CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Yanxuan Xiao,Caiyong Song,Hongping Ye,Dan Li,Jiayi Shi,Xiaoke Huang,Qianming Chen,Rui Liu
Radiation-induced oral mucositis (RIOM) is a common complication among patients undergoing radiotherapy. Ionizing radiation (IR) has been shown to induce the excessive production of reactive oxygen species (ROS) and ferroptosis, both of which play critical roles in the development of RIOM. This study fabricates a novel detachable dissolvable microneedle patch DC@MNs for the therapy of RIOM. The nano-enzyme Ceria nanoparticles (Ceria NPs) at the top of needle tips can scavenge ROS and enhance penetration capability of DC@MNs. Additionally, the microneedles (MNs) incorporate deferoxamine (DFO), a known ferroptosis inhibitor, to form a combined therapeutic strategy for RIOM. Cell viability assays demonstrate that the combination of DFO and Ceria NPs effectively mitigates IR-induced cell death. Furthermore, in vivo studies using rat RIOM models further confirm that DC@MNs can penetrate the mucosal epithelium, thereby facilitating drug delivery. Finally, measurement of intracellular ROS, lipid peroxidation, and ferrous ion levels reveals that the DC@MNs protect oral mucosal cell through ROS scavenging and ferroptosis inhibition. This study provides a novel radiation protection strategy and highlights its potential applicability in drug delivery to oral mucosal for patients receiving radiotherapy.
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Journal of Materials Chemistry A
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2024
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IF 10.7
Song Xue,Fengliang Cao,Yin Huang,Shujin Hou,Xiying Fan
Metal-organic framework (MOF) glasses can be used as references to investigate the atomic structure-activity correlation of bimetallic electrocatalysts, considering their stable framework structure as well as well-defined active sites. In this work, a bimetallic MOF glass, the cobalt-based zeolitic imidazole framework with guest nickel ions (ZIF-62(Co)-Ni), is fabricated to study the bimetallic functions on oxygen and hydrogen evolution, using a simple dipping-melting-quenching approach based on the ZIF-62(Co) glassy behavior. We elucidate the specific roles of the host cobalt and guest nickel sites in these two electrocatalytic processes through in-situ Raman analysis and density functional theory calculations. When generating oxygen, nickel sites facilitate the process by utilizing the hydroxyl spillover from the cobalt sites. However, when producing hydrogen, nickel sites dominate. This distinct bimetallic functionality enables the superior electrocatalytic performance of the ZIF-62(Co)-Ni. The cell voltage for overall water splitting is as low as 1.74 V at a current density of 100 mA cm-2 and remains stable for over 200 h, outperforming most state-of-the-art bifunctional non-precious electrocatalysts.
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JOURNAL OF MOLECULAR LIQUIDS
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2012
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IF 1.58
Xiaoqing Wang,Li Yu,Jingjing Jiao,Huina Zhang,Rui Wang,Hui Chen
A series of novel COOH-functionalized imidazolium-based surface active ionic liquids (SAILs), N-alkyl-N′-carboxymethyl imidazolium bromide ([N-C n , N′-CO 2 H-Im]Br, n = 10, 12, 14), was synthesized. Their aggregation behavior in aqueous solution was investigated by surface tension and steady-state fluorescence measurements. From surface tension data, a group of micellization parameters was obtained. Compared with 1-alkyl-3-methylimidazolium bromide ([C n mim]Br) bearing the same hydrocarbon chain, [N-C n , N′-CO 2 H-Im]Br exhibits considerably lower critical micelle concentration (cmc) and surface tension at cmc (γ cmc ), higher adsorption efficiency ( pC 20 ) and effectiveness of surface tension reduction ( π cmc ), indicating the incorporation of carboxyl group favors micelle formation. The average aggregation number (N agg ) values of [N-C n , N′-CO 2 H-Im]Br, determined by fluorescence quenching method, are slightly different from those of [C n mim]Br. The effect of temperature on the aggregation behavior of [N-C 12 , N′-CO 2 H-Im]Br was also studied. It is found that there exists a minimum cmc at nearly 38 °C, which is higher than that of [C 12 mim]Br.
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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2025
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IF 2.2
Haoqi Li,Zijie Cheng,Huimin Li,Yun Yin,Yuqing Li,Tao Chen,Xin Dong,Qingxun Hu,Dan Wu
Nitric oxide (NO) has been highlighted as a key gaseous signaling molecule in the body, playing a central role in various physiological and pathological processes. However, a comprehensive analysis of NO metabolism dynamics in living cells remains a significant challenge. To address this, we have developed and characterized a novel genetically encoded NO fluorescence sensor, GefiNO, to investigate NO metabolism dynamics in living cells and subcellular organelles. In the study, we described the protein detection capabilities and subcellular spatiotemporal localization of GefiNO sensors. By analyzing NO metabolic responses in macrophages of different subtypes, we provide a comprehensive view of NO dynamics at the cellular level. The GefiNO sensor represents a valuable tool for monitoring extensive NO dynamics in living cells and offers potential for uncovering new insights into cellular metabolic mechanisms.
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PubMed
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 2
·483
·
IF 4.2
Linlin Cui,Li Zhao,Guanghuan Shen,Dahai Yu,Tian Yuan,Yingyu Zhang,Bo Yang
Cordycepin has good antitumor activity, but its clinical application is limited due to the easy deamination of N6 in structure. In this study, a large lipolysis group was introduced at the cordycepin N6 to improve the problem, cordycepin derivatives (3a–4c) were synthesized, and biological evaluation of compounds was studied. In this study, the vitro antitumor activity of the compounds against MCF7 cells, HepG2 cells and SGC-7901 cells was evaluated by MTT assay. In the results, compound4ashowed the most obvious inhibitory effect on MCF7 cells with an IC50value of 27.57 ± 0.52 μM, which was much lower than cordycepin. Compound4ashowed high selectivity between MCF7 and normal MCF-10A cells. Further biological evaluation showed that compound4apromoted apoptosis and blocked the cell cycle in the G0/G1 phase. Then, Western Blot was used to detect related apoptotic proteins. It was found that Compound4acould down-regulate the expression of Bcl-2 protein and up-regulate the expression of p53, Bax, Caspase-3 and Caspase-9 proteins. The mitochondrial membrane potential decreased continuously and the positive expression rate decreased. It was speculated that compound4ainduced the apoptosis of MCF7 cells through the mitochondrial pathway.Keywords:cordycepin derivatives;antitumor;structural modification
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高影响因子
LANGMUIR
·
2024
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IF 3.7
Yueji Li,Yuteng Zhang,Xue Liu,Bin Dong,Pan Xu,Bo Song
Heparin is widely used to treat thrombosis because it is an effective anticoagulant. However, excessive use of heparin can lead to an increased risk of bleeding, which makes the quantitative detection of heparin very important. An amphiphilic perylene bisimide molecule (denoted PBI-9) was developed, which presented a near-infrared emission peak at 730 nm when it was aggregated. PBI-9 has been utilized in the detection of heparin, as the pyridine cation in PBI-9 binds strongly to highly sulfated heparin through electrostatic interactions. Charge neutralization triggers the self-assembly of PBI-9, which leads to an emission peak shift from 540 nm to 690 nm, corresponding to monomeric emission to excimer emission. This shift was applied for the detection of heparin. Importantly, the interaction between PBI-9 and heparin is not affected by protamine, resulting in high selectivity and minimal interference. PBI-9 is a promising tool for detecting heparin in clinical settings after excess heparin has been neutralized by protamine.
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BIOMACROMOLECULES
·
2024
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IF 5.5
Qingjie Li,Jinhao Yan,Wenlong Jiang,Yunpeng Zhang,Peng Gao,Longxiang Tao,Jun Yin
Supramolecular assembly has attracted significant attention and has been applied to various applications. Herein, a β–γ-CD dimer was synthesized to complex different guest molecules, including single-strand polyethylene glycol (PEG)-modified C60 (PEG-C60), photothermal conversion reagent (IR780), and dexamethasone (Dexa), according to the complexation constant-dependent specific selectivity. Spherical or cylindrical nanoparticles, monolayer or bilayer vesicles, and bilayer fusion vesicles were discovered in succession if the concentration of PEG-C60 was varied. Moreover, if near-infrared light was employed to irradiate these nanoassemblies, the thermo-induced morphological evolution, subsequent cargo release, photothermal effect, and singlet oxygen (1O2) generation were successfully achieved. The in vitro cell experiments confirmed that these nanoparticles possessed excellent biocompatibility in a normal environment and achieved superior cytotoxicity by light regulation. Such proposed strategies for the construction of multilevel structures with different morphologies can open a new window to obtain various host–guest functional materials and achieve further use for disease treatment.
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FUEL
·
2025
·
IF 7.5
Tao Wang,Xiqing Wang,Tianshu Liu,Yujie Fu
Realizing high catalytic efficiency and stability always be the core guiding principle and continuous optimization in industrial production. Fatty Acid Methyl Esters (FAMEs) are a key component of biodiesel, serving as a renewable, environmentally friendly alternative to conventional petroleum-based diesel fuel. In this study, a series of novel Brønsted acidic cellulose-based ionic liquids (PCM-ILs) were successfully prepared using cellulose as the raw material through chemical grafting and ionic bonding. These PCM-ILs were first applied to catalyze the transesterification of Pistacia chinensis Bunge seed oil for FAMEs production. PCM-ILs can be tailored by varying anions. Under optimal conditions—methanol/oil ratio (10:1), catalyst (10 wt%), temperature (80 °C), and time (6 h)—the FAME yield reached 98.6 %. In addition, the conversion yield remained above 85 % after the prepared catalyst be recycled for six times. Thus, the development of this straightforward and economically viable cellulose-based assembly opens up innovative avenues for the design of high-performance biocatalysts suitable for industrial applications.
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ANALYST
·
2011
·Vol. 136
·期 24
·5302-5307
·
IF 3.913
Hongyue Guo,Changhu Chu,Yan Li,Bingcheng Yang,Xinmiao Liang
Ion chromatography (IC) is one of the most powerful analysis technologies for the determination of charged compounds. A novel click lysine stationary phase was prepared viaCu(I) catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC) and applied to the analysis of inorganic ions. The chromatographic evaluation demonstrated good performance (e.g. the plate number of thiocyanate is ∼50 000 plates m−1) and effective separation ability for the common inorganic anions with aqueous Na2SO4 eluent. The separation mechanism was observed to be mainly dominated by ion exchange interaction. The retention of these analytes is highly dependent on the pH value of eluent. Compared with the lysine stationary phase prepared via the conventional manner, the click lysine exchanger demonstrated shorter retention time and better ion separation characteristics under the same chromatographic conditions, which is a great advantage for rapid separation and analysis of inorganic ions.
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高影响因子
Journal of Central South University
·
2017
·Vol. 24
·期 8
·1727-1735
·
IF 0.601
Gao Zheng-cai,Li Li-qing,Li Hai-long,Chen Ruo-fei,Wang S.,Wang Yang-gang
A zeolitic imidazolate hybrid membrane (Co-IM-mIM) containing two imidazolate ligands deposited on a macroporous α-alumina support was prepared by pre-depositing and secondary growth technique. XRD, TGA and SEM characterizations demonstrate that a stable and thin, but dense and pure-phase Co-IM-mIM membrane can be obtained on the macroporous-alumina discs in Teflon-lined autoclave at 120 °C after pre-depositing by dip-coating at room temperature. No visible cracks, pinholes or other defects were observed on the membrane layer. The gas separation studies of Co-IM-mIM membrane were carried out at 25 °C and 1×10 5 Pa, showing ideal selectivity of 6.95, 5.25, 3.40 for H 2 /CO 2 , H 2 /N 2 and H 2 /CH 4 , respectively, and a permeance of 17.37× 10 −6 mol/(m 2 ·s·Pa) for H 2 . The influence of temperature and trans-membrane pressure on hydrogen separation and permeation was also carried out. The gas permeation and selectivity demonstrate that this membrane may have potential applications for efficient H 2 separation.
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Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 36
·7538-7546
·
IF 4.543
Peilian Liu,Bowen Li,Chenyue Zhan,Fang Zeng,Shuizhu Wu
A light-activated cleavage strategy for the concomitant release of active drugs and generation of fluorescence changes is highly desirable. Herein a molecular prodrug featuring real-time monitoring of drug localization and release by manipulating fluorophores has been created by constructing a cleavable structure which comprises a photoremovable coumarinyl, an anticancer drug camptothecin, a cleavable linker and a near infrared fluorescent dye dicyanomethylene-4H-pyran (DCM). The fluorescence of coumarinyl and CPT is completely quenched by the DCM moiety via fluorescence resonance energy transfer (FRET). The internalization of the prodrug by cells and its subsequent intracellular location can be tracked by collecting the red fluorescence of DCM; while the release of active CPT as a result of one- or two-photon irradiation can be monitored by observing the newly emerged fluorescence of CPT under one- or two-photon excitation. The prodrug also shows highly controllable cytotoxicity toward HeLa cells and A549 cells, with low IC50 values of 4.01 and 2.53 μM, respectively, upon light irradiation and with much higher IC50 values (>40 μM) without light irradiation. This strategy may provide an approach for the development of light-activatable theranostic anticancer therapeutics.
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高影响因子
ENERGY & FUELS
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2017
·
IF 3.091
Umar Adli Amran,Sarani Zakaria,Chin Hua Chia,Zhen Fang,Mohamad Zulfahdli Masli
Optimization of microwave-assisted liquefaction of oil palm empty fruit bunch fiber (EFB) and cellulose (EFBC) in ethylene glycol (EG) was carried out to produce polyols. The liquefaction residues and hydroxyl numbers of the resultant polyols from respective sources were studied and compared. EFB produced a minimum residue of 3.22% at the optimal parameters of 160 °C and 15 min. Meanwhile, optimum liquefaction of EFBC produced 1.03% residue at 175 °C and 40 min. The maximum hydroxyl numbers of both EFB (749.22 mg KOH/g) and EFBC (639.91 mg KOH/g) polyols were obtained at optimum conditions. FTIR analysis revealed the degradation mechanism of cellulose and lignin in EFB at different temperatures. Lignin was found to be liquefied easily at lower temperatures (130 and 145 °C). However, most of the cellulose began to be liquefied at the optimum temperature (160 °C) and severely degraded at higher temperatures (175 and 190 °C).
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危险品化学品经营许可证（带存储）