INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Ya-Qing Zhou,Xudong Deng,Zi-Xu Zhao,Xue-Ting Wang,Xiao-Qian Jin,Jun-Bin Xiong,Liang-Liang Chen,Wei-Hong Guo,Ren-Bin Zhou,Da-Chuan Yin
Developing chitosan-based hemostatic cryogels with simultaneously excellent mechanical properties and good biocompatibilities is still a challenge yet crucial for hemostasis of deep tissue bleeding. Typical approaches to enhancing the mechanical properties sacrifice biocompatibility of chitosan cryogels, thereby increasing the potential application risk. In this study, we develop a chitosan-sericin-ε-polylysine (CS-Ser-EPL) cryogel with synergistically reinforced networks achieved by physical and chemical crosslinking to address the limitations. The chitosan-sericin (CS-Ser) cryogel exhibits enhanced mechanical properties, improved thermal stability, erythrocyte aggregation capability, biocompatibilities and superior hemostatic performance. The addition of ε-polylysine further improves composite cryogel antibacterial activity, accelerating the wound healing process. In tests using a liver penetrating injury model, CS-Ser-EPL outperformed commercial gelatin sponges in hemostasis. Additionally, it exhibits faster wound healing in full-thickness skin defects exposed to S. aureus due to its antibacterial and angiogenic properties. Overall, the CS-Ser-EPL cryogel, with its enhanced mechanical and antibacterial properties, shows great promise for deep tissue hemostasis and wound healing.
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BIOMASS & BIOENERGY
·
2026
·
IF 7
Linlin Li,Jiang Zhao,Qingmei Ge,Yin-Hui Huang,Hang Cong,Wenfeng Zhao
Converting CO 2 into value-added chemicals using sustainable, biomass-derived catalytic systems is a key strategy for carbon mitigation and resource utilization. In this study, a heterogeneous biomass-derived zwitterionic polymer was fabricated from chitosan for CO 2 cycloaddition and N-methylation reactions. The synthesized porous bio-based polymer exhibits a robust structure and exceptional CO 2 adsorption capacity, leading to high catalytic efficiency. Under mild conditions, this catalyst achieved yields of up to 95% for 8 cyclic carbonates and 99% for 10 N-methylamines. Furthermore, the chitosan-based polymer demonstrates remarkable stability, maintaining its activity over at least 6 reuse cycles without significant degradation. Mechanistic studies indicate that the inherent –NH 2 or –OH groups on chitosan facilitate CO 2 and epoxide activation, while the zwitterionic structure provides active sites for ring-opening and cyclization processes.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.5
Na Wang,Hanyu Ren,Tongtong Li,Chunhui Luo
Designing hydrogels with antibacterial, antifouling, lubricating, wet-adhesive, and highly mechanical properties is crucial for articular cartilage replacement. However, achieving such a combination remains a big challenge. To tackle this issue, a PCG matrix with a compressive strength of 42 MPa was prepared from polyvinyl alcohol, grape seed protein and chitosan via the multiple linkages (crystalline domains, hydrogen bonds, and ionic interactions). Next, the introduction of sulfobetaine methacrylate in the top layer endowed the hydrogel antifouling and lubricating performances. Subsequently, ciprofloxacin (CIP) was encapsulated via the self-assembly of soybean lecithin (SL) in water using the thin-film hydration method, followed by soaking the pre-hydrogel into the aqueous dispersion. Compared with PCG hydrogel, the antibacterial effects on E. coli and S. aureus were increased by 2250% and 1700% respectively. Meanwhile, the SPA gel achieved antibacterial rate of ~100% against both types of bacteria. In addition, the hydrophilic phosphatidylcholine groups of SL formed a boundary lubrication layer, reducing the coefficient of friction to 0.018. Finally, a gelatin-tannic acid adhesive layer was coated on the bottom to obtain the resultant SPA gel. The amino acids and polyphenol groups endowed the hydrogel with robust wet adhesion. Owing to the biocompatible materials and green process, the obtained SPA hydrogel had a cell viability of 96.7%, indicating excellent cytocompatibility. This biomimetic design successfully replicated the structures and performances of articular cartilages, making it promising for cartilage replacements.
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International Journal of Minerals Metallurgy and Materials
·
2024
·Vol. 31
·期 11
·2518-2527
·
IF 5.6
Chen Wencan,Li Chao,Tao Yehan,Lu Jie,Du Jian,Wang Haisong
Although biopolymers have been widely utilized as triboelectric materials for the construction of self-powered sensing systems, the annihilation of triboelectric charges at high temperatures restricts the output signals and sensitivity of the assembled sensors. Herein, a novel chitosan/montmorillonite/lignin (CML) composite film was designed and employed as a tribopositive layer in the assembly of a self-powered sensing system for use under hot conditions (25–70°C). The dense contact surface resulting from the strong intermolecular interaction between biopolymers and nanofillers restrained the volatilization of induced electrons. The optimized CML-TENG delivered the highest open-circuit voltage ( V oc ) of 262 V and maximum instantaneous output power of 429 mW/m 2 . Pristine CH-TENG retained only 39% of its initial V oc at 70°C, whereas the optimized CM 5 L 3 -TENG retained 66% of its initial V oc . Our work provides a new strategy for suppressing the annihilation of triboelectric charges at high temperatures, thus boosting the development of self-powered sensing devices for application under hot conditions.
研究领域:
材料科学
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生物医学工程
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CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Dedai Lu,Hongsen Wang,Xiangya Wang,Yunfei Li,Hongyun Guo,Shaobo Sun,Xiaolong Zhao,Zhiwang Yang,Ziqiang Lei
Inspired by the mussel foot protein and chitosan-based macromolecular adhesives, a series of chitosan- graft -polypeptides were synthesized by ring-opening polymerization of three N -carboxyanhydrides (NCAs) - 3,4-dihydroxyphenylalanine- N -carboxyanhydride (DOPA-NCA), cysteine-NCA (Cys-NCA) and arginine-NCA (Arg-NCA) - using partial-NH 2 -protected chitosan as an initiator. These copolymers demonstrated good biodegradability and low cytotoxicity. The results of lap-shear adhesion test showed that the maximum lap-shear adhesion strength on the porcine skin and aluminum sheet were 195.97 ± 21.1 kPa and 3080 ± 320 kPa, respectively, and the maximum tensile adhesion strength on bone was 642.70 ± 61.1 kPa. The rat experiment in vivo showed that these copolymers exhibited good hemostatic performance and can promote the healing of skin wound and bone fracture. It is expected that thesecopolymeric adhesives will have broad applications in hemostasis and soft tissue adhesions.
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RSC Advances
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2015
·Vol. 5
·期 62
·50523-50531
·
IF 3.84
Honghui Zhang,Xiaoxing Lv,Xinping Zhang,Hongjun Wang,Hongbing Deng,Yuejun Li,Xiaoli Xu,Rong Huang,Xueyong Li
This study reports the preparation and properties of a chitosan (CS)–organic rectorite (OREC)/sodium alginate (SA) composite sponge. The novel sponge was fabricated by solution intercalation and chemical cross-linking techniques. The structure and composition of the CS/SA and CS–OREC/SA composite sponges were characterized by FE-SEM, FT-IR, XRD and EDX. The results showed that the polyelectrolyte with a highly cross-linked structure and uniform pore distribution could be obtained by mixing CS and SA with or without the addition of OREC into them. Besides, the low cytotoxicity and excellent antibacterial efficacy of the prepared CS/SA and CS–OREC/SA sponges were demonstrated by an MTT assay and an antibacterial assay. Moreover, the results of the hemostatic tests on ear-artery, ear-vein and liver injuries of rabbits showed that the addition of OREC into the CS/SA composite sponge significantly improved the hemostatic efficiency of the as-prepared sponge without compromising the biocompatibility and antibacterial property of CS. This study indicated that the CS–OREC/SA composite sponge had the potential to be a potent hemostat for controlling wound infection and bleeding in medical fields.
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MATERIALS LETTERS
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2017
·
IF 2.572
Meng He,Xinjiang Zhang,Wei Yao,Chengshuang Wang,Lei Shi,Panghu Zhou
Novel alternate layered chitosan/alginate composite hydrogels (CACH) were fabricated successfully by a multi-step alternate interrupted gelation process. The structure and properties of the hydrogels were characterized. The results indicated that the shape, size and layer thickness could be controlled by changing the gel core shape, chitosan/alginate concentration and soaking time. The CACH exhibited good architectural stability. Endothelial cells could adhere and proliferate on the layer surface, showing great potential as cell culture carriers and matrix for the control release of molecules due to the distinct physical barriers. This work opens up a new avenue for the construction of other polymer based alternate layered hydrogels.
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Journal of Materials Chemistry A
·
2015
·Vol. 3
·期 29
·15235-15240
·
IF 7.443
Yilei Chen,Naiqiang Liu,Hongyuan Shao,Weikun Wang,Mengyao Gao,Chengming Li,Hao Zhang,Anbang Wang,Yaqin Huang
Chitosan with abundant hydroxyl and amine groups as an additive for cathodes and separators has been proven to be an effective polysulfide trapping agent in lithium–sulfur batteries. Compared with common sulfur cathodes, the cathode with chitosan shows an enhanced initial discharge capacity from 950 to 1145 mA h g−1 at C/10. The reversible specific capacity after 100 cycles increases from 508 mA h g−1 to 680 mA h g−1 and 473 to 646 mA h g−1 at rates of C/2 and 1 C, respectively. In addition, batteries with separators that are coated with a carbon/chitosan layer can exhibit a high discharge capacity of 830 mA h g−1 at C/2 after 100 cycles and 675 mA h g−1 at 1 C after 200 cycles with the capacity fading to as low as 0.11% per cycle. This study demonstrates the benefits of using chitosan for not only lithium–sulfur batteries but also potentially other sulfur-based battery applications.
研究领域:
材料科学
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储能
·
电化学
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电池技术
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Desalination and Water Treatment
·
2024
·
IF 1
Weili Wang,Yangyang Du,Mingyu Liu,Mengmeng Yang,Runping Han
Chitosan (CS) modified multi-walled carbon nanotubes (MWCNTs) were used as adsorbents (CS-MWCNTs) to adsorb Congo red (CR, anionic dye) from solution in batch mode. The structure and morphology of CS-MWCNTs were characterized by TEM, FTIR, Raman and XPS. The results from analysis of FTIR and XPS showed that CS was successfully loaded onto the MWCNTs. Raman analysis showed that the basic structure of MWCNTs after CS modification did not change. Adsorption studies were performed at different pH, coexisted ions concentrations, contact time and CR concentrations in the batch mode. Results showed that the pH of CR solution at 4.0 was best for the adsorption and the adsorption capacity could reach up to 623 mg-g -1 at 303K. The adsorption of the CR solution reached equilibrium within 8 h. Adsorption equilibrium data can be predicted by the Freundlich model while the kinetic adsorption data follow a pseudo-second-order model. Thermodynamic results showed that the adsorption process was spontaneous, and endothermic. The CR-loaded adsorbent can be regenerated using a 0.01 mol-L -1 NaOH solution, the regeneration rate can still reach 71% after three cycles. CS-MWCNTs may be available in removal of anionic dyes from solution.
研究领域:
环境科学
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材料科学
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化学工程
·
水处理
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Fire-Switzerland
·
2026
·Vol. 9
·期 7
·272
·
IF 3.2
Mei Zhao,Guoqiang Dong,Xu Lu,Yajie Zhao,Jingjing Gao,Xinxin Wei,Chenhui Xu,Yu Liu,Lianqiang Li,Yachao Wang
A novel material, chitosan oligosaccharide@melamine polyphosphate (CMP), with enhanced flame-retardant and hydrophobic properties, was synthesized by cross-linking melamine polyphosphate (MPP) with chitosan oligosaccharide. Compared with MPP, the CMP overcomes its inherent drawbacks when used as a flame retardant in polylactic acid (PLA) composites, namely the high loading demand and unsatisfactory interfacial compatibility with the polymer matrix. The results demonstrated that the peak heat release rate (p-HRR) dropped significantly in comparison to pure PLA, from 304.69 kW·m−2to 210.39 kW·m−2, while the fire performance index (FPI) increased from 0.1 to 0.48 s·m−2·kW−1. Furthermore, the fire growth index (FGI) decreased from 1.51 kW·m−2·s−1to 1.03 kW·m−2·s−1. Additionally, the CMP demonstrated enhanced thermal stability, making the pyrolysis activation energy Eαincrease from 135.04 to 191.97 kJ/mol during 308~416 °C by pyrolysis kinetics. Compared to composite PLA incorporating pristine MPP, the CMP-modified counterpart exhibits superior mechanical properties and significantly enhanced hydrophobicity, evidenced by a maximum water contact angle reaching 93.96°. It provides a strategy for adapting phosphorus-based flame retardants for PLA, thereby broadening their applicability across diverse scenarios.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Jialin Liu,Dongzi Zhou,Zitong Wang,Fangli Sun,Haicun Yang,Junfeng Cheng,Dong Wang,Dun Wu,Cheng Zhang,Chunlin Liu,Louis C. P. M. de Smet,Zheng Cao
Sn nanoparticle–carbonized (Sn@C) nanofibers via electrospinning + calcination • Sn@C + chitosan (CS) ⇒ CS/Sn@C layers by spin coating • Layer tested for humidity sensing by quartz crystal microbalance (QCM) • High repeatability and reversibility; low humidity hysteresis • Combining structural integrity (Sn@C) + water adsorption sites (CS) SnCl₂·2H₂O was introduced into polyacrylonitrile (PAN) nanofibers through a simple electrospinning method, and composite Sn nanoparticle–carbonized (Sn@C) nanofibers were prepared by two-stage calcination. After dispersing different amounts of composite nanofibers in a 2.5 wt% chitosan (CS) solution via ultrasonication, a series of CS/Sn@C composite humidity-sensitive layers were spin-coated on quartz crystal microbalance (QCM) sensor surfaces. The morphology, structure, and composition of Sn@C nanofibers were analyzed by SEM, TEM, XPS, and BET. The diameter of Sn@C nanofibers was decreased from 180 nm to 95 nm upon decreasing the PAN content from 90% to 60%. The presence of metallic Sn nanoparticles, formed on the surface of Sn@C nanofibers, resulted in an increase in specific surface area from 5.1 m²·g⁻¹ to 106.5 m²·g⁻¹. Using an electrospinning solution with PAN:SnCl₂·2H₂O (8:2 w/w) and a Sn@C dispersion (0.05 mg/mL) in 2.5 wt% CS solution, a QCM sensor with a fitting correlation coefficient of 0.9998 was fabricated. The sensor parameters were optimized through QCM testing under varying conditions. The sensor demonstrated fast response/recovery times: <1.2 s (response)/50 s (recovery) in 11–33% RH and 67 s/37 s in 11–98% RH. Additionally, the CS/Sn@C-modified QCM sensor exhibited high repeatability, reversibility, and low humidity hysteresis. Download: Download high-res image (169KB) Download: Download full-size image
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BIOMACROMOLECULES
·
2026
·
IF 5.9
Shaohua Xiong,Chaoxing Chen,Zikang Yang,Xiaoyan Wang,Hongli Zhang,Bowen Huang,Qiong Wu,Genxi Yu,Tian Gao,Hao Xu,Huan Xu
Hydrogel dressings offer a promising treatment option for the bacterial infection of skin wounds. In this work, we developed multifunctional hydrogels by incorporating carbon nanotubes and protocatechualdehyde into a thiolated chitosan network via multiple interactions. The hydrogels exhibited tunable adhesion (2.7–3.1 kPa), on-demand detachment, as well as restorable antioxidant activity, approximately 80% of its original level. They demonstrated electrical conductivity, in the range of 0.009–0.027 S/m, and maintained stability for nearly 400 s under pressing cycles, suitable for monitoring physiological signals. They demonstrated potent mild photothermal antibacterial capability under near-infrared (NIR) light, with the temperature increasing to 48 ± 0.85 °C and the antibacterial rate up to 99.9%. In an infected mouse wound model, the hydrogels with NIR irradiation achieved ∼ 99.9% wound closure by day 9, outperforming a commercial antibiotic ointment. This work presents a comprehensive strategy for integrated biomass-based wound management systems, combining advanced therapy with smart bioelectronic sensing.
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