CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Maruthupandy Muthuchamy,Rajivgandhi Govindan,Kadaikunnan Shine,Veeramani Thangasamy,Naiyf S. Alharbi,Muneeswaran Thillaichidambaram,Jamal M. Khaled,Jun-Li Wen,Khalid F. Alanzi
In this study graphene/chitosan nanoparticles (GR/CS NCs) were developed. The homogenous combination of GR and CS was confirmed by FTIR spectroscopy. The combination of CS with GR sheets reduced the XRD intensity of the GR peak in GR/CS NCs, while TEM images revealed the immobile CS coating of GR sheets. Further, the anti-biofilm activity of GR/CS NCs was tested. The tests showed that the formation of biofilm by Pseudomonas aeruginosa and Klebsiella pneumoniae was inhibited at 40□g/mL GR/CS NCs up to 94 and 92 %, respectively. The intracellular and cell surface damage of the bacteria was observed by CLSM and SEM. Also, GR/CS NCs produced a toxic effect of 90 % on Artemia franciscana at 70□g/mL upon 24 h incubation. The recorded properties of the synthesized GR/CS NCs qualify them as potential agents against multi-drug resistant bacteria.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2012
·
IF 1.58
Mengyin Hou,Yingjie Xu,Yajuan Han,Bin Chen,Wenxia Zhang,Qinghua Ye,Jinzhi Sun
Densities ( ρ ), refractive indices ( n D ) and electrical conductivities ( κ ) of ethylammonium acetate (N2Ac) protic ionic liquid + water and propylammonium acetate (N3Ac) protic ionic liquid + water binary mixtures over the entire composition range were measured at 298.15 K under atmospheric pressure. The excess molar volumes ( V E ), apparent molar volumes ( V ϕi ), partial molar volumes ( V ¯ m , i ) and excess partial molar volumes ( V ¯ m , i E ) of the binary mixtures were calculated from the density data. The refractive index deviations (Δ n D ) of the binary mixtures were determined using the refractive index data. The excess molar volumes and refractive index deviations were correlated with the Redlich–Kister equation. The excess molar volumes of the above-mentioned systems are negative over the whole composition range, while the refractive index deviations are positive. The concentration dependence of electrical conductivity was fitted according to the empirical Casteel–Amis equation. The intermolecular interactions and structural effects were analyzed on the basis of the measured and the derived properties.
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2015
·
IF 3.545
Shenguang Ge,Lina Zhang,Yan Zhang,Haiyun Liu,Jiadong Huang,Mei Yan,Jinghua Yu
A low-cost, simple, portable and sensitive paper-based electrochemical sensor was established for the detection of K-562 cell in point-of-care testing. The hybrid material of 3D Au nanoparticles/graphene (3D Au NPs/GN) with high specific surface area and ionic liquid (IL) with widened electrochemical windows improved the good biocompatibility and high conductivity was modified on paper working electrode (PWE) by the classic assembly method and then employed as the sensing surface. IL could not only enhance the electron transfer ability but also provide sensing recognition interface for the conjugation of Con A with cells, with the cell capture efficiency and the sensitivity of biosensor strengthened simultaneously. Concanavalin A (Con A) immobilization matrix was used to capture cells. As proof-of-concept, the paper-based electrochemical sensor for the detection of K-562 cells was developed. With such sandwich-type assay format, K-562 cells as model cells were captured on the surface of Con A/IL/3D AuNPs@GN/PWE. Con A-labeled dendritic PdAg NPs were captured on the surface of K-562 cells. Such dendritic PdAg NPs worked as catalysts promoting the oxidation of thionine (TH) by H 2 O 2 which was released from K-562 cells via the stimulation of phorbol 12-myristate-13-acetate (PMA). Therefore, the current signal response was dependent on the amount of PdAg NPs and the concentration of H 2 O 2 , the latter of which corresponded with the releasing amount from cells. So, the detection method of K-562 cell was also developed. Under optimized experimental conditions, 1.5×10 −14 mol of H 2 O 2 releasing from each cell was calculated. The linear range and the detection limit for K-562 cells were determined to be 1.0×10 3 –5.0×10 6 cells/mL and 200 cells/mL, respectively. Such as-prepared sensor showed excellent analytical performance with good fabrication reproducibility, acceptable precision and satisfied accuracy, providing a novel protocol in point-of-care testing of cells.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2013
·
IF 2.004
Fuqiong Lei,Qinbo Wang,Xing Gong,Binwei Shen,Bingyan Mao,Xiang Ye
Liquid–liquid equilibrium (LLE) data for the ternary system water + cyclohexane + acetic acid have been measured at (303.2 to 333.2) K under atmospheric pressure. The Othmer–Tobias and Bachman equations were used to check the reliability of the obtained tie-line data. The experimental data were correlated by NRTL (nonrandom two-liquid) activity coefficient model, and the relevant interaction parameters were regressed with the experimental data. The predicted values by NRTL method show good consistency with the measured data. The obtained interaction parameters can be used in the calculation of LLE for the ternary system water + cyclohexane + acetic acid as well as for the design and optimization of the related separation process.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2016
·
IF 2.196
Hengde Li,Zhangni Feng,Li Wan,Cheng Huang,Tianfei Zhang,Yanxiong Fang
As an eco-friendly compound from essential oils, 1,8-cineole (cineole, eucalyptol) has the potential to replace the ozone depleting industrial solvents. This paper presents experimental (liquid + liquid) equilibrium (LLE) data for four alcohol–water systems containing 1,8-cineole. To evaluate the phase equilibrium properties of 1,8-cineole in aqueous alcohol mixtures, LLE values for the ternary systems (water + methanol or ethanol or 1-propanol or 1-butanol + 1,8-cineole) were determined with a tie-line method at T = 298.15 K under atmospheric pressure. The well-known Hand, Bachman and Othmer–Tobias equations were used to test the reliability of the experimental results. The binodal curves and distribution ratios of alcohol in the mixtures are shown and discussed. The experimental LLE values were satisfactorily correlated by the NRTL and UNIQUAC models.
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS TODAY
·
2017
·
IF 4.636
Zhibiao Shi,Haiyan Yang,Peng Gao,Xiaopeng Li,Liangshu Zhong,Hui Wang,Hongjiang Liu,Wei Wei,Yuhan Sun
A series of TiO 2 supported Co–Cu catalysts with the weight percent of potassium oxides ranged from 0 to 3.5 wt.% were synthesized. This work investigates the influence of potassium promoter on CO 2 hydrogenation to long-chain (C 5+ ) hydrocarbons. The introduction of suitable amount of K into the CoCu/TiO 2 catalyst remarkably promoted the formation of C 5+ hydrocarbons and suppressed methane formation. The temperature-program desorption measurements demonstrate that the addition of K increases the chemisorption of CO 2 , whereas H 2 adsorption is decreased, which enhanced production of liquid fuels. However, these effects were not obvious with the addition of excess amount of K due to the slight change of surface K content. A maximum C 5+ yield with CO 2 conversion of 13% and C 5+ selectivity of 35.1 C-mol% is obtained over the CoCu/TiO 2 catalyst with 2.5 wt.% of potassium promoter loading, which also exhibits a substantial stability.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Li Gao,Tenghong Kong,Yanqing Ye,Peng Ren,Qiang Zhou,Huaijun Tang,Zhengliang Wang
Red-emitting Mn 4+ -doped fluoride phosphors are recognized as promising materials for high-performance warm white light-emitting diodes (WLEDs). However, the extensive use of toxic hydrofluoric acid in traditional synthesis methods hinders their development and commercialization. Furthermore, the traditional solid-phase method often has cumbersome sintering steps, high temperature, long holding time, and certain safety hazards, so it is very necessary to develop a green synthesis method with simple steps and low energy consumption. In this study, a low-temperature solid-state method is proposed to synthesize Rb A SiF 6 :Mn 4+ ( A = K, Cs) phosphors by one step. Optimal emission intensities were observed at Mn 4+ concentrations of 1.2 % in RbKSiF 6 and 2.1 % in RbCsSiF 6 . These phosphors demonstrated high thermal stability. At 423 K, the photoluminescence intensities of RbKSiF 6 :1.2 %Mn 4+ and RbCsSiF 6 :2.1 %Mn 4+ reached 114 % and 87 % of their respective values at room temperature. Meanwhile, the chromaticity shifts were almost negligible, and high color purity was achieved for both phosphors. The electro-optical performance of WLED devices utilizing these phosphors, in combination with YAG:Ce 3+ and GaN chips, showed high color rendering indices (CRI) and low correlated color temperatures (CCT) across varying currents. Specifically, under a driving current of 20 mA, the device incorporating RbKSiF 6 :1.2 %Mn 4+ exhibited a CRI of 94 and a CCT of 3732 K, with a luminous efficacy of 61 lm/W. These findings highlight the potential of green-synthesized RASFM phosphors in advancing the application of warm WLEDs.
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Jue-Ying Gong,Yao Li,Po Wang,Xu Peng,Rui Xie,Wei Wang,Zhuang Liu,Da-Wei Pan,Xiao-Jie Ju,Liang-Yin Chu
Intracellular bacteria can evade the attack of the immune system and the bactericidal effects of most antibiotics due to the protective effect of the host cells. Herein, inspired by the stimuli-responsive behaviors of biological ion channels, a kind of synergistic cascade potassium ion (K+)-responsive nanoparticles gated with K+-responsive polymers is ingeniously designed to target intracellular bacteria and then control drug release. Due to the cooperative interaction of host–guest complexation and conformational transition of K+-responsive polymers, the grafted gates based on these polymers could recognize high K+ concentration to reverse the negatively charged nanoparticles into positively charged ones for targeting bacteria and subsequently inducing a switch from the hydrophobic shrinking “off” state to the hydrophilic stretching “on” state for drug release. The K+-responsive nanoparticles can effectively load antibiotics and be endocytosed into the infected cells, and K+-responsive gates can be actuated by a high intracellular K+ concentration. With the efficient synergistic cascade strategy, these K+-responsive nanocarriers can deliver antibiotics to the subcellular region where intracellular bacteria reside and show superior elimination efficiencies in vitro and in vivo than the free drug in delivering vancomycin. The K+-responsive nanocarriers are expected to improve the bioavailability of drugs and enhance their antibacterial efficacy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2024
·
IF 3.3
Wenxian Liu,Liting Xu,Haina Cheng,Zhu Chen,Hongbo Zhou,Yuguang Wang
BACKGROUND The potential for the efficient conversion of lignocellulosic biomass has been extensively explored to produce a wide range of bioproducts. Many approaches have been sought for the deep conversion of lignin to generate products that are toxin-free and beneficial for processing into high-value-added components. RESULTS This study reported a fungus isolated from the deep sea with strong synthesis of multiple lignocellulases, conversion of lignin and guaiacol (0.1%) by 71.6% and 86.1% within 9 days at 30 °C respectively, and outstanding environmental adaptability (20–50 °C and pH 3–8). Metabolic pathway profiling showed that this fungus utilized lignin to rapidly activate multiple ring-opening reactions including the 2,3- and 3,4-cleavage pathways, with the 2,3-cleavage pathway predominating after 5 days. Conversion of metabolic intermediates confirmed the superb potential of this strain for lignin treatment. Meanwhile, its shikimic acid pathway was metabolically active under lignin. CONCLUSION This further expands the potential to produce valuable bioproducts during lignin treatment, especially under ambient conditions, which can significantly enhance high-value precursor compound production. © 2024 Society of Chemical Industry.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2024
·Vol. 16
·期 3
·405
·
IF 4.7
Xiaoyan You,Hui Liu,Yue Chen,Guoping Zhao
Liposomes show promise for anti-cancer drug delivery and tumor-targeted therapy. However, complex tumor microenvironments and the performance limitations of traditional liposomes restrict clinical translation. Hyaluronic acid (HA)-modified nanoliposomes effectively target CD44-overexpressing tumor cells. Combination therapy enhances treatment efficacy and delays drug resistance. Here, we developed paclitaxel (PTX) liposomes co-modified with ginsenoside compound K (CK) and HA using film dispersion. Compared to cholesterol (Ch), CK substantially improved encapsulation efficiency and stability. In vitro release studies revealed pH-responsive behavior, with slower release at pH 7.4 versus faster release at pH 5. In vitro cytotoxicity assays demonstrated that replacing Ch with CK in modified liposomes considerably decreased HCT-116 cell viability. Furthermore, flow cytometry and fluorescence microscopy showed a higher cellular uptake of PTX-CK-Lip-HA in CD44-high cells, reflected in the lower half maximal inhibitory concentrations. Overall, CK/HA-modified liposomes represent an innovative, targeted delivery system for enhanced tumor therapy via pH-triggered drug release and CD44 binding.Keywords:liposomes;compound K;tumor-targeted therapy;PTX;hyaluronic acid
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF PHYSICS
·
2024
·
IF 4.6
Zhuojia Xie,Zhengguang Zou,Changji Xu,Shenglin Zhong,Min Feng,Xinyu Jiang,Weijian Zhang,Xiuxin Zheng,Wenbin He
We prepared La 0.8- x K x Sr 0.2 Mn 0.95 Co 0.05 O 3 (0 ⩽ x ⩽ 0.1) (LKSMCO) through the modified sol-gel method (S-G) and its structure. Then, the magnetic, magnetocaloric, and critical behavior were analyzed. LKSMCO was confirmed to be the rhombohedral structure within the R-3c space group (No.167) using transmission electron microscopy and X-ray diffraction. For validating the chemical composition of LKSMCO, X-ray photoelectron spectroscopy and EDS were applied, showing that K + was successfully doped. Phase transition of LKSMCO from paramagnetic to ferromagnetic phase near Curie temperature (Tc) was confirmed with a Magnetic Property Measurement System (MPMS). Using normalization and Banerjee's criterion, LKSMCO was demonstrated to be the second-order magnetic phase transition (SOMPT). As shown from the applied magnetic field, the maximal magnetic entropy ( − Δ S M m a x ) of LKSMCO near Tc was 3.87 J/(kg K) ( x = 0.00), 4.28 J/(kg K) ( x = 0.05) and 4.44 J/(kg K) ( x = 0.10). We employed the Kouvel-Fisher approach (KF) and modified Arrott plots to confirm the values of γ, δ , and β . This indicates that critical exponents of LKSMCO were consistent with the Mean-filed model.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
Zhang Shi-Nan,Gao Peng,Liu Qian-Yu,Zhang Zhao,Leng Bing-Liang,Chen Jie-Sheng,Li Xin-Hao
Electrochemical nitrate reduction reaction offers a sustainable and efficient pathway for ammonia synthesis. Maintaining satisfactory Faradaic efficiency for long-term nitrate reduction under ampere-level current density remains challenging due to the inevitable hydrogen evolution, particularly in pure nitrate solutions. Herein, we present the application of electron deficiency of Ru metals to boost the repelling effect of counter K + ions via the electric-field-dependent synergy of interfacial water and cations, and thus largely promote nitrate reduction reaction with a high yield and well-maintained Faradaic efficiency under ampere-level current density. The pronounced electron deficiency of Ru metals boosts the repelling effect on hydrated K + ions, as indicated by the distance of K + ions to catalyst surface, which can loosen the water layer to depress hydrogen evolution and accelerate nitrate conversion. Consequently, the optimized electrode loaded with electron-deficient Ru atomic layers can directly produce 0.26 M ammonia solution in pure nitrate solution in 6 h, providing a high yield (74.8 mg mg cat –1 h –1 ) and well-maintained the Faradaic efficiency for over 120 h under ampere-level reduction.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）