POLYMERS FOR ADVANCED TECHNOLOGIES
·
2018
·Vol. 29
·期 5
·1360-1371
·
IF 2.137
Lei Zheng,Hui Wang,Xiaomin Cheng
In this study, a series of imprinted poly(methacrylic acid- co -ethylene glycol dimethacrylate) nanocarriers for diclofenac and corresponding nonimprinted polymer nanocarriers have been synthesized in 4 different types of solvents by precipitation polymerization. The products were characterized by Fourier transform infrared, scanning electron microscopy, dynamic light scattering, and Brunauer-Emmett-Teller measurement. Results showed that uniformly sized molecularly imprinted polymer (MIP) nanospheres with relatively good porosity could only be obtained in acetonitrile. The effects of solvents on the recognition and release properties of polymer particles were also carefully investigated. The binding experiments indicated that MIPs prepared in acetonitrile displayed much higher binding capacity than other MIPs with a maximum binding capacity of 65.18 mg g −1 . The Scatchard analysis showed that synthetic MIPs have special recognition sites for diclofenac, while nonimprinted polymers have not. The Sips model could provide a best fit to the equilibrium data of nanocarriers over whole concentrations. The experimental data of an adsorption kinetic study were well fitted to the pseudo–second-order kinetic model, indicating the chemisorption mechanism between diclofenac and MIPs in the process of adsorption. The drug release of diclofenac from MIPs could well be described by the Ritger-Peppas model, suggesting a non-Fickian diffusion mechanism. In addition, we successfully used MIPs to extract diclofenac at low levels from fetal bovine serum.
研究领域:
药学
·
材料科学
·
纳米技术
·
药物递送系统
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DOI
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2018
·Vol. 26
·期 7
·2945-2953
·
IF 1.971
Chen Huayao,Lin Guanquan,Zhou Hongjun,Zhou Xinhua,Xu Hua,Huang Suqing
Avermectin (AVM) is a highly efficient pesticide against a variety of insects and is widely used in agriculture. However, it is susceptible to oxidation and photolysis, resulting in instability under UV irradiation and a short half-life. Herein, sodium carboxymethyl cellulose (CMC) was grafted by styrene (St), Methyl methacrylate (MMA) and butyl acrylate (BA) respectively to prepare grafted polymer nanoparticles in application for AVM sustained released. And the influence of different grafted monomer and the grafted rate on the AVM/grafted polymer nanoparticles performance was discussed. The larger the grafted rate of St was, the larger the particle size of AVM/grafted polymer nanoparticles had with a higher drug loading rate and stronger resistance to ultraviolet light. Besides, the particle size, drug loading rate and the ability of anti-ultraviolet light of grafted CMC emulsion was also influenced by the modifying agent. While the concentration of AVM was kept the same, the acrylic esters (MMA and BA) grafted emulsion have smaller particle sizes with higher drug loading rates and stronger anti-ultraviolet ability comparing to styrene (St) grafted emulsion. The effect of different amount of St and different monomer grafted on the sustained release performance of AVM/grafted polymer was also investigated. As the grafted rate of St increased, the release rate became smaller. The release speed has a sequence of CMC-g-PBA > CMC-g-PS > CMC-g-PMMA when CMC grafted with different monomer. Their sustained release curves can be described by Korsmeyer-Peppas equation. Finally, the insect toxicity test showed that insecticide toxicity against diamondback moth ( Plutella xylostella L.) has no apparent difference among the AVM and AVM/grafted polymer nanoparticles indicating that AVM/grafted polymer nanoparticles can reduce the amount of organic solution used for dissolution and prolonged its service life without decreasing its insecticide toxicity.
研究领域:
农业科学
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材料科学
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农药学
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Liang Qiao,Fuhua Deng,Xulin Hu,Tianfang Huang,Junlin An,Dong Pan,Junqiang Yan,Gaofeng Liang,Jian He
It is still a considerable research challenge to design biodegradable drug delivery systems that efficiently transport lipid-soluble drugs with controlled release. In the present study, a microsphere delivery system, γ-cyclodextrin (γ-CD)/glutathione (GSH)-atorvastatin (AT) fibrous nanoparticles (γ-CD/GSH-AT FNs) loaded polytrimethylene carbonate (PTMC)/polycaprolactone (PCL) microspheres (PTMC/PCL/γ-CD/GSH-AT MPs), was constructed through an exquisite method. The results show that a large number of γ-CD/GSH-AT FNs can be encapsulated during the formation of microspheres and released in a controllable manner. Notably, the high dispersibility and drug loading of FNs can load with lipid-soluble drugs and protect the drugs from the solvent during microsphere preparation. FNs and MPs can achieve dual release. First, with the degradation of the microspheres, the encapsulated FNs were gradually released into the local microenvironment. Subsequently, the FNs began to dissolve and release the loaded AT over a period of more than 3 days. Therefore, the dual sustained-release drug delivery system can maintain the blood drug concentration for a longer time and reduce the number of administrations and the side effects of the drug. This study provides new ideas for the on-demand manufacture of controllable degradable drug delivery platforms to treat diseases.
研究领域:
药学
·
材料科学
·
药物递送系统
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产品关联
DOI
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2022
·Vol. 36
·期 6
·e6680
·
IF 4.072
Kai-Xin Wang,Meng-Ru Cai,Dong-Ge Yin,Xue-Ling Hu,Hulin-Yue Peng,Rong-Yue Zhu,Man-Ting Liu,Yu-Chen Xu,Chang-Hai Qu,Jian Ni,Xing-Bin Yin
Metal-organic frameworks (MOFs) are porous coordination polymers formed by metal ions and organic ligands through coordination bonds. In drug delivery applications, MOFs can impart sustained release, targeting, protection of easily degradable drugs, and improved drug solubility. Isoreticular metal-organic framework-8 (IRMOF-8) is a mesoporous MOF with a network topology bridged in the form of an octahedral cluster. Compared with other materials, it has the remarkable advantages of high porosity and a regular pore structure. Curcumin (CUR) is a diketone compound with potent antitumor effects. Due to its poor solubility and stability, its clinical application is limited. Therefore, we used IRMOF-8 as a carrier for the encapsulation of CUR to overcome the shortcomings of CUR itself and expand its clinical application. In this study, IRMOF-8 was synthesized through direct mixing of triethylamine (TEA). In vitro cell experiments demonstrated the biocompatibility of IRMOF-8. Using the solvent adsorption method, CUR was encapsulated by IRMOF-8 with a drug loading content of 58.86 ± 0.98 wt%. In vitro drug release experiments performed at pH levels of 7.2 and 5.5 showed that the preparation had a sustained-release effect over 7 days. Through cytotoxicity experiments after drug loading, it was found that CUR@IRMOF-8 had a strong cytotoxic effect on HepG2 cells, promoted cell apoptosis and intracellular uptake, decreased mitochondrial membrane potential, and increased reactive oxygen species. Hence, CUR@IRMOF-8 is expected to become an excellent sustained-release preparation for potential applications in tumor treatment.
研究领域:
药学
·
纳米技术
·
癌症研究
·
材料科学
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产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Xin Jin,Chengxiong Wei,Chengwei Wu,Wei Zhang
The metformin hydrochloride is the only oral guanidine anti glycemic agent and is used as the first-line drug for the treatment of type II diabetes. Owing to its high water solubility and short half-life, however, this drug is difficult to be released sustainedly. Here, a core–shell structured hydrogel assembly as gastroretentive carrier is proposed for the sustained release of metformin hydrochloride. The hydrogel assembly can be ingested orally into the stomach. On contact with the gastric juice, the shell rapidly swells to prevent the hydrogel to be expelled from the pylorus, and the core serves as a drug reservoir for loading metformin hydrochloride. The core–shell structure can decrease the driving force of drug release and extend the drug diffusion pathway. As a result, the hydrogel assembly can release metformin hydrochloride sustainedly for 72 h in vitro and maintain stable blood drug concentration for nearly 80 h in vivo. Moreover, the hydrogel assembly can be biodegraded by the gastric environment.
研究领域:
药剂学
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药物递送系统
·
药理学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Luqi Xiao,Ju Bai,Wei Lai,Yang Jiao,Qi Wu,Hongyan Liu,Yizhou Zhang,Linglong Shan,Shuangjiang Luo
Controlling the diffusion of amine monomers plays a crucial role in fabricating well-defined architecture and high-performance nanofiltration (NF) membranes through interfacial polymerization (IP). Herein, a sustained-release strategy was proposed to regulate the interfacial polymerization through a zwitterionic liquid hydrogel transition layer. The hydrogel (Gel) was fabricated via in-situ one-step UV photo-initiated free-radical polymerization between 1-vinyl-3-ethylimidazolium chloride ([VEIm][Cl]) and 3-sulfopropyl methacrylate potassium salt (SMP) on the polyethersulfone (PES) substrate. The polyamide (PA) layer was then formed on the Gel layer by mitigating the diffusion of amine monomers. Low-field time-domain nuclear magnetic resonance (TD NMR) analysis demonstrated that the Gel layer significantly enhanced the water-absorbing capacity of the composite membrane. Positron annihilation lifetime spectroscopy (PALS) also confirmed the Gel-PA composite membrane possessed enlarged free volumes. The obtained Gel-PA composite membrane displayed a permeance of 13.22 L m −2 h −1 bar −1 , a high Na 2 SO 4 rejection of 98.23 %, a favorable NaCl/Na 2 SO 4 selectivity of 49.75, outstanding long-term operational stability, and membrane antifouling properties. This sustained-release strategy provides a facile and feasible approach to controlling the IP process and obtaining high-performance nanofiltration membranes.
研究领域:
材料科学
·
化学工程
·
环境科学
·
膜技术
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产品关联
DOI
高影响因子
Toxics
·
2023
·Vol. 11
·期 10
·829
·
IF 4.6
Xueqiang Zhu,Hanghang Ji,Gang Hua,Lai Zhou
Sustained-release materials are increasingly being used in the delivery of oxidants for in situ chemical oxidation (ISCO) for groundwater remediation. Successful implementation of sustained-release materials depends on a clear understanding of the mechanism and kinetics of sustained release. In this research, a columnar sustained-release material (PS@PW) was prepared with paraffin wax and sodium persulfate (PS), and column experiments were performed to investigate the impacts of the PS@PW diameter and PS/PW mass ratio on PS release. The results demonstrated that a reduction in diameter led to an increase in both the rate and proportion of PS release, as well as a diminished lifespan of release. The release process followed the second-order kinetics, and the release rate constant was positively correlated with the PS@PW diameter. A matrix boundary diffusion model was utilized to determine the PS@PW diffusion coefficient of the PS release process, and the release lifespan of a material with a length of 500 mm and a diameter of 80 mm was predicted to be more than 280 days. In general, this research provided a better understanding of the release characteristics and kinetics of persulfate from a sustained-release system and could lead to the development of columnar PS@PW as a practical oxidant for in situ chemical oxidation of contaminated aquifers.Keywords:persulfate;sustained release;model fitting;soil and groundwater remediation;in situ chemical oxidation
研究领域:
环境科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 39
·32967-32978
·
IF 3.289
Jianqun Gan,XiaoXiao Guan,Jian Zheng,Huilong Guo,Kun Wu,Liyan Liang,Mangeng Lu
A series of novel thermoresponsive biodegradable hydrogels (TBHs) was prepared from N-isopropyl acrylamide (NIPAM) and two biodegradable crosslinkers, poly(ε-caprolactone) dimethacrylate (PCLDMA) and bisacryloylcystamine (BACy). The morphology, thermal behavior, swelling/deswelling kinetics, compression properties, in vitro drug delivery and biodegradation were investigated. The results indicated that the properties of the TBHs strongly depended on temperature and the feeding molar ratio of the PCLDMA to BACy components. Levofloxacin (LVF)-loaded hydrogels were prepared to explore their stimuli-responsive release process. The cumulative release profile of LVF-loaded TBHs exhibited a thermo-induced slow sustained drug release and a reduction-induced fast release. At a physiological pH, TBHs could be biodegraded slowly in glutathione (GSH) at 37 °C. Due to their homogeneous pore diameter, highly interconnected architecture, degradable chemistry and thermoresponsive properties, the TBHs developed herein are highly attractive with respect to tissue engineering scaffold applications.
研究领域:
材料科学
·
药剂学
·
生物医学工程
·
药物递送系统
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DOI
高影响因子
iScience
·
2025
·Vol. 29
·期 2
·
IF 4.1
Han-Ping Wang,Chen-Yu Xu,Wen Su,Yin-Song Wang,Yue Wang,Ming-Xin Cao
Periodontitis is a chronic inflammatory disease that leads to periodontal attachment loss and is a major cause of adult tooth loss. Current treatment of mechanical debridement is often ineffective in deep periodontal pockets, and antibiotic adjuncts carry the risk of bacterial resistance. Octyl gallate (OG), a natural plant-derived compound with antibacterial and antioxidant properties, is limited by poor water solubility and stability. This study aimed to develop a sustained-release ointment (OG-Ointment) using Pluronic F127 and ethylcellulose to enhance the delivery and efficacy of OG. The formulated OG-Ointment demonstrated excellent rheological properties, sustained drug release, and potent ABTS + radical scavenging. In vitro , it enhanced bacterial membrane permeability, inhibited P. gingivalis growth, and reduced ROS in macrophages. In a rat periodontitis model, OG-Ointment significantly reduced alveolar bone resorption, decreased ROS and inflammatory cytokines, and exhibited good biocompatibility. These findings suggest that OG-Ointment is a promising non-antibiotic adjunctive therapy for periodontitis, combining dual antioxidant and antibacterial functions with sustained release.
研究领域:
药剂学
·
牙科学
·
传染病学
·
药物递送
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Polymers
·
2022
·Vol. 14
·期 10
·2002
·
IF 4.967
Chengyuan Xing,Xia Xu,Lei Song,Xiaoling Wang,Bangjing Li,Kun Guo
Poly (vinyl alcohol)/β-cyclodextrin (PVA/CD) composite fibers are prepared by wet spinning followed by hot stretching. XRD results show that β-CDs are in an amorphous state in fiber, and β-CD can help maintain the fibrous crystal that exists in the composite fiber. The DSC results show that the total crystalline ratio of the composite fibers decreased with the increase of β-CD. The as-prepared composite fibers were further crosslinked with glutaraldehyde (GA) to improve their usability. The crosslinked structure, together with amorphous β-CD, contributes to the loading and sustained release of fragrance molecules that were studied. The fragrance retention ratio of PVA/CD/GA is 55.63% and 48.25% forcis-jasmone and citronella, even after 25 days. The inclusion complexes of β-CD and fragrance molecules are confirmed by 2D-FTIR, which is responsible for the sustained release of fragrance. This study may contribute to the mass production of wearable long-term scented fabrics.Keywords:β-cyclodextrin;polyvinyl alcohol;wet spinning;functional fibers;fragrance retention
研究领域:
材料科学
·
纺织工程
·
化学
✓ 已验证
DOI
PubMed
高影响因子
ChemistrySelect
·
2026
·Vol. 11
·期 2
·e03878
·
IF 2
Wenfeng Xie,Zhongxiao Li,Yuwei Hao,Shouzheng Jiao,Siqiao Zhang,Fanghua Pan,Lu Han,Ruping Liu,Zhicheng Sun
In this study, grapefruit essential oil (GEO)-loaded microcapsules encapsulated within silver/calcium alginate (Ag/CA) composite shells were successfully fabricated through an electrostatic spray technique. First, a pre-emulsion of GEO was prepared in the presence of sodium dodecyl sulfate (SDS) and sodium alginate (SA). Subsequently, the pre-emulsion was sprayed into an aqueous calcium chloride solution using electrostatic spray technique in the form of microdroplets, yielding calcium alginate (CA) gel microcapsules encapsulating GEO. Then, the previously prepared CA@GEO microcapsules were introduced into hydroxymethyl aminomethane (Tris) buffer solution, followed by the addition of dopamine hydrochloride. This enabled dopamine adsorption onto the microcapsule surface and subsequent polymerization to form a polydopamine layer. Finally, the dopamine hydrochloride-treated CA@GEO microcapsules were placed into a silver ammonia solution, where coordination interaction occurred between the polydopamine (PDA) on the microcapsule surface and silver ammonia particles. Subsequent in situ reduction, facilitated by glucose acting as a reducing agent, resulted in the formation of a silver shell on the microcapsule surface. The morphology and structure of the microcapsules were comprehensively characterized using scanning electron microscopy (SEM), particle size distribution analysis, x-ray photoelectron spectroscopy (XPS), etc. Moreover, the sustained release and antibacterial properties of Ag/CA@GEO microcapsules were investigated. Graphical A pre-emulsion of grapefruit essential oil (GEO) was prepared with sodium dodecyl sulfate and sodium alginate as stabilizers. Calcium alginate (CA) gel microcapsules encapsulating GEO were prepared by electrostatically spraying the pre-emulsion as microdroplets into an aqueous calcium chloride solution. Subsequently, a polydopamine layer was deposited onto the microsphere surfaces; this layer chelated silver ammonia ions and facilitated in-situ reduction in the presence of glucose, ultimately yielding a dense silver shell on the microspheres.
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产品关联
DOI
高影响因子
Nano Research
·
2019
·Vol. 12
·期 12
·3129-3134
·
IF 8.515
Yang Hewei,Feng Yaqing,Tu Zhiyu,Su Kuo,Fan Xiaozhi,Liu Bingjie,Shi Zhiping,Zhang Yuzhe,Zhao Chenyang,Zhang Bao
Blue emitting perovskite ink obtained from cesium lead halide quantum dots bearing chlorine (CsPbCl x Br 3− x , 0 < x ≤ 3) suffers from the low photoluminescence quantum yield and poor stability. Cesium lead bromine (CsPbBr 3 ) quantum dots free of chlorine have more stable crystal structure and fewer crystal defects. Precise control of crystal sizes and surface passivation components of CsPbBr 3 quantum dots is crucial for the best use of quantum confinement effect and blueshift of emission wavelength to blue region. Here, by polymerizing acrylamide under UV-light irradiation to form polymer gel networks in dimethyl sulfoxide (DMSO) with CsPbBr 3 precursors and passivating agents trapped, we successfully prepared novel sustained release tablets with different shapes and sizes. Thanks to the limitation of the polymer networks on solvent releasing, the resulting CsPbBr 3 quantum dots have the average size of 1.1 ± 0.2 nm. On the basis of the excellent quantum confinement effect and optimized surface passivation, the obtained PQD ink can emit high quality blue light for more than 6 weeks. This work elucidates a new and convenient technique to prepare blue emission perovskite quantum dots ink with high stability and photoluminescence quantum yield and provides a great potential technology for the preparation of perovskite optoelectronic devices.
研究领域:
材料科学
·
纳米技术
·
光电子学
·
量子点
·
钙钛矿材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）