Advanced Healthcare Materials
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2025
·
IF 9.6
Zhou Wu,Li Chang,Changling Li,Pengxiang Xu,Liuying Liu,Aidi Tong,Yilong Li,Chunyi Tong,Bin Liu
Healing of infected chronic wounds faces dual challenges: persistent inflammation and impaired angiogenesis. To address these, SN-PB@PG nanocomplexes were prepared by hybridisation of nitroprusside (SNP) with Prussian blue (SN-PB NPs) and loaded with prodigiosin (PG). Under near-infrared (NIR) irradiation, SN-PB NPs generated mild hyperthermia, facilitating the release of nitric oxide (NO) and PG to combat bacterial biofilms and multidrug-resistant pathogens. The in vivo assay using diabetic infected wounds demonstrated that SN-PB@PG NPs with NIR reduced the wound area to 10.6% by the 11th day, which is superior to that of control group (29.6%). In the flap transplantation experiments, the data showed SN-PB@PG NPs with NIR group only have a necrobiosis of 3.8% of flaps on the 8th day, which is superior to 31.3% of the control group. Additionally, the release of NO promoted vascular regeneration by up-regulating vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule-1 (CD31), and regenerated sarcomeric tissue by down-regulating MMP-9. The results indicated that the combination of SN-PB@PG NPs with gas and photothermal therapy exerted a combined antibacterial and wound healing effect. Compared to traditional clinical methods such as surgical debridement and hyperbaric oxygen therapy, this new strategy efficiently addresses issues of infection and healing, which is convenient for clinical application.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xueling Liu,Yajing Wang,Xiaofen Wu,Yi Wang,Guozhi Fan,Yanjun Huang,Lei Zhang
In this study, magnetic DTPA-modified chitosan composite microspheres (MDCM) were prepared by reverse emulsion-double crosslinking method (carbodiimide followed by glutaraldehyde) for removal of Pb(II) from aqueous solution. The obtained magnetic adsorbents were characterized by FTIR, SEM, XRD, VSM, BET, and 13 C NMR. The effects of the pH, contact time, initial concentration, and competitive metal cations (Na(I), Ca(II), or Mg(II)) on Pb(II) adsorption were investigated. The results revealed that MDCM exhibited high removal performance over a wide pH range and in the presence of competitive metal cations. The maximum adsorption capacity of MDCM for Pb(II) is 214.63 mg g −1 at pH 3, which is higher than most recently reported magnetic adsorbents. Adsorption kinetics and isotherms can be described by the pseudo-second-order model and Langmuir model, respectively. In addition, MDCM is easy to regenerate and can be reused five cycles with high adsorption capacity. Finally, the adsorption mechanism was further revealed by FTIR and XPS analysis. Overall, MDCM has practical application potential in removing Pb(II) from contaminated wastewater due to its high adsorption efficiency, good reusability, and convenient magnetic separation.
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Journal of Building Engineering
·
2024
·
IF 6.7
Baomin Wang,Weigao Ding,Chengcheng Fan,Fei Liu,Wenxin Lu,Haoxiang Yang
C-S-H gel is a complex cementitious system, and the properties present significant difference with various Ca/Si ratios. The immobilization mechanism of three heavy metals in C-S-H gel at various Ca/Si ratios was investigated in this work from the prospect of the physical adsorption and chemical immobilization. Results showed that higher Ca/Si ratios can result in an increase in silicon chain polymerization, and lower BET specific area, and C-S-H gel with various Ca/Si ratios showed the excellent immobilization for heavy metals. Pb(II) and Zn(II) can form hydroxyl complex polyhedra in C-S-H under strongly alkaline environments, and increase the silicon chain polymerization degree similar to the doping of C-S-H gel by Al. However, Cd(II) was immobilized in the C-S-H gel with the formation of a solid solution under the action of ion exchange with Ca(II), rather than in the form of hydroxyl complex polyhedral and cadmium hydroxide coprecipitates. The highest adsorption capacity of Pb(II) was realized in C-S-H gel with a Ca/Si molar ratio of 0.9, reaching 95.6006 mg/g. Pb(II) was mainly immobilized in C-S-H gel via physical and chemical adsorption, and the effect of chemical adsorption tended to be significant as the Ca/Si molar ratio increased. And the formation of Pb 8 Ca(Si 2 O 7 ) 3 can be detected in C-S-H gel with a higher Ca/Si molar ratio.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2018
·
IF 4.005
Zhongbo Shang,LiWen Zhang,Xuyang Zhao,Shanhu Liu,Deliang Li
A low-cost mercapto-modified coal gangue (CG-SH) was fabricated by modification of coal gangue (CG) with (3-mercaptopropyl) trimethoxysilane. The structure and composition for as-prepared CG-SH were characterized by using X-ray diffraction (XRD), Fourier transfer infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray fluorescence (XRF). Results indicated that larger amounts of mercapto-groups (-SH) was successfully introduced onto CG, which followed by acted as active sites for the removal of heavy metal cations, such as Pb(II), Cd(II) and Hg(II). The factors that affected the adsorption equilibrium as well as the removal efficiency, i.e., contact time, initial concentration, pH and temperature, were investigated in detail. The adsorption isotherms for Pb(II), Cd(II) and Hg(II) were well fitted with Langmuir model. The maximum adsorption capacity of CG-SH for Pb(II), Cd(II) and Hg(II) were calculated to be 332.8, 110.4 and 179.2 mg g −1 , respectively. The adsorption for Pb(II), Cd(II) and Hg(II) on CG-SH could be well described by pseudo-second-order kinetic model . And thermodynamic analysis suggests that the adsorption process for Pb(II) is exothermal, while that for Cd(II) and Hg(II) are endothermal. The results suggest CG-SH have great potential to be used as efficient absorbent for the removal of heavy metal cations from water.
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NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Xin Chen,Yingjie Wan,Xiaobao Hou,Baofeng Wang,Fuqiang Huang
A green and sustainable strategy was proposed to efficiently convert polyvinyl chloride (PVC) waste into high-value porous carbon adsorbents for simultaneous waste plastic resourcing and heavy metal pollution control. The synthesis integrates solvothermal pretreatment with dimethylformamide (DMF), followed by KOH activation and heteroatom doping using thiourea as the N/S source. Solvothermal pretreatment increases carbon yield to 40 wt%. NS-PVC has a hierarchical pore structure with a high specific surface area of 1096.53 m2 g−1, moderate pore size distribution, and rich oxygen-containing, sulfur-containing, and nitrogen-containing functional groups, and comparative experiments confirmed that the doped N and S heteroatoms had a synergistic effect and promoted the adsorption performance, demonstrating exceptional removal efficiency (96%) for the high-concentration Pb(II) solution (1500 mg L−1), with a maximum adsorption capacity of 149.2 mg g−1. Through adsorption kinetics and isotherm studies, it was confirmed that the adsorption process of Pb(II) on NS-PVC was endothermic and consistent with the pseudo-second-order kinetic model and Langmuir models. By comparing the physicochemical properties of NS-PVC before and after the adsorption of Pb(II), it was confirmed that the adsorption of Pb(II) on NS-PVC was controlled by a combination of chemisorption and physisorption, including ion exchange, surface complexation, pore filling and electrostatic attraction.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2021
·
IF 6.291
Lin Bai,Rundong Liu,Ruike Wang,Yongjuan Xin,Zuntao Wu,Yue Ba,Huizhen Zhang,Xuemin Cheng,Guoyu Zhou,Hui Huang
This study examined the neuroprotective properties of resveratrol (Res) and its target sirtuin1 (SIRT1) against lead (Pb)-mediated toxicity and discovered that both resveratrol treatment and SIRT1 overexpression restored blocked autophagic flux as well as reduced β-amyloid (Aβ) contents. Four-week-old male C57BL/6 mice were employed to consumed 0.2% Pb(Ac) 2 solution or deionized water for 3 months followed by 12 months of Res (50 mg/kg BW) or vehicle gavage. In in vitro study, SH-SY5Y cells were pretreated with the SIRT1 activator SRT1720 (2 μM) or the inhibitor EX527 (2 μM) for 2 h, then 25 μM of Pb(Ac) 2 was added and incubated for 48 h. Western blotting, RT-qPCR, enzyme-linked immunosorbent assay (ELISA), and Lyso-Tracker Red Staining were next used to estimate the potential alterations of the autophagic pathway as well as BACE1-mediated amyloid processing in response to Pb exposure, respectively. Our data revealed that Res treatment or SIRT1 activation resisted the induction of autophagy by Pb exposure through inhibition of LC3 and Beclin-1 expression and promoted the degradation of Aβ and Tau phosphorylation. Besides, the SIRT1 activator (SRT1720) downregulated the expression of BACE1, the rate-limiting enzyme for Aβ production, by inhibiting the activation of nuclear factor-κB (NF-κB) in Pb-treated SH-SY5Y cells, which resulted in reduced Aβ production. Collectively, we verified the role of Res-SIRT1-autophagy as well as the SIRT1-NF-κB-BACE1 pathway in Pb-induced neuronal cell injury by in vivo or in vitro models. Our findings further elucidate the important role of SIRT1 and Res in counteracting Pb neurotoxicity, which may provide new interventions and targets for the subsequent treatment of neurodegenerative diseases.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Xinzhong Deng,Wanting Wang,Ying Jiang,Junping Li,Hai Liang
Defect-enriched magnesium oxide with a specific structure exhibits great potential for the effective removal of heavy metals from wastewater. However, its practical application is significantly hindered by the high cost and tedious manufacturing process due to the reliance on templates and auxiliary agents. Herein, defect-enriched coral-like magnesium oxide (DFC-MgO) was synthesized via a self-sacrificing/transitioning strategy without using templates or auxiliary agents. The defects and coral-like structure endow DFC-MgO with abundant active sites and high porosity. Benefiting from these structural advantages, the DFC-MgO achieves an ultra-high adsorption capacity of 2955.07 mg/g for Pb ions in wastewater. Notably, lead contaminants can be completely removed with an extremely low dosage of 0.1 g/L at a typical concentration of 50 mg/L. In addition, DFC-MgO maintained high Pb 2+ removal efficiency in real water samples and effectively adsorbed multiple divalent metal ions. Dynamic adsorption tests further demonstrated that the effluent Pb 2+ concentration remained below the national standard limit of 1 mg/L for a treated volume of 1600 mL. Kinetic analysis indicated that adsorption occurs via a combination of chemisorption on heterogeneous sites and physisorption, while equilibrium behavior was best described by a combined Sips and Toth model, reflecting complex adsorption mechanisms. Several possible mechanisms, including ion exchange, precipitation, and oxygen vacancies, are involved in the Pb 2+ adsorption process. A preliminary cost evaluation further indicates that DFC-MgO can be prepared at a relatively low material cost. This study provides a facile approach for designing MgO with special structures and defect features for efficient wastewater treatment.
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Materials Today Bio
·
2025
·
IF 10.2
Qiang Feng,Hui Zhang,Guixian Ye,Jialiang Zhang,Jianbin Xiao,Zhiyu Wang,Jinyu Zhang,Meiqi Pan,Jukai Feng,Yang Zhong,Zhongying Shi,Jianmin Wang,Jingfeng Liu
Photothermal therapy (PTT) is a promising tumor treatment with high selectivity, precise targeting, and low side effects. It induces photothermal ablation of tumors, and activates anti-tumor immune response by promoting immunogenic cell death (ICD) of tumor cells. Prussian Blue (PB) mediated PTT has made great progress, but high interstitial fluid pressure and solid stress in tumors significantly inhibited PB accumulation and diffusion, seriously affecting its PTT effect. Herein, we constructed a novel biohybrid system EcN@PB to enhance the PB-mediated photothermal immunotherapy. EcN@PB utilized the inherent tumor targeting ability of EcN to achieve precise delivery of PB to the tumor. On tumor-bearing mouse model, we demonstrated that EcN@PB selectively accumulated in tumors and achieved efficient photothermal ablation upon near-infrared laser irradiation, effectively inhibited the growth of primary tumor. Moreover, EcN@PB-mediated PTT induced ICD in tumor cells, promoted the maturation of dendritic cells, enhanced the infiltration of cytotoxic T lymphocytes and inhibited the recruitment of regulatory T cells in tumor tissues. Notably, EcN, as an immune adjuvant, effectively induced the polarization of tumor-associated macrophages towards the anti-tumor M1 phenotype, further reshaped the tumor immune microenvironment and activated systemic anti-tumor immune response. Therefore, EcN@PB-mediated photothermal-immunotherapy significantly inhibited the growth of distant tumors and prevented recurrence. Overall, EcN@PB significantly enhanced the targeted delivery of PB to tumor tissues and offered a promising strategy for photothermal-immunotherapy by leveraging the pathogen-associated molecular patterns carried by EcN to activate anti-tumor immune response.
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BRAIN RESEARCH BULLETIN
·
2022
·
IF 3.715
Lin Bai,Yingying Wu,Ruike Wang,Rundong Liu,Mengchen Liu,Qiong Li,Yue Ba,Huizhen Zhang,Guoyu Zhou,Fangfang Yu,Hui Huang
As a ubiquitous toxic heavy metal, lead (Pb) exposure is known to be implicated in the onset and development of neurodegenerative diseases which may cause more serious health hazards with age and the accumulation of Pb in the body. Autophagy is the main degradation route for abnormal aggregated proteins and damaged cell organelles. Here, we aimed to study the effects of adolescent Pb exposure on autophagy at different life nodes. In this study, we developed a time-series model of Pb exposure in mice and randomly divided 4-week-old male C57BL/6 mice into six groups (4 C, 13 C, 16 C, 4Pb, 13Pb and 16Pb). Mice in Pb groups was consumed deionized water containing 0.2 % Pb(Ac) 2 for 3 months and then reared to anticipated life nodes, while the control group consumed deionized water. Western blot and Real-time qPCR were used to assess the effects of developmental Pb exposure on individual components of the autophagy machinery and modulation of microtubule-associated protein 1 light chain 3 (LC3) at each age stage. Our results showed that Pb exposure during adolescence reduced the p-mTOR/mTOR ratios with enhanced expression of Beclin-1, Atg12 and Atg7in both the hippocampus (HPC) and prefrontal cortex (PFC) of senescent mice while upregulation of LC3II/LC3I ratios and p62 suggested that autophagy mediates degradation was interrupted. Overall, we confirm that Pb exposure during adolescence promotes autophagic processes in the aged mice brain and that autophagic degradation is hindered, ultimately leading to a failure of autophagic degradation.
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Analysis & Sensing
·
2026
·Vol. 6
·期 6
·e70134
·
IF 3.3
Xinzhu Wang,Jingjing Zhao,Jingyi Peng,Weiming Tian,Shubin Li,Xiaojun Han
High-precision and rapid screening of harmful heavy metal contaminants like cadmium and lead ions in water bodies plays an indispensable role in ecological supervision and human health maintenance. This study fabricates V 2 CT x doped screen-printed electrodes to realize concurrent electrochemical quantification of the two metallic ions in aquatic samples. The target V 2 CT x material was obtained through selective corrosion treatment on V 2 AlC raw material. Its surface structure and internal element dispersion state were analyzed with SEM and EDS characterization techniques. Under optimized experimental parameters, square wave anodic stripping voltammetry was adopted to carry out sample measurement. Independent testing yielded LOD of 1.01 μg/L for cadmium ions and 1.91 μg/L for lead ions, respectively. When the two ions were measured concurrently, the LOD reached 2.20 and 2.39 μg/L, respectively. The V 2 CT x /SPE possessed good anti-interference property, reusability, reproducibility, and favorable preservation stability. Real water sample recovery tests (mineral water and tap water) gave recoveries between 101% and 104%, confirming its practical applicability. The V 2 CT x /SPE holds great potential for on-site rapid detection of heavy metal ions owing to its disposability, low cost, and robust performance. Graphical This work constructs a V 2 CT x MXene-modified screen-printed electrode (SPE) for square wave anodic stripping voltammetry (SWASV) synchronous quantification of aqueous cadmium (II) (Cd 2+ ) and lead (II) (Pb 2+ ). After optimizing modifier doping ratio, deposition parameters and buffer pH, the fabricated V 2 CT x /SPE achieves favorable linearity (5–50 μg L −1 ) and low limits of detection (LOD).
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MOLECULES
·
2021
·Vol. 26
·期 11
·3180
·
IF 4.412
Yina Cai,Binxue Ren,Chifang Peng,Cunzheng Zhang,Xinlin Wei
New nanocomposites, Fe3O4@Au–FITC, were prepared and explored to develop a fluorescent detection of Pb2+. The Fe3O4@AuNPs–FITC nanocomposites could be etched by Pb2+in the presence of Na2S2O3, leading to fluorescence recovery of FITC quenched by Fe3O4@Au nanocomposites. With the increase of Pb2+concentration, the fluorescence recovery of Fe3O4@AuNPs–FITC increased gradually. Under optimized conditions, a detection limit of 5.2 nmol/L of Pb2+with a linear range of 0.02–2.0 µmol/L were obtained. The assay demonstrated negligible response to common metal ions. Recoveries of 98.2–106.4% were obtained when this fluorescent method was applied in detecting Pb2+spiked in a lake-water sample. The above results demonstrated the high potential of ion-induced nanomaterial etching in developing robust fluorescent assays.Keywords:gold nanoparticles;magnetic nanoparticles;FRET;nanomaterial etching;lead ions
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ANALYTICA CHIMICA ACTA
·
2019
·
IF 5.256
Junqi Cheng,Qing Li,Mingyue Zhao,Zheng Wang
A novel method for the determination of ultratrace Pb in seawater by solution-cathode glow discharge atomic emission spectrometry (SCGD-AES) coupled with hydride generation (HG) has been developed. In the SCGD process, the hollow Ti tube, which can introduce gas instead of a solid tungsten rod is used as a discharge anode and combined with hydride generator. HG technology can not only separate Pb from a seawater matrix and reduce the matrix interference on detection, but can also significantly improve the transfer and atomization efficiencies for SCGD-AES. The optimum working conditions for HG and SCGD-AES for quantitative analysis of Pb were determined as 1% H 2 C 2 O 4 as the masking agent and addition of 3% formic acid to increase Pb volatilization . The limit of detection (LOD) for Pb was decreased by two orders of magnitude in comparison to the SCGD-AES process alone. Under optimal conditions, the LOD for Pb was 0.17 μg L −1 , and the relative standard deviation was 2.1% ( n = 11) for 100 μg L −1 Pb in artificial seawater. The proposed quantification method was verified using a seawater reference material (BWQ7001-2016), and the obtained results agreed well with certified values. Finally, the approach was used to quantitatively analyse Pb in seawater, and the results agreed well with those obtained by inductively coupled plasma mass spectrometry . The recoveries of standard addition were between 96.0% and 103.0%.
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