Nature Biomedical Engineering
·
2025
·
IF 26.6
Li Cuifeng,Li Yuxin,Zhou Bini,Li Tong,Wei Xiaohui,Chen Kun,Chen Wenlong,Shi Ziwei,Dai Xiaobin,Zhang Jiachen,Yang Chen,Ji Zhenglin,Sun Wenbo,Gao Ji,Wu Jing,Zhao Binbin,Min Xin,Li Yujie,Lin Lin,Yang Wei,Wang Min,Liu Zezhong,Liu Yaping,Zhu Chenyou,Yang Bo,Xu Jiang-Fei,Yan Li-Tang,Shi Yi,Lu Lu,Zhang Linqi,Ding Qiang,Xue Jing,Hou Baidong,Qi Hai,Liu Jiangning,Yang Yuhe R.,Liu Dongsheng,Liu Wanli
The emergence of novel infectious disease has intensified demand for more advanced vaccine development and more potent adjuvants to enhance immunogenicity. Here we introduce a dynamic DNA supramolecular matrix assembled from five unmodified, short DNA single strands, serving as a safe, multifaceted adjuvant platform. This DNA matrix elicits a robust humoral response with minimal adverse effects, generating potent neutralizing antibodies and conferring robust protection against SARS-CoV-2 and Streptococcus pneumoniae infections. Its dynamic colloidal feature prolongs the in vivo retention of both DNA and antigen, facilitating lymphatic-targeted transportation and presentation. This process leads to a robust pro-inflammatory response in both the vaccinated site and draining lymph node, which, in turn, promotes the recruitment and activation of immune cells, leading to a rapid, effective antigen-specific antibody response. The enhanced function of DNA matrix depends on the canonical TLR9–MyD88 signalling axis in dendritic cells. In addition, only right-handed, not left-handed, chirality of the DNA strands forms d -DNA matrix and promotes immune activations. Thus, this DNA matrix functions as an all-in-one adjuvant platform, opening promising avenues for future vaccine design.
研究领域:
免疫学
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微生物学
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生物材料
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疫苗学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 49
·2305359
·
IF 19
Ke Su,Lefu Mei,Qingfeng Guo,Pengfei Shuai,Yujia Wang,Yukun Liu,Yang Jin,Zhijian Peng,Bo Zou,Libing Liao
Optical manometry is a highly promising method for measuring pressure. However, its wider application is limited by the lower sensitivity and influenced by environmental factors. Herein, multi-mode optical pressure sensors based on Eu 2+ -doped Li 4 SrCa(SiO 4 ) 2 phosphors suitable for a variety of complex pressure-measuring environments are designed. The phosphors contain two separate luminescence centers at 443 nm (Eu Sr ) and 584 nm (Eu Ca ), respectively. In the lower pressure range, the emission peak undergoes a massive redshift of 5.19 nm GPa −1 of Eu Ca , which is 14× better than commercially available ruby sensors. In order to improve the pressure response range and the accuracy of pressure measurement, for the first time, a new approach in the pressure readout method in which single Eu 2+ ions doping based on fluorescence intensity ratio (FIR) pressure measurement is realized in designed materials. Meanwhile, the measured full width at half maximum (FWHM) as an indicator of pressure sensor performance also reveals that the sensing performance is d FWHM /d P ≈ 1.23 nm GPa −1 and d FWHM /d P ≈ 0.84 nm GPa −1 for Eu Sr and Eu Ca positions, respectively. Additionally, the structural stability of the phosphor is confirmed by in situ Raman spectrum. The above results indicate that the Li 4 SrCa(SiO 4 ) 2 :0.04Eu 2+ phosphor is a good candidate for multi-mode optical pressure sensors.
研究领域:
光学传感
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材料科学
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压力测量
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发光材料
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固态物理
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DOI
高影响因子
FirePhysChem
·
2022
·
IF 0
Kunkai Wang,Xiangzhi Li,Kaidi Yang,Huan Huo,Qi Xue,Bozhou Wang,Fuqiang Bi
1,1,4,4-Tetramethyl-2-tetrazene (TMTZ), a potential candidate for replacing 1,1-dimethylhydrazine (UDMH), has excellent properties including a high specific impulse, non-toxicity and non-volatility. However, most synthetic methods depicted in the literature use stoichiometric oxidative coupling, and the oxidizing agents are usually heavy metals or halogens, leading to low synthetic efficiency and high environmental pollution. In order to overcome these problems, it is necessary to explore more environmentally friendly and catalytic synthetic methods. In this paper, a method of photocatalytic oxidative coupling for the preparation of TMTZ was reported for the first time. By using an organic photocatalyst Eosin Y, TMTZ was synthesized rapidly and efficiently. The thermal decomposition properties of TMTZ were studied, and different performance characteristics between TMTZ and UDMH were determined and analyzed, which provided a basis for the application of TMTZ based new liquid propellant.
研究领域:
有机化学
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催化化学
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能源材料
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推进剂化学
✓ 已验证
DOI
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 45
·19868-19879
·
IF 3.288
Sleshi Fentie Tadesse,Dong-Hau Kuo,Worku Lakew Kebede,Lalisa Wakjira Duresa
Discharging of organic pollutants from industrial activities into the water bodies is a common worldwide problem, which can adversely affect human life and the environment. Recently, many efficient, eco-friendly, and cost-effective photocatalytic methods have been investigated for environmental remediation. In this study, a simple and facile precipitation method at low temperature was proposed for the synthesis of V-doped Mo(O,S)2 oxysulfide. The crystallinity, morphology, elemental composition, and optical and electrical properties of the as-synthesized materials were characterized by XRD, Raman spectroscopy, FT-IR spectroscopy, FE-SEM, TEM, XPS, PL, and EIS. The photocatalytic performance of both bare and V-doped Mo(O,S)2 was evaluated in the degradation of methylene blue (MB) dye. The holes (h+) and hydroxyl radicals (OH˙) were identified as the main oxidative species for MB degradation. V-Mo(O,S)2-10 synthesized with 10% vanadium precursor showed the highest photocatalytic efficiency for MB degradation under visible light irradiation with an apparent rate constant of 0.028 min−1, which was much greater than that of bare Mo(O,S)2 at 0.0098 min−1. Besides, V-Mo(O,S)2-10 had the lowest recombination rate of electron–hole pairs and charge transfer resistance to enhance the photocatalytic activity, as evidenced by PL and EIS analyses. Therefore, V-doped Mo(O,S)2 can be a potential candidate for photocatalytic degradation of organic dyes for environmental remediation.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
CATALYSIS LETTERS
·
2025
·Vol. 155
·期 5
·1-19
·
IF 2.4
Hu Xinyin,Xiao Guoqing,Chen Chunlin,Chen Chunyan,Zeng Xiang,Li Ruili,Yang Zhengwei
Recently, several emerging pollutants have caused increasing damage to aquatic ecosystems. Reducing antibiotic concentrations in water by visible light is one of the most promising strategies for sustainable development. Here, a Bi 2 S 3 /CeO 2 /Ni(OH) 2 Z-scheme heterojunction photocatalyst was prepared by the hydrothermal method, which could effectively utilize free radicals to degrade tetracycline. Ni(OH) 2 was used for co-catalysing in photodegradation experiments to improve electron transfer and enhance photocatalytic performance. The degradation rate of the Z-scheme heterojunction photocatalyst for 20 mg/L TC was 91.35% after reacting 60 min under visible light irradiation. Besides, it also investigated such operational parameters influencing the photocatalytic reaction as catalyst dosage, initial concentration of tetracycline hydrochloride (TC), and solution pH. Studies using free radical scavenging experiments and electron spin resonance (ESR) measurements demonstrated that hydroxyl radicals (·OH) and superoxide radicals (·O 2 − ) both contributed to the photodegradation of TC. Finally, with high-performance liquid chromatography-mass spectrometry (LC-MS), potential degradation pathways of the intermediate products were logically inferred as well as the photocatalytic mechanism. The experimental results surface that the prepared Z-scheme heterojunction photocatalyst Bi 2 S 3 /CeO 2 /Ni(OH) 2 exhibits superior photocatalytic performance, offering a novel approach to addressing TC contamination in environmental settings. Graphical
研究领域:
环境科学
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材料科学
·
光催化技术
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产品关联
DOI
高影响因子
Bioengineering & Translational Medicine
·
2024
·
IF 6.1
Jihong Ma,Haiyan Yang,Xue Tian,Fanhu Meng,Xiaoqing Zhai,Aimei Li,Chuntao Li,Min Wang,Guohui Wang,Chunbo Lu,Jingkun Bai
Conventional chemotherapeutic agents are limited by their lack of targeting and penetration and their short retention time, and chemotherapy might induce an immune suppressive environment. Peptide self-assembly can result in a specific morphology, and the resulting morphological changes are stimuli responsive to the external environment, which is important for drug permeation and retention of encapsulated chemotherapeutic agents. In this study, a polypeptide (Pep1) containing the peptide sequences PLGLAG and RGD that is responsive to matrix metalloproteinase 2 (MMP-2) was successfully developed. Pep1 underwent a morphological transformation from a spherical structure to aggregates with a high aspect ratio in response to MMP-2 induction. This drug delivery system (DI/Pep1) can transport doxorubicin (DOX) and indomethacin (IND) simultaneously to target tumor cells for subsequent drug release while extending drug retention within tumor cells, which increases immunogenic cell death and facilitates the immunotherapeutic effect of CD4 + T cells. Ultimately, DI/Pep1 attenuated tumor-associated inflammation, enhanced the body's immune response, and inhibited breast cancer growth by combining the actions of DOX and IND. Our research offers an approach to hopefully enhance the effectiveness of cancer treatment.
研究领域:
肿瘤学
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药剂学
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分子生物学
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DOI
PubMed
高影响因子
BioNanoScience
·
2025
·Vol. 15
·期 2
·1-12
·
IF 3.2
Liang Tisong,Jing Pu
The poor stability of chlorophyll has inhibited its application in food industry. Our previous study showed that the stability of chlorophyll can be enhanced by incorporating with sodium caseinate (NaCas). This present work further explored the characteristics of NaCas–chlorophyll dispersion in simulated gastrointestinal digestion and its inhibitory effects on human epithelial colorectal adenocarcinoma cells (Caco-2 cells). Results indicated that the gastrointestinal digestion resulted in alterations to the physical appearance of the NaCas–chlorophyll dispersion. Fourier-transform infrared spectroscopy illustrated that the second structure of NaCas underwent alterations during gastrointestinal digestion. Morphological observation revealed that the digested NaCas–chlorophyll dispersion exhibited granular morphology with smaller particle size. The Caco-2 cells exposed to digested NaCas–chlorophyll dispersion exhibited decreased viability and destroyed mitochondrial structure, which may be related to the enhanced absorptivity of the NaCas–chlorophyll dispersion following gastrointestinal digestion. These findings provided theoretical basis for understanding the characteristics changes and biological activity of NaCas–chlorophyll dispersion during gastrointestinal digestion.
研究领域:
食品科学
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生物化学
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营养学
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产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6
Zhiran Ju,Junde Xu,Keshuang Tang,Fener Chen
COX-2/NLPR3-targeted therapy might be beneficial for the inflammation diseases. To discover novel anti-inflammatory compounds with favorable safety profiles, three new series of non-carboxylic diclofenac analogues bearing various ring systems, such as oxadiazoles 4a - 4w , triazoles 6a - 6m , and cyclic imides 7a and 7b , were synthesized. The synthesized analogues were evaluated for their inhibitory activity against COX-2 enzyme. Among them, compound 6k exhibited potent selective COX-2 inhibition (IC 50 = 1.53 μM; selectivity ((IC 50 (COX-1)/IC 50 (COX-2) = 17.19). Treatment with compound 6k effectively suppressed the NF-κB/NLRP3 signaling pathway, resulting in reduced expression of pro-inflammatory factors. The in vivo ulcerative colitis assay demonstrated that compound 6k significantly ameliorated histological damages and showed strong protection against DSS-induced acute colitis. The collected results indicated that compound 6k displays anti-inflammatory activity through COX-2/NLRP3 inhibition. Therefore, compound 6k represents a promising candidate for further development as a new lead compound with reduced colitis side effects.
研究领域:
药理学
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药物化学
·
炎症研究
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DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2024
·
IF 4.8
Yongyan Zhu,Ao Duan,Qianqian Yu,Shuo Tian,Zishan Zhou,Ping Li,Dongmei Pan,Huaming Tao,Quanhong Zhu
Ethnopharmacological relevance Fangji Huangqi Decoction (FHD) is a classical Chinese compound formula for treating rheumatoid arthritis (RA) with satisfactory effects. FHD is reputed for its ability to tonify qi with strengthening exterior, and dispel wind while removing dampness, but its mechanisms and bioactive compounds for treating RA remain unclear. Aim of the study The aim of this study was to explore the key target and bioactive compounds that were responsible for FHD-mediated improvements in RA. Materials and methods Using network pharmacology, we discovered that cyclooxygenase-2 (COX-2) was the key target of FHD against RA. We utilized a ligand fishing technique with COX-2 immobilized magnetic beads to recognize the bioactive components that act on COX-2. Then we carried out an in vitro assay of COX-2 enzyme inhibition and in vivo assay of carrageenan-induced inflammation and collagen-induced arthritis (CIA) to validate the bioactive effects of these captured ingredients. In the CIA assay, micro-CT, hematoxylin‒eosin staining and safranin-O/fast green staining were employed to assess the influence of the captured ligand on bone damage, pathological injury and cartilage destruction, respectively. Immunohistochemistry (IHC) and enzyme-linked immunosorbent assays (ELISAs) were used to detect the expression of COX-2 target in the ankle joint. interleukin-6 (IL-6) levels in the serum were also detected by ELISA. Molecular docking was used to reveal the binding mechanism of the COX-2 protein and the captured ligand. Results Eleven ligands, including tetrandrine, fangchinoline, cyclanoline, licochalcone B, ononin, calycosin and liquiritin, were specifically bound to the COX-2 protein, as determined by ultrahigh-performance liquid chromatography–mass spectrometry (UPLC–MS), seven of which were present at high levels. One ligand, tetrandrine, not only had a great inhibitory effect on COX-2 enzyme activity but also significantly reduced carrageenan-induced inflammation. In the CIA assay, middle- and high-dose tetrandrine (25 and 50 mg/kg) had effects comparable to those of FHD and celecoxib on ameliorating RA symptoms in CIA mice via the COX-2 target. Furthermore, compared with the low-dose tetrandrine group (12.5 mg/kg), the FHD group exhibited significantly lower arthritis index scores and serum IL-6 expression, although the content of tetrandrine in FHD extract solution was approximately 0.1% of that in the low-dose tetrandrine group. Conclusions Hence, we inferred that tetrandrine was the main bioactive component responsible for the effects of FHD against RA by suppressing the expression of the COX-2 protein and inhibiting the enzyme catalytic activity of COX-2. The reason for these effects may be that tetrandrine can interact with the residue Tyr385 of COX-2, the enzymatic catalytic site of COX-2 to transform arachidonic acid (AA) to prostaglandin E2 (PGE2), and thereby reduce the production of prostaglandins and inflammatory metabolites. Moreover, in addition to tetrandrine, FHD contains other compounds that could supplement the activity of tetrandrine when FHD was used to treat RA, which is manifested the “multi-component” characteristic of how Traditional Chinese Medicine formulas treat diseases.
研究领域:
民族药理学
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药物化学
·
炎症研究
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DOI
PubMed
高影响因子
Landslides
·
2019
·Vol. 16
·期 7
·1313-1324
·
IF 4.252
Yang Wentao,Wang Yunqi,Sun Shao,Wang Yujie,Ma Chao
Detecting slope movement before landslides occur in mountain regions is crucial for disaster reduction. In October 2018, a gigantic landslide occurred on the Jinsha River, causing dammed-lake breach flood 500 km downstream. In this work, we used 25 Sentinel-2 images from November 2015 to August 2018 to explore the capability of this high temporal resolution optical images in detecting slope movement before the Jinsha River landslide. Normalized difference vegetation index (NDVI) was calculated to composite temporal profiles using all Sentinel-2 images. With this NDVI time series, unsupervised K-means classifier was applied to initially classify the study area and find the best thresholds for automatically extracting landslide scars in the image series. These extracted landslide scars were validated using interpreted results from two high spatial resolution images of similar dates in 2015 (user’s accuracy 89.7%, producer’s accuracy 83.6%) and 2018 (user’s accuracy 90.8%, producer’s accuracy 74.9%). After validation, extracted landslide scars of different years were counted and displayed in an RGB composite image to highlight slope movement. In addition, monotonous decrease/increase of NDVI was also observed, indicating continuous expansion of landslide scarps and movement of landslide head along the slope on the landslide surface. This work demonstrated the capability of Sentinel-2 time series images to capture slope movement with short revisit time at low cost. By incorporating other environmental information (such as elevation), this proposed method has the potential to consistently map pre-landslide slope movements over a large region.
研究领域:
遥感地质学
·
环境灾害监测
·
地理信息系统
·
山地灾害防治
·
地球观测
✓ 已验证
DOI
高影响因子
ADSORPTION SCIENCE & TECHNOLOGY
·
2019
·
IF 1.2
Yue Sun,Weisheng Zheng,Deqiang Yin
Two novel weakly basic anion exchange resins BNH and BN2 bearing two different functional groups was fabricated via the two-step amination of chloromethylated polystyrene-divinylbenzene beads with dibutylamine and dimethylamine. The adsorption properties of BNH and BN2 for the 2-naphthalenesulfonic acid (NSA) removal from wastewater were compared with two synthesized monofunctional anion exchange resins BN0 and BN6 (derived from dimethylamine and dibutylamine, respectively). The experimental data revealed that the adsorption process on the four resins fitted well with the pseudo-second-order kinetics equation and the equilibrium isotherms were in good agreement with the Langmuir model. Thermodynamic analyses illustrated that 2-naphthalenesulfonic acid adsorption onto resins was an endothermic and spontaneous process. Importantly, BN2 still displayed relatively high adsorption capacity in the existence of Na2SO4, indicative of an excellent selectivity for 2-naphthalenesulfonic acid over sulfate than other resins. The obtained results elucidate that BN2 could have potential industrial application in effluent disposal fields because of its superior selectivity, acceptable kinetics, and desorption capability.
研究领域:
环境科学
·
化学工程
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Peng Ye,Qiancheng Zou,Luyang An,Yi Wei,Aihua Xu,Xiaoxia Li
Due to low cost and low toxicity, manganese oxides have been extensively explored to reduce organic pollutants in wastewater via peroxymonosulfate (PMS) activation; but the development of manganese-based catalysts with facile synthesis process at low temperatures and high efficiency is still of significant practical interest. In this paper, a simple room temperature method has been successfully developed to synthesize cryptomelane-type manganese octahedral molecular sieves (OMS-2) from KMnO 4 and MnSO 4 in the presence of carbon nanotubes (CNTs). The redox reaction between amorphous manganese oxide and CNTs results the decrease of manganese valences and the formation of OMS-2 phase at a low temperature of 25 °C. The changes of synthesis time, temperature and CNTs dosage altered the characteristics of the prepared materials. Compared with CNTs, OMS-2 and other manganese oxides hybrids, the synthesized catalysts demonstrated a remarkable efficiency for PMS activation to degrade organic dyes and a superior reusability during ten successive cycles. Sulfate radicals were formed as the active species in the system from the oxidation of low valent Mn species by PMS. This study not only provides a simple method to synthesize OMS-2 at room temperature, but also improves the understanding of PMS activation on manganese-based catalysts for pollutants degradation.
研究领域:
环境科学
·
催化化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）