Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 46
·16626-16633
·
IF 7.393
Yuzhen Wang,Yanan Wang,Chaoyang Ma,Yanbin Li,Chong Zhao,Wanggui Ye,Zicheng Wen,Xuanyi Yuan,Yongge Cao
Bifunctional luminescence materials have aroused considerable concern due to their wide application and high utilization. In this study, we have successfully integrated bright green up-conversion luminescence of K0.5Bi0.5TiO3 (KBT): Er/In ceramics with potential applications on cryogenic optical thermometry and photomemory. By employing the fluorescence intensity ratio based on thermally coupled levels of Er3+: 2H11/2/4S3/2, the splendid low-temperature sensing properties were demonstrated as the maximum relative sensitivities were 7.14% K−1 and 8.73% K−1 at 137 K for KBT: Er and KBT: Er/In ceramics, respectively. Moreover, the reversible photochromism performance could be triggered by the 365 nm irradiation and vanished by thermal stimulation at 150 °C. Remarkably, the coupling of up-conversion luminescence and photochromism performance has a promising application on rewritable photomemory. For the KBT: Er/In ceramic, the emission intensity could be reduced by 76.59% after coloration, and restored to its original value after bleaching. In order to evaluate the practicability of applying on photomemory, a reversible experiment was designed and successfully executed. It is believed that the KBT: Er/In bifunctional ceramic can be a great candidate for low-temperature sensing and optical information storage devices.
研究领域:
材料科学
·
光学工程
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DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 89
·56229-56238
·
IF 3.108
Wei Wang,Yunxi Li,Shanshan Hu,Xuemei Zhang,Jianfeng Tang,Jun Yang
Ba3Sc2F12:Yb3+, Ln3+ (Ln = Er, Ho, Tm) crystals with various morphologies have been synthesized via a one step hydrothermal route. X-ray diffraction (XRD), scanning electron microscopy (SEM), and up conversion photoluminescence (UCPL) spectra were used to characterize the samples. The influences of surfactants, pH values, and molar ratio of F−/Sc3+ on the crystal phase, size and shape of final products have been studied in detail. The aspect ratio of products increased gradually with the increase of F−/Sc3+ molar ratio. Additionally, the luminescence properties of Ba3Sc2F12:Yb3+, Ln3+ (Ln = Er, Ho, Tm) crystals were systematically studied. The blue emission is attributed to the 1G4 → 3H6 transition of Tm3+; the green emission can be obtained due to the 2H11/2/4S3/2 → 4I15/2 transitions of Er3+ and the 5S2/5F4 → 5I8 transition of Ho3+; the red emission comes from the 4F9/2 → 4I15/2 transition of Er3+ and the 1G4 → 3F4 transition of Tm3+. Based on the generation of red, green, and blue emissions in the different Ln ion-doped Ba3Sc2F12, the white light emission can be obtained by appropriately doping Yb3+, Er3+, and Tm3+ in the present Ba3Sc2F12 crystals due to the color superposition principle. Here, the sample Ba3Sc1.5856F12:0.4Yb3+, 0.01Er3+, 0.0044Tm3+ crystals showed suitable intensity ratio of blue, green and red (RGB) emissions resulting in bright white light with CIE-x = 0.274 and CIE-y = 0.287, which was illustrated by a photograph under excitation of 980 nm. The prepared Ba3Sc2F12:Ln3+ phosphor has potential applications in the fields of three dimensional displays, back lighting and white light sources.
研究领域:
材料科学
·
光学材料
·
发光学
·
光子学
·
无机化学
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DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2019
·
IF 2.961
Manli Zhang,Xuesong Zhai,Pengpeng Lei,Shuang Yao,Xia Xu,Lile Dong,Kaimin Du,Chengyu Li,Jing Feng,Hongjie Zhang
Temperature sensors based on upconversion luminescence (UCL) intensity ratio have attracted great attention due to the high sensitivity. The enhancement of UCL is helpful to improve the sensitivity of temperature sensor. Doping is an effective way to achieve the UCL enhancement. Ga 3+ ions doped NaYF 4 :18%Yb,2%Er have been prepared through a facile one-pot solvothermal method . Upconversion (UC) emission intensity was significantly enhanced by introducing Ga 3+ ions into the lattice of NaYF 4 :Yb,Er, especially the green UC emission. With Ga 3+ concentration increasing, the size of the resulting NaYF 4 :Yb,Er,x%Ga particles decreases gradually. By doping 25% Ga 3+ , the green UC emission is increased by 30 times, while the red emission is enhanced by only 8 times. The morphology of particles and local symmetry around Er 3+ ions have been changed, resulting in the selective enhancement of green UC emission. In addition, the temperature-dependent UCL properties of NaYF 4 :Yb,Er,25%Ga and NaYF 4 :Yb,Er were investigated. The maximum thermal sensitivity of NaYF 4 :Yb,Er,25%Ga could reach 0.0046 K −1 at 498 K. Therefore, NaYF 4 :Yb,Er,25%Ga with strong green UCL could be served as a potential candidate for sensitive temperature sensing.
研究领域:
材料科学
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光学传感器
·
发光材料
·
纳米技术
✓ 已验证
DOI
高影响因子
BRAIN RESEARCH
·
2026
·
IF 3.2
Yan Zhu,Puyi Liu,Peng Zhang,Haimin Ye,Xuehui Shi,Weiai Liu,Zhen Kang
This study investigated the complex mechanisms underlying post-stroke depression (PSD) and the challenges associated with its clinical prevention and treatment. Specifically, it examined the effects of electroacupuncture at the “Siguan” acupoints on PSD and the relationship with the PERK-ATF4-CHOP endoplasmic reticulum stress (ERS) pathway. A rat model of PSD was established by combining middle cerebral artery occlusion (MCAO) with solitary rearing and chronic unpredictable mild stress (CUMS). Successfully modeled rats were randomly assigned to four groups: the model group, the electroacupuncture group, the drug group, and the sham operation group. The electroacupuncture group received 21 days of electroacupuncture at the “Siguan” acupoints (bilateral Hegu LI4 and Taichong LR3). Behavioral changes were assessed using a blinded method. Histopathological and molecular biological methods were then employed to comprehensively examine neuronal damage, apoptosis, and the expression of key proteins in the ERS pathway in the prefrontal cortex. The results showed that, compared with the model group, both electroacupuncture and medication significantly improved depressive‑like behavior, alleviated neuronal injury in the prefrontal cortex, and reduced apoptosis. At the molecular level, these effects were significantly associated with inhibition of the PERK-ATF4-CHOP ERS pathway, as evidenced by decreased levels of GRP78, p-PERK, CHOP, and downstream pro‑apoptotic proteins (Bax and cleaved caspase‑3). Notably, electroacupuncture demonstrated particular efficacy in promoting weight gain and modulating pathways such as p-PERK. These findings suggest that electroacupuncture at the “Siguan” acupoints may alleviate depressive‑like behavior in PSD rats by inhibiting the PERK-ATF4-CHOP pathway in the prefrontal cortex, thereby reducing endoplasmic reticulum stress‑induced neuronal apoptosis. This provides a novel potential molecular mechanism for electroacupuncture treatment of PSD.
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DOI
PubMed
高影响因子
PLoS Pathogens
·
2026
·Vol. 22
·期 6
·e1013865
·
IF 4.9
Lin Zhao,Jiawen Fu,Swaroop Peddiraju,Heming Chen,Keqin Huang,Ying Zhang,Nishith Gupta,Qian Jiang,Honglin Jia
All alveolates including apicomplexan parasites contain an inner membrane complex (IMC) underneath the plasma membrane. The IMC is synthesized de novo during asexual replication (including endodyogeny, endopolygeny, and schizogony) and serves as a crucial scaffold for supporting cytoskeletal structures and the glideosome machinery for parasite locomotion. However, the mechanism(s) underlying the membrane biogenesis in the IMC are not well understood. Using a clinically-relevant and globally-prevalent pathogenic protist model, Toxoplasma gondii , we identified the TgVPS13A bridging the IMC to the endoplasmic reticulum (ER) – the major site of phospholipid synthesis. The multi-modular TgVPS13A plays a crucial role in the IMC biogenesis, functioning in concert with an ER-resident VAP protein (TgVAP) and a novel lipid scramblase (TgDAT1). TgDAT1 is recruited for the progeny formation sites during the early stages of budding. Conditional depletion of TgVPS13A, TgDAT1 or TgVAP results in collapse of the inner membrane complex, leading to parasite death, as visualized by endodyogeny-specific organelle markers. GFP-Lact-C2, a biosensor of phosphatidylserine and phosphatidylthreonine lipids made in the ER and enriched in the IMC, also mislocalizes upon protein depletion. In conclusion, we propose that TgVPS13A, together with TgVAP and TgDAT1, bridge the ER and IMC and mediate the inter-organelle transport of lipids, thus contributing to the organelle biogenesis and daughter budding in T. gondii.
The inner membrane complex (IMC) in apicomplexan parasites is essential for maintaining the structural stability of the parasite, as well as for its budding and motility. The IMC is composed of flattened vesicles, alveolins, and microtubules. However, the mechanism behind the biogenesis of these flattened vesicles remains unclear. In this study, we provide evidence that a bridge-like protein TgVPS13A, together with TgVAP and TgDAT1 drive the biogenesis of the IMC alveoli. Phenotypic analysis indicates that the absence of any individual of these proteins disrupts the biogenesis of daughter IMCs, which in turn affects the budding of daughter parasites. We also demonstrated that TgDAT1 functions as a scramblase. Based on our findings, we propose a model in which the TgVPS13A, functioning in concert with TgVAP and TgDAT1 mediates lipid transport from the ER to the nascent IMC to drive the expansion of the IMC membrane and the budding of daughter parasites in T. gondii . Furthermore, TgDAT1 may facilitate the transfer of lipids from the outer leaflet to the inner leaflet of the IMC sacs, promoting a balanced composition of the IMC membrane components.
✓ 已验证
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Shanlin Zhu,Jintao Xu,Weijun Zhao,Canyuan Liao,Xinyi Huang,Hongwei Hu,Ting Shi,Jiuping Zhong
Rare-earth-doped upconversion materials play a crucial role in the development of temperature sensing based on fluorescence intensity ratio (FIR). In this work, the upconversion (UC) luminescence of GdAlO 3 (GAP):Yb 3+ ,RE 3+ (RE = Ho, Er, Tm) phosphors was investigated. Under 980 nm laser excitation, GAP:Yb 3+ ,Ho 3+ emitted green ( 5 F 4 , 5 S 2 → 5 I 8 ) and red ( 5 F 5 → 5 I 8 , 5 F 4 → 5 I 7 ) light, GAP:Yb 3+ ,Er 3+ emitted green ( 2 H 11/2 , 4 S 3/2 → 4 I 15/2 ) and red ( 4 F 9/2 → 4 I 15/2 ) light, GAP:Yb 3+ ,Tm 3+ emitted blue ( 1 G 4 → 3 H 6 ) and red ( 1 G 4 → 3 F 4 , 3 F 3 → 3 H 6 ) light. Within the temperature range of 260–500 K, GAP:Yb 3+ ,Ho 3+ exhibits a maximum absolute sensitivity ( S a ) of 0.0078 K −1 at 460 K and a maximum relative sensitivity ( S r ) of 1.391% K −1 at 300 K, corresponding to the non-thermally coupled levels (NTCLs) 5 S 2 / 5 F 5 . Meanwhile, GAP: Yb 3+ ,Er 3+ shows a maximum S a of 0.00367 K −1 at 500 K and a maximum S r of 1.562% K −1 at 260 K, associated with the thermally coupled levels (TCLs) 2 H 11/2 / 4 S 3/2 . Remarkably, the maximum S a and S r of GAP:Yb 3+ ,Tm 3+ reached 0.03576 K −1 at 500 K and 6.740% K −1 at 260 K for NTCLs 1 G 4 / 3 F 3 . These results demonstrate significant potential for applications in high-sensitivity thermal sensing and non-contact optical thermometry.
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产品关联
DOI
高影响因子
Materials Today Bio
·
2026
·
IF 11
Zhipeng Li,Yaoyao Wu,Jialin Wu,Cheng Zhang,Xinsheng Cheng,Hongzhen Zhang,Shikai Wang
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized clinically by recurrent abdominal pain and bloody diarrhea, for which there is currently a lack of curative therapeutic strategies. In recent years, neutrophil extracellular traps (NETs) have been identified as playing a key role in the pathogenesis of UC, emerging as a potential therapeutic target. Although deoxyribonuclease I (DNase I) can exert therapeutic effects by degrading the DNA backbone of NETs, its clinical application is limited by inherent drawbacks, including poor in vivo stability, low bioavailability, and inefficient penetration of biological barriers. Herein, this study constructed a biomimetic membrane-based nanodelivery system. Initially, zeolitic imidazolate framework-8 (ZIF-8) was used to encapsulate DNase I, forming ZD nanoparticles to enhance enzymatic stability. Subsequently, these nanoparticles were coated with bacterial outer membrane vesicles (BOMVs), yielding the final BVZD composite system, designed to improve targeting to inflammatory sites. The BVZD system exhibited suitable particle size, good biocompatibility, and a demonstrated ability to specifically accumulate in the inflamed intestinal regions of a UC model. Both in vitro and in vivo experiments confirmed that BVZD effectively degraded NETs, suppressed endoplasmic reticulum stress (ERS) by downregulating the expression of prostaglandin-endoperoxide synthase 2 (PTGS2), and promoted the repair of the intestinal epithelial barrier. These findings highlight the promising therapeutic potential of BVZD for the treatment of UC.
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产品关联
DOI
高影响因子
NEUROPHARMACOLOGY
·
2025
·
IF 4.6
Wei Wang,Yingzhuo Ding,Chunxia Yu,Qingqing Chi,Xia Fu,Mengjiao Deng,Dongxia Duan,Jinbao Wei,Ronghua Ding,Yufei Xi,Qin Li,Le Ma
Neuro-inflammation contributes to neuropathic pain by sensitizing ionic channels. Kinsenoside, a traditional Chinese medicine, has recognized anti-inflammatory properties. However, it remains unclear whether kinsenoside can be used for pain therapy. Network pharmacology analysis revealed that 57 % of its targets are associated with pain, including inflammation and synaptic transmission. The analgesic effects of kinsenoside were confirmed in SNL and formalin rat models, with ED50 values of 47.99 μg and 36.80 μg, respectively. Transcriptome and WGCNA analyses indicated the involvement of cytokine release, anti-inflammatory activity, and synapse enrichment in the blue module. Furthermore, we confirmed that kinsenoside's efficacy was mainly mediated by IL-10 induction, phosphorylation of STAT3, and SOCS3 expression. Pretreatment with kinsenoside significantly inhibited the release of TNF-α, IL-1β, and IL-6. Kinsenoside also attenuated ER stress in both microglia and neural cells. Molecular docking analysis demonstrated significantly high binding energies of IL-10, STAT3, and SOCS3 with MHC. Additionally, whole-cell recordings revealed that bath application of kinsenoside reduced the frequency and amplitude of spinal glutamatergic transmission in a dose-dependent manner. In summary, pharmacological prediction and biological validation collectively indicate that kinsenoside significantly exerts significant analgesic effects by attenuating ER stress and inhibiting inflammatory responses via the IL-10/p-STAT3/SOCS3 axis, precisely regulating spinal glutamatergic transmission for pain relief.
研究领域:
药理学
·
神经科学
·
分子生物学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaoxian Zhang,Xuequan Zhang,Jiahui Zhu,Tinghua Li,Lianyi Yang,Lei Lei,Fang Wu,Bin He,Jun Cao
Targeted modulation of metal ion homeostasis in tumor cells has emerged as a promising method for cancer therapy. However, the coordination efficiency and stability of different metal ions posed significant challenges for current multi-metal ions delivery systems. In this study, we presented an innovative strategy that utilized a single-metal ion nanoregulator capable of precisely modulating intracellular dual-metal ions homeostasis. This regulation induced endoplasmic reticulum (ER) stress and cuproptosis, which worked synergistically to inhibit tumor growth. Specifically, a calcium-selective chelator, BAPTA, formed a metal coordination complex with copper ions (Cu 2+ ), which remained stable in the extracellular environment but disassembled upon internalized by tumor cells. Once inside, the released BA selectively chelated cytoplasmic calcium ions (Ca 2+ ), depleting ER Ca 2+ stores and triggering ER stress. This stress activated the PERK/p-eIF2α/ATF4/CHOP apoptotic pathway, leading to tumor cell apoptosis. Meanwhile, Cu 2+ induced cuproptosis and was reduced to Cu + in the cytosol, where it consumed hydrogen peroxide and generated cytotoxic hydroxyl radicals. These radicals induced oxidative stress, which, combined with glutathione depletion, further amplified ER stress and promoted tumor cell apoptosis. Both in vitro and in vivo experiments exhibited that the nanoregulator effectively suppressed tumor growth through apoptosis and cuproptosis pathways, with favorable biocompatibility. This study highlighted the synergistic roles of copper and calcium ions in tumor therapy and introduced a novel strategy for modulating intracellular dual-metal ions homeostasis, offering more efficient and low toxicity anti-cancer treatments.
研究领域:
肿瘤学
·
药理学
·
分子生物学
·
生物医学工程
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产品关联
DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2025
·
IF 8.9
Qian Ren,Xiaoyu Zhang,Xin Zhang
Carbon fiber reinforced polymers (CFRP) are utilized in a variety of fields, but they are prone to delamination, which can cause substantial degradation to the properties and limit the usage. Here, Ni/PUF/PU@ER (NPPER) microcapsules were introduced into the composites to improve the interlaminar shear strength (ILSS). The PUF/PU@ER (PPER) microcapsules were first synthesized with epoxy resin as the healing agent, followed by electroless plating to deposit metal Ni on the surface. The microsphere compression tests demonstrated that the NPPER had superior strength (41.7 MPa) compared to the PPER. When 20 w.t.% PPER was added, the ILSS reduced to 32.8 MPa compared with the ILSS of the original specimen (36.7 MPa), and the healing efficiency increased to 81.8 %. However, due to the robustness of the NPPER, the ILSS increased to 40.3 MPa with 5 w.t.% NPPER, which was 9.8 % higher than that of the original specimen, and the highest healing efficiency was 52.0 % with 20 w.t.% NPPER. Furthermore, the NPPER with damage visualization was prepared using epoxy resin and 2′,7′-Dichlorofluorescein as core materials, which can be utilized to imply the occurrence and healing of damage by the change of color, promoting the development of intelligent and high-performance self-healing CFRP.
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产品关联
DOI
高影响因子
Science China-Materials
·
2025
·
IF 7.4
Chen Haisheng,An Yu,Wang Yinghan,Du Xiaona,Hu Minghao,Bai Gongxun,Ye Shi,Liu Weiwei,Zhang Yang
Thermal quenching, a pervasive challenge in luminescent materials, severely limits the performance of lanthanide-based optical sensors at elevated temperatures. While negative thermal expansion (NTE) hosts have shown promise in bulk systems for countering this effect, their potential in thin-film architectures, critically for integrated photonics and miniaturized sensing, remains unexplored. Here, we demonstrate a Yb 3+ /Er 3+ co-doped Sc 2 Mo 3 O 12 thin film that leverages anisotropic NTE dynamics to achieve 42-fold thermal enhancement in green upconversion luminescence from 300 to 560 K. In situ thermodiffraction and time-resolved spectroscopy reveal a dual mechanism: (1) lattice contraction along the a - and c -axes reduces the cell volume of Sc 2 Mo 3 O 12 by 11.3 Å 3 , thereby amplifying Förster-type energy transfer ( k ET ∝ R −6 ) from Yb 3+ to Er 3+ , and (2) symmetry-breaking distortions suppress nonradiative 2 H 11/2 → 4 F 9/2 relaxations, extending Er 3+ lifetimes by 358%. Crucially, the film’s strain-engineered crystal field enables multi-modal thermometry with record sensitivities: a relative sensitivity ( S r ) of 4.33% K −1 at 300 K, and maximum S r = 1.28% K −1 through lifetime-based sensing, which outperforms conventional Boltzmann-limited approaches. The sub-200 nm thickness and SiO 2 /Si compatibility further position this platform for on-chip integration, addressing unmet needs in high-resolution thermal mapping for quantum devices, aerospace diagnostics, and wearable sensors. This work not only deciphers the interplay between NTE and luminescence at the atomic scale but also establishes a universal strategy to design anti-thermal-quenching thin films for extreme-environment photonics.
研究领域:
材料科学
·
光学
·
传感器技术
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DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2020
·
IF 7.632
Xiaokai Xu,Wei Li,Chaofan Hu,Bingfu Lei,Xuejie Zhang,Yadong Li,Qiuqiang Zhan,Yingliang Liu,Jianle Zhuang
In recent years, the application of nanomaterials in promoting plant growth and augmenting photosynthesis has aroused great interest. Herein, carbon dots (CDs) are combined with NaYF4:Yb,Er to achieve an enhanced upconversion red emission. The effects of the obtained NaYF4:Yb,Er@CDs nanocomposites on the growth of mung bean plants are investigated. It is found that an appropriate concentration of the NaYF4:Yb,Er@CDs nanocomposites (0.5 mg/mL) can enhance the water absorption ability of hydroponic mung beans and promote their growth after incubation for 7 days. Confocal imaging shows that the nanocomposites can transfer from the roots to the stems and leaves. Interestingly, after spraying the nanocomposite solution on the surface of the mung bean seedling leaves and placing them under sunlight for 2 weeks, the root/stem lengths and wet/dry weight clearly increase. Moreover, the photosynthetic rate of the mung bean seedling is found to increase by more than 2 times, while the transpiration rate and stomatal conductance are improved by 144 and 148%, respectively. Such a promoting effect is ascribed to the ability of the NaYF4:Yb,Er@CDs nanocomposites to convert near-infrared (NIR) radiation into red light, which is beneficial for plant photosynthesis. This work provides a promising strategy for promoting plant growth by the application of nanomaterials.
研究领域:
植物学
·
纳米生物学
·
农业科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）