ACS Applied Polymer Materials
·
2024
·
IF 4.4
Zhonghua Lv,Xi Chen,Ling Yang,Mengting Li,Changjun Xia,Chunjia Luo,Min Chao,Luke Yan
We present a biomimetic switchable MXene membrane for water treatment inspired by chloride ion transmembrane transport. The MXene membrane was modified with poly(2-diethylaminoethyl methacrylate), resulting in increased hydrophilicity and enlarged channels. The membrane exhibited a permeability of 4.42 × 104 L m–2 h–1 bar–1, surpassing conventional MXene membranes. The membrane also separated Methylene Blue positively charged at pH = 12 and Amido Black 10B negatively charged at pH = 2 with separation efficiency above 98%, thanks to controllable channel size and adjustable electrostatic interactions in response to pH or CO2. This research offers valuable insights into the design of pH-responsive membranes with adjustable selectivity, representing a significant advancement in smart filtration with versatile applications.
研究领域:
材料科学
·
环境工程
·
生物仿生学
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产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 68
·63874-63879
·
IF 3.289
Liqiang Yan,Tingting Qing,Renjie Li,Zhongwei Wang,Zhengjian Qi
A series of schiff base derivatives with salicylaldehyde moieties were designed and synthesized. These materials exhibit typical AIE properties and high fluorescence quantum yields in an aggregated state based on the excited-state intramolecular proton transfer (ESIPT) mechanism. Then, the effect of substituted group types and positions on the fluorescence of these novel compounds was investigated through fluorescence spectra analysis and theoretical calculations. And it was found that the salicylaldehyde derivatives can be used as potential pH and Zn2+ sensors.
研究领域:
化学
·
材料科学
·
分析化学
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DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Yayuan Guan,Yuling Su,Lili Zhao,Fancui Meng,Quanxin Wang,Yongchao Yao,Jianbin Luo
Polyurethane micelles with disulfide linkage located at the interface of hydrophilic shell and hydrophobic core (PU-SS-I) have been shown enhanced drug release profiles. However, the payloads could not be released completely. The occurrence of aggregation of hydrophobic cores upon shedding hydrophilic PEG coronas was considered as the reason for the incomplete release. To verify the above hypothesis and to develop a new polyurethane based micelles with dual stimuli respond properties and controllable location of pH and reduction responsive groups in the PU main chains, a tertiary amine was incorporated into the hydrophobic core PU-SS-I, which resulted polyurethane with both reduction and pH sensitive properties (PU-SS-N). Biodegradable polyurethane with only disulfide linkages located between the hydrophilic PEG segment and the hydrophobic PCL segments (PU-SS-I) and polyurethane with only pH sensitive tertiary amine at the hydrophobic core (PU-N-C) were used as comparisons. Paclitaxel (PTX) was chosen as mode hydrophobic drug to evaluate the loading and redox triggered release profiles of the PU micelles. It was demonstrated that PU-SS-N micelles disassembled instantly at the presence of 10 mM GSH and at an acidic environment (pH = 5.5), which resulted the nearly complete release (~ 90%) of the payloads within 48 h, while about ~ 70% PTX was released from PU-SS-I and PU-SS-N micelles at neutral environment (pH = 7.4) with the presence of 10 mM GSH. The rapid and complete redox and pH stimuli release properties of the PU-SS-N nanocarrier will be a promising anticancer drug delivery system to ensure sufficient drug concentration to kill the cancer cells and to prevent the emergency of MDR. The in vitro cytotoxicity and cell uptake of the PTX-loaded micelles was also assessed in H460 and HepG2 cells.
研究领域:
材料科学
·
药学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2020
·
IF 3.693
Ai Qiushuang,Fu Qiang,Liang Feng
Recognition tunneling technique owns the capability for investigating and characterizing molecules at single molecule level. Here, we investigated the conductance value of cucurbit[7]uril (CB[7]) and melphalan@CB[7] (Mel@CB[7]) complex molecular junctions by using recognition tunneling technique. The conductances of CB[7] and Mel@CB[7] with different pH values were studied in aqueous media as well as organic solvent. Both pH value and guest molecule have an impact on the conductance of CB[7] molecular junction. The conductances of CB[7] and Mel@CB[7] both showed slightly difference on the conductance under different measurement systems. This work extends the molecular conductance measurement to aqueous media and provides new insights of pH-responsive host-guest system for single molecule detection through electrical measurements.
研究领域:
生物物理学
·
纳米科学
·
分子电子学
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DOI
PubMed
高影响因子
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
·
2025
·
IF 2.4
Genpei Zhang,Xilong Zhang,Kai Yue,Weishen Zhong
Liposomes serving as nanocarriers offer significant advantages in drug delivery for tumor treatment. There still exists challenges in controlling drug release by disintegrating the liposome membrane for the improvement of therapeutic efficiency. In this paper, a novel method involving the mixture of short peptides with pH-responsive characteristics into the cargo has been introduced. This approach facilitates the release of doxorubicin (DOX) in the acidic tumor tissue environment. The efficacy of this improvement was elucidated through molecular dynamics simulations and experiments. Liposomes incorporating a 1:1 ratio of peptides–DOX exhibited pronounced pH sensitivity and an enhanced drug release profile. The underlying mechanism is attributed to the peptides entering tumor tissues and undergoing protonation in acidic conditions, which increases the hydrophilicity of the peptide–DOX clusters and the internal surface tension of the liposomes. This alteration disrupts the balance between the inner and outer surface tensions of the nanocarrier, causing the liposomes to structurally disintegrate and thus enhancing drug release. The results from both thermodynamic analysis results and experimental data confirm the augmented drug release efficiency of this method, offering valuable theoretical insights for nanoparticle design and determining the optimal mixing ratio for therapeutic applications.
CAS / MDL:
研究领域:
药剂学
·
生物医学工程
·
纳米医学
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产品关联
DOI
PubMed
高影响因子
Cancer Nanotechnology
·
2025
·Vol. 16
·期 1
·1-20
·
IF 4.8
Li Fangling,Liu Chengjing,Gu Wenyi,Xu Qianhe,Li Dongmei,Cao Dongdong,Liu Zhiyong
Kaposi's sarcoma-associated herpesvirus (KSHV) infection can cause a variety of tumors and is one of the leading causes of death in acquired immune deficiency syndrome (AIDS) patients. As a small molecule antiviral drug, ganciclovir (GCV) can be used for anti-KSHV treatment. However, GCV has non-specific action and toxic side effects in vivo, and how to make it safer and more effective against KSHV is still a great challenge. By encapsulating GCV into metal–organic skeleton material zeolitic imidazolate framework-8 (ZIF-8) and further modification of hyaluronic acid (HA), the nanomedical delivery system of GCV (HA/GCV@ZIF-8) has been developed for efficient GCV delivery and targeted anti-KSHV treatment. The modification of HA leads to the targeted binding of the nanocomplex with the overexpressed CD44 receptors in tumor cell membranes, resulting in the increased accumulation and cellular uptake of GCV. Exploiting the decomposition property of ZIF-8 under acidic conditions, the nanocomplex exhibits pH-responsive drug release in slightly acidic tumor environment. In addition, HA/GCV@ZIF-8 not only suppresses expression of KSHV pathogenic genes with less drug dose, but also inhibits the ability of cell proliferation and migration. In vivo anti-tumor results showed that HA/GCV@ZIF-8 accumulated in tumor cells and effectively inhibited tumor growth. The results open a gate for the targeted anti-KSHV treatment. Graphical
研究领域:
医学
·
药学
·
病毒学
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产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Xiaodan Wu,Weiyong Tao,Ziyang Lan,Yaping Tian,Zhenyu Zhong,Jianwei Wang,Jiaqi Li,Xulong Liu,Xin Zhang,Yifan Wang,Jianglin Wang,Bin Zhang,Yingying Du,Shengmin Zhang
Trauma or inflammation-caused cartilage injury leads to joint dysfunction and pain. Exogenous hyaluronic acid (HA) injection is a well-established treatment, but it has a short duration in vivo and requires multiple injections. Here, a new strategy for in situ reprogramming chondrocytes to continuously produce endogenous high molecular weight HA is developed. This involves a pH-responsive engineered exosome decorated with vesicular stomatitis virus glycoprotein (VSV-G) and hyaluronan synthase type 2 (HAS2). Such engineered exosomes successfully deliver HAS2 to the chondrocyte membranes via VSV-G-mediated membrane fusion triggered by low pH, rather than being degraded in lysosomes. This results in the generation of HAS2-chondrocytes, which are characterized to produce high molecular weight HA in vitro and in vivo. With increased endogenous HA, the injected engineered exosomes enhance cartilage regeneration and inhibit osteoarthritis (OA) progression. Notably, one-shot administration of engineered exosomes drastically increases the intra-articular concentration of high molecular weight HA to 145% of the exogenous HA injection group. Importantly, such endogenous HA is sustained for 4 weeks, whereas the injected exogenous HA rapidly decreases within 2 weeks. The findings demonstrate that pH-responsive engineered exosomes capable of generating endogenous HA hold great potential to replace the treatment of multiple injections of exogenous HA for cartilage repair.
研究领域:
医学
·
生物工程
·
组织工程
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Kaiqiang Zhang,Yulin Shi,Liang Wu,Long Chen,Tingting Wei,Xin Jia,Zhang Chen,Manqiu Li,Yisheng Xu,Yu Wang,Yanfeng Gao,Xuhong Guo
A thermo and pH dual-responsive starch (TPDS) was successfully synthesized by etherification, in which butyl glycidyl ether (BGE) was used as the hydrophobic reagent followed by addition of 2-chloro-4, 6-diglycino-[1,3,5]-triazine (CDT) groups. The obtained materials were characterized by Fourier transform–infrared spectroscopy (FTIR), 1 H nuclear magnetic resonance ( 1 H NMR) and elemental analysis to confirm the structure and the average substitution degree of BGE and CDT on starch molecule. It was observed that the lower critical solution temperature (LCST) of the TPDS could be modulated from 31 °C to 47 °C by increasing pH of the solution. The effects of pH and the concentration of such materials on the energy-saving performance of TPDS which could be potentially used as smart windows were investigated by UV-vis-NIR spectrophotometry. The solar modulating ability (△T sol ) and the luminous transmittance (△T lum ) of the sample were 40.1% and 47.1% when 10 g/L TPDS was chosen at pH 3. The results indicate that TPDS exhibits excellent optical performance with a controllable LCST, which shows great potential for the application as a smart window.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2025
·
IF 14.1
Hui Li,Fengzhen Meng,Chengwei Hu,Zhiyun Wu,Liuzhi Hao,Caijun Sun,Lijing Fang,Fan Pan,Shaoquan Bian,Huipeng Li,Mingjun Li,Bo Liu,Xiaoli Zhao
The microneedle, a minimally invasive transdermal system, provides a convenient and painless method for drug delivery. Among the various types of microneedles, hydrogel-forming microneedles (HFMs) demonstrate distinct advantages in terms of high-dose drug loading and biocompatibility. However, HFMs usually require drying to obtain sufficient puncture strength, which may destroy drug activity and increase storage costs. Herein, a high-strength HFM patch with pH-responsiveness for post-drug loading and long-term release is developed based on acrylonitrile-acrylic acid copolymer. The dipole-dipole and hydrogen bonding interactions formed through gradient solvent replacement are evenly distributed within the cross-linked network, significantly enhancing the mechanical properties of the hydrogel required for epidermal penetration. The prepared hydrogel exhibits a tensile strength of 26 MPa and a Young's modulus of 407 MPa. The microneedles formed from this hydrogel display a single needle mechanical force of 1.18 N. The post-loading mode conferred by pH responsiveness allows the drug to be encapsulated in both the tips and the substrate, acting as a reservoir. Once applied to the skin, the microneedle is activated by body fluids to achieve long-term drug release. Overall, this high-strength HFM improves the mechanical properties in the hydrated state, making it a promising minimally invasive transdermal delivery platform.
研究领域:
药剂学
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Yaning Fang,Lefei Zhou,Jun Yang,Junkai Zhao,Yali Zhang,Changqing Yi
The increasing demand for large-scale integrated logic systems urges the development of multireadout molecular logic gates. Especially, it is of great significance to explore dual-readout logic devices with both fluorescence (FL) and magnetic resonance (MR) signals as measurable outputs, since the signal combination of FL/MR might render molecular logic devices better practicality in biomedical applications. In this study, holmium(III)-doped carbon nanodots (Ho-CDs), which exhibited pH-responsive behaviors in both FL and MR signals, were synthesized by a facile one-pot pyrolysis method. When triggered by H+, Fe3+, or Fe2+, the Ho-CDs served as a switch for both FL and MR signals, leading to dual-readout and multiaddressable logic gates. A series of elementary Boolean operations including YES, NOT, OR, NOR, XOR, PASS 0, and INH have been successfully demonstrated by varying the chemical inputs of H+/Fe3+/Fe2+. More importantly, multilevel integrative Boolean operations with higher functions (NOR–INH and MR (XOR + INH)–OR), which realize the concatenation of different logic gates, have also been successfully demonstrated. This study may pave an avenue to design multilevel, dual-readout molecular logic systems with better operation stability, which hold great potential for biomedical applications in the future.
研究领域:
材料科学
·
生物医学工程
·
化学
✓ 已验证
DOI
JOURNAL OF MOLECULAR LIQUIDS
·
2012
·
IF 1.58
Yi-Tian Tang,Xiao-Qiu Dou,Zhi-Ang Ji,Ping Li,Shen-Min Zhu,Jia-Jun Gu,Chuan-Liang Feng,Di Zhang
Dye/water separation is a worldwide challenge because of the increasing industrial dye wastewater. In this paper, a novel pH-responsive C 2 -symmetric cyclohexane based hydrogel was developed and was capable of rapidly adsorbing dye molecules in minutes. This hydrogel dye adsorbent was characterized by Fourier transform infrared (FT-IR) spectroscopy, Ultraviolet–visible (UV–vis) spectroscopy, Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM). The adsorption equilibrium of the dyes is in good agreement with Langmuir adsorption isotherm model. Moreover, the hydrogel adsorbent can be recovered easily just by changing the pH of the medium, which is promising to be used an efficient dye adsorbent in water purification .
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 11
·1337-1347
·
IF 4.927
Lulu Cheng,Tingting Luan,Di Liu,Ju Cheng,Hongping Li,Hua Wei,Lifen Zhang,Jingfeng Lan,Yali Liu,Guanghui Zhao
A new type of reduction- and pH-mediated glyco-polymeric micelles was synthesized for the antitumor drug doxorubicin (DOX) delivery in this study. The micelles were constructed by a diblock copolymer (MH-S-S-AcMH) with a disulfide linkage between hydrophilic block maltoheptaose (MH) and hydrophobic block acetalated maltoheptaose (AcMH). The experimental results showed that the amphiphilic MH-S-S-AcMH with 20 nm average size could self-assemble into micelles under physiological conditions and rapidly release the conjugated drug DOX when exposed to weakly acidic (pH = 5) and reductive (10 mM DTT) environment. Fluorescence microscopy detection indicated that drug carriers can be endocytosed effectively, making the anticancer agents flow into cells and suppress the growth of HeLa tumor cells. Compared with DOX at higher dosage and MH-S-S-AcMH micelles which are non-toxic to tumor cells, cytotoxicity assays manifested that the DOX-loaded MH-S-S-AcMH micelles exhibited better toxicity to HeLa tumor cells. According to these results, the copolymer mentioned above as practically non-toxic, highly stable, novel reduction- and pH-mediated glyco-polymeric micelles could be employed in improving drug delivery efficiency and enhancing anticancer efficacy.
研究领域:
药物递送
·
肿瘤学
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）