RSC Advances
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2021
·Vol. 11
·期 9
·5044-5054
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IF 3.361
Botao Qu,Yahong Han,Juan Li,Qian Wang,Bingyu Zhao,Xiaoyang Peng,Ruiping Zhang
Photoacoustic (PA) imaging has emerged as a promising bio-imaging technique due to its non-invasive visualization of lesions at great penetration depths. Fluorescence (FL) imaging in the second near-infrared window (NIR-II, 1000–1700 nm) achieves a higher imaging resolution and lower background signals compared to NIR-I. However, the single imaging method possesses its own disadvantages. Thus, we have demonstrated ZIF-8–IR820–MnPc–HA nanoparticles (ZIMH NPs) that can achieve visualization and localization of tumors in mice models with the help of a dual-modality PA/NIR-II FL imaging performance. Meanwhile, these excellent nanoparticles also induce the efficient generation of singlet oxygen (1O2) upon 808 nm laser illumination, and display excellent photodynamic therapy efficacy in cells, further indicating their potential application for in vivo PDT. In ZIMH NPs, hyaluronic acid (HA) impressively acts as a “sponge”, enhancing the generation of 1O2 and facilitating the cellular therapeutic effects. We believe that ZIF-8–IR820–MnPc–HA NPs present a brand-new strategy for the exploration of efficient PDT photosensitizers with dual-modality imaging performance for use in various biomedical applications.
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MOLECULAR PHARMACEUTICS
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2020
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IF 4.321
Lipeng Zhu,Duyang Gao,Lisi Xie,Yunlu Dai,Qi Zhao
The limited tumor tissue penetration of many nanoparticles remains a formidable challenge to their therapeutic efficacy. Although several photonanomedicines have been applied to improve tumor penetration, the first near-infrared window mediated by the low optical tissue penetration depth severely limits their anticancer effectiveness. To achieve deep optical tissue and drug delivery penetration, a near-infrared second window (NIR-II)-excited and pH-responsive ultrasmall drug delivery nanoplatform was fabricated based on BSA-stabilized CuS nanoparticles (BSA@CuS NPs). The BSA@CuS NPs effectively encapsulated doxorubicin (DOX) via strong electrostatic interactions to form multifunctional nanoparticles (BSA@CuS@DOX NPs). The BSA@CuS@DOX NPs had an ultrasmall size, which allowed them to achieve deeper tumor penetration. They also displayed stronger NIR II absorbance-mediated deep optical tissue penetration than that of the NIR I window. Moreover, the multifunctional nanoplatform preferentially accumulated in tumor sites, induced tumor hyperthermia, and generated remarkably high ROS levels in tumor sites upon NIR-II laser (1064 nm) irradiation. More importantly, our strategy achieved excellent synergistic effects of chemotherapy and phototherapy (chemophototherapy) under the guidance of photothermal imaging. The developed nanoparticles also showed good biocompatibility and bioclearance properties. Therefore, our work demonstrated a facile strategy for fabricating a multifunctional nanoplatform that is a promising candidate for deep tumor penetration as an effective antitumor therapy.
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Materials Today Bio
·
2025
·
IF 10.2
Jiaqi Zhou,Hao Li,Hui Li,Jiayi Ding,Zhong Du,Jiabao Xiong,Hongyang Yao,Xueliang Zhang,Nuernisha Alifu,Biao Dong
Cyanine molecules with the second near-infrared (NIR-II) emission hold great potential for bioimaging owing to their great biocompatibility, but the scissor-like structure of these molecules poses a major bottleneck in obtaining efficient NIR-II fluorescence probes. Constructing J-aggregates represents a promising strategy for obtaining biomedical NIR-II emissive materials. However, achieving J-aggregates in cyanine dyes with large torsion angles between the heterocyclic rings poses a challenge. In this study, we introduced the guanidine of tumor molecular targeted peptide 1 (TMTP1) to increase steric hindrance of IR-783 and reduce the angle of IR-783 scissors. The near-coplanar structure of IR-783@peptide TMTP1 composite facilitates the formation of a novel J-aggregates (IR-783-LP-TMTP1) with super-stable effect for NIR-II in vivo dynamic vascular imaging and remarkable tumor targeting capbility. The stable emision wavelength and high spatial resolution of J-aggregates was demostrated for brain and ear vasculature bioimaging under 808 nm laser excitation. Additionally, J-aggregates exhibits robust tumor-targeting capability towards cervical tumors, indicating their potential in cervical cancer diagnosis. This work develops a molecular design strategy to construct bright NIR-II J-aggregates with super-stable and robust tumor-targeting properties and paving the way for improving bioimaging performance of similar molecules.
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ACS Applied Nano Materials
·
2025
·
IF 5.5
Yang Xuan,Zhou Su,Meng Guan,Yinan Zhao,Wenliang Zhang,Yating Gao,Xinyu Bian,Mingfan Zhang,Donghui Zhao,Shubiao Zhang
Subcellular targeted therapy has recently emerged as a significant approach in cancer treatment. Mitochondria, as crucial organelles that not only provide cellular energy but also play roles in cell differentiation, signal transmission, reactive oxygen species production, apoptosis, and calcium homeostasis, are considered potential targets for cancer therapy. Silver sulfide quantum dots (Ag2S QDs) have demonstrated exceptional capabilities in near-infrared fluorescence and photoacoustic imaging as well as photothermal treatment. Therefore, the development of Ag2S QDs with mitochondrial-targeting ability is of particular significance. Herein, we developed a simple method for synthesizing aqueous-phase Ag2S QDs using lipoic acid, an enzymatic substrate involved in cellular respiration, as a ligand and mitochondrial-targeting molecule. These Ag2S QDs, which exhibit excellent water solubility and biocompatibility, can be produced in a single step and act as a mitochondrial-targeted theranostics. By adsorbing doxorubicin (DOX), we successfully created multifunctional nanoprobes called Ag2S-DOX. In vitro and in vivo experiments demonstrated that Ag2S-DOX was suitable for fluorescence and photoacoustic dual-mode imaging as well as synergistic mitochondrial-targeted chemotherapy and photothermal treatment, offering a promising strategy for tumor therapy.
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Journal of Materials Chemistry C
·
2025
·
IF 5.1
Xuejiao Wang,Sihan Yang,Feng Jiang,Jiantong Wang,Changshuai Gong,Ji-Guang Li
Cr3+-activated near-infrared (NIR) phosphors are the most promising materials for commercialization. However, the emission of most Cr3+-activated phosphors is typically located in the NIR-I region and achieving luminescence towards the NIR-II region (>900 nm) via Cr3+ doping remains challenging. This study reports a novel Cr3+-activated NaBaScSi2O7 phosphor that exhibits broadband NIR emission centred at 974 nm with a full width at half maximum of 140 nm under 493 nm blue light excitation. The emission wavelength exceeds that of most Cr3+-activated NIR phosphors. The underlying mechanism for the encouraging phenomenon is attributed to the strong charge polarisation arising from the intrinsic local coordination environment of the Cr3+ ions, as confirmed by charge differential density (CDD) and the electron localization function (ELF) analyses. The photoluminescence properties of phosphors were systematically investigated, and the performance of the fabricated NIR pc-LED device was evaluated for night vision and non-invasive imaging. Notably, the NaBaScSi2O7 phosphor displayed a bright green colour with excellent colour properties and its potential as a stable green ceramic pigment was explored.
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Materials Today Bio
·
2025
·
IF 10.2
Jupei Zhang,Hangbin Xia,Xuerui Zhou,Zhaoxu Meng,Qishu Jin,Dongmin Chen,Xiaojuan Xia,Yiren Jiao,Jiang Chang,Zhihong Dong,Zhen Zeng,Hongshi Ma,Chen Yang
Breast reconstruction after mastectomy aims to restore breast appearance and function. Current scaffolds often fail to meet the complex clinical demands of post-mastectomy breast reconstruction, which include personalized shaping, prevention of tumor recurrence and metastasis, and promotion of adipose tissue regeneration. This study aims to address these challenges by combining a readily processable biopolymer, polycaprolactone (PCL), with a multifunctional bioactive ceramic, cobalt orthosilicate (Co 2 SiO 4 , CoSi) to form a multi-functional CoSi/PCL composite scaffold through 3D printing technology. The scaffold exhibits a controllable shape with designed macroporous architecture. Its photothermal performances are well presented in both near-infrared (NIR) I and NIR-II regions, enabling effective tumor ablation with minimal side effects. Additionally, the release of bioactive silicate and cobalt ions promotes adipogenesis and angiogenesis, thereby enhancing the integration of the scaffold with surrounding tissues. This approach offers a promising strategy for combining tumor therapy with breast reconstruction, providing a clinically relevant solution for post-mastectomy patients.
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TALANTA
·
2025
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IF 6.1
Min He,Yuzhen Ma,Lixian Huang,Yanni Luo,Jinzhe Liang,Shulin Zhao
Near-infrared II (NIR-II) photoacoustic (PA) imaging offers enhanced performance through reduced photon scattering, minimized background interference, and improved resolution at greater depths, thereby driving urgent demand for NIR-II PA nanoprobes in translational biomedicine. In this study, we developed a smart stannous sulfide@cuprous oxide (SnS@Cu 2 O) nanoprobe for colorectal cancer PA imaging within NIR-II window. Under the existence of HS − , the SnS@Cu 2 O nanoprobe exhibits a broad absorption peak within the 1000–1300 nm range, enabling concentration-dependent NIR-II PA signal amplification in colorectal cancer tissues with overexpression of endogenous H 2 S. The in vitro PA intensity was linearly correlated to HS − concentration in the range of 0–1.2 mM. Intratumoral injection of SnS@Cu 2 O nanoprobe (10 mg/kg) induced time-dependent PA signal amplification at the tumor site, exhibited rapid intensification, peaking at 4-h post-administration. Additionally, the SnS@Cu 2 O can catalyze the Cu + with H 2 O 2 in the tumor tissue yielding ·OH via Fenton-like reactions for photothermal-enhanced chemodynamic therapy, enabling NIR-II PA imaging-guided therapy against deep-tissue colorectal tumor. This paper reports on the synthesis and application of a smart SnS@Cu 2 O nanoprobe that was activated by colorectal tumor microenvironment.
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Small
·
2024
·
IF 13
Danping Wu,Xiaoyi Chen,Shijie Yao,Yichen He,Gongning Chen,Xiaojuan Hu,Yang Chen,Zhenye Lv,Jing Yu,Ketao Jin,Yu Cai,Xiaozhou Mou
Triple-negative breast cancer (TNBC) is a highly aggressive and uncommon subtype of breast cancer with a poor prognosis. It is crucial to prioritise the creation of a nanotherapeutic method that is highly selective and actively targeting TNBC. This study explores a new nanosystem, Cu 9 S 8 -SNAP@PM (C-S@P), composed of Cu 9 S 8 -SNAP coated with a platelet membrane (PM). The purpose of this nanosystem is to cure TNBC using multimodal therapy. The utilisation of PM-coated nanoparticles (NPs) enables active targeting, leading to the efficient accumulation of C-S@P within the tumour. The Cu 9 S 8 component within these NPs serves the potential to exert photothermal therapy (PTT) and chemodynamic therapy (CDT). Simultaneously, the S-Nitroso-N-Acetylvanicillamine (SNAP) component enables nitric oxide (NO) gas therapy (GT). Furthermore, when exposed to NIR-II laser light, Cu 9 S 8 not only increases the temperature of the tumour area for PTT, but also boosts CDT and stimulates the release of NO through thermal reactions to improve the effectiveness of GT. Both in vitro and in vivo experimental results validate that C-S@P exhibits minimal side effects and represents a multifunctional nano-drug targeted at tumors for efficient treatment. This approach promises significant potential for TNBC therapy and broader applications in oncology.
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Bioactive Materials
·
2025
·
IF 20.3
Guangyu Jian,Si Wang,Xinlu Wang,Qinyi Lu,Xingyu Zhu,Shucheng Wan,Shan Wang,Dize Li,Chao Wang,Qingqing He,Tao Chen,Jinlin Song
Background Osteosarcoma (OS) is a malignant tumor originating from primitive mesenchymal cells, characterized by rapid metastasis, high invasiveness, and significant mortality. The primary challenges in OS management include the effective elimination of residual tumor cells to prevent recurrence and the repair of extensive bone defects caused by surgical intervention. Objective This study aims to develop an innovative biomimetic 3D-printed bioactive glass ceramic (BGC) scaffold modified with two-dimensional nanosheets to address both tumor ablation and bone tissue repair. Materials and methods The nanosheets were constructed via ellagic acid (EA) and ruthenium (Ru) coordination, leveraging the non-topological adhesion properties of catechol in EA to deposit the nanosheets onto the BGC scaffold (EARu-BGC). The therapeutic effects of EARu-BGC were evaluated in vitro and in vivo . Results EARu-BGC sequentially responds to the local microenvironment during OS treatment. During the tumor ablation phase, EARu-BGC induced ferroptosis through the synergistic effects of photothermal and chemodynamic therapy, achieving over 90 % tumor cell ablation and significantly inhibiting tumor volume and weight. In the bone tissue repair phase, EARu-BGC exhibited adaptive ROS scavenging and facilitated a pro-healing microenvironment, promoting osteogenic differentiation. The gradual degradation of the BGC scaffold provided essential minerals and space for new bone formation. In vivo experiments demonstrated that EARu-BGC significantly enhanced osteogenesis, increasing the trabecular number to 1.51 ± 0.15/mm and reducing trabecular separation to 1.50 ± 0.04 mm. Conclusion The EARu-BGC scaffold presents a promising multifunctional platform for OS treatment by effectively balancing antitumor efficacy with bone repair capabilities.
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EUROPEAN POLYMER JOURNAL
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2025
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IF 6.3
Junqi Zhao,Zicheng Chen,Aijian Cao,Jiahao Huang,Suiping Deng,Jingxian Zhang,Langhuan Huang,Shaozao Tan
Bacterial infections pose a significant threat to the healing of human skin wounds, as the reactive oxygen species (ROS) they produce can significantly delay the wound healing process, ultimately leading to the formation of chronic wounds and even endangering human life. Therefore, this study successfully constructed a dynamically reversible hydrogel network through dual crosslinking of Schiff base bonds and hydrogen bonds using oxidized hyaluronic acid (OHA), carboxymethyl chitosan (CMCS), and tannic acid (TA). By loading Cu@PDA, the OCTC2 hydrogel wound dressing was prepared, exhibiting synergistic antibacterial and antioxidant properties through TA/Cu 2+ release and NIR-II photothermal effects. We used FTIR, XRD, SEM, and TEM to thoroughly analyse the specific composition and morphology of the Cu@PDA and hydrogel. We measured the injectability, adhesion, NIR-II photothermal, and antibacterial properties of each group of hydrogels. The results showed that TA and Cu@PDA endowed the hydrogel with excellent antioxidant properties, enabling effective scavenging of various free radicals. Additionally, OCTC2, which possesses sustained-release TA/Cu 2+ capability, achieves antibacterial rates of over 94 % against S. aureus and E. coli . Under the combined effect of NIR-II photothermal therapy, it can achieve highly efficient bacterial killing (99.8 %), effectively promoting the healing of bacterial infection wounds. OCTC2 holds promise as a potential ideal hydrogel dressing for treating bacterial-infected wounds.
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Advanced Science
·
2022
·Vol. 9
·期 16
·2200732
·
IF 17.521
Huiling Zhou,Dongsheng Tang,Xiaoxu Kang,Haitao Yuan,Yingjie Yu,Xiaolu Xiong,Nier Wu,Fangzhou Chen,Xing Wang,Haihua Xiao,Dongsheng Zhou
Photothermal therapy based on conjugated polymers represents a promising antibacterial strategy but still possesses notable limitations. Herein, degradable pseudo conjugated polymers (PCPs) containing photothermal molecular backbones and reactive oxygen species (ROS)-sensitive thioketal bonds are designed. Triphenylphosphine (PPh 3 ) is introduced into PCPs to generate phosphonium-based PCPs (pPCPs), which further assembled with hyaluronic acid into pPCP nanoparticles (pPCP-NPs). pPCP-NPs with quaternary phosphonium cations selectively anchor on and destroy bacterial cell membranes through electrostatic action. Under 1064 nm laser irradiation, pPCP-NPs (pPCP-NPs/+L) produce near-infrared-II (NIR-II) photothermal antibacterial effect, thereby killing bacteria in a sustained manner. pPCP-NPs are readily degraded upon ROS abundant at infection sites, therefore exhibiting enough biosafety. pPCP-NPs/+L display an almost 100% bacterial inhibition rate in vitro and resultin a nearly complete recovery of bacteria-induced mouse wounds. A further metabolomics analysis denotes that pPCP-NPs/+L work in a concerted way to induce bacterial DNA damage, inhibit bacterial carbon/nitrogen utilization and amino acid/nucleotide synthesis. Taken together, degradable pPCP-NPs with both NIR-II photothermal effect and cationic phosphonium structural bacteriostasis provide a new avenue for antibiotics-alternative anti-infection therapy.
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ACS Applied Electronic Materials
·
2025
·
IF 4.7
Xin Yan,Sijie Su,Zitao Chen,Yongchao Jia,Yajie Li,Enhai Song,Qinyuan Zhang
The development of highly efficient near-infrared-II (NIR-II) emission phosphors is crucial for advancing compact light sources and their emerging applications. However, the discovery of target phosphors remains a major challenge. Herein, a high-efficiency apatite phosphor, Ba10(PO4)6F2:Mn5+, peaking at 1171 nm with a full width at half-maximum of 11 nm, is synthesized under an oxygen atmosphere. Benefiting from the crystallographic site confinement and oxygen partial pressure control in stabilizing pentavalent manganese, the phosphor exhibits a record internal quantum efficiency (IQE) of 84.2% and external QE of 56%, alongside good thermal stability. By combining Ba10(PO4)6F2:Mn5+ with a red light-emitting diode (LED) chip, a phosphor-converted compact LED with an NIR-II output power of 40.86 mW at 300 mA and a high photoelectric conversion efficiency of 6.82% is presented, demonstrating applications in nondestructive testing, etc. Furthermore, the different temperature-dependent behaviors of the zero-phonon line emission (1171 nm) and vibrational sidebands (1224/1289 nm) of Mn5+ in Ba10(PO4)6F2:Mn5+ enable the fabrication of a high-efficiency fluorescence intensity ratio optical fiber temperature sensor, exhibiting a maximum relative sensitivity value of 0.518% K–1 at 373 K. This work offers some insights into Mn5+-activated high-efficiency NIR-II emission phosphors and their potential for temperature sensing and compact light source applications.
研究领域:
材料科学
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光学材料
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光子学
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固态照明
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温度传感
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发光材料
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