INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Tianwen Ma,Xiaojie Tan,Qingshan Zhao,Zhuangzhuang Wu,Fengliang Cao,Jingyan Liu,Xiaocui Wu,Hui Liu,Xiaobo Wang,Hui Ning,Mingbo Wu
In this study, we demonstrate noble metal-free Fe–N-codoped graphene nanoshells (Fe–N/GNS) derived from petroleum pitch as highly efficient and cost-effective catalysts for nitroaromatics reduction. By employing α-Fe2O3 nanoparticles simultaneously as both the hard template and the metal source, Fe–N/GNS can be facilely synthesized through the template-oriented method, followed by thermal annealing with urea for nitrogen doping. Owing to the high-dispersed synergetic Fe–N active sites as well as the hierarchical porous nanoshell structure, the Fe–N/GNS catalysts show remarkable catalytic performance and good tolerance for the reduction of nitroaromatics with NaBH4 aqueous solution. The optimized Fe–N/GNS-800 corresponds to pseudo-first-order kinetics for p-nitrophenol reduction at room temperature, with the rate constant (k) reaching 1.23 min–1. The reinforced structure also allows the catalyst to be readily recycled a dozen times without activity deterioration. This work may provide a new avenue to facilely fabricate cost-effective but powerful catalysts for nitroaromatics reduction and beyond.
研究领域:
材料科学
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催化化学
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环境化学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2022
·
IF 7.139
Weilin Zhong,Chao Wang,Bo Jiang,Suqing Peng,Hailun Zhao,Riyang Shu,Zhipeng Tian,Yanping Du,Ying Chen
Combining solar energy utilization and hydrogen production is an ideal model for renewable energy development. Especially the conversion of broad-spectrum solar energy into chemical energy of hydrogen and thermal energy can enrich solar energy storage methods. Herein, novel multifunctional Au/TiO 2 @n-octadecane microcapsules with core-shell structure were design and synthesized by wet chemical reduction and electrostatic adsorption self-assembly methods for photothermal hydrogen production and thermal storage . The results showed that microencapsulation of photothermal catalysts could provide an effective reaction area and excellent dispersion stability , where hydrogen production and light to hydrogen efficiency were increased in the 43% and 0.3% respectively, compared to the nanoparticle suspension system. Based on the recorded temperature variations caused by the photothermal effect, the calculated photothermal conversion efficiency and specific absorption rate of Au/TiO 2 @n-octadecane was 25.01% and 277% higher than that of Au/TiO 2 suspension. The proposed hydrogen production and thermal storage method via multifunctional microcapsules might shed some light on the study of improving full-spectrum energy conversion efficiency of solar energy.
研究领域:
材料科学
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能源科学
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纳米技术
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2021
·
IF 6.165
Yannan Du,Hongjun Zang,Yimo Feng,Kai Wang,Yaxin Lv,Zhipeng Liu
This paper briefs the emerging strategies for the designing of catalytic systems, which direct conversion of chitin biomass monomer N -acetyl- d -glucosamine (NAG) to 3-acetylamino-5-acetylfuran was studied systemically. Twelve catalysts were investigated, and pyrazine hydrochloride ([Pyz]Cl) ionic liquid exhibited the good performance-achieving 3A5AF with yields of 36.94% from NAG . Further adding boric acid and CaCl 2 , treating at 190 °C for 60 min, the conversion rate of NAG is 100%, and the yield of 3A5AF can be increased to 69.54% in DMA. Furthermore, functional group changes before and after the reaction have been characterized by FTIR, HPLC-MS and 13 C NMR were applied to monitor the reaction process with [Pyz]Cl as the catalyst. The reactive intermediate was clearly detected by these techniques. Accordingly, a possible reaction pathway was proposed. The results of this experiment provide a mild and efficient reaction route for the degradation of biomass, and enrich the theoretical research of quaternary amine catalysts in the conversion of biomass waste into high value-added chemicals.
研究领域:
生物化学
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催化化学
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2015
·Vol. 40
·期 2
·1454-1459
·
IF 3.086
Limei Zhou,Mengyun Yin,Xiaohui Jiang,Qiang Huang,Wencheng Lang
1,3-Diamino-graphene (NH2-G-NH2) materials were synthesized using a simple chemical method. The as-prepared materials were characterized using FT-IR, TG, XRD, XPS, and SEM measurements. The results revealed that a 1,3-diamino group was successfully grafted on graphene and could immobilize CuI by coordination interactions. The NH2-G-NH2 materials can be used as heterogeneous ligands for CuI-catalyzed C–N coupling reactions, and the desired products were obtained with good yields. The reaction system is much smoother at lower temperature compared with others previously reported. Additionally, the new method can easily realize the purification of products and recycling of catalysts.
研究领域:
材料科学
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有机化学
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催化化学
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Yani Liu,Xueao Wang,Zheng Li,Liping Chen,Xinyi Cai,Zhigang Sun,Wei Cheng,Xiangjie Luo,Hai-Liang Zhu,Yong Qian
Hydrogen sulfide (H2S), a critical gas signaling molecule, and N-acetyltransferase 2 (NAT2), a key enzyme in drug metabolism, are both known active biomarkers for liver function. However, the interactions and effects of H2S and NAT2 in living cells or lesion sites remain unknown due to the lack of imaging tools to achieve simultaneous detection of these two substances, making it challenging to implement real-time imaging and precise tracking. Herein, we report an activity-based two-photon fluorescent probe, TPSP-1, for the cascade detection of H2S and NAT2 in living liver cells. Continuous conversion from TPSP-1 to TPSP-3 was achieved in liver cells and tissues. Significantly, leveraging the outstanding optical properties of this two-photon fluorescent probe, TPSP-1, has been effectively used to identify pathological tissue samples directly from clinical liver cancer patients. This work provides us with this novel sensing and two-photon imaging probe, which can be used as a powerful tool to study the physiological functions of H2S and NAT2 and will help facilitate rapid and accurate diagnosis and therapeutic evaluation of hepatocellular carcinoma.
研究领域:
生物化学
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医学影像学
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肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
Catalysis Science & Technology
·
2022
·Vol. 12
·期 21
·6384-6397
·
IF 6.177
Zhi Zhu,Reeti Kumar,Liwen Luo,Sunita Varjani,Pengwei Huo,Jonathan Woon-Chung Wong,Jun Zhao
Photocatalytic degradation of pharmaceuticals in the aquatic environment is considered a promising strategy to address water pollution. In this study, a novel photocatalyst was constructed by decorating g-C3N4 (CN) with α-MoC1−x quantum dots (α-MoC1−x-QDs) through a facile calcination method. The catalyst showed enhanced tetracycline (TC) degradation performance under visible light. The unique Mo–N surface bonding states and quantum effect leading to superior TC degradation activity (89.1%) compared to pure CN (21.8%) were reported and revealed. More importantly, the mechanism for the significant enhancement of photocatalytic activity of the catalyst was investigated by DFT (density functional theory) calculations and photo-electrochemistry measurements. The results confirmed that the effect of α-MoC1−x-QDs on CN improved the light absorption capacity obviously, and the Mo–N surface bonding states accelerated the charge migration from CN to α-MoC1−x-QDs. Moreover, the TC degradation pathway, intermediates and photogenerated carrier transfer behaviors were also discussed in depth. This research provides a new strategy for the construction of noble-metal-free co-catalyst/semiconductor composite materials in the photocatalytic degradation of antibiotics.
研究领域:
环境科学
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材料科学
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化学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2017
·Vol. 22
·期 6
·970
·
IF 2.861
Ming-Xia Song,Song-Hui Li,Jiao-Yang Peng,Ting-Ting Guo,Wen-Hui Xu,Shao-Feng Xiong,Xian-Qing Deng
Due to the rapidly growing bacterial resistance to antibiotics and the scarcity of novel agents under development, bacterial infections are still a pressing global problem, making new types of antibacterial agents, which are effective both alone and in combination with traditional antibiotics, urgently needed. In this paper, seven series ofN-arylsulfonylindole analogs5–11bearing rhodanine moieties were synthesized, characterized, and evaluated for antibacterial activity. According to the in vitro antimicrobial results, half of the synthesized compounds showed potent inhibition against four Gram-positive bacteria, with MIC values in the range of 0.5–8 µg/mL. For multidrug-resistant strains, compounds6aand6cwere the most potent, with MIC values of 0.5 µg/mL, having comparable activity to gatifloxacin, moxiflocaxin and norfloxacin and being 128-fold more potent than oxacillin (MIC = 64 µg/mL) and 64-fold more active than penicillin (MIC = 32 µg/mL) againstStaphylococcus aureusATCC 43300.
研究领域:
药物化学
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微生物学
·
感染与免疫
✓ 已验证
DOI
高影响因子
Catalysts
·
2023
·Vol. 14
·期 1
·23
·
IF 3.9
Zi-Han Zhang,An-Qi Wang,Bao-Di Ma,Yi Xu
The effective synthesis ofN-benzyl cyclo-tertiary amines using imine reductase, key components in natural products and pharmaceutical synthesis, is a green approach. Traditional methods faced challenges with enzyme activity and selectivity. This study focused on enhancingMesorhizobiumimine reductase (MesIRED) for betterN-benzyl cyclo-tertiary amine production. Through alanine scanning and consensus mutation, 12 single-siteMesIRED mutants were identified from 23 candidates, showing improved conversion ofN-benzylpyrrolidine andN-benzylpiperidine. Notably, mutants from I177, V212, I213, and A241 significantly boosted conversions. The best-performing mutant forN-benzylpyrrolidine,MesIREDV212A/I213V(M1), increased conversion from 23.7% to 74.3%. ForN-benzylpiperidine,MesIREDV212A/I177A/A241I(M2) enhanced conversion from 22.8% to 66.8%. Tunnel analysis revealed M1 and M2 have more efficient tunnels for larger product movement compared to wild-typeMesIRED. Using recombinantE. colicoexpressingMesIRED and glucose dehydrogenase (GDH), high conversions were achieved: 75.1% forN-benzylpyrrolidine (M1) and 88.8% forN-benzylpiperidine (M2). A preparative experiment resulted in 86.2% conversion and 60.2% yield forN-benzylpiperidine. This research offers an efficient method for engineering IRED, significantly improving conversion and selectivity forN-benzyl cyclo-tertiary amines, aiding drug synthesis and providing insights into rational design of other enzymes.Keywords:imine reductase;N-benzyl cyclo-tertiary amines;alanine scanning;consensus mutation;whole-cell biocatalysis;coexpression
研究领域:
生物化学
·
酶工程
·
药物合成
✓ 已验证
DOI
高影响因子
TALANTA
·
2015
·
IF 3.545
Xiaohua Zhou,Xiaole Li,Aijuan Cao,Qiao Lijun,Ajuan Yu,Shusheng Zhang,Yangjie Wu
A new stationary phase for high-performance liquid chromatography was prepared by covalently bonding N-ferrocenyl(benzoyl)amino-acid esters (L 1 ) onto silica gel using 3-aminopropyltriethoxysilane as coupling reagent. The structure of new material was characterized by infrared spectroscopy , elemental analysis and thermogravimetric analysis . The chromatographic behavior of the phase was illustrated in reversed-phase (RP) and normal-phase (NP) modes using polycyclic aromatic hydrocarbons (PAHs), aromatics positional isomers, amines, 5-nitroimidazoles, organophosphorus pesticides and phenols as probes. Multiple mechanisms including hydrophobic, hydrogen bonding , π–π, dipole–dipole, charge-transfer and acid–base equilibrium interactions are involved. Thus, multi-interaction mechanisms and mixed-mode separation of the new phase can very likely guarantee its excellent chromatographic performance for the analysis of complex samples. The L 1 AminoSil column was successfully employed for the analysis of organophosphorus pesticides in vegetable.
研究领域:
分析化学
·
色谱技术
✓ 已验证
DOI
高影响因子
ChemPlusChem
·
2024
·
IF 3
Yong Wang,Xueying Lin,Xianyu Ying,Shan Hu,Hongjun Zhu
A facile C–H amination of quinazoline employing N-fluorobenzenesulfonimide (NFSI) as the amination source has been disclosed in the absence of any metal, oxidant or additive. The methodology shows a board range of quinazolines with different functional groups in moderate to good yields up to 87%. Furthermore, gram-scale reaction, desulfonylation to amine and synthesis of pharmaceutical intermediate were also investigated, which demonstrates potential applications in medicinal chemistry. A plausible amination mechanism is proposed via F+ transfer accompanied by the removal of one molecule of PhSO2F. DFT studies with experimental work suggest that the mechanism via F+ transfer is more favorable than the free radical one.
研究领域:
有机化学
·
药物化学
·
合成化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2020
·
IF 3.442
Dafeng Zhang,Changhua Su,Shujuan Yao,Hong Li,Xipeng Pu,Yanling Geng
BiPO 4 /BiOCl p-n heterojunction photocatalysts were successfully prepared by a facile in situ chemical transformation method with the aim of degrading rhodamine B under simulated sunlight. X-ray diffraction, field emission scanning electron microscopy , ultraviolet–visible diffuse reflectance spectroscopy , photoluminescence , and electrochemistry tests were used to characterized the structure, morphology, optical properties , and inhibited recombination of photoinduced charges. BiPO 4 /BiOCl composites exhibited significantly higher photocatalytic activity for the degradation of rhodamine B than pure BiOCl, and the apparent rate constant is 3.18 times higher than that of BiOCl. The significantly increased photocatalytic activity of the BiPO 4 /BiOCl composites can be ascribed to the formation of a p-n heterojunction , which can effectively boost the separation of photoinduced electron-hole pairs during the photocatalytic process. Additionally, the main active species were investigated and a plausible mechanism is proposed.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2022
·
IF 3.269
Xin Li,Taotao Zhan,Yongbo Zhang,Yuqi Su,Maogang He,Ying Zhang
As one of higher n -alkanes, n -dodecane is an important component of surrogate fuels for aviation kerosene, of which the accurate knowledge of its thermophysical properties is necessary for industrial application. The speed of sound in n -dodecane was measured by the Brillouin light scattering (BLS) in the vicinity of the critical point, of which the examined regions are T = (433.49 to 678.84) K along seven isobaric lines at p = (1.85, 2.0, 2.2, 4.0, 6.0, 8.0, and 10.0) MPa. The relative expanded uncertainty of BLS experimental system is estimated to be less than 1.2% with the confidence level of 95% (coverage factor, k = 2). Polynomial representations for the speed of sound in liquid n -dodecane was fitted by the experimental results, and the average absolute deviation and maximum absolute deviation are 0.70% and 1.96%, respectively. Moreover, the accuracy of the multiparameter equation of state proposed by Lemmon were assessed by the experimental speeds of sound in the whole investigated p - T region.
研究领域:
化学工程
·
物理化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）