INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2019
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IF 4.213
Jiaxin Liu,Shuang Li,Ge Li,Xiang Li,Changhui Yu,Zhijiang Fu,Xiangyu Li,Lesheng Teng,Youxin Li,Fengying Sun
Bevacizumab, a vascular endothelial growth factor (VEGF)-targeting drug, is widely used as an off-label therapeutic for age-related macular degeneration (AMD). To reduce the monthly administration frequency, this study investigated microspheres comprising a poly( d , l -lactide-co-glycolide)/poly(cyclohexane-1,4-diyl acetone dimethylene ketal) (PLGA/PCADK) blend that could be loaded with bevacizumab-dextran particles using solid-in-oil-in-water (S/O/W) emulsification. Control microspheres were also prepared through water-in-oil-in-water (W/O/W) emulsification. The structural stability of bevacizumab in the polymer monomers was analyzed using dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), size exclusion chromatography (SEC-HPLC), circular dichroism (CD) and fluorescence spectroscopy. Subsequently, microspheres were prepared and evaluated in terms of their morphology, encapsulation efficiency and release behavior. PLGA/PCADK microspheres prepared by the S/O/W method with <20% PCADK showed a smooth spherical structure with a uniform distribution of bevacizumab. The microspheres exhibited a release behavior comprising a slight initial burst and an increasing total release over 50 days both in vitro and in vivo . Additionally, the microspheres were well tolerated by ocular tissue. Finally, a chorioallantoic membrane (CAM) assay revealed that the bioactivity of bevacizumab was retained by PCADK. In conclusion, these results suggest the potential for bevacizumab-loaded PLGA/PCADK microspheres prepared by the S/O/W method as a means of intravitreal therapy for ocular diseases.
研究领域:
药物学
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眼科学
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药物递送系统
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DOI
PubMed
高影响因子
MATERIALS SCIENCE FORUM
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2019
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IF 0
Ke Jia Kang,Peng Fan,Jian Zhang,Qiang Guo Luo,Qiang Shen,Lian Meng Zhang
In this study, the W-Si-C multi-phase composites were fabricated by an arc melting method. With addition of SiC, the grain size of W is obviously reduced, and the small angle misorientation becomes dominate, which is beneficial for the improvement of deformability. The effects of SiC additions (from 0.5 to 3wt%) on the microstructure and mechanical properties are mainly investigated. With 1 wt% SiC addition, the flexural strength reaches the highest value. The self-generation of W5Si3 may enhance the strength and ductility, but too much W5Si3 exists as brittle BP (Brittle to Plastic) microstructure. The highest flexural strength is obtained at approximately 1 vol% W5Si3.
研究领域:
材料科学
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机械工程
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DOI
FOOD HYDROCOLLOIDS
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2021
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IF 9.147
Junmeng Lu,Xinglian Xu,Xue Zhao
In the current study, the interfacial rheological properties of alkali pH-shifted MP under pH 11.0 → 7.0, pH 11.5 → 7.0 and pH 12.0 → 7.0 have been firstly investigated. The molecular weight and microstructure of myofibrillar protein (MP) treated by alkali pH-shifting were investigated by gel-permeation chromatography (GPC) and transmission electron microscopy (TEM). Results indicated a swollen, organized and aggregated structure of refolded MP. Overall, the molecular change in refolded MP led to faster protein adsorption towards the O/W interface, enhanced intermolecular interaction between adsorbed proteins and improved elasticity of interfacial film compared to native MP. After β-mercaptoethanol (β-ME) was added, the advantage of refolded MP in diffusion phase no more existed due to the disruption of aggregation and decreased molecular size, besides the penetration and rearrangement were interfered because the disruption of disulfide bond inhibited the formation of interfacial protein layers. With the protein concentration increasing, MP molecules crowding at O/W (oil in water) surface limited the development of a highly elastic network. As revealed by Tween 20 displacement, MP layers with higher interfacial elasticity were more resistant to displacement. Moreover, after displacement the coalescence stability of emulsion droplet was enhanced but the mechanical strength of interfacial MP layer was reduced. Altogether MP (0.04 or 0.2 mg/mL) treated by pH 11.0 → 7.0 exhibited the best adsorption performance and interfacial properties, which were important in stablizing emulsions. Thus, interfacial behavior regulation by alkali pH-shifting may be a applicable process for developing meat protein-based emulsions in food industry.
研究领域:
食品科学
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蛋白质化学
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胶体科学
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DOI
高影响因子
Carbohydrate Polymer Technologies and Applications
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2021
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IF 0
Renliang Lyu,Zeqin Li,Cheng Liang,Cheng Zhang,Ting Xia,Ming Wu,Yi Wang,Lichun Wang,Xiaogang Luo,Caili Xu
In this work, due to its excellent adsorption performance, biodegradability, and low toxicity, chitosan was used as the raw material to synthesize a series of new oil-in-water (O/W) type crude oil demulsifiers. First, an acyl group was introduced onto the chitosan molecule. Then, sodium chloroacetate was used as a carboxymethylation reagent to introduce a carboxymethyl group into the acylated chitosan. Furthermore, polyethylene glycol monomethyl ether with an average molecular weight of 1900 (MPEG-1900) was used to react with acylated carboxymethyl chitosan to synthesize chitosan-based O/W type demulsifiers. The molecular structures of the synthetic chitosan derivatives were characterized using Fourier-transform infrared spectroscopy (FTIR) and 1 H nuclear magnetic resonance techniques. The results showed that the surface tension decreased with an increase in the concentration of polysaccharide demulsifiers, which included MPEG-1900-A 4 CMC, MPEG-1900-A 6 CMC, and MPEG-1900-A 8 CMC. The demulsification efficiency of these synthetic demulsifiers reached a maximum over 100 min at a concentration of 200 ppm at 50 °C. The as-synthesized chitosan derivatives showed good demulsification performance.
研究领域:
化学工程
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材料科学
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环境科学
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DOI
FUEL
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2026
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IF 7.8
Haoxuan Tan,Jianhao Jiao,Yun Zu,Qiang Li,Yucai Qin,Ye Yang,Kai He,Zhongxing Geng,Lijuan Song
Silica-supported tungsten oxides (WO x /SiO 2 ) as industrial catalysts are widely applied for the metathesis of ethylene and butylene to propylene, yet often suffer from limited dispersion and stability due to ill-defined interactions between tungsten species and surface silanols microenvironment of silica support. In this work, the type and density of specific surface silanols in silica were successfully tailored by precisely controlling thermal pretreatment temperature. Multiple advanced characterizations and theoretical calculations revealed that vicinal-silanol-rich surface microenvironments were strongly associated with the formation of highly dispersed and stable isolated dioxo W (VI) -O-Si structure, while effectively suppressing the formation of less-active W-O-W aggregates. Under the comparable conditions, the optimized WO x /SiO 2 ‑ 550 catalyst with rich W (VI) -O-Si sites delivered an enviable propylene yield of over 67.9% in the olefin metathesis with a lower deactivation rate (0.069 h −1 ), far outperforming conventional catalysts. Moreover, the catalyst demonstrated satisfactory long-term stability over 200 h on stream and partial activity recovery upon oxidative regeneration. Mechanistic studies further suggested that the dioxo W (VI) -O-Si structure enhanced the adsorption and activation of olefins and favored the formation of surface species consistent with literature-proposed metal‑carbene intermediates, thereby improving both catalytic activity and propylene selectivity. These findings provide a fundamental understanding and a practical strategy for the rational design of highly-dispersed and stable supported tungsten catalysts for olefin metathesis.
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DOI
高影响因子
WATER SCIENCE AND TECHNOLOGY
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2026
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IF 2.8
Wu Wei,Ma Xiaoqian,Wang Rui,Hao Mengqi
View large Download slide View large Download slide Close modal This paper delves into the impact of electrostatic interaction and wettability of MNPs on the efficiency of demulsifiers. Fe 3 O 4 magnetic nanocomposites (Fe 3 O 4 /HA/PDDA/OLA MNPs, S1–S5) were synthesized with varying wettability and zeta potential by adjusting the surface modification ratio of poly-dimethyl-diallyl-ammonium chloride (PDDA) and oleylamine (OLA). S1–S5 were then used to demulsify O/W (hexadecane) nanoemulsions. The oil/water separation efficiency (SE) initially increased (S1–S4) and then decreased (S4–S5) with their increasing water contact angles (WCA). S4 with a WCA about 90° exhibited the maximum SE, although S4 has a negative charge and shows electrostatic repulsion with oil droplets, indicating that the wettability of MNPs, rather than electrostatic interaction, played a dominant role in demulsification. Adsorption energy of S1–S5 at the water–oil interface aligned with the variation in their demulsification efficiency. Based on previous reports, a possible demulsification mechanism was proposed. Hydrogen bond and hydrophobic long chains present in PDDA and OLA increased the interfacial activity of S4, which facilitated the spontaneous migration of MNPs to the interface of oil and water. With oil droplet aggregation by magnetic recovery, a good oil–water separation performance was achieved. The study provides a theoretical foundation for the design and synthesis of magnetic demulsifiers. Wettability of MNPs plays a crucial role in demulsification performance. Surface charge of MNPs shows less function than wettability. MNPs with a WCA of approximately 90° showed the maximum demulsification efficiency. The study provides a theoretical foundation for the design and synthesis of magnetic demulsifiers.
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产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2026
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IF 4.6
Li Ding,Jiayu Lin,Zhiqiang Wang,Aixue Jia,Changwu Cai,Zhong Xie,Yongde Yan
The recovery of cerium via molten salt electrolysis with the liquid zinc (Zn) cathode is considered a highly promising strategy for rare earth resource recycling. To reveal the electrochemical reduction of cerium (Ce) ions and the alloy formation process on the Zn electrode, in this work, multiple electrochemical methods were adopted to study the electrode reactions and thermodynamic properties during the Ce deposition process at high temperatures. A concentration-dependent test of the co-deposition reaction indicated that the alloying behaviour of reduced Ce was affected by ion concentration. The electrochemical results showed that four Ce Zn alloys were formed in the electrode reaction. The Gibbs free energy of alloy formation was determined. Furthermore, in order to understand the reaction kinetics on the liquid electrode and the thermodynamic behaviour of the reduced Ce in the electrode, the exchange current density and activity coefficient during electrodeposition were determined by Tafel analysis and coulometric titration, respectively. The temperature dependence of both exchange current density and activity coefficient was further revealed
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产品关联
DOI
高影响因子
Tungsten
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2026
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IF 9
Li Zhi-Bo,Sun Guo-Dong,Liu Jia-Heng,Zhu Wen-Tan,Zhang Wei,Chang Guo,Guo Long-Fei,Hong Zheng-Kai,Zhang Yong,Han Yong,Ye Nan,Tang Jian-Cheng,Sun Wen-Wen,Huo Wang-Tu,Chou Kuo-Chih
Tungsten heavy alloys (WHAs) designed via ductile-phase toughening strategies show promise in overcoming the intrinsic brittleness of W, enabling broad applications. However, as application scenarios demand increasingly stringent properties, achieving strength–ductility synergy has become an urgent challenge. In the present work, novel fine-grained (92- x )W–4.9Ni–2.1Fe– x Sn–1Y 2 O 3 ( x = 0, 0.125 wt.%, 0.25wt.%, 0.5wt.%, 1 wt.%) composites were developed through microalloying with low-melting-point Sn and the incorporation of Y 2 O 3 second-phase particles. Significant grain refinement of W grains was achieved in the composite, accompanied by the formation of Sn-rich and Sn-depleted regions in the binder phase through spinodal decomposition. Moreover, Y 2 O 3 particles are uniformly dispersed within the grains and along grain boundaries. The sample with 0.25 wt.% Sn exhibited an optimal combination of tensile strength (1077 MPa) and elongation (30.1%). The exceptional properties arise from synergistic mechanisms: the addition of Sn significantly lowers the liquid-phase sintering temperature, dropping from ~ 1500 to 1300 ℃, while Y 2 O 3 particles exert a pinning effect, promoting rapid densification and pronounced refinement of W grains (only 6.56 ± 0.31 μm). In addition, spinodal decomposition creates a rugged chemical landscape, coupled with abundant interfaces from Y 2 O 3 particles, establishing high heterogeneous deformation-induced stresses. The long-range internal stresses enhance twin activation and dislocation interactions in the binder phase, significantly improving strain-hardening capacity. Meanwhile, enhanced interfacial load transfer promotes obvious plastic deformation in W grains via the formation of incidental dislocation boundaries and geometrically necessary boundaries. These findings open new avenues for a deeper understanding of the deformation behavior of biphasic composites, rendering this material design strategy a promising approach for achieving strength–ductility synergy across various alloy systems. Graphical abstract The alternative text for this image may have been generated using AI.
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Ming Li,Jingsi Sun,Liang Guo,Ruofei Jia,Shanshan Huang,Shanping Li
W-modified blue TiO 2 nanotube anodes enhanced FPF oxidation and mineralization. • Intermittent current operation lowered energy input and mitigated activity decay. • Quenching and EPR analyses identified •OH as the dominant oxidizing species. • Transformation pathways and predicted toxicity evolution were evaluated. This study developed W-modified blue TiO 2 nanotube arrays (W-modified B-TiO 2 NTA) as an energy-efficient anode for electrochemical oxidation of flupyradifurone (FPF), with boron-doped diamond (BDD) used as a benchmark. W modification and cathodic reduction retained the anatase nanotubular structure, increased double-layer capacitance, and facilitated interfacial charge transfer. Compared with B-TiO 2 NTA, W-modified B-TiO 2 NTA accelerated FPF degradation, enhanced mineralization, and reduced energy consumption, with an apparent rate constant of 1.77 × 10 −2 min −1 , compared with 1.97 × 10 −2 min −1 for BDD under the tested conditions. The 50 s on/10 s off intermittent current mode further lowered energy input and mitigated activity decay during cycling. Quenching and EPR analyses showed that •OH dominated FPF oxidation, with a possible contribution from sulfate-derived radicals. HRMS-based tentative product assignment and DFT calculations suggested hydroxylation, oxidative C N cleavage, butenolide ring opening, dealkylation, and further oxidation as plausible transformation routes. Toxicity prediction indicated an overall decline in predicted residual toxicity after prolonged electrolysis. Download: Download high-res image (172KB) Download: Download full-size image
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
·
IF 9.7
Ze Liu,Yadong Hu,Chengkai Li,Zhenyu Zhang,Tingzhe Shen,Danni Zeng,Rongfeng Guan,Changjian Zhou,Pengyu Dong
Photocatalysis technology can degrade organic pollutants in wastewater, improving the ecological environment and protecting biodiversity. The BiVO 4 stable chemical properties of BiVO 4 make it a robust candidate for photochemical applications. Moreover, its broad light absorption spectrum and optimal band structure further enhance its potential, driving widespread research interest. The introduction of the eco-friendly biperovskite Cs 2 AgBiBr 6 enhanced BiVO 4 ′s surface area and visible light absorbance. Simultaneously, the doping process introduces impurities that modify charge transfer pathways, thereby enhancing the separation efficiency of photogenerated electron-hole pairs. When contrasted with pure BiVO 4 , the W-BiVO 4 /Cs 2 AgBiBr 6 composite demonstrates superior surface area characteristics and exhibits stronger absorption within the visible light spectrum. Within 40 min after exposure to visible light, the efficiency of W-BiVO 4 /Cs 2 AgBiBr 6 photocatalyst to degrade ofloxacin (OFX) and meloxicam (MEL) was 93.15 % and 92.70 %, respectively. Based on the toxicity analyses and antimicrobial assays simulated by the software, no highly toxic substances were found in the degradation intermediate products of OFX and MEL. The catalysts’ energy band structure and photoelectrochemical properties showed that W-BiVO 4 /Cs 2 AgBiBr 6 followed the S-scheme heterojunction charge transfer mechanism. By integrating BiVO 4 with other semiconductors in the form of S-scheme heterojunctions, this study explores a strategy that may effectively improve photocatalytic efficiency, particularly in pollutant degradation applications.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
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2025
·
IF 6.9
Xuesong Peng,Fan Meng,Jie Jiang,Yaqiang Li,Guangzhao Wang,Ruopeng Li,Jialuo Lin,Longhao Zhu,Linghui Meng,Zongtai Wang,Maozhong An
Ultra-thin copper foil is critical for high-density interconnects and flexible electronics, yet developing a reliable release layer remains challenging. Here, we report an amorphous Ni–W alloy release layer and systematically evaluate its performance through experimental characterization and theoretical analysis. The Ni–W alloy (59.9 % Ni, 40.1 % W) forms a smooth, defect-free surface with an average roughness of 0.9 μm. In 50-cycle peel tests, the average peel strength stabilizes at 0.038 N/mm with a standard deviation of only 0.003, demonstrating highly controllable and stable cyclic peel behavior. The release layer maintains thermal stability below 600 °C, and atomic diffusion of Ni and W at 200 °C over 50 h has negligible impact on the copper foil conductivity. Theoretical calculations indicate that the Cu/Ni–W interface exhibits lattice mismatch, leading to weak adhesion (W a d = 1.45 J/m 2 ); in contrast, a co-deposited Ni-enriched transition layer achieves coherent lattice matching, significantly enhancing Ni–W/Cu interfacial strength and enabling differential control of interface bonding. This study represents the first scalable electro-deposition of an amorphous alloy release layer, providing precise control over peel strength and robust industrial applicability for ultra-thin copper foil production.
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产品关联
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2025
·
IF 3.4
Chonghui Niu,Mingjie Dan,Yi Yu,Xiurong Zhu,Yixin Fu,Yeqing Wang,Wang Zhao,Kenneth R. Poeppelmeier
In this study, a series of novel Eu3+-activated NaLu(MoO4)2 (NLMO) red phosphors were synthesized for the first time using hydrothermal, sol–gel, and microemulsion methods with varying active agents. The properties of these phosphors, including phase purity, crystal structure, DFT calculations, morphology, luminescence characteristics, thermal stability, and internal quantum efficiency, were comprehensively characterized. The results indicate that the ethylenediaminetetraacetic acid disodium salt (EDTA-2Na)-assisted hydrothermal method is the most suitable approach for the preparation of the phosphor. This method yields phosphors with a regular morphology, outstanding luminescence performance, relatively good thermal stability, and significantly high internal quantum efficiency. The internal quantum efficiency reaches 96.45%, and the phosphor exhibits good thermal stability, with the emission intensity at 423 K remaining about 73% compared to the initial temperature. The CIE chromaticity coordinate of the NLMO/0.13Eu3+ sample (0.667, 0.333) is very close to the standard chromaticity coordinate value (0.670, 0.330) from the National Television Standards Committee (NTSC). Remarkably, the color purity of the NLMO:0.13Eu3+ phosphor is an impressive 97%. Furthermore, Tb3+ was cointroduced in the NLMO:0.13Eu3+ phosphor, and its positive effects are discussed. Ultimately, a warm white light-emitting diode (W-LED) was fabricated using the studied NLMO:0.13Eu3+ phosphor with a 394 nm near-ultraviolet-emitting LED chip as the excitation source. The W-LED exhibits excellent properties such as high color purity, excellent correlation color temperature, and high color rendering index. Considering all of the results, the NLMO/Eu3+ red phosphor obtained by the EDTA-2Na-assisted hydrothermal method is an ideal red component for W-LEDs in various lighting applications.
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）