MATERIALS CHEMISTRY AND PHYSICS
·
2019
·
IF 2.781
Fengbo Yu,Jinghua Wang,Lei Tong,Xiuping Zhang
Nanosized drug delivery systems are promising tools in the field of nanomedicine applied to cancer. A novel temozolidomidehydroxyapatite (TMZ/HAp) sustained-release nanopreparation for implantation in glioblastoma multiforme (GBM) patients was designed, synthesized and characterized in this study. The structure, morphology, drug loading and in vitro delivery properties of the HAp particles and the novel polysuccinimide (PSI)-coated HAp(HAp-PSI) nanoparticles were evaluated using X-ray powder diffraction (XRD), Fourier Transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and high-performance liquid chromatography. The TMZ/HAp-PSI nanoparticles consist of a flower-like HAp core enclosed by a smooth PSI layer, which presents a spherical or nearly spherical form. The TMZ/HAp-PSI nanoparticles further strengthen the encapsulation efficiency to 93.0%. Compared with TMZ/HAp alone, both the TMZ/HAp-PSI nanoparticles and TMZ/HAp-PSI tablets can prolong the drug release time to more than 350 h and avoid an early burst drug release, suggesting a great potential for the brain or bone implantation drug delivery applications.
研究领域:
药学
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肿瘤学
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纳米医学
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高影响因子
Toxics
·
2023
·Vol. 11
·期 10
·829
·
IF 4.6
Xueqiang Zhu,Hanghang Ji,Gang Hua,Lai Zhou
Sustained-release materials are increasingly being used in the delivery of oxidants for in situ chemical oxidation (ISCO) for groundwater remediation. Successful implementation of sustained-release materials depends on a clear understanding of the mechanism and kinetics of sustained release. In this research, a columnar sustained-release material (PS@PW) was prepared with paraffin wax and sodium persulfate (PS), and column experiments were performed to investigate the impacts of the PS@PW diameter and PS/PW mass ratio on PS release. The results demonstrated that a reduction in diameter led to an increase in both the rate and proportion of PS release, as well as a diminished lifespan of release. The release process followed the second-order kinetics, and the release rate constant was positively correlated with the PS@PW diameter. A matrix boundary diffusion model was utilized to determine the PS@PW diffusion coefficient of the PS release process, and the release lifespan of a material with a length of 500 mm and a diameter of 80 mm was predicted to be more than 280 days. In general, this research provided a better understanding of the release characteristics and kinetics of persulfate from a sustained-release system and could lead to the development of columnar PS@PW as a practical oxidant for in situ chemical oxidation of contaminated aquifers.Keywords:persulfate;sustained release;model fitting;soil and groundwater remediation;in situ chemical oxidation
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2022
·
IF 9.136
Luqi Xiao,Ju Bai,Wei Lai,Yang Jiao,Qi Wu,Hongyan Liu,Yizhou Zhang,Linglong Shan,Shuangjiang Luo
Controlling the diffusion of amine monomers plays a crucial role in fabricating well-defined architecture and high-performance nanofiltration (NF) membranes through interfacial polymerization (IP). Herein, a sustained-release strategy was proposed to regulate the interfacial polymerization through a zwitterionic liquid hydrogel transition layer. The hydrogel (Gel) was fabricated via in-situ one-step UV photo-initiated free-radical polymerization between 1-vinyl-3-ethylimidazolium chloride ([VEIm][Cl]) and 3-sulfopropyl methacrylate potassium salt (SMP) on the polyethersulfone (PES) substrate. The polyamide (PA) layer was then formed on the Gel layer by mitigating the diffusion of amine monomers. Low-field time-domain nuclear magnetic resonance (TD NMR) analysis demonstrated that the Gel layer significantly enhanced the water-absorbing capacity of the composite membrane. Positron annihilation lifetime spectroscopy (PALS) also confirmed the Gel-PA composite membrane possessed enlarged free volumes. The obtained Gel-PA composite membrane displayed a permeance of 13.22 L m −2 h −1 bar −1 , a high Na 2 SO 4 rejection of 98.23 %, a favorable NaCl/Na 2 SO 4 selectivity of 49.75, outstanding long-term operational stability, and membrane antifouling properties. This sustained-release strategy provides a facile and feasible approach to controlling the IP process and obtaining high-performance nanofiltration membranes.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Liang Qiao,Fuhua Deng,Xulin Hu,Tianfang Huang,Junlin An,Dong Pan,Junqiang Yan,Gaofeng Liang,Jian He
It is still a considerable research challenge to design biodegradable drug delivery systems that efficiently transport lipid-soluble drugs with controlled release. In the present study, a microsphere delivery system, γ-cyclodextrin (γ-CD)/glutathione (GSH)-atorvastatin (AT) fibrous nanoparticles (γ-CD/GSH-AT FNs) loaded polytrimethylene carbonate (PTMC)/polycaprolactone (PCL) microspheres (PTMC/PCL/γ-CD/GSH-AT MPs), was constructed through an exquisite method. The results show that a large number of γ-CD/GSH-AT FNs can be encapsulated during the formation of microspheres and released in a controllable manner. Notably, the high dispersibility and drug loading of FNs can load with lipid-soluble drugs and protect the drugs from the solvent during microsphere preparation. FNs and MPs can achieve dual release. First, with the degradation of the microspheres, the encapsulated FNs were gradually released into the local microenvironment. Subsequently, the FNs began to dissolve and release the loaded AT over a period of more than 3 days. Therefore, the dual sustained-release drug delivery system can maintain the blood drug concentration for a longer time and reduce the number of administrations and the side effects of the drug. This study provides new ideas for the on-demand manufacture of controllable degradable drug delivery platforms to treat diseases.
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高影响因子
EUROPEAN POLYMER JOURNAL
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2022
·
IF 5.546
Xin Jin,Chengxiong Wei,Chengwei Wu,Wei Zhang
The metformin hydrochloride is the only oral guanidine anti glycemic agent and is used as the first-line drug for the treatment of type II diabetes. Owing to its high water solubility and short half-life, however, this drug is difficult to be released sustainedly. Here, a core–shell structured hydrogel assembly as gastroretentive carrier is proposed for the sustained release of metformin hydrochloride. The hydrogel assembly can be ingested orally into the stomach. On contact with the gastric juice, the shell rapidly swells to prevent the hydrogel to be expelled from the pylorus, and the core serves as a drug reservoir for loading metformin hydrochloride. The core–shell structure can decrease the driving force of drug release and extend the drug diffusion pathway. As a result, the hydrogel assembly can release metformin hydrochloride sustainedly for 72 h in vitro and maintain stable blood drug concentration for nearly 80 h in vivo. Moreover, the hydrogel assembly can be biodegraded by the gastric environment.
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高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2022
·Vol. 36
·期 6
·e6680
·
IF 4.072
Kai-Xin Wang,Meng-Ru Cai,Dong-Ge Yin,Xue-Ling Hu,Hulin-Yue Peng,Rong-Yue Zhu,Man-Ting Liu,Yu-Chen Xu,Chang-Hai Qu,Jian Ni,Xing-Bin Yin
Metal-organic frameworks (MOFs) are porous coordination polymers formed by metal ions and organic ligands through coordination bonds. In drug delivery applications, MOFs can impart sustained release, targeting, protection of easily degradable drugs, and improved drug solubility. Isoreticular metal-organic framework-8 (IRMOF-8) is a mesoporous MOF with a network topology bridged in the form of an octahedral cluster. Compared with other materials, it has the remarkable advantages of high porosity and a regular pore structure. Curcumin (CUR) is a diketone compound with potent antitumor effects. Due to its poor solubility and stability, its clinical application is limited. Therefore, we used IRMOF-8 as a carrier for the encapsulation of CUR to overcome the shortcomings of CUR itself and expand its clinical application. In this study, IRMOF-8 was synthesized through direct mixing of triethylamine (TEA). In vitro cell experiments demonstrated the biocompatibility of IRMOF-8. Using the solvent adsorption method, CUR was encapsulated by IRMOF-8 with a drug loading content of 58.86 ± 0.98 wt%. In vitro drug release experiments performed at pH levels of 7.2 and 5.5 showed that the preparation had a sustained-release effect over 7 days. Through cytotoxicity experiments after drug loading, it was found that CUR@IRMOF-8 had a strong cytotoxic effect on HepG2 cells, promoted cell apoptosis and intracellular uptake, decreased mitochondrial membrane potential, and increased reactive oxygen species. Hence, CUR@IRMOF-8 is expected to become an excellent sustained-release preparation for potential applications in tumor treatment.
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高影响因子
ACS Applied Bio Materials
·
2021
·
IF 0
Shuguang Wang,Kun Shi,Jiawei Lu,Weilian Sun,Qinghui Han,Lingbin Che,Dong Zhang
As a common complication of spine surgery, postoperative epidural fibrosis is an important cause of failed back surgery syndrome (FBSS), yet there is no effective clinical intervention to tackle it. Herein, for the first time, we develop a strategy of combining a gelatin methacryloyl (GelMA) hydrogel matrix with poly(lactic-co-glycolic acid) (PLGA) microsphere-encapsulated resveratrol (RSV), which aims to synergistically promote the inhibition effect on epidural fibrosis. The resultant RSV@PLGA-GelMA (8% w/v) hydrogels possess optimal mechanical properties and prompt the matrix sustainably and stably to release RSV for several weeks. It is further shown that the hybrid hydrogels without the drug exhibit good biosafety without distinct cytotoxicity, while RSV@PLGA-GelMA could prevent fibroblast proliferation and migration. Further rat laminectomy model indicates that the RSV@PLGA-GelMA hydrogels reduce epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overexpression and deposition via a TGF-β/Smad signaling pathway. Consequently, we believe that such a creative structural combination will be a promising strategy for preventing postoperative epidural fibrosis of spine surgery.
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DOI
PubMed
LANGMUIR
·
2025
·
IF 3.9
Fengrui Li,Yue Xiu,Anqi Wang,Yuhang Zhang,Xinyue Zhang,Shuang Gao,Fei Ye,Ying Fu
The development of hydrophobic pesticide formulations remains constrained by complicated manufacturing processes, excessive reliance on organic solvents, and indispensable surfactants. The practical application of dimethomorph (DIM) is hindered by its hydrophobic nature, posing risks to nontarget organisms. Inspired by the uptake of nanomaterials by plants, DIM was encapsulated in the cyclodextrin (CD) cavity to optimize its water-solubility and the sustained-release rate. The spatial confinement effect of CD could facilitate the thermostability of DIM. DIM/CD inclusion complex solutions were electrospun to fabricate nanofibers with bead-free and smooth morphology. As predicted, the release of DIM/CD inclusion complex nanofibers reached plateaus with accumulative release values of approximately 75%. The antifungal activity of DIM/CD inclusion complex nanofibers possesses much higher than DIM for controlling Rhizoctonia solani and Haematonectria hematococco, thereby enhancing its antifungal bioactivity and reducing pesticide spraying frequency. The inhibition rates of Rhizoctonia solani by DIM/HPβCD and DIM/HPγCD inclusion complex nanofibers are found to be 55.8% and 53.6% within 144 h, respectively. This work explores the feasibility of inclusion of complex nanofibers as a delivery platform for application in sustained agriculture production.
研究领域:
农业科学
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材料科学
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植物保护
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DOI
PubMed
高影响因子
RSC Advances
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2016
·Vol. 6
·期 39
·32967-32978
·
IF 3.289
Jianqun Gan,XiaoXiao Guan,Jian Zheng,Huilong Guo,Kun Wu,Liyan Liang,Mangeng Lu
A series of novel thermoresponsive biodegradable hydrogels (TBHs) was prepared from N-isopropyl acrylamide (NIPAM) and two biodegradable crosslinkers, poly(ε-caprolactone) dimethacrylate (PCLDMA) and bisacryloylcystamine (BACy). The morphology, thermal behavior, swelling/deswelling kinetics, compression properties, in vitro drug delivery and biodegradation were investigated. The results indicated that the properties of the TBHs strongly depended on temperature and the feeding molar ratio of the PCLDMA to BACy components. Levofloxacin (LVF)-loaded hydrogels were prepared to explore their stimuli-responsive release process. The cumulative release profile of LVF-loaded TBHs exhibited a thermo-induced slow sustained drug release and a reduction-induced fast release. At a physiological pH, TBHs could be biodegraded slowly in glutathione (GSH) at 37 °C. Due to their homogeneous pore diameter, highly interconnected architecture, degradable chemistry and thermoresponsive properties, the TBHs developed herein are highly attractive with respect to tissue engineering scaffold applications.
研究领域:
材料科学
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药剂学
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生物医学工程
·
药物递送系统
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DOI
高影响因子
Polymers
·
2022
·Vol. 14
·期 10
·2002
·
IF 4.967
Chengyuan Xing,Xia Xu,Lei Song,Xiaoling Wang,Bangjing Li,Kun Guo
Poly (vinyl alcohol)/β-cyclodextrin (PVA/CD) composite fibers are prepared by wet spinning followed by hot stretching. XRD results show that β-CDs are in an amorphous state in fiber, and β-CD can help maintain the fibrous crystal that exists in the composite fiber. The DSC results show that the total crystalline ratio of the composite fibers decreased with the increase of β-CD. The as-prepared composite fibers were further crosslinked with glutaraldehyde (GA) to improve their usability. The crosslinked structure, together with amorphous β-CD, contributes to the loading and sustained release of fragrance molecules that were studied. The fragrance retention ratio of PVA/CD/GA is 55.63% and 48.25% forcis-jasmone and citronella, even after 25 days. The inclusion complexes of β-CD and fragrance molecules are confirmed by 2D-FTIR, which is responsible for the sustained release of fragrance. This study may contribute to the mass production of wearable long-term scented fabrics.Keywords:β-cyclodextrin;polyvinyl alcohol;wet spinning;functional fibers;fragrance retention
研究领域:
材料科学
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纺织工程
·
化学
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DOI
PubMed
高影响因子
iScience
·
2025
·Vol. 29
·期 2
·
IF 4.1
Han-Ping Wang,Chen-Yu Xu,Wen Su,Yin-Song Wang,Yue Wang,Ming-Xin Cao
Periodontitis is a chronic inflammatory disease that leads to periodontal attachment loss and is a major cause of adult tooth loss. Current treatment of mechanical debridement is often ineffective in deep periodontal pockets, and antibiotic adjuncts carry the risk of bacterial resistance. Octyl gallate (OG), a natural plant-derived compound with antibacterial and antioxidant properties, is limited by poor water solubility and stability. This study aimed to develop a sustained-release ointment (OG-Ointment) using Pluronic F127 and ethylcellulose to enhance the delivery and efficacy of OG. The formulated OG-Ointment demonstrated excellent rheological properties, sustained drug release, and potent ABTS + radical scavenging. In vitro , it enhanced bacterial membrane permeability, inhibited P. gingivalis growth, and reduced ROS in macrophages. In a rat periodontitis model, OG-Ointment significantly reduced alveolar bone resorption, decreased ROS and inflammatory cytokines, and exhibited good biocompatibility. These findings suggest that OG-Ointment is a promising non-antibiotic adjunctive therapy for periodontitis, combining dual antioxidant and antibacterial functions with sustained release.
研究领域:
药剂学
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牙科学
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传染病学
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药物递送
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生物医学工程
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PubMed
高影响因子
Acta Biomaterialia
·
2024
·
IF 9.4
Yuanfang Huo,Yannan Cheng,Xianzhen Dong,Qiang Cheng,Xinyue Liang,Ping Duan,Yongle Yu,Lesan Yan,Tong Qiu,Zhenyu Pan,Honglian Dai
The regenerative microenvironment after peripheral nerve injury is imbalanced and difficult to rebalance, which is mainly affected by inflammation, oxidative stress, and inadequate blood supply. The difficulty in remodeling the nerve regeneration microenvironment is the main reason for slow nerve regeneration. Traditional drug treatments have certain limitations, such as difficulty in penetrating the blood-nerve barrier and lack of pleiotropic effects. Therefore, there is an urgent need to build multifunctional nerve grafts that can effectively regulate the regenerative microenvironment and promote nerve regeneration. Nitric oxide (NO), a highly effective gas transmitter with diatomic radicals, is an important regulator of axonal growth and migration, synaptic plasticity, proliferation of neural precursor cells, and neuronal survival. Moreover, NO provides potential anti-inflammation, anti-oxidation, and blood vessel promotion applications. However, excess NO may cause cell death and neuroinflammatory cell damage. The prerequisite for NO treatment of peripheral nerve injury is that it is gradually released over time. In this study, we constructed an injectable NO slow-release system with two main components, including macromolecular NO donor nanoparticles (mPEG-P(MSNO-EG) nanoparticles, NO-NPs) and a carrier for the nanoparticles, mPEG-PA-PP injectable temperature-sensitive hydrogel. Due to the multiple physiological regulation of NO and better physiological barrier penetration, the conduit effectively regulates the inflammatory response and oxidative stress of damaged peripheral nerves, promotes nerve vascularization, and nerve regeneration and docking, accelerating the nerve regeneration process. Statement of Significance The slow regeneration speed of peripheral nerves is mainly due to the destruction of the regeneration microenvironment. Neural conduits with drug delivery capabilities have the potential to improve the microenvironment of nerve regeneration. However, traditional drugs are hindered by the blood nerve barrier and cannot effectively target the injured area. NO, an endogenous gas signaling molecule, can freely cross the blood nerve barrier and act on target cells. However, excessive NO can lead to cell apoptosis. In this study, a NO sustained-release system was constructed to regulate the microenvironment of nerve regeneration through various pathways and promote nerve regeneration.
研究领域:
神经科学
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药理学
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生物医学工程
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组织工程
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DOI
PubMed
高影响因子
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