fe Co MOF@MIP and OTC. In the presence of interference, the blotting factor of Fe Co MOF@MIP was 11.77, which demonstrated that the as-synthesized materials possess the excellent selectivity. Moreover, the synthesized nanosheets exhibited excellent reusability, with 16.61 mg/g OTC removal achieved using the Fe Co MOF@MIP after reuse on three occasions. These findings highlighted here is the promising role of Cu Co MOF nanosheets in wastewater treatment, particularly for the selective removal of antibiotics.
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MICROBIOLOGICAL RESEARCH
·
2026
·
IF 8.5
Wei Zhao,Jingying Hu,Jitong Lin,Yanhong Lou,Hui Wang,Quangang Yang,Hongjie Di,Haojie Feng,Yuping Zhuge,Hong Pan
Co-contamination of agricultural soils with cadmium (Cd) and oxytetracycline (OTC) from organic fertilizers and wastewater irrigation threatens food safety. A pot experiment was conducted to examine the responses of soil and pak choi ( Brassica rapa subsp. chinensis ) to combined Cd (2/5 mg kg −1 ) and OTC (1/10/30 mg kg −1 ) exposure. Soil available Cd was primarily governed by the Cd addition level (F = 886.70, p < 0.001), but its response to OTC was concentration-dependent (F = 53.39, p < 0.001): available Cd increased by 2.89–3.11-fold with rising OTC under the Cd2 background but decreased under the Cd5 background, whereas the Cd bioconcentration factor was consistently lower in Cd5- than Cd2-treated soils ( p < 0.001), largely independent of OTC. The combined pollution reshaped bacterial communities and drove co-enrichment of antibiotic resistance genes (e.g., sul 1, sul 2, tet G, tet C) and the mobile genetic element int I1, whose abundance under Cd5 was up to 3.13-fold higher than under Cd2 in rhizosphere soils. The O10 treatments (Cd2O10 and Cd5O10) exhibited the highest comprehensive toxicity, with soil enzymatic IBR values reaching 3.79 and leaf IBR values reaching 7.9 × 10 −4 , alongside fewer negative microbial co-occurrence correlations and reduced network modularity. Under these high-toxicity conditions, the stress-tolerant genera Cupriavidus (Cd2O10) and Nocardiopsis (Cd5O10) were selectively enriched in root endophytes, and plant antioxidant defense responses (SOD, POD, GSH) were activated. Structural equation modeling indicated that Cd contamination directly and indirectly governed the edible safety of pak choi (λ = 0.75, p < 0.001). These findings reveal non-linear, dose-dependent risk patterns under Cd–OTC co-contamination and suggest microbial-assisted mitigation strategies for co-contaminated agricultural soils, providing insights for pollution control without compromising productivity.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2023
·Vol. 170
·期 4
·047508
·
IF 3.9
Jinhong Liu,Rui Yin,Xiaoyu Wang,Fei Li,Linru Xu
Oxytetracycline (OTC) is one of the widely used antibiotics in veterinary practices because of its broad-spectrum antibacterial activity and low cost. However, drug abuse has triggered adverse effects on human health, which brings a growing demand for on-site diagnosis of OTC residues in animal-derived foods. In this study, we demonstrated the combined use of interdigital electrode microarray and electrochemiluminescence (ECL) imaging for parallel multiplex measurement of OTC. Well-ordered and vertically aligned mesoporous silica nanochannels modified on microarray substrate could exert a strong electrostatic attraction to the ECL luminophores and accelerate their mass transport to generate enhanced ECL signal. The performance of the integrated ECL microarray sensor was fully validated with respect to linearity (0.5 μM to 50 μM), sensitivity (limit of detection 0.26 μM), accuracy (recovery rate between 96.78% and 106.1%), low operating sample volume (480 nL), short assay time (1.5 min), and antifouling ability toward complex media. The multiplex microarray platform can serve as a simple, fast, and low-cost tool for the detection of a wide spectrum of antibiotics in the field of food safety.
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APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Shiwei Gao,Zheng Wang,Haoran Wang,Yannan Jia,Nannan Xu,Xue Wang,Jiahao Wang,Chenyue Zhang,Tian Tian,Wei Shen
In the present study, B-doped biochar (BBC) materials with different B contents were prepared and used for the adsorption/degradation of oxytetracycline (OTC) through the activation of peroxydisulfate (PDS). The catalytic activity of BBC was improved to different degrees compared with that of pristine BC owing to enhanced OTC adsorption and PDS activation. Furthermore, the best adsorption and degradation achieved in this study was when the ratio of boric acid to biochar was 2:1, and we defined it as BBC 2 . The degradation rate of OTC (20 mg/L) after 120 min was increased to 94% by adding BBC 2 and PDS. Furthermore, B-doping increased the BC pore size and introduced Lewis-acidic sites to its surface for PDS activation. The effects of PDS concentration, initial pH, and catalyst dosage on the removal of OTC were also evaluated. Using free-radical-quenching experiments, two main pathways for OTC degradation were identified, i.e., that via radicals on the BBC surface and that via non-radicals ( 1 O 2 ) in solution. B atom doping positively charged the adjacent C atoms, thus allowing direct electron transfer with S 2 O 8 2− and facilitating the generation of 1 O 2 . Furthermore, the C O groups generated upon BBC activation also generate 1 O 2 in a similar manner. Finally, nine OTC degradation products were identified and two possible degradation pathways were proposed.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Ciyang Zhang,Xingen Xie,Shasha Feng,Wu Lei,Mingzhu Xia,Fengyun Wang,Hualai Wang
The novel CuMnS nanoflower fluorescent probe based on Mn-doped CuS was developed to achieve the fluorescence detection of oxytetracycline hydrochloride (OTC), the fluorescent sensor has good selectivity and stability. The doping of Mn significantly increased the fluorescence intensity of CuS, which was above 10 times that of CuS. When the predominant species of OTC molecule was zwitterionic OTC +/− at the solution pH of about 5.00, the fluorescence quenching efficiency of CuMnS by OTC reached the highest. Through fluorescence lifetime and UV absorption, the sensing mechanism between CuMnS and OTC was found to be static quenching. Moreover, Multiwfn wavefunction analysis program based on density function theory (DFT) calculation was applied to compare the interactions between different OTC species and CuMnS at different pH, to reveal the micromechanism of fluorescence quenching of CuMnS by OTC from the views of atoms. The molecular surface quantitative analysis and basin analysis of different OTC species demonstrated that the N atom and O atoms of tricarbonylamide moiety of zwitterionic OTC +/− can provide lone pair electrons to form a non-fluorescent ground state complex with CuMnS. Meanwhile, the electrostatic attraction of OTC +/− with negatively charged CuMnS was also beneficial to the interaction, resulting in the effective fluorescence quenching of CuMnS. This work offers a convenient method for sensitively detecting OTC and broadens the application of CuMnS in the field of fluorescence detection.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Zhi-feng Cai,Hao-yang Li,Xian-song Wang,Can Min,Jia-qi Wen,Rui-xin Fu,Zi-yue Dai,Jing Chen,Ming-zhu Guo,Hui-juan Yang,Ping-ping Bai,Xiao-mi Lu,Tao Wu,Ying Wu
Polyethyleneimine (PEI), playing roles as a templating agent, has been successfully applied to prepare blue-green-emitting copper nanoclusters (Cu NCs@PEI) on the basis of a rapid chemical reduction synthesis method. Some characterization methods, such as fluorescence spectrophotometer , UV spectrophotometer, Fourier transform infrared instrument (FTIR), X-ray photoelectron spectroscopy (XPS), transmission electron microscope (TEM) and fluorescence lifetime , were used for the analysis of physical, chemical and optical properties of Cu NCs@PEI. The Cu NCs@PEI displayed a blue-green emission wavelength at 485 nm and the corresponding quantum yield ( QY ) was 2.24%. Subsequently, the as-synthesized Cu NCs@PEI were applied for the trace analysis of oxytetracycline on the basis of the inner filter effect (IFE) and static quenching, which caused the fluorescence to be effectively quenched. Additionally, this proposed platform based on the Cu NCs@PEI for oxytetracycline sensing possessed an excellent linear range from 0.5 to 300 μM with a lower detection limit of 0.032 μM ( S/N = 3) and correlation coefficient R 2 of 0.9972. Surprisingly, as the temperature increased, the fluorescence intensities of Cu NCs@PEI decreased gradually. Thence, the Cu NCs@PEI could be applied for the sensing of temperature. Finally, the practicability of the detection method have been successfully verified by analyzing oxytetracycline in real samples, enlarging its applicable fields for oxytetracycline sensing.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Yubin Wang,Yang Jin,Lianyu Jia,Chenxi Xiong,Jun Li,Ming Chen
The combination of a photocatalytic reaction and microfluidic technology is an increasingly popular method utilized to continuously degrade wastewater. In this work, a novel photocatalytic microreactor with TiO2 loaded on the channel center insert was designed and the photocatalytic degradation process of oxytetracycline (OTC) was investigated. Parameters such as TiO2 loading, OTC initial concentration, light intensity, and ion (NO3– and SO42–) concentrations were systematically investigated. The results show that the degradation efficiency of OTC was 56% under the optimal experimental conditions. Compared with the conventional miniaturized photocatalytic reactors, the reaction rate constant and space–time degradation efficiency of the plug-in three-dimensional photocatalytic microreactor proposed in this work were 1–2 orders of magnitude higher. In addition, dimensionless correlation was obtained to predict the degradation efficiency. This work provides a promising microfluidic technology for the process intensification of photocatalytic reaction and wastewater treatment.
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DIAMOND AND RELATED MATERIALS
·
2021
·
IF 3.315
Jiao Wu,Jingyu Hu,Honghong Qian,Jianjun Li,Ran Yang,Lingbo Qu
The Nickel‑cobalt alloys/zinc oxide/graphitic carbon nitride (NiCo/ZnO/g-C 3 N 4 , NCZg) nanocomposites , magnetic Z-scheme heterojunction nanoparticles , were successfully synthesized. A series of characterization techniques were used to study the morphologies, chemical compositions and optical properties of the prepared NCZg. Using oxytetracycline (OTC) and tetracycline (TC) as target contaminants, the visible light degradation activity of NCZg nanocomposites was investigated. Under visible light, NCZg showed high photocatalytic degradation activity. The photocatalytic degradation rates of OTC and TC reached 71.3% and 81.29% in 50 min. The photocatalytic degradation efficiency of NCZg was obviously better than other materials reported in literatures. The capture experiments of reactive species showed that photogenerated holes (h + ) were the primary reason of photocatalytic degradation. This study provides a novel idea for the construction of high-performance photocatalyst for the degradation of OTC.
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JOURNAL OF FLUORESCENCE
·
2020
·Vol. 30
·期 3
·463-470
·
IF 2.093
Chen Hongxia,Peng Junxiang,Yu Long,Chen Hui,Sun Mingtai,Sun Zhenli,Ni Runyan,Alamry Khalid A.,Marwani Hadi M.,Wang Suhua
Herein, we report an interesting finding about the new application of oxytetracycline (OTC), as a fluorescent probe for the detection of calcium ion (Ca 2+ ), which proved that it can offer an expeditious, highly sensitive, and selective detection method for Ca 2+ . Upon the addition of Ca 2+ , the fluorescence of OTC could be significantly enhanced with rapid response and high sensitivity, and achieved a good limit of detection as low as 125 nM in aqueous solution. The complex formed via Ca 2+ coordinating to the hydroxyl group of OTC contributes to the fluorescence enhancement, which has been proved by several characterization methods including UV-vis analysis, binding constant determination, and fluorescence titration. The method avoided complexity for EDTA measurement of Ca 2+ in running water as proposed previously. Taking advantage of good availability, stability and operability, the OTC was further successfully applied to the detection of Ca 2+ in a real environment.
Graphical Abstract
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