CHEMOSPHERE
·
2022
·
IF 8.943
Sen Lu,Xuechuan Li,Yunkai Liao,Zhenghua Zhang,Haijian Luo,Guan Zhang
Photoelectrocatalytic (PEC) process combining the merits of photocatalysis and electrocatalysis is considered as a promising ammonia oxidation technology for water treatment . However, some key issues, such as the limited in situ generation of oxidants on photoanode, slow mass transfer problem and generation of nitrate/nitrite by–products hinder the further application of PEC process in the treatment of ammonia pollutant. In this study, the graphite felt (GF) cathodes modified by different transition metals (Ni, Fe, Mn, Co, Cu) were screened by physicochemical and photoelectrochemical characterizations. The results show that the Ni–GF cathode with more Ni 0 uniformly distributed on the GF surface had the best electrocatalytic activity to generate H 2 O 2 . The PEC system composed of 10.0 wt% Ni–GF cathode and optimized titania nanotubes (TNTs) photoanode selectively converted about 96.1% ammonia to N 2 within 90 min. Compared with the single TNTs photoanode system, the ammonia oxidation reaction rate constant of the synergistic PEC oxidation system was increased by about two times, which demonstrated the role of the oxidants simultaneously generated on both anode and cathode. The in situ generated reactive oxygen-based oxidants and chlorine-based oxidants interacted together, and ClO• acted a leading role in the ammonia oxidation which were confirmed by quenching and probe experiments. In addition, the contributions of •OH and ClO• were significantly improved in the synergistic PEC oxidation system, compared with the single TNTs photoanode system. Furthermore, the nitrate by–products generated by the ammonia oxidation were further reduced on the Ni–GF cathode. The large amount of active chlorine and active oxygen generated on the electrode diffused into the bulk, effectively overcoming the mass transfer limitation of direct oxidation. Therefore, the developed TNTs photoanode/Ni-GF cathode system can continuously and efficiently convert ammonia to N 2 without the formation of nitrate/nitrite by–products.
研究领域:
环境科学
·
水处理技术
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DOI
PubMed
高影响因子
LUMINESCENCE
·
2020
·Vol. 36
·期 3
·668-673
·
IF 1.855
Xiao Gao,Mingwei Guo,Ming Liu,Li Zhang,Zhiyi Yao
In this report, we develop a dual-output sensor with fluorometric and colorimetric responses, for the rapid and simple detection of berberine hydrochloride (BRH) in 100% aqueous solution based on an anionic polythiophene derivative, poly(2-(2-(4-methylthiophen-3-yloxy)-ethyl) malonic acid) (PTMA). The sensing performance and mechanism were carefully examined by absorption and emission spectra. It can be applied to quantitatively detect BRH in aqueous solution with a detection limit 0.27 μM. The appealing performance of the sensor was demonstrated to originate from the electrostatic and π–π interactions between PTMA and BRH, which promoted the conformational change and aggregation of the PTMA backbone. Moreover, this method allowed rapid detection of BRH in urine samples and BRH tablets with high accuracy.
研究领域:
分析化学
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药物分析
·
材料科学
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DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2019
·
IF 4.018
Long He,Yun Zhang,Haiqing Xiong,Jingpei Wang,Yani Geng,Benhua Wang,Yangang Wang,Zhaoguang Yang,Xiangzhi Song
A ratiometric fluorescent probe , FPT , was designed and synthesized for the selective and sensitive detection of hypochlorous acid (HClO) based on a flavone derivative under a single wavelength excitation. The addition of HClO to the solution of FPT induced a distinct fluorescence color change from orange to green. Probe FPT was successfully used to detect and image intracellular HClO in living zebra fish in a ratiometric manner.
研究领域:
生物化学
·
医学检测
·
荧光成像
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DOI
高影响因子
Journal of Biobased Materials and Bioenergy
·
2022
·Vol. 16
·期 3
·424-430
·
IF 0.687
Wang Jue,Abdoulaye Maman Galandi,Jiang Zhongqin,Xiao Bing,Zhang Jiaming,Liang Yinna,Xiong Jianhua,Chen Guoning,Zhu Hongxiang,Zhao J. R.
With the increasing environmental pollution, it is urgently needed to develop efficient methods to remove recalcitrant organic pollutants. Herein, intimately coupled photocatalysis and biodegradation (ICPB) technology was fabricated using bagasse cellulose-TiO2 composite
(SBC-TiO2) as the carrier for photocatalyst and biofilm, Trichoderma mixed with activated sludge as a novel biological source for the removal of 1,2,3-Trichlorobenzene (1,2,3-TCB) and 1,3,5-Trichlorobenzene (1,3,5-TCB). The effects of different degradation conditions (carrier
dosage, pH of reaction solution, and light intensity) on the degradation efficiency were investigated separately. Under the optimal process conditions (carrier dosage of 5%, pH of the reaction solution was 5, and light intensity was 700 lm/m2), the removal rates of 1,2,3- and 1,3,5-TCB
reached 92.02% and 95.00% within 6 h, respectively. The degradation rate of TCB and the variation of microbial dehydrogenase activity (DHA) showed that the ICPB system exhibited good photocatalytic performance and biodegradation stability.
研究领域:
环境科学
·
微生物学
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DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 121
·99664-99668
·
IF 3.84
Zheng Tang,Xiao-Ling Ding,Ying Liu,Zhi-Min Zhao,Bao-Xiang Zhao
We have developed a novel fluorescent probe (RBT) based on rhodamine B and benzothiazole hydrazine units for the detection of hypochlorite in living cells and real water samples with excellent selectivity and sensitivity. In the presence of hypochlorite in a mixture solution of MeCN–PBS (v/v = 3 : 7, pH = 7.4) at room temperature, the fluorescence intensity of RBT increased by 350 fold with the color change from colorless to red. The detection limit of the probe for hypochlorite is 1.06 × 10−9 M. Moreover, RBT was successfully used to image endogenous hypochlorite in living cells and detect hypochlorite in real water samples.
研究领域:
生物化学
·
分析化学
·
环境科学
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DOI
高影响因子
Desalination and Water Treatment
·
2016
·
IF 1.272
Xiao-ling Shao,Cheng-fei Zou,Fu-xing Wang,Yang Xiong,Xiang-yang Wu
The kinetics of the oxidation of chlorophenols (CPs) by potassium permanganate was studied in the present study, along with the changes in oxidant dosage, pH, temperature, and real water matrices. The reactions between permanganate and three kinds of CPs, i.e. 4-chlorophenol (4-MCP), 2,4-dichlorophenol (2,4-DCP), and 2,4,6-trichlorophenol (2,4,6-TCP), are second order overall and first-order with respect to each reactant. The degradation rates of the CPs increase with increasing permanganate dosage or temperature. pH plays an important role during permanganate oxidation. With the increase in pH from 4.0 to 10.0, the reaction rates of 4-MCP and 2,4-DCP decrease first and then increase, and finally decrease rapidly when pH > pKa, while the rates of 2,4,6-TCP decrease continuously. The degradation rates of the CPs are obviously higher in real water than in pure water. The reaction rate follows the order of 2,4,6-TCP > 2,4-DCP > 4-MCP under acidic conditions, and follows the reverse order under alkaline conditions in both pure water and real water.
研究领域:
环境科学
·
化学
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DOI
高影响因子
Molbank
·
2015
·Vol. 2015
·期 4
·M871
·
IF 0
Shuitao Yu,Xiaohu Feng,Weiyou Zhou,Zhengjun Xia,Mingguang Zhang,Yang Chen,Zaixin Chen
A new tetrahalogenated benzoic acid 4-chloro-2,3,5-trifluorobenzoic acid was synthesized from methyl 2,3,4,5-tetrafluorobenzoate via three steps. The structure of the newly synthesized compound was established by FTIR, NMR, MS and elemental analysis.Keywords:4-chloro-2,3,5-trifluorobenzoic acid;synthesis;amination;Sandmeyer reaction
研究领域:
有机化学
·
药物化学
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DOI
CELL PROLIFERATION
·
2018
·Vol. 51
·期 6
·e12486
·
IF 4.936
Yuedi Yang,Zhongbing Huang,Ximing Pu,Guangfu Yin,Lei Wang,Fabao Gao
Objective Five-year survival rate at early lung tumour was about 70%; however, its early diagnosis rate was still at a low level, so the enhancement of diagnosis level for early lung tumour is the key factor to increase the survival rate. Diagnosis and therapy of early lung tumour are still challenged. Methods The magnetic nanochains (NCs) with biocompatibility and transverse relaxivity (r 2 = 231 Fe mmol l −1 s −1 ) were fabricated through a co-precipitation method in the assistance of dextran, and then, linked with chlorotoxin (CTX) and curcumin (Cur) via the PEGylation and carbodiimide technique (named as CTX-NCs-Cur). Results The results of cell test indicated that CTX-conjugated NCs could obviously target non–small-cell lung cancer cells and limit their growth. The in vivo results of magnetic resonance imaging and fluorescence imaging indicated that the CTX-NCs-Cur significantly targeted the tumour site and enhanced images contrast of the small-size tumour. Moreover, the results of everyday tail-vein injection confirmed that CTX-NCs-Cur could significantly limit the growth of early tumour, due to blocking Cl ion channels from CTX-NCs-Cur-MMP-2 composite and intracellular ROS increase from Cur treatment. Conclusions We provided a mechanism about the effect of CTX-NCs-Cur on the targeting and limiting early tumour, and these results indicated the application foreground of CTX-NCs-Cur in tumour diagnosis and therapy.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
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DOI
PubMed
高影响因子
BIOMEDICAL CHROMATOGRAPHY
·
2015
·Vol. 30
·期 1
·81-84
·
IF 1.723
Congcong Wen,Meiling Zhang,Yuan Zhang,Fa Sun,Jianshe Ma,Lufeng Hu,Guanyang Lin,Xianqin Wang
In this study, we developed a brain metabolomic method, based on gas chromatography–mass spectrometry (GC/MS), to evaluate the effect of ketamine on rats. Pattern recognition analysis, including both principal component analysis and partial least squares-discriminate analysis revealed that ketamine induced metabolic perturbations. Compared with the control group, the levels of glycerol, uridine, cholesterol in rat brain of the ketamine group (50 mg/kg, 14 days) decreased, while the urea levels increased. Our results indicate that metabolomic methods based on GC/MS may be useful to elucidate ketamine abuse through the exploration of biomarkers. Copyright © 2015 John Wiley & Sons, Ltd.
研究领域:
药理学
·
代谢组学
·
神经科学
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DOI
PubMed
高影响因子
Frontiers in Pharmacology
·
2021
·
IF 5.811
Ning Chen,Su Shengdi,Li Jiaming,Kong Dexuan,Cai Hui,Qin Zhiying,Xing Han,Chen Xijing,He Jiake
Purpose: The combination therapy of rosuvastatin (RSV) and the platelet inhibitor clopidogrel (CP) is widely accepted in the management of cardiovascular diseases. The objective of the present study was to identify the mechanism of RSV–CP DDI and evaluate the risk of hepatotoxicity associated with the concomitant use of CP.Methods: We first studied the effect of CP and its major circulating metabolite, carboxylic acid metabolite (CPC), on RSV transport by overexpressing cells and membrane vesicles. Second, we investigated whether a rat model could replicate this DDI and then be used to conduct mechanistic studies and assess the risk of hepatotoxicity. Then, cytotoxicity assay in hepatocytes, biochemical examination, and histopathology were performed to measure the magnitude of liver injury in the presence and absence of DDI.Results: CP inhibited OATP1B1-mediated transport of RSV with an IC50 value of 27.39 μM. CP and CPC inhibited BCRP-mediated RSV transport with IC50 values of <0.001 and 5.96 μM, respectively. The CP cocktail (0.001 μM CP plus 2 μM CPC) significantly inhibited BCRP-mediated transport of RSV by 26.28%. Multiple p.o. doses of CP significantly increased intravenous RSV plasma AUC0-infinity by 76.29% and decreased intravenous RSV CL by 42.62%. Similarly, multiple p.o. doses of CP significantly increased p.o. RSV plasma AUC0-infinity by 87.48% and decreased p.o. RSV CL by 43.27%. CP had no effect on cell viability, while RSV exhibited dose-dependent cytotoxicity after 96 h incubation. Co-incubation of 100 μM CP and RSV for 96 h significantly increased intracellular concentrations and cell-to-medium concentration ratios of RSV and reduced hepatocyte viability. Histological evaluation of liver specimens showed patterns of drug-induced liver injury. Cholestasis was found in rats in the presence of DDI.Conclusion: CP is not a clinically relevant inhibitor for OATP1B1 and OATP1B3. The primary mechanism of RSV–CP DDI can be attributed to the inhibition of intestinal BCRP by CP combined with the inhibition of hepatic BCRP by CPC. The latter is likely to be more clinically relevant and be a contributing factor for increased hepatotoxicity in the presence of DDI.
研究领域:
药理学
·
毒理学
·
临床医学
✓ 已验证
DOI
PubMed
高影响因子
ARCHIVES OF ORAL BIOLOGY
·
2015
·
IF 1.735
Yu-Ting Xu,Qiong Wu,Ya-Ming Chen,Roger J. Smales,Shu-Ya Shi,Meng-Ting Wang
Objective The objective of this study was to investigate the antibacterial effects on a cariogenic biofilm of a bioactive glass (BAG) combined with either sodium fluoride (NaF) or triclosan (TCS). Design According to minimal bactericidal concentrations, 37.5 mg/ml of BAG, 4.69 mg/ml of NaF, and 15.53 μg/ml of TCS solutions were prepared. When used alone, the three antimicrobial solutions were increased to double-dosage strength (2MBC). The study contained the following experimental groups: group 1, BAG (2MBC); group 2, NaF (2MBC); group 3, TCS (2MBC); group 4, BAG + NaF; group 5, BAG + TCS; group 6, control (saline). Streptococcus mutans biofilm was cultured with 0.1% sucrose anaerobically on 66 sterilized coverslips (1 × 1 cm 2 ) for 24 h uninterrupted. After 10 min of exposure to the experimental groups, the microbial kinetics, morphology, and viability of the S. mutans biofilms were assessed by evaluation of colony-forming units (CFUs), scanning electron microscopy (SEM), and confocal laser scanning microscopy (CLSM). Results BAG (2MBC) used alone showed significantly stronger antibacterial effects than the other two antimicrobials used alone. The combination groups also displayed the same or greater biofilm inactivation effects as BAG (2MBC) in the plate count test. SEM showed smaller stacks (towers) and fewer surrounding bacteria in groups BAG (2MBC), BAG + NaF, and BAG + TCS. Confocal microscopy also determined higher live/dead ratios in groups NaF (2MBC), TCS (2MBC), and control than in groups BAG (2MBC), BAG + NaF, and BAG + TCS. Conclusions The combinations of BAG with either NaF or TCS enhanced the inactivation effects of BAG (2MBC) on S. mutans biofilm, and these findings should be further investigated clinically for the control of dental biofilms.
研究领域:
口腔医学
·
微生物学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2015
·Vol. 132
·期 35
·
IF 1.768
Jie Chen,Zengshe Liu,Ke Li,Jinrui Huang,Xiaoan Nie,Yonghong Zhou
A natural plasticizer with multifunctional groups, similar in structure to phthalates, cardanol derivatives glycidyl ether (CGE) was synthesized from cardanol by a two-step modification process and characterized by FT-IR, 1 HNMR, and 13 CNMR. The resulting product was incorporated to PVC (CGE/PVC), and plasticizing effect was compared with PVC incorporated with two kinds of commercial phthalate ester plasticizers bis (2-ethylhexyl) benzene-1,4-dicarboxylate (DOTP) and diisononyl phthalate (DINP). Dynamic mechanical analysis and mechanical properties testing of the plasticized PVC samples were performed in order to evaluate their flexibility, compatibility, and plasticizing efficiency. SEM was employed to produce fractured surface morphology. Thermogravimetric analysis and discoloration tests were used to characterize the thermal stabilities. Dynamic stability analysis was used to test the processability of formulations. Compared with DOTP and DINP plasticized samples, CGE/PVC has a maximum decrease of 9.27% in glass transition temperature ( T g ), a maximum increase of 17.6% in the elongation at break, and a maximum increase of 31.59°C and 25.31 min in 50% weight loss (T50) and dynamic stability time, respectively. The obtained CGE also has slightly lower volatility resistance and higher exudation resistance than that of DOTP and DINP. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42465.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）