JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 5.2
Fanfan Zhang,Xuemei Hu,Yue Zhang,Baiyuan Sha,Fengshi Shang,Wenjie Wang,Rui Liu,Hao Wang
Hepatocellular carcinoma (HCC) poses a severe threat to public health, with clinical therapy limited by narrow surgical indications, chemotherapeutic side effects, and targeted drug resistance. Herein, we developed Fe 3+ coordination Polydopamine@Poly (lactic-co-glycolic acid)-Curcumin (Fe 3+ -PDA@PLGA-Cur, FePPC) nanoparticles integrating photothermal therapy (PTT), chemodynamic therapy (CDT), sonodynamic therapy (SDT), and curcumin (Cur)'s intrinsic anticancer activity for synergistic HCC treatment. FePPC was fabricated via emulsion solvent evaporation, in-situ dopamine polymerization, and Fe 3+ coordination chelation, with its structure and physicochemical properties characterized by FT-IR, UV-vis, SEM, XPS, and particle size analysis. FePPC exhibited uniform spherical morphology (198.58 nm), favorable stability, 73.60 ± 0.51% encapsulation efficiency, and NIR-triggered temperature-dependent Cur release. Under 808 nm NIR light (2 W/cm 2 , 4 cm), FePPC achieved a 24.4 °C temperature elevation with robust photothermal stability. Catalytic assays confirmed FePPC generated ·OH via Fe 3+ -mediated Fenton-like reactions, 1 O 2 under NIR irradiation, and ·O₂⁻ upon ultrasound stimulation, realizing synergistic reactive oxygen species (ROS) production. In vitro experiments on HepG2 cells showed time-dependent FePPC internalization; the FePPC + PTT + CDT + SDT group reduced cell viability to 53.45%, induced 47.55% apoptosis, elevated intracellular ROS, disrupted mitochondrial membrane potential, downregulated LDH, modulated Bax/Bcl-2 expression, and inhibited cell migration. This study highlights FePPC's potential as a multifunctional nanoplatform for HCC therapy via coordinated chemical-biological interactions.
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高影响因子
Soft Matter
·
2019
·Vol. 15
·期 37
·7404-7411
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IF 3.399
Jianfei Tie,Hongchen Liu,Jingchun Lv,Bijia Wang,Zhiping Mao,Linping Zhang,Yi Zhong,Xueling Feng,Xiaofeng Sui,Hong Xu
Herein, a PVA (polyvinyl alcohol)-based multi-responsive hydrogel was prepared by introducing the dynamic and reversible supramolecular complexation between polyvinyl alcohol acetoacetate (PVAA) and Fe3+ ions within 20 s at room temperature. PVAA–Fe hydrogels could be achieved by the simple mixing process of a PVAA aqueous solution with FeCl3 aqueous solution. The soluble PVAA was synthesized by the reaction of PVA with tert-butyl acetoacetate (t-BAA) via transesterification in dimethyl sulfoxide (DMSO). The chemical structure of PVAA was systematically characterized by FT-IR and 1H NMR spectroscopy. The resulting hydrogel showed excellent self-healing behavior without other external stimuli. It was also demonstrated that the PVAA–Fe hydrogel exhibited multi-responsive properties, such as responsiveness to pH, redox, light irradiation and temperature. In addition, the presence of Fe3+ ions and Cl− ions in the gel imparted the PVAA–Fe hydrogel with favorable conductivity. Therefore, the strategy for the facile preparation of the hydrogel in this work could provide a benign and versatile method for achieving multi-functional soft materials for various applications such as smart devices, logic gates, and sensors.
研究领域:
材料科学
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化学工程
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Bioactive Materials
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2021
·
IF 14.593
Caili Lv,Linlong Li,Zixue Jiao,Huanhuan Yan,Zongliang Wang,Zhenxu Wu,Min Guo,Yu Wang,Peibiao Zhang
The development of an excellent, bioabsorbable hemostatic material for deep wound remains a challenge. In this work, a biodegradable cotton-like biomimetic fibrous mat of poly ( l -lactic acid) (PLLA) was made by melt spinning. Subsequently, SD composite was prepared by cross-linking sodium alginate (SA) with dopamine (DA). It was immobilized on the fibre surface, which inspired by mussel byssus. Finally, Fe 3+ was loaded onto the 0.5SD/PLLA composite by chelation with the carboxyl of alginate and phenolic hydroxy of dopamine. The haemostasis experiment found that the hemostatic time 47 s in vitro. However, the bleeding volume was 0.097 g and hemostatic time was 23 s when 20Fe 3+ -0.5SD/PLLA was applied in the haemostasis of the rat liver. As a result of its robust hydrophilicity and bouffant cotton-like structure, it could absorb a large water from blood, which could concentrate the component of blood and reduce the clotting time. Furthermore, the addition of Fe 3+ in the 0.5SD/PLLA had a significant effect on improve hemostatic property. It also displayed excellent antibacterial property for Escherichia coli and Staphylococcus aureus . Notably, it possesses superior hemocompatibility, cytocompatibility and histocompatibility. Hence, 20Fe 3+ -0.5SD/PLLA has high potential application in haemostasis for clinical settings due to its outstanding properties.
研究领域:
生物医学工程
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材料科学
·
血液学
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高影响因子
MICROCHEMICAL JOURNAL
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2020
·
IF 3.594
Hui Zhang,Xingcen Liu,Jia Sun,Xia Wu
A novel luminescence phenomenon of homovanillic acid (HVA) that the excitation wavelength is longer than the emission wavelength (LExL, λ ex-L > λ em ) was observed, which was monitored by using a common spectrofluorometer with a xenon lamp as an excitation light source. As the addition of Fe 3+ , the intrinsic fluorescence of HVA at 310 nm was obviously quenched and a new emission peak at 424 nm emerged and raised under 557 nm excitation. The similar emission spectra of HVA-Fe 3+ were also obtained at 287 nm excitation. Thus, a dual-mode ratiometric fluorescence (RF) method for detecting Fe 3+ was developed based on LExL and Stokes fluorescence (SF) of HVA. The RF signals of lg( I 424 nm / I 310 nm ) had excellent linearity with Fe 3+ concentration in the range of 0.50–100 μM. Their detection limits were 0.073 μM and 0.090 μM for the LExL and SF methods, respectively. The LExL and SF methods exhibited high selectivity for detecting Fe 3+ , and the former has stronger anti-interference ability to Cu 2+ , Fe 2+ etc. The proposed two methods were successfully applied for the determination of Fe 3+ in actual water samples. The interaction mechanism of HVA with Fe 3+ was also studied.
研究领域:
分析化学
·
生物化学
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
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IF 4.6
Li Zheng,Yao Mu-Tian,Qiu Zi-Yang,Xu Jing-Kun,Lu Bao-Yang
The development of solar-driven interfacial evaporation technology is pivotal for addressing global water scarcity. However, it is hindered by the difficulty in synergizing high photothermal conversion with low water evaporation enthalpy into a single material. Herein, we propose an iron-aldehyde-cooperative dynamic covalent anchoring strategy, successfully constructing a covalently locked, hydroxymethyl-functionalized PEDOT-PVA integrated dual-network hydrogel (MEPH). This strategy employs Fe 3+ to achieve the one-step in situ oxidative polymerization of hydroxymethyl EDOT while concurrently forming a physical hybrid network with PVA, which is subsequently reinforced by covalent cross-linking using glutaraldehyde. This design endows the MEPH with exceptional broadband light absorption (>99%), efficient water transport, and regulated water state within the hydrogel matrix, leading to a reduced evaporation enthalpy of 732 J·g −1 . The resulting evaporator achieves an ultrahigh evaporation rate of 4.95 kg·m −2 ·h −1 under 1-sun illumination, corresponding to an energy conversion efficiency exceeding 95%, while maintaining stable, salt-resistant operation in high-salinity environments. Outdoor experiments validate its outstanding practicality for seawater and wastewater purification, with the produced freshwater significantly promoting plant growth, highlighting its great potential in sustainable agricultural water cycles. This iron-aldehyde-cooperative dynamic covalent anchoring strategy provides an innovative design paradigm for a new generation of high-performance and robust solar evaporators.
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ACS Omega
·
2026
·
IF 4.3
Juefei Wu,Yawei Ge,Qinying Tang,Kang Hu,Yi Wang,Ru Zhang,Yuxiao Mao,Bin Li
Sensitive and biocompatible fluorescent probes capable of simultaneously detecting pH and Fe3+ are crucial for applications in environmental monitoring, biomedical diagnostics, and food safety. In this study, we present an environmentally friendly, one-step hydrothermal synthesis of multifunctional carbon dots (ECDs) utilizing epigallocatechin gallate (EGCG) as a natural carbon precursor. The synthesized ECDs exhibit pronounced pH-dependent fluorescence quenching over a broad pH spectrum (1.3–13.5), characterized by a sigmoidal response (R2 = 0.9918) and remarkable sensitivity within the physiological range (pH 6–8). The mechanism of pH-induced quenching of ECDs has been verified to be the aggregation of ECDs and surface deprotonation under high-pH conditions. Furthermore, the ECDs facilitate highly selective detection of Fe3+ through fluorescence quenching, a process attributed to electron transfer from EGCG-derived phenolic groups. Its fluorescence response shows a linear relationship within the Fe3+ concentration range of 1–125 μM with R2 = 0.995. Additionally, the ECDs demonstrate excellent biocompatibility (cell viability >90%, hemolysis <5%) and exhibit significant antibacterial activity against Escherichia coli and Staphylococcus aureus. This research illustrates a straightforward approach to developing eco-friendly, cost-effective, and multifunctional probes for integrated sensing and antimicrobial applications.
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PubMed
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
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2022
·
IF 1.193
Guan-Ting XU,Tian-Sheng ZHAO,Kun ZHANG,Li-Zhen GUO,Yong-Qin HE,Jian-Hua HU,Yi-Jing LIAO,Xi MAI,Na LI
Iron ions (Fe 3+ ) and ascorbic acid (AA) are of great significance to living organisms. Herein, carbon dots (C-dots)-based “off-on” fluorescent probe was designed for Fe 3+ and AA analysis. In presence of Fe 3+ , the fluorescence of C-dots was immediately quenched, and the quenching mechanism was deduced to be inner filter effect (IFE). The fluorescent C-dot probe shows response to Fe 3+ in range of 10–500 µM with a limit of detection (LOD) of 0.9 µM. Interestingly, when AA was introduced to the C-dots-Fe 3+ system, the fluorescence of C-dots was significantly recovered, which could be ascribed to the oxidation-reduction reaction between Fe 3+ and AA. Based “off-on” fluorescent C-dots probe, the linear range of 5–500 µM was obtained with LOD of 0.4 µM. Moreover, the AA-induced fluorescence enhancement can be recognized by smartphone, which greatly extends the application in resource-limited areas.
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CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Haotian Ma,Li Guan,Mingjun Chen,You Zhang,Yue Wu,Zhenyang Liu,Dawei Wang,Fenghe Wang,Xu Li
The utilization of biomass is an important approach to supplying sustainable carbon sources for green chemistry, by which the product could be more environmentally friendly and lower toxicity. In this work, the local fruit Mopan persimmons were used to be a carbon source to prepare carbon quantum dots (MP-CQDs) via the hydrothermal method. A series of characteristics were applied to the carbon dots to study the structural and optical properties. The results demonstrated that the MP-CQDs were well synthesized and coated by N, O-related surface functional groups. The PL of MP-CQDs showed an excitation-dependent behavior, whose peak shifted from 446 nm to 545 nm under the excitation wavelength from 350 nm to 450 nm. After a selectivity study on different metal ions, we found that MP-CQDs were sensitive to Fe 3+ ions, and the limit of detection (LOD) was determined as 0.324 μM with the 3σ rule. Further, by mixing MP-CQDs with sugar, we successfully applied MP-CQDs to the anti-counterfeiting field by painting anti-counterfeiting patterns with the combination of commercial fluorescent ink (CFI) and MP-CQDs@sugar ink (MPI). The pattern can present different fluorescent properties under 365 nm, 395 nm, and 450 nm respectively. The results revealed that biomass-derived MP-CQDs were a promising candidate for Fe 3+ ions detection and anti-counterfeiting application.
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高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Xuqian Wang,Zhimei He,Yi Xie,Yongkui Zhang,Yabo Wang
Peroxymonosulfate (PMS) activation-based advanced oxidation technology possesses great potential for antibiotic-containing wastewater treatment . Herein, we developed an iron phosphide/carbon composite and verified its capability and superiority towards a model antibiotic pollutant (sulfathiazole, STZ) degradation through PMS activation. Benefiting from the chelating ability of phytic acid (PA) with metal ions and its abundance on phosphorous element, a PA-Fe 3+ complex was firstly formed and then served as sole precursor for iron phosphide formation by anoxic pyrolysis . Well crystalized FeP particle were found loading on the simultaneously formed thin layer carbon structure. Catalytic activity evaluation showed that FeP/carbon composite could remove over 99% of STZ (20 mg L −1 ) in 20 min adsorption and 30 min catalysis process under the reaction conditions of catalyst dosage 0.2 g L −1 , PMS loading 0.15 g L −1 . A pseudo-first-order reaction rate constant of 0.2193 min −1 was obtained, which was among the highest compared with reported studies. Further investigations indicated that the developed FeP/carbon composite worked well in a wide solution pH range of 3–9. Reaction mechanism study showed that reactive species of SO 4 − • and 1 O 2 generated from PMS activation played major roles for STZ degradation. Based on liquid chromatography-mass spectroscopy (LC-MS) analysis, a few STZ degradation intermediate products were identified, which facilitated the proposal of STZ degradation pathways. The possible ecological risk of STZ and related degradation intermediates were also considered by toxicity assessment using the Ecological Structure Activity Relationships (ECOSAR) Class Program. The obtained acute and chronic toxicity values implied the relatively low ecological risk of FeP/carbon-PMS reaction system for STZ treatment.
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PubMed
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Haiying Gao,Hui Yu,Jun Yu,Tianhui Xu,Yiming Feng,Yan Wang,Jun Qian,Chaoqun Tan
An origin Fenton-like system was discussed for the abatement of refractory contaminants. Sodium percarbonate (SPC) was utilized as the source of H 2 O 2 and crystal boron ( C -boron) was applied to enhance the activation of H 2 O 2 . Under the conditions of 0.50 mM Fe 3+ , 0.34 mM SPC, and heterogeneous catalysis using 100 mg L −1 C -boron, four target pollutants, at the initial concentrations of 20 μM, could be efficiently degraded by the Fenton-like system, with a degradation rate within 20 min up to 81.1% (aspirin, ASA), 92.8% (nitrobenzene, NB), 94.7% (flunixin meglumine, FMME), and 94.3% (benzoic acid, BA) respectively and total organic carbon removal up to 25.0%. The increase of Fe 2+ concentration indicated that the conversion of Fe 2+ /Fe 3+ was remarkably promoted by C -boron. Degradation reactions at acidic pH were comparatively fast, with pH-dependent k obs of 9.9 × 10 −2 min −1 (ASA), 1.5 × 10 −1 min −1 (NB), 1.7 × 10 −1 min −1 (FMME), and 1.9 × 10 −1 min −1 (BA), whereas those at neutral and alkaline pH were slower. Furthermore, reactive oxygen species including · OH, 1 O 2 , and O 2 · − were identified by in-situ electron paramagnetic resonance tests. The contribution ratios of · OH turned out to be about 71.3–86.7% for the decomposition of four contaminants. The elimination of natural organic matter and the performance of material recycling highlighted the potential for its application in water treatment . The inhibition rate of Chlorella pyrenoidosa reached 211.9% in the C -boron/Fe 3+ /SPC system. The relatively high algae toxicity limited its application scope, which requires additional research to resolve.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yanqin Wang,Yu Zhu,Xuehui Zhang,Fengbo Zhu,Yi-Xian Qin,Weiyi Chen,Qiang Zheng
It is quite urgent to develop a smart and high through-put confidential information storage, protection, and display platform based on the fluorescent hydrogels that could exhibit diverse fluorescent variation behavior during each stimulus-based shape memory and recovery process. Herein, it proposed an effective approach to develop a novel fluorescent composite gel with Fe 3+ , pH, and glucose-dependent diversity fluorescence variation and shape memory behavior. For this composite gel system, based on the reversible coordination interactions between Fe 3+ and carboxylic acid groups of carboxymethyl cellulose (CMC), boric acid groups of carbon dots (CDs), and hydroxyl groups of PVA , it can stabilize and memorize the temporary shapes under the stimulus of Fe 3+ and pH, respectively. Meanwhile, the fluorescence of the CDs within the gels can also exhibit diversity variation behaviors during each shape recovery process. Furthermore, the compositions of the composite gel were optimized to realize relatively high efficiency of shape recovery and fluorescence variation under each type of stimulus. In summary, this study presented a universal strategy for multi-shape memory hydrogels with diverse fluorescence variation properties which exhibited prominent prospective in the field of information encryption with high-level security.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Qu Zeng,Sihui Wan,Shujuan Yang,Xinyu Zhao,Furui He,Yamei Zhang,Xinyu Cao,Qiyan Wen,Yuhong Feng,Gaobo Yu,Lisha Pan,Jiacheng Li
Bionic hydrogel sensors have been known as promising alternatives to biomimetic skins. Here, a bionic hydrogel sensor based on sodium alginate (Alg), polyacrylamide (PAAM) and Fe 3+ have been fabricated by a simple one-pot method, shows super stretchability, excellent adhesion and conductivity. The Fe 3+ /Alg-PAAM hydrogel was endowed with a dynamic coordination dual-network structure based on controllable Fe 3+ penetration and free radical polymerization dual effect, which was equipped with the synergistic properties of high storage modulus (2200 KPa), super stretchability (1800%) and strong adhesion to various substrates (glass adhesion with 61.8 KPa). Moreover, due to abundant free ions, the Fe 3+ /Alg-PAAM hydrogel displays good conductive behavior, and further shows excellent sensing behavior and strain sensitivity as a skin sensor to monitor human movement. This work enriches the design and preparation strategies of flexible hydrogels to promote the application of Alg-based materials for the wearable electronic devices and intelligent monitoring systems.
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