COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Yucai Lu,Jiuyu Chen,Baozhong Zhu,Jiquan Wang,Cong Jiang,Minggao Xu,Yunlan Sun
Aluminum-containing hydrocarbon fuels cannot fully release their energy due to the poor dispersion and easy agglomeration of aluminum nanoparticles (ANPs). To solve the issues, oleic acid (OA) was used to modify the surface of ANPs, and then Al@OA particles were incorporated into exo-tetrahydrodicyclopentadiene (JP-10) to form Al/JP-10 bi-phase system. Experimental and molecular simulation methods were used to analyze the stability, ignition, and combustion performance of the Al/JP-10 bi-phase system. The results show that at low temperatures, OA can improve the antioxidant and hydrophobic performance of Al@OA particles, which can effectively protect the ANPs from deep oxidation . At high temperatures, OA can accelerate the oxidative exothermic process of ANPs, and the Al@OA particles can shorten the ignition delay time of JP-10 droplets and intensify the combustion. Notably, when the ratio of Al and OA is 10:3 in the Al@OA particles, the Al/JP-10 droplet exhibits the shortest ignition delay.
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Cell Communication and Signaling
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2023
·Vol. 21
·期 1
·1-18
·
IF 8.4
Liao Zhaohong,Lan Haiqiang,Jian Xiaoting,Huang Jingwen,Wang Han,Hu Jijie,Liao Hua
Background To explore the role of skeletal muscle specific TGF-β signaling on macrophages efferocytosis in inflamed muscle caused by Cardiotoxin (CTX) injection. Methods CTX myoinjury was manipulated in TGF-βr2 flox/flox (control) mice or transgenic mice with TGF-β receptor 2 (TGF-βr2) being specifically deleted in skeletal muscle (SM TGF-βr2 −/− ). Gene levels of TGF-β signal molecules, special inflammatory mediators in damaged muscle or in cultured and differentiated myogenic precursor cells (MPC-myotubes) were monitored by transcriptome microarray or qRT-PCR. TGF-β pathway molecules, myokines and embryonic myosin heavy chain in regenerating myofibers, the phenotype and efferocytosis of macrophages were evaluated by immunofluorescence, immunoblotting, Luminex, or FACS analysis. In vitro apoptotic cells were prepared by UV-irradiation. Results In control mice, TGF-β-Smad2/3 signaling were significantly up-regulated in regenerating centronuclear myofibers after CTX-myoinjury. More severe muscle inflammation was caused by the deficiency of muscle TGF-β signaling, with the increased number of M1, but the decreased number of M2 macrophages. Notably, the deficiency of TGF-β signaling in myofibers dramatically affected on the ability of macrophages to conduct efferocytosis, marked by the decreased number of Annexin-V − F4/80 + Tunel + macrophages in inflamed muscle, and the impaired uptake of macrophages to PKH67 + apoptotic cells transferred into damaged muscle. Further, our study suggested that, the intrinsic TGF-β signaling directed IL-10-Vav1-Rac1 efferocytosis signaling in muscle macrophages. Conclusions Our data demonstrate that muscle inflammation can be suppressed potentially by activating the intrinsic TGF-β signaling in myofibers to promote IL-10 dependent-macrophages efferocytosis.
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INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
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2018
·Vol. 42
·期 6
·3093-3104
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IF 2.784
Yang Zhou,Tao Hong,Li Tong,Wei Liu,Xueting Yang,Jianghan Luo,Fuling Wang,Jian Li,Lijun Yan
Non‑small cell lung carcinoma (NSCLC) is a life‑threatening malignancy. The level of the cell growth regulator mitogen‑activated protein kinase kinase kinase kinase 3 (MAP4K3) has been shown to be correlated with a high risk of NSCLC recurrence and poor recurrence‑free survival rate. The present study examined the effects of Astragalus polysaccharide (APS) and 10‑hydroxycamptothecin (HCPT), which are associated with marked suppression and dephosphorylation of the MAP4K3/mammalian target of rapamycin (mTOR) signaling pathway, in the H1299 NSCLC cell line. APS and HCPT decreased H1299 cell viability, induced apoptosis and altered the cell cycle stages, as evaluated using an 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide assay and flow cytometric analysis. Furthermore, APS increased the expression of apoptosis‑associated genes B‑cell lymphoma 2 (Bcl‑2) and Bcl‑2‑associated X protein (BAX), of proteases cysteine‑aspartic acid protease (caspase)‑3 and ‑9, and of cytochrome c. HCPT promoted autophagy in H1299 cells, with concomitant suppression of the expression of MAP4K3 and downregulation of mTOR signaling. Notably, combination treatment with the two agents reduced the migration and invasion of H1299 cells compared with the single treatments. It was also demonstrated that the overexpression of MAP4K3 promoted the migration and invasion of H1299 cells, and that the kinase activity was essential to this. These findings suggested that MAP4K3 may be an attractive target for the treatment of NSCLC.
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RSC Advances
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2018
·Vol. 8
·期 23
·12944-12950
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IF 2.936
Yang Su,Li-Na Hao,Kun Liu,Jun Zhang,Liang Dong,Yunjun Xu,Yang Lu,Hai-Sheng Qian
Upconversion core–shell nanoparticles have attracted a large amount of attention due to their multifunctionality and specific applications. In this work, based on a NaGdF4 sub-10 nm ultrasmall nanocore, a series of core–shell upconversion nanoparticles with uniform size doped with Yb3+, Er3+ and NaDyF4 shells with different thicknesses were synthesized by a facile sequential growth process. NaDyF4 coated upconversion luminescent nanoparticles showed an obvious fluorescence quenching under excitation at 980 nm as a result of energy resonance transfer between Yb3+, Er3+ and Dy3+. NaGdF4:Yb,Er@NaDyF4 core–shell nanoparticles with ultrathin layer shells exhibited a better T1-weighted MR contrast.
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RSC Advances
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2017
·Vol. 7
·期 20
·12185-12193
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IF 3.108
Yuhua Zhang,Keming Jiang,Degang Qing,Bing Huang,Jiayi Jiang,Shumei Wang,Chunyan Yan
Camptotheca acuminata Decne (Nyssaceae) is a major natural source of the anticancer drug camptothecin (CPT) and its derivatives. The leaves and stems are two of the main regions that accumulate CPT in C. acuminata. In this study, we successfully isolated cambial meristematic cells (CMCs) and dedifferentiated cells (DDCs) from C. acuminata stems and leaves, identified their characteristic features using micrograph analysis, and assessed their hypersensitivity to γ-irradiation and zeocin. The growth and kinetics curves of CMCs and DDCs were also studied. Furthermore, the accumulation of CPT and 10-hydroxycamptothecin (HCPT)—a more potent and less toxic CPT derivative—was assessed by liquid chromatography, and the transcriptional levels of nine genes encoding key enzymes involved in CPT and HCPT biosynthesis was assessed using quantitative real-time polymerase chain reaction (PCR) in CMCs and DDCs. The results showed that CMCs induced were particularly hypersensitive to γ-irradiation and zeocin and presented with abundant and small vacuoles, whereas DDCs were not. The above morphological and physiological characteristics of CMCs were consistent with previous reports. B5 medium was determined as the best growth medium for CMCs and DDCs. The accumulation of CPT and HCPT was higher in CMCs than DDCs, and the expression of IPI, G10H, ASA1, TSB, TDC1, TDC2, and STR was significantly upregulated in CMCs compared with DDCs; HMGR2 and HMGR3 were downregulated in CMCs. We speculate that the high accumulation of CPT and HCPT in CMCs was due to the upregulation of these seven genes.
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JOURNAL OF POWER SOURCES
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2025
·
IF 7.9
Yirui Lu,Linhan Jia,Daijun Yang,Yu Leng,Jie Chen,Pingwen Ming,Junying Min,Xiangmin Pan
Understanding the corrosion behavior of bipolar plates (BPPs) and their coatings under dynamic load cycling (DLC) is crucial for the commercial application of proton exchange membrane fuel cells (PEMFCs). This study employs a PEMFC stack comprising titanium anode plates coated with ruthenium oxide to investigate the degradation of these components after DLC testing, specifically under conventional operating conditions (75 °C for 1000 and 3000 h) and accelerated aging conditions (95 °C for 100 h). The corrosion behavior and degradation mechanisms of the coating and TA1 substrate in Ti-BPP samples after various DLC tests are analyzed using electrochemical tests, morphological evaluations, and elemental characterization. The results indicate that the morphological and structural changes in BPP after different DLC tests show significant differences. The coating suffered severe damage under high temperature aging conditions. The generation and dissolution of metal oxides on the BPP surface, along with the corrosion and exfoliation of the coating, resulted in increased surface roughness, decreased corrosion resistance, reduced electrical conductivity, and weakened bonding strength between the coating and the BPP substrate. These findings offer insights for optimizing coating materials under high temperature operating conditions and for assessing the corrosion resistance of metallic BPPs.
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CHEMICAL ENGINEERING JOURNAL
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2025
·
IF 13.2
Jiancheng Sun,Chi Zhang,Rubing Zhang
Conventional rigid patch antennas, constrained by high-permittivity substrates ( ε r > 3.0) with severe dielectric loss ( tanδ > 0.02), suffer from catastrophic performance degradation at elevated frequencies (>3 GHz) and inherent inflexibility that fundamentally prohibits their integration in wearable electronics. This work presents a breakthrough in synthesizing PMMA-reinforced polyimide aerogels (PIAs) via a 10-min ambient pressure drying (APD) strategy, enabling tunable porosity (>90%) and ultra-low dielectric constants ( ε r = 1.35, tanδ < 0.01). The incorporation of PMMA into the PI matrix endows the aerogel skeleton with outstanding mechanical resilience (tensile strength of 7.2 MPa and fracture energy of 45.8 kJ/m 2 ), while effectively suppressing capillary-induced shrinkage to below 2.1% during solvent evaporation. The synergistic interplay between PMMA encapsulation and APD-optimized solvent exchange yields a hierarchical nanoporous structure (30 nm average pore size) with exceptional thermal insulation (0.036 W/m·K). When deployed as a substrate for flexible Sub-6 GHz patch antennas, the aerogel exhibits 106% gain enhancement (9.92 dBi) and broad impedance bandwidth (3.862–3.941 GHz), outperforming conventional FR-4 substrates. This work establishes a scalable, low-cost paradigm for multifunctional aerogels in wearable electronics and high-frequency communication systems.
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RSC Advances
·
2016
·Vol. 6
·期 70
·66215-66223
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IF 3.289
Fa-Shuo Shan,Jia-Ping Lai,Hui Sun,Ping Zhang,Chong Luo,Yan-Hui He,Huan-Ran Feng
A fast responsive and highly selective mercury(II) sensor was developed using the fluorescence quenching mechanism of 2,9-dimethyl-1,10-phenanthroline (2,9-DMP) towards mercury(II). Furthermore, two kinds of metal–organic frameworks (MOFs) of 2,9-DMP–Hg(II) have been synthesized and characterized by X-ray diffraction. The probe 2,9-DMP exhibited a fast and highly selective response to mercury(II) ions in aqueous solution, showing a good linear relationship over the concentration range of 0.050–2.0 μM for Hg(II) with R2 = 0.9994. The established procedure was used to monitor the concentration of mercury(II) in drinking water and Zhujiang River water samples with satisfactory recoveries of 85.42–101.5% and 81.72–96.09%, respectively. Furthermore, the fluorescence quenching mechanism of 2,9-DMP by mercury(II) was investigated and clarified by the data of single crystal X-ray diffraction of MOFs and the Job's plot analyses of 2,9-DMP towards Hg(II).
研究领域:
分析化学
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环境科学
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材料科学
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2019
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IF 3.973
Menghang Zu,Heliang Song,Jiabin Zhang,Qiubing Chen,Shiqin Deng,Brandon S.B. Canup,Yi Yuan,Bo Xiao
Edible plant-derived nanoparticles (NPs) have attracted increasing attention in the treatment of ulcerative colitis (UC). Lycium barbarum (LB), a popular functional fruit, possesses various biological functions. Here, fat-soluble contents were extracted from LB and further processed into LB lipid-derived NPs (LBLNs). The resultant NPs had an average hydrodynamic diameter around 189.2 nm, narrow size distribution (polydispersity index = 0.2), and negative surface charge (-34.9 mV). Moreover, they could be efficiently taken up by UC therapy-related target cells (macrophages), and over 69.0 % of macrophages internalized LBLNs after 4 h co-incubation. We further found from the in vitro results that LBLNs had strong capacities to inhibit the secretion of the main pro-inflammatory cytokines (TNF-α and IL-12) and up-regulate the expression of the typical anti-inflammatory factor (IL-10). Finally, mice experiments confirmed that LBLNs after oral administration could specifically accumulate into inflamed colon tissues, and further attenuate UC-relevant symptoms ( e.g. , bodyweight loss, colon shortening, increase of spleen weight, and histopathological appearance, as well as ulceration). Collectively, this study demonstrates the excellent therapeutic outcomes of LBLNs against UC and provides a promising edible nanotherapeutic for UC treatment.
研究领域:
药理学
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纳米技术
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炎症性肠病
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药物递送系统
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ACS Biomaterials Science & Engineering
·
2025
·
IF 5.5
Jie Zhao,Tao Xue,Zhiyuan Liu
Managing neuropathic pain is challenging due to the complex pathogenetic mechanisms and limited available drugs and therapeutic options. Innovative nanofiber systems offer a novel method to effectively administer therapeutic cytokines, drugs, or small molecule compounds to achieve better relief of neuropathic pain. Here, we report a novel nanofiber with controlled release of IL-10 for implantation into ligated nerve roots and hemisection-injured spinal cords to exert anti-inflammatory effects and attenuate neuropathic pain. An electrospun poly(l-lactide) (PLLA) nanofiber was modified by a polydopamine (PDA) coating, and this nanofiber demonstrated sustained release of IL-10 in vitro. We showed that L5 spinal nerve ligation and T13 spinal cord hemisection induced peripheral and below-level central neuropathic pain in rats, along with the development of neuroinflammation. Spinal IL-10 was also markedly changed after spinal nerve ligation (SNL) or spinal cord injury (SCI), especially in the spinal dorsal horn. Rats were treated postsurgically with IL-10 that was loaded on PDA@PLLA nanofibers as an implantable cytokine delivery system. IL-10 levels were significantly upregulated after the implantation of PDA@PLLA nanofibers in SNL and SCI rats. We further demonstrated that the implantation could inhibit glial activation and neuronal excitability in vivo, along with suppressing the expression levels of pro-inflammatory cytokines. Most importantly, IL-10-loaded PDA@PLLA nanofiber treatment attenuated the development and maintenance of peripheral and central neuropathic pain. Together, the combination of IL-10 and PDA@PLLA nanofibers provides a novel implantable delivery system for treating neuroinflammatory conditions and may emerge as a promising agent to prevent chronic neuropathic pain.
研究领域:
纳米医学
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神经科学
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疼痛管理
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生物材料
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药物递送
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MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2025
·
IF 2.7
Zhigeng Chen,Siqi Lin,Yan Li,Zhenxun Huang
Poly(ester-imide)s (PEIs) are well-known for their ultralow dissipation factor (D f ) of 0.003 at 10 GHz recently. However, the dielectric constant (D k ) and D f seem to be two difficult-to-reconcile indexes in PEIs, a relatively high D k of 3.2 confines the insulating capability of PEIs, owing to the trade-off between the polymer's free volume and rigidity. To address this difficulty, a cross-linking strategy of polymer backbones is proposed to increase the free volume and maintain a rigid structure in PEIs. In this research, the crystallinity of a liquid-crystal-like PEI is gradually diminished, and the molecular chain spacing is slightly enlarged as the degree of cross-linking increases. Besides, the degree of the in-plane orientation of this PEI is obviously reduced, indicating the loose stacking of molecular chains. Consequently, the D k at 10 GHz of this PEI is decreased from 3.26 to 2.85 after cross-linking. Furthermore, the D f of the cross-linked PEI is remained as low as 0.00237. In addition, the tensile strength and elongation at break of this PEI are increased from 219 MPa and 7.4% to 231 MPa and 9.7% after cross-linking, respectively. And the thermal stabilities of the cross-linked PEI are also decent as a candidate for low dielectric materials.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2022
·
IF 3.119
Zhengxu Li,Hao Wu,Baifeng Hu,Jin Guo,Yuxiang Liu,Han Yue,Hongkang Zhao,Qunsheng Li
The solubility of 2′,4′-dihydroxyacetophenone (2′,4′-DHAP) in 10 monosolvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, methyl acetate, ethyl acetate, propyl acetate, and benzene) and two binary solvents (ethanol + ethyl acetate and n-propanol + ethyl acetate) was determined using a gravimetric method at 101.3 kPa from 293.15 to 333.15 K. The experimental solubility was demonstrated to increase with the increasing temperature. The solubility of 2′,4′-DHAP is the highest in pure isopropanol, and the two binary solvents present a solubilizing effect on the solute. Furthermore, six thermodynamic models were employed to fit the solid–liquid equilibrium data, and the correlation results manifested that the modified Apelblat model had minimum ARD values of less than 1%. Finally, the KAT-LSER model was employed to analyze the solvent effect at 298.15 K. The results show that the contribution of the four interaction types α, β, π*, and δH account for 15.84%, 15.30%, 18.33%, and 50.53% of the total interaction force, respectively, and the solvent–solvent interaction represented by δH is the dominant factor affecting the solubility of 2′,4′-DHAP.
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