Soft Matter
·
2022
·Vol. 18
·期 14
·2814-2828
·
IF 4.046
Xian-hui Shao,Xiao Yang,Yue Zhou,Qing-chang Xia,Yun-ping Lu,Xiao Yan,Chen Chen,Ting-ting Zheng,Lin-lin Zhang,Yu-ning Ma,Yu-xia Ma,Shu-zhong Gao
Making a hydrogel-based first-aid bandage with green resources, desirable biocompatibility, universal adhesive properties, low cost and simple production is a long-standing research aspiration. Considering this, three naturally existing organic acids, namely tannic acid, thioctic acid and phytic acid, were used to construct a novel adhesive gel (TATAPA hydrogel) for epidermal tissue bandage applications. This hydrogel could be synthesized under mild conditions with no need for a freeze–thawing shaping procedure, and was transparent, moldable and stretchable with good stability under continuous water immersion. In lap-shear tests, the TATAPA hydrogel could adhere to various hydrophilic and hydrophobic surfaces. Moreover, in the case of skin tissue adhesion, the hydrogel could be easily peeled off from the skin, meeting wearability requirements. Rheological tests showed that the hydrogel possessed thermal sensitive properties derived from multi-supramolecular interactions. The methicillin-resistant Staphylococcus aureus (MRSA)-infected burn wound test demonstrated that the hydrogel had desirable antibacterial activity and was beneficial for wound healing. A femoral artery bleeding assay was also used to reveal that the TATAPA hydrogel could be directly pasted onto the bleeding site for hemostasis. Overall, this hydrogel demonstrates potential as a surgical bioadhesive for a broad range of medical applications.
研究领域:
材料科学
·
生物医学工程
·
伤口护理
·
药剂学
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高影响因子
RARE METALS
·
2026
·Vol. 45
·期 5
·e70256
·
IF 12.1
Qiang Miao,Sijun Huang,Zhexing Wang,Jiachen Lv,Huan Li,Ying Wang,Yi Guo,Li Xu
en This link goes to a English section zh This link goes to a Chinese section Selective molecular recognition is central to chemical sensing yet discriminating structurally similar molecules at complex interfaces remains challenging. Traditional strategies based on tuning size, charge, or binding-site chemistry often suffer from limited flexibility. Here, we employ dimensionality engineering of cerium-based metal-organic frameworks (Ce-MOFs), comparing 2D and 3D Ce-MOFs to modulate molecular interactions via spatial conformation matching. Phytic acid (PA), with its distinct 3D inositol hexaphosphate structure, exhibits dimension-dependent interfacial assembly behavior. In 2D Ce-MOF, PA acts as a “molecular bridge” inducing interlayer stacking (∼fivefold thickness increase) and leading to strong noncompetitive inhibition (IC 50 = 0.053 mM) of its hydrolase (phosphatase)-mimetic activity. Conversely, confinement within the large pores (14.42 Å) of 3D Ce-MOF allows partial pore penetration (PA cross section: 10.46 Å) resulting in weak competitive inhibition (IC 50 = 1.7 mM). Spectroscopy ( 31 P NMR, FTIR) and zeta potential testing confirmed analogous PA-Ce coordination modes in Ce-MOFs ruling out chemical disparity as the cause. Density functional theory (DFT) calculations further verified the interlayer bridging in 2D MOF and intrapore confinement in 3D MOF as distinct adsorption modes. This fundamental difference—interlayer stacking versus confined penetration driven by dimensionality engineering creates a unique “dimensional fingerprint” for PA. Leveraging this orthogonal response (noncompetitive vs. competitive inhibition), we demonstrate a sensing strategy for selective PA identification. This work establishes dimensionality engineering as a powerful paradigm for rational interface design and selective recognition based on analyte spatial architecture. 摘要 en This link goes to a English section zh This link goes to a Chinese section 选择性分子识别是化学传感的核心,但在复杂界面上实现对结构相似分子的精准区分仍具有挑战性。传统通过调整尺寸、电荷或结合位点化学性质的策略往往灵活性不足。本研究提出一种基于铈基金属有机框架(Ce-MOFs)的维度设计方法,通过构建二维与三维Ce-MOFs,并利用空间构型匹配调控其与植酸(PA)的相互作用。PA具有独特的三维肌醇六磷酸酯结构,因而呈现出显著的维度依赖界面组装行为: 在二维Ce-MOF中,PA作为“分子桥”诱导层间堆叠(厚度增加约5倍),从而对其水解酶活性产生强烈的非竞争性抑制; 而在具有大孔道(14.42 Å)的三维Ce-MOF中,PA(横截面约10.46 Å)可部分进入孔道,仅引起较弱的竞争性抑制。 31 P 核磁共振(NMR)、傅里叶变换红外光谱(FTIR)以及Zeta电位结果表明,两种Ce-MOFs中的PA-Ce配位方式相近,排除了配位化学差异导致响应分化的可能。密度泛函理论(DFT)计算进一步验证了两种截然不同的吸附模式: 二维MOF中的层间桥连与三维MOF中的孔内限域。这种由维度设计驱动的根本差异——层间堆叠与限域渗透,赋予PA独特的“维度指纹”。基于这种正交抑制响应(非竞争性 versus 竞争性),我们构建了用于PA选择性识别的传感策略。该研究确立了维度设计作为一种通用范式,可用于基于分析物空间结构的理性界面设计和选择性识别。
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 42
·19494-19503
·
IF 3.3
Mengfei Zhang,Yang Wang,Jing Huang,Dong Wang,Ting Li,Shibo Wang,Weifu Dong
White pollution substantially impairs people's quality of life nowadays. Bio-based polymers that are environmentally friendly and biodegradable have garnered interest. Among them, polylactic acid (PLA) has attracted wide attention due to its excellent biodegradability, high transparency, and easy processing. However, its inherent flammability, low toughness, and poor compatibility with flame retardants severely limit its application scope. In this paper, a phytic acid-based flame retardant glycidyl methacrylate phytate (GPA) was prepared by epoxy ring-opening and phosphate transesterification. GPA was grafted onto PLA through free radical polymerization, and the introduction of GPA improved both the mechanical properties and flame retardancy of PLA. The LOI of PLA composite rose to 28% after adding a 6 wt% GPA. A reduction of 11.7% in the total heat release of the PLA-GPAX was observed in comparison to neat PLA, demonstrating that the prepared PLA composite exhibits high flame retardancy. Due to the improved dispersion and compatibility of GPA in the matrix after grafting onto PLA, the mechanical strength of PLA increased by 19.9%. This study provides a feasible method for improving the compatibility between flame retardants and bio-based polymers, achieving a mutually beneficial situation in flame retardancy and mechanical strength, and further expanding the application range of bio-based materials.
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JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 3
·1200-1213
·
IF 4.5
He Chunming,Yan Ru,Xue Qingwang,Li Shuxian,Wang Huaisheng
In this work, polyaniline (PANI) and overoxidized polyaniline (oPANI) nanorods doped by phytic acid (PA) with uniform size of 60–100 nm were prepared and modified on glassy carbon electrode (GCE) as non-enzymatic malathion sensors. Doping of PA has deep influence on structural and morphological properties, conductivity and detection performance of electrode materials. The obtained PANI nanorods doped with PA (PA-PANI) possess high affinity toward malathion, and thus the redox reaction of PANI molecules could be hindered and redox currents were inhibited. The electrode reaction process on PA-PANI/GCE is a typical adsorption-controlled process. By contrast, the oPANI nanorods doped with PA (PA-oPANI) presents good catalytic performance to malathion and the electron transfer process was enhanced and redox currents increased. Correspondingly, the electrochemical reduction process on PA-oPANI/GCE is a typical diffusion-controlled process. Both enzyme-free electrochemical sensors exhibit good stability, anti-interference ability, recovery in real samples and excellent detection performance, with a wide linear range of 0.01–200 ppb and low detection limit (1.58 ppt for PA-PANI and 2.23 ppt for PA-oPANI, respectively), indicating that PA-PANI and PA-oPANI could be used as an excellent malathion sensor. Moreover, the PA-oPANI sensor has some degree of reproducibility through further anodic polarity processing, and the detailed application needs to be further explored.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2018
·
IF 4.229
Chongjun Zhao,Pengwei Li,Danmin Shao,Ruizhi Zhang,Shengqi Wang,Zhaoqiang Zhu,Chunhua Zhao
A phytic acid-derived Co 2-x Ni x P 2 O 7 -C/RGO composite was designed and facilely synthesized, in which phytic acid acted as both a phosphoric source and carbon source. Both carbon derived from phytic acid and reduced graphene oxide (RGO) in composite, enhanced the conductivity and thus improve its electrocatalytical capability. As-synthesized Co 1.22 Ni 0.78 P 2 O 7 -C/RGO composite exhibited excellent oxygen evolution reaction (OER) catalytic performances: At the current density of 10 mA cm −2 , only a low overpotential of 283 mV and a small Tafel slope of 51 mV dec −1 were observed. Good OER catalytic performance was retained even after 10 h continuously running at a constant voltage, which is even comparable to those of first-rate noble metal catalyst RuO 2 . In addition, the performances of Co 2-x Ni x P 2 O 7 -C/RGO catalysts were also strongly dependent on Ni content.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Junfei Ou,Xing Chen
By alternative immersion into the aqueous solutions of phytic acid (PA) and CeCl 3 for n cycles, a nanocomposite coating coded as (PA/Ce) n was fabricated on the magnesium substrate. The Ce 3+ ions were supposed to coordinate with the phosphate groups of the PA molecules and the (PA/Ce) n coatings adhered to the substrate firmly (5B according to the ASTM D 3359 method). Compared with the PA coating, the Ce 3+ ions enhanced the corrosion resistance of the PA/Ce nanocomposite coating . To further improve the corrosion resistance , the (PA/Ce) n coatings were immersed into the ethanol solution of hexadecyltrimethoxysilane (HDMS) and followed by heating in air. The so-obtained sample coded as Mg-H 2 O-(PA/Ce) n -HDMS was superhydrophobic and possessed much better corrosion resistance as compared with the Mg-H 2 O-(PA/Ce) n sample due to the retained thin layer of air at the solid/water interface in the NaCl aqueous solution. For four cycles, the Mg-H 2 O-(PA/Ce) 4 -HDMS sample showed the most excellent superhydrophobicity with a contact angle of 167.3 ± 2.1° and a sliding angle of 2.7 ± 0.8° due to its hierarchical surface morphology . Moreover, for four cycles, the retained air was most durable and remained intact after immersion for 80 h; consequently, the corrosion resistance of the Mg-H 2 O-(PA/Ce) 4 -HDMS sample was found the best. In one word, the corrosion resistance of PA to the Mg substrate was improved by incorporating with Ce 3+ ions and further modifying by HDMS molecules. The present study provided a new conversion coating by combining the synergistic anti-corrosion effect of PA, Ce 3+ ions, and the surface superhydrophobicity.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Lujia Li,Qingxue Fu,Mengxin Xia,Lei Xin,Hongyi Shen,Guowen Li,Guang Ji,Qianchao Meng,Yan Xie
Phytic acid (IP6) is a natural phosphorylated inositol, which is abundantly present in most cereal grains and seeds. This study investigated the effects of IP6 regulation on P-glycoprotein (P-gp) and its potential mechanisms using in situ and in vitro models. The effective permeability of the typical P-gp substrate rhodamine 123 (R123) in colon was significantly increased from (1.69 ± 0.22) × 10–5 cm/s in the control group to (3.39 ± 0.417) × 10–5 cm/s (p < 0.01) in the 3.5 mM IP6 group. Additionally, IP6 can concentration-dependently decrease the R123 efflux ratio in both Caco-2 and MDCK II-MDR1 cell monolayers and increase intracellular R123 accumulation in Caco-2 cells. Furthermore, IP6 noncompetitively inhibited P-gp by impacting R123 efflux kinetics. The noncompetitive inhibition of P-gp by IP6 was likely due to decreases in P-gp ATPase activity and P-gp molecular conformational changes induced by IP6. In summary, IP6 is a promising P-gp inhibitor candidate.
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高影响因子
LANGMUIR
·
2022
·
IF 4.331
Yuntong Ge,Wei Wang,Kai Li,Fan Xiao,Zhipeng Yu,Jing Gong,Hang Jin,Ang Li
Crude oil adhesion issues are widespread in the petroleum industry, leading to inefficient production and high maintenance costs. Developing efficient antifouling materials and investigating the microscopic adhesion mechanism are of substantial significance. In the present work, a superhydrophilic/underwater superoleophobic PAFC coating with excellent antifouling properties was constructed by the coordination-driven self-assembly of phytic acid (PA) and FeCl3 (FC). The atomic force microscope (AFM) droplet probe technique was employed to elucidate the underlying mechanism of the anti-oil-adhesion property of the PAFC coating. Results showed that the PAFC modification achieved the optimum effect at a molar ratio of 1:3 between PA and FeIII. Applying a (3-aminopropyl)triethoxysilane (APTES) interlayer can effectively improve the performance of the PAFC coating on silica substrates. AFM droplet probe experiments indicated that the adhesion force between submerged micrometer-sized oil droplets and PAFC-modified substrates was significantly weaker than that with the untreated substrate. Meanwhile, the adhesion forces between oil droplets and surfaces were inversely proportional to the contact angle of the oil in water and were enhanced by higher salinity, lower collision velocity, and stronger loading force. The oil injection and wall sticking tests also confirmed the effectiveness of the PAFC modification in resisting the adhesion of crude oil.
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高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 10
·期 21
·4012-4019
·
IF 7.571
Zhen Zhao,Hua Zhang,Hongda Chen,Yuanhong Xu,Lina Ma,Zhenxin Wang
In this work, the polyacrylamide/phytic acid/polydopamine (termed as PAAM/PA/PDA) hydrogel is used as a drug loading matrix and photothermal conversion reagent, which is prepared by copolymerization of dopamine with acrylamide through a phytic acid crosslinker. Due to the porous structure of PAAM and strong near-infrared light (NIR)-absorption of PDA, the PAAM/PA/PDA hydrogel exhibits a high doxorubicin (DOX)-loading capacity (170 mg g−1) and efficient photothermal transduction efficiency (47.4%) even under low power density 808 nm NIR laser (0.75 W cm−2) irradiation, which is superior to those of most conventional photothermal conversion agents reported in the literature. With NIR laser irradiation, the PAAM/PA/PDA hydrogel loaded with DOX (termed as PAAM/PA/PDA/DOX) shows excellent synergistic interaction between photothermal therapy (PTT) and enhanced chemotherapy, resulting in the completely suppressed growth of mouse-bearing SW620 tumors. Furthermore, the PAAM/PA/PDA hydrogel shows good physicochemical stability, negligible cytotoxicity and low toxicity in vivo. All these characteristics render the as-prepared PAAM/PA/PDA hydrogel promising for biomedical applications.
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高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Zhisen Wang,Zhengxin Ma,Shuaibing Wang,Menghan Pi,Xiaoyu Wang,Min Li,Honglang Lu,Wei Cui,Rong Ran
Common hydrogels containing abundant water are insulating materials and lose stretchability easily below the freezing point of water, holding limited potential in emerging applications such as wearable soft devices. The introduction of compatible biomass-derived materials into hydrogel systems could be a potential solution that simultaneously enables anti-freezing ability, mechanical enhancement, and antibacterial properties . Based on such a hypothesis, here we report the facile development of biocompatible hydrogels that are capable of maintaining satisfying mechanical properties and electrical conductivity well below zero degrees centigrade. The strategy is to reinforce neat polyacrylamide (PAAm) hydrogels with biomass-derived cellulose nanocrystal (CNC) and phytic acid (PA), transforming the originally weak, insulating hydrogels into tough, highly conductive ones. Anti-freezing and antibacterial properties also emerge in the reinforced hydrogels, enabling them to work as efficient wearable sensors below zero degrees centigrade. Considering that numerous polymer hydrogel systems are compatible with CNC and PA, we believe that this simple biomass-based strategy can work universally to enhance and functionalize various weak and insulating hydrogels that are traditionally susceptible to frost and bacteria.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Lili Liang,Hao Zhang,Xiaoyan Lin,Kaiyin Yan,Mengsha Li,Xunhai Pan,Yang Hu,Yan Chen,Xuegang Luo,Ran Shang
Although various kinds of adsorbents have good uranium adsorption capacity, they still meet the challenge in capturing uranium under highly acidic condition. Therefore, efficiently extracting uranium under strong acidic condition become the pursuit of researchers. In this study, a new phytic acid decorated porous organic polymers (POPs) named MA-U-PA was prepared by synthesizing a organic framework (MA-U) using melamine and uracil and with subsequent phytic acid modification. The results showed that the excellent stability of the prepared organic framework and strong uranium chelating ability of phytic acid endowed the as-prepared material being an excellent adsorbent under strong acidic condition. The adsorption capacity achieved 106.7 mg·g -1 at the pH of 1 which was much higher than that of MA-U and most of other adsorbents. The study of modification mechanism confirmed that the hydrogen bonds interaction of phytic acid with MA-U lead to the successful modification. In addition, the phosphonate groups of PA was mainly the active groups chelated with uranium. Moreover, the uranium adsorption process of MA-U-PA was in accordance with the pseudo-second-order kinetic and Langmuir isothermal model. The newly prepared phytic acid decorated porous organic material could achieve efficient uranium capturing from highly acidic nuclear wastewater.
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Asia-Pacific Journal of Chemical Engineering
·
2020
·Vol. 16
·期 1
·e2584
·
IF 1.06
Hao Xu,Guangming Lu,Shuan Liu,Jibin Pu,Shu Tian,Chunlong Mao,Shanjun Chen
A phytic acid-based surface tolerant epoxy coating was prepared, and the effect of phytic acid on the corrosion resistance of the composite coating on rusty carbon steel substrate was investigated. The results showed that the low-frequency impedance modulus of the composite coating on rusty carbon steel could reached 10 8 Ω·cm 2 order of magnitude after immersing for 480 h in 3.5 wt% NaCl solution. Compared with pure epoxy coating, the phytic acid-based surface tolerant epoxy coating on the rusty substrate exhibited better corrosion resistance even if with some artificial defects in the composite coating. The protective performance of the composite coating mainly came from the formation of a stable iron phytate chelate in the reaction of phytic acid and rust. For the rusty carbon steel, the original Fe 3+ on its surface was also transformed by phytic acid penetrating to the interface between the coating and the substrate. Therefore, a dense film was formed with the reaction of phytic acid and rust on the substrates, and the dense film became a part of the whole paint film, which could improve the corrosion resistance of the surface tolerant coating.
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