Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2022
·
IF 2.216
Feifei Shao,Tao Xue,Yijing Wang,Yesheng Xu,Xinjie Wang,Xinxin Li
The smart responsive materials have become one of the hottest areas of research in oil/water separation field and there are various studies on preparation technologies. However, most of the materials reported were prepared by coating or coupling to attach functional polymer to substrates, which generally had unstable physical and chemical properties and were difficult to be applied in harsh environments. In this work, we fabricated a smart and durable oil/water separation material by one-step foaming method to graft pH-responsive copolymer onto a polyurethane foam (PUF) substrate. The foam exhibited reversible wettability under different pH environments, had excellent oil adsorption capacity (24.78–64.27g/g) and high oil/water separation efficiency (above 98%). Besides, the foam also showed stable performance and excellent recyclability in a series of durability experiments, including mechanical abrasion, light radiation and chemical immersion. The foam with simple preparation process and excellent stability will have promising application prospects in the field of oil/water separation.
研究领域:
材料科学
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化学工程
·
环境科学
·
高分子科学
✓ 已验证
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2018
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IF 6.14
Cheng Cai,Xuejuan Zhan,Hongming Lou,Qi Li,Yuxia Pang,Yong Qian,Haifeng Zhou,Xueqing Qiu
Enzymatic conversion of lignocelluloses into fermentable sugars is a key step in producing liquid fuels and chemicals in an ecofriendly and sustainable manner. However, because of the large quantities of cellulase required in enzymatic hydrolysis, the high cellulase cost make the production cost of glucose still high. To reduce the overall production cost and achieve the comprehensive utilization of lignocelluloses. A new intensive production process for enzymatic saccharification was developed: lignin, the residue of lignocellulosic substrates after enzymatic hydrolysis, was modified to a pH-responsive carrier (pH-LC) by simple graft reactions and used to recycle cellulase through electrostatic interaction. pH-LC exhibited reversible soluble–insoluble property as solution pH changed, and it did not inhibit cellulase activity. By simply adjusting the pH of the solution contained pH-LC and cellulase, cellulase could be precipitated or dissolved for recycling. pH-LC could recover more than 90% of filter paper activity in solution for cellulase CTec2. During the enzymatic hydrolysis of corncob residue, pH-LC could not only recover more than 50% of cellulase but also increase the yield of glucose from 78.1% to 93.0%. This new process is not only green and convenient but also well integrated with existing processes and easily applied.
研究领域:
生物化学
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生物技术
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可持续化学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2021
·
IF 5.268
Ning Wang,Chenyu Liu,Weihe Yao,Hengjun Zhou,Simiao Yu,Hailiang Chen,Weihong Qiao
Constructing highly efficient and multifunctional nanoparticles to overcome the multiple challenges of targeted drug delivery is a new strategy urgently needed in tumor therapy. Here, we synthesized pH-responsive prodrug ( PEG 2K -NH -N- DOX ), GSH-responsive prodrug ( PEG 2K -S-S-CPT ), folate-receptor targeting polymers ( FA-PEG 2K -L8 , FA-PEG 2K -TOS) and T1-enhanced magnetic resonance imaging contrast agents ( Gd-DTPA-N16−16) , used to encapsulate combrestatinA4 (CA4) to prepare multifunctional nanoparticles ( FTDCAG NPs). Unlike other nanoparticles, FTDCAG NPs contains three drugs with the ability to control the release in time and space, which can maximize the effectiveness of precise cancer chemotherapy. We first confirmed that specific binding between FTDCAG NPs and overexpressed folate-receptor cells by flow cytometry and confocal laser scanning microscopy. We then investigated the spatiotemporally controlled release ability of FTDCAG NPs loaded with doxorubicin (DOX), CA4 and camptothecin (CPT). Relative to pH = 7.4, the release efficiency of CA4 in the pH = 6.5 increased by 63.4 %. The first released CA4 is able to destroy the angiogenesis and help tumor cells to be exposed to the remaining FTDCG NPs. After being internalized into the tumor cells, FTDCG NPs is disassembled and the CPT and DOX were released due to the increase of intracellular GSH concentration and the decrease of pH value. Besides, the relaxation time of FTDCAG NPs is 3.86 times that of clinical Gd-DTPA, and the in vitro and vivo T1-weighted imaging is brighter, which can be used to trace the nanoparticles by MRI. Therefore, FTDCAG NPs provide an efficient strategy for the design of multifunctional drug delivery systems for enhancing antitumor efficacy.
研究领域:
纳米医学
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癌症治疗
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药物递送系统
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
·
2025
·
IF 7.5
Zilong Liu,Wenqi Zhao,Yanxiao Hei,Yaru Xin,Fengzhi Guo,Yufei Xiao,Wenxiu Leng,Weichao Sun
Owing to its ability to be reversibly switched on-demand, pH-responsive surfactants show promising applications in agriculture, detergents, and oil recovery. However, maintaining the stability of pH-responsive emulsions under harsh shear and salinity conditions remains challenging. To address this issue, we developed novel Pickering emulsions with both pH-responsiveness and high environmental robustness stabilized by a series of synthesized pH-responsive surfactants, (CH 3 ) x NCOONa (x = 2, 4, 6), and investigated their interfacial behavior and emulsion stability using experiments and dissipative particle dynamics (DPD) simulations. Among them, (CH 3 ) 4 NCOONa showed a better surface activity and pH responsiveness. Pickering emulsion composed of (CH 3 ) 4 NCOONa and SiO 2 nanoparticles was found to exhibit excellent viscosity response with 26 times decrease from 204.1 to 7.8 mPa·s when pH increased from 7.3 ± 0.5 to 9.2 ± 0.5. To further enhance the shear and salinity resistance of Pickering emulsions, three green polymers were introduced into the system. Among the tested polymers, chitosan most effectively enhanced the static viscosity from 204.1 to 550.2 mPa·s and kept stable at a high shear rate of 60 s −1 at pH = 7.3 ± 0.5, whereas its viscosity slightly changed at pH = 9.2 ± 0.5, indicating that the chitosan synergistic-stabilized Pickering emulsion showed a good pH response. Notably, the chitosan stabilized Pickering emulsion also remained stable in 4 wt% simulated seawater. Additionally, the stability mechanism of Pickering emulsions with pH-responsive surfactants was demonstrated by DPD, revealing denser interfacial packing of zwitterionic DEU z over anionic DEU a , consistent with experimental stability trends. These findings demonstrate a novel strategy for constructing environmentally responsive and mechanically robust emulsions, providing both mechanistic understanding and practical pathways for demanding applications in harsh field conditions.
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2017
·
IF 8.402
Fei Duan,Xiaochen Feng,Xinjian Yang,Wentong Sun,Yi Jin,Huifang Liu,Kun Ge,Zhenhua Li,Jinchao Zhang
Tumor-associated antigens (TAAs)-loaded nanoparticles are able to be actively internalized by antigen-presenting cells (APCs) and have shown promising potential in cancer immunotherapy . However, current TAAs delivery strategy exhibits limitations of complicated synthesis process, low loading efficiency and inefficient CD8 + cytotoxic T lymphocyte activation leading to unsatisfactory therapeutic effect. Thus, the construction of novel TAAs-delivery systems for enhanced cancer therapy is highly desirable. In this work, we fabricated a very simple yet powerful antigens-delivery system for cancer immunotherapy based-on pH-responsive metal-organic frameworks (MOFs) with size about 30 nm. TAAs can be loaded into MOFs in the one-pot synthesis process and released with the degradation of MOFs in the acidic environment of endo/lysosome as the result of relatively labile metal-ligand bonds. The endosomolytic nanoparticles would facilitate protein antigens escape from endo/lysosome and optimal for enhancing antigen cross-presentation. Furthermore, the introduction of immunostimulatory unmethylated cytosine-phosphate-guanine oligonucleotide (CpG) through Watson−Crick base pairing would further enhance CD8 + cytotoxic T lymphocyte responses. We demonstrated that the method to co-delivery antigens and immunostimulatory molecules was very simple, convenient and effective and showed no obvious toxicity both in vitro and in vivo . This method gave a high antigens-loading capacity and the maximal antigen encapsulating efficiency was about 55% (w/w). Additionally, the pH-responsive co-delivery system exerted enhanced antitumor outcome (about 100% survival) in B16-OVA melanoma cancers in vivo . Furthermore, we confirmed that this high rating of therapeutic effect was attributed to the recruitment of tumor-killing immunocyte. This work demonstrates the ability of pH-responsive, endosomolytic MOFs to induce strong cellular immune responses for cancer therapy by co-delivery of CpG ODN and antigens.
研究领域:
生物医学工程
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免疫学
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癌症研究
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纳米技术
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-19
·
IF 10.2
Chen Bing,Zheng Kaifan,Fang Shubin,Huang Kangping,Chu Chengchao,Zhuang Junyang,Lin Jin,Li Shaoguang,Yao Hong,Liu Ailin,Liu Gang,Lin Jizhen,Lin Xinhua
Background The combination of drug delivery with immune checkpoint targeting has been extensively studied in cancer therapy. However, the clinical benefit for patients from this strategy is still limited. B7 homolog 3 protein (B7-H3), also known as CD276 (B7-H3/CD276), is a promising therapeutic target for anti-cancer treatment. It is widely overexpressed on the surface of malignant cells and tumor vasculature, and its overexpression is associated with poor prognosis. Herein, we report B7H3 targeting doxorubicin (Dox)-conjugated gold nanocages (B7H3/Dox@GNCs) with pH-responsive drug release as a selective, precise, and synergistic chemotherapy-photothermal therapy agent against non-small-cell lung cancer (NSCLC). Results In vitro, B7H3/Dox@GNCs exhibited a responsive release of Dox in the tumor acidic microenvironment. We also demonstrated enhanced intracellular uptake, induced cell cycle arrest, and increased apoptosis in B7H3 overexpressing NSCLC cells. In xenograft tumor models, B7H3/Dox@GNCs exhibited tumor tissue targeting and sustained drug release in response to the acidic environment. Wherein they synchronously destroyed B7H3 positive tumor cells, tumor-associated vasculature, and stromal fibroblasts. Conclusion This study presents a dual-compartment targeted B7H3 multifunctional gold conjugate system that can precisely control Dox exposure in a spatio-temporal manner without evident toxicity and suggests a general strategy for synergistic therapy against NSCLC.
研究领域:
癌症治疗
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纳米医学
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药物递送系统
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免疫学
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生物偶联化学
✓ 已验证
DOI
高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2019
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IF 1.479
Foster Dodzi Gomado,Yanling Wang,Forson Kobina,Caili Dai,Augustus Owusu-Boadi
An experimental investigation was conducted to evaluate the impact of silica nanoparticles concentration on a pH-responsive emulsion system in terms of its emulsification, phase inversion mechanisms and long-term stability. Also, the adsorption studies of the pH-responsive emulsifier and the nanoparticles were evaluated in order to comprehend the synergism between the nanoparticles and the emulsifier. The sorption of the emulsifier onto the surfaces of the nanoparticles caused wettability alteration enabling the nanoparticle to act as nanocomposite emulsifier. It was found out that the emulsions undergoes phase inversion upon treating it with a minimum of 1 ml of 0.5 M HCl and also increasing the nanoparticles concentration had no noticeable effect on the phase mechanism, However, the nanoparticles cannot stabilized the O/W formed after the phase inversion. The presence of the nanoparticles improves the thermal stability of the reversible emulsion and also protects the emulsions against the presence of NaBr and otherwise for salts like NaCl and Na2SO4. These outcomes reveal the various properties of a pH-responsive emulsion which are affected by the presences of nanoparticles in order to fully control stimuli-responsive emulsions to our advantage.
研究领域:
化学工程
·
胶体科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Surfaces and Interfaces
·
2025
·
IF 6.3
Xinnian Meng,Jingqi Chen,Zeyang Liu,Yongming Tang
An important issue regarding halloysite nanotubes as inhibitor containers is the stimuli-responsive performance. A novel approach to constructing pH-sensitive halloysite nanocontainers is developed in this study. The silicate-mediated tannic acid complexes (Si-TA) are deposited on the etched halloysite nanotubes (EHNTs) loading Na 2 MoO 4 , endowing the Si-TA/Mo@EHNTs nanocontainers with the high pH-sensitivity. Both the release rate and ratio of the inhibitor increase with increasing pH. The sensitivity of the nanocontainers to the high pH value arises from the rapid hydrolysis of Si-TA encapsulation layers in the basic media. It is evidenced that gallic acid (GA), generated from the hydrolysis of the Si-TA complexes, can further dimerize into ellagic acid (EA) in the basic media. The smart epoxy coatings with the stimuli-responsive performance are prepared by incorporating the Si-TA/Mo@EHNTs nanocontainer, and exhibit better corrosion resistance compared with the epoxy coatings without the nanocontainers as well as directly incorporated with Na 2 MoO 4 . The elevated pH in the cathodic region of corrosion cell trigger the release of MoO 4 2- ions from the nanocontainers, inhibiting the corrosion of the exposed substrates effectively. Furthermore, the EA-Fe(III) depositions could be formed by the combination of the EA compounds from the damage of the encapsulation layers with the Fe 3+ ions, acting as the barrier on the exposed substrates to improve the corrosion resistance of the coating.
研究领域:
材料科学
·
纳米技术
·
表面工程
·
腐蚀科学
·
高分子科学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Liaoliao Xie,Zhaomeng Sun,Xiaoqing Zhang,Baoxin Li,Mei Liu
Identifying and detecting bacteria are crucial for ensuring food safety and environmental monitoring. We have developed a detection system based on pH-responsive fluorescent carbon dots (pH-CDs). This system leverages the fact that Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) exhibit significantly higher sugar metabolism capabilities compared to other foodborne pathogens, enabling the identification and detection of S. aureus and E. coli. As the pH of the solution increased from 3 to 7.5, the fluorescence intensity of the pH-CDs gradually decreased. In the presence of glucose and lactose, S. aureus and E. coli participated in metabolic processes, which converted these sugars into acidic products, thereby inducing a reduction in the solution pH. The decrease in pH, in turn, triggered an enhancement in the fluorescence intensity of pH-CDs. Therefore, the pH-CD sensor enabled quantitative detection of S. aureus and E. coli with a robust linear response (R2 > 0.99), detection limits of 3–6 CFU mL−1, and reliable recoveries of 97–102% in real water samples, confirming its suitability for application. Furthermore, pH-CDs can also be utilized to identify S. aureus and E. coli, which differ in their capacity to metabolize lactose. The proposed fluorescent sensing system provides a novel approach for the rapid identification and quantification of S. aureus and E. coli, holding significant potential for practical applications.
研究领域:
分析化学
·
生物传感器
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纳米技术
·
微生物学
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食品安全
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
BIOCONJUGATE CHEMISTRY
·
2017
·
IF 4.818
Zhu Jiang,Qixian Chen,Xi Yang,Xiyi Chen,Zhen Li,De-E Liu,Wei Li,Yingjie Lei,Hui Gao
Tetraphenylene (TPE), characterized as a lipophilic and aggregation-induced-emissive fluorophore, was used to incorporate into an electrostatic self-assembled polyethylenimine-poly(ethylene glycol) (PEI–PEG)/plasmid DNA (pDNA) complexed micelle. The hydrophobic character of TPE appeared to drive a higher degree of condensation of the pDNA payload, which consequently resulted in not only strengthened colloidal stability of the constructed polyplex micelle but also improved biocompatibility by virtue of the elevated PEG crowdedness owing to the TPE-induced collapse of pDNA. These beneficial consequences potentially permitted a larger number of polyplex micelles to be internalized into the cells. PEG segments were designed to enable selective detachment from polyplex micelles in acidic milieu, e.g., the tumor microenvironment, and intracellular endosome compartment, based on the strategic arrangement of acid-responsive cleavable linkage between PEG and PEI. Upon PEG detachment, the exposure of cationic PEI/TPE polyplex was allowed to directly interact with the cell membrane, endosome membrane, and charged intracellular species, thus promoting cell internalization, endosome escape, and the release of the pDNA payload. Of note, this association of cationic PEI/TPE polyplex with the endosomal membrane could be further facilitated with the aid of lipophilic TPE, thereby eliciting pronounced destabilization potency to the endosome membrane and exerting an endosomal escape function. Eventually, the proposed system of these facile strategies, including responsive PEG detachment and functional TPE incorporation, was proven to provide efficient gene expression in the targeted tumors with an appreciable safety profile via systemic administration.
研究领域:
纳米医学
·
基因治疗
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Jinya Du,Yuchun Qiao,Xiangdan Meng,Wei Wei,Wenhao Dai,Lingzhi Yang,Changying Yang,Haifeng Dong
Mitochondrial microRNAs (mitomiRs) critically orchestrate mitochondrial functions. Spatial imaging of mitomiRs is essential to understand its clinical value in diagnosis and prognosis. However, the direct monitoring of mitomiRs in living cells remains a key challenge. Herein, we report an AIE nanoreporter strategy for mitomiRs imaging in living cells through pH-controlled exonuclease (Exo)-assisted target cycle signal amplification. The AIE-labeled DNA detection probes are conjugated on Exo III encapsulated polymeric nanoparticles (NPs) via consecutive adenines (polyA). The amplified sensing functions are off during the cytoplasm delivery process, and it can be spatially switched from off to on when in the alkaline mitochondria (about pH 8) after triphenylphosphonium (TPP)-mediated mitochondrial targeting. Where the NPs degraded to release Exo III and cancer-specific mitomiRs hybridize with AIE-labeled DNA detection probes to expose the cleavage site of released Exo III, enabling spatially restricted mitomiRs imaging. The mitomiRs expression fluctuation was also realized. This study contributes to a facile strategy that could easily extend to a broad application for the understanding of mitomiRs-related pathological processes.
研究领域:
生物学
·
生物化学
·
分子生物学
·
癌症研究
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Sustainable Materials and Technologies
·
2025
·
IF 9.2
Qianyun Tan,Gege Zhang,Xiaoyu Xu,Tiantian Hu,Yabei Zhang,Xu Zhang,Zhongyao Zhang,Fa-Qian Liu
While copper-based antifoulants represent effective solutions for marine biofouling prevention, their utilization efficiency remains a critical challenge. This investigation demonstrates a pH-responsive hydrogel composite through synergistic integration of poly(acrylic acid) networks with histidine-coordinated cupric nanoclusters. The main ligand configuration of histidine and Cu 2+ was identified as “imidazole-dominated and carboxyl-assisted” by density functional theory (DFT) simulation, which provides theoretical support for the pH sensitivity of hydrogel. This coating releases Cu 2+ precisely “on demand” in response to external pH changes, effectively preventing algae and fouling organisms from adhering and achieving high bactericidal rates against Pseudomonas aeruginosa and E. coli . The distinctive molecular design of the coating combines multiple amide motifs that self-assemble into a honeycomb network via strong hydrogen bonding, while the coordination between Cu 2+ and histidine establishes a dynamic metal-ligand interaction with tunable dissociation kinetics and cohesion strength. This intelligent controlled-release composite hydrogel significantly reduces the risk of marine fouling by releasing antifouling agents precisely and efficiently, providing an innovative solution for building a sustainable marine antifouling system.
研究领域:
海洋科学
·
材料科学
·
表面工程
·
环境化学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）