CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Ding Qu,Mengying Jiao,Haijiao Lin,Chunli Tian,Guowei Qu,Jingwei Xue,Lingjing Xue,Caoyun Ju,Can Zhang
Controlled release and tumor-selective distribution are highly desirable for anticancer nanomedicines. Here, we design and synthesize an anisamide-conjugated N -octyl- N,O -maleoyl- O -phosphoryl chitosan (a-OMPC) which can form amphiphilic micelles featuring pH-responsive release and high affinity to sigma-1 receptor-overexpressed tumors for paclitaxel (PTX) delivery. Thereinto, maleoyl and phosphoryl groups cooperatively contribute to pH-responsive drug release due to a conversion from hydrophile to hydrophobe in the acidic microenvironment of endo/lysosomes. We demonstrated that PTX-loaded a-OMPC micelles (PTX-aM) enhanced the cellular internalization via the affinity between anisamide and sigma-1 receptor, rapidly released drug in endo/lysosomes and elevated the cytotoxicity against PC-3 cells. The in vivo studies further verified that PTX-aM could largely accumulate at the tumor site even after 24 h of administration, resulting in obvious inhibition effect and prolonged survival period in PC-3 tumor xenograft-bearing mice. Moreover, OMPC showed no obvious hemolytic and acute toxicity. Collectively, this chitosan derivate holds a promising potential in application of prostate cancer-targeted drug delivery system.
研究领域:
药剂学
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2014
·
IF 4.058
Nantong Zhang,Xuan Yang,Xinyao Yu,Yong Jia,Jin Wang,Lingtao Kong,Zhen Jin,Bai Sun,Tao Luo,Jinhuai Liu
In this study, adsorption potential of a typical aluminum-based metal–organic frameworks (MOFs), Al 12 O(OH) 18 (H 2 O) 3 (Al 2 (OH) 4 )(BTC) 6 ·24H 2 O (referred as MIL-96), was investigated for defluoridation of drinking water using batch experiment. The effects of different parameters such as pH, contact time, initial fluoride concentration, and competing anions were studied to understand the adsorption behavior of the adsorbent under various conditions. Optimum removal of fluoride ions occurred in a pH range of 3–10. The results indicated that the defluoridation efficiency and aluminum residual of MIL-96 were far superior to that of activated alumina (AA) or nano-alumina (NA). The Langmuir equilibrium model was found to be suitable for describing the fluoride sorption on MIL-96. The maximum fluoride uptake capacity for MIL-96 was calculated to be 31.69 mg g −1 at the temperature of 298 K. Moreover, there were no significant influence on fluoride removal by MIL-96 in the presence of chloride, nitrate, sulfate, bicarbonate and phosphate. Temperature study was carried out at 298 K, 308 K and 318 K revealed that the adsorption process was endothermic reactions. In column tests using real groundwater as influent, about 140 bed volumes (BVs) of groundwater were treated before breakthrough was reached under space velocities (SVs) of 4 h −1 . Results from this study demonstrated the MIL-96 is a promising adsorbent that can be potentially used into drinking water processes.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
Advanced Materials Interfaces
·
2025
·
IF 4.4
Lei Sun,Fei Ye,WenHui Zhu,Wenrui Tan,Leixin Xiang,Yang Liu,Shiming Zhang
Macroemulsions are thermodynamically unstable and prone to phase separation. Traditional stabilization methods using surfactants to reduce interfacial tension are limited due to the physical barrier's instability—thermal motion can cause surfactant desorption, leading to interface collapse and phase separation. Strengthening this physical barrier is therefore crucial for extending the lifespan of macroemulsions. This manuscript presents an innovative stabilization method for macroemulsions, utilizing homogeneous phase Schiff base polymerization at the oil-water interface. The Schiff base reaction between polyethyleneimine (PEI), which accumulates at the interface, and glutaraldehyde (GA) to form a robust interfacial film is exploited. This simple method prevents the phase separation of oil-in-water high internal phase emulsions (HIPEs) for over 110 days. More importantly, the acid degradation of the interfacial film, together with the protonation state of polyethyleneimine under varying pH conditions, offers a stability programmable emulsion system that leads to pH-responsive emulsions, HIPEs, and capsules.
研究领域:
材料科学
·
化学工程
·
界面化学
✓ 已验证
产品关联
DOI
高影响因子
Precision Chemistry
·
2025
·
IF 6.2
Er-Fei Zhen,Bing-Yu Liu,Meng-Ke Zhang,Lu−Lu Zhang,Chen-Yu Zhang,Jun Cai,Marko M. Melander,Jun Huang,Yan-Xia Chen
Understanding how the electrolyte pH affects electrocatalytic activity is a topic of crucial importance in a large variety of systems. However, unraveling the origin of the pH effects is complicated often by the fact that both the reaction driving forces and reactant concentrations in the electric double layer (EDL) change simultaneously with the pH value. Herein, we employ the hydrogen evolution reaction (HER) at Au(111)-aqueous solution interfaces as a model system to disentangle different pH-dependent factors. In 0.1 M NaOH, the HER current density at Au(111) in the potential range of −0.4 V < ERHE < 0 V is up to 60 times smaller than that in 0.1 M HClO4. A reaction model with proper consideration of the local reaction conditions within the EDL is developed. After correcting for the EDL effects, the rate constant for HER is only weakly pH-dependent. Our analysis unambiguously reveals that the observed pH effects are mainly due to the pH-dependent reorganization free energy, which depends on the electrostatic potential and the local reaction conditions within the EDL. Possible origins of the pH and temperature dependence of the activation energy and the electron transfer coefficients are discussed. This work suggests that factors influencing the intrinsic pH-dependent kinetics are easier to understand after proper corrections of EDL effects.
研究领域:
电化学
·
催化
·
物理化学
·
表面科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Min Li,Yinan Zhao,Jiao Sun,Huiying Chen,Zhanbiao Liu,Kexin Lin,Pengfei Ma,Wenjun Zhang,Yuhong Zhen,Shufen Zhang,Shubiao Zhang
Polymer-based prodrug nanocarriers with tumor-targeting and controlled-release properties are in great demand for enhanced cancer treatment. Hyaluronic acid (HA), which has excellent biocompatibility and targeting ability for cluster determinant 44 (CD44), has been proposed for delivering drugs that have poor solubility and high toxicity. Herein, podophyllotoxin (PPT) was conjugated to HA via ester and disulfide linkages to construct a pH- and reduction-responsive prodrug (HA-S-S-PPT). The micelles self-assembled from HA-S-S-PPT prodrug efficiently accumulated at tumor site due to HA receptor-mediated endocytosis . HA-S-S-PPT micelles exhibited 33.1% higher cumulative release than HA-NH-CO-PPT micelles (sensitive only to pH) owing to their dual responsiveness to pH and reduction. HA-S-S-PPT micelles achieved excellent antitumor activity in vivo , with the tumor inhibition rate reaching 92%, significantly higher than that of HA-NH-CO-PPT micelles (65%), and negligible systemic toxicity. This controllable-targeting nanoparticle system provides a potential platform for clinical application of PPT.
研究领域:
药物学
·
癌症研究
·
纳米技术
·
药物递送系统
✓ 已验证
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2021
·Vol. 21
·期 6
·2100055
·
IF 4.979
Peihong Li,Yanlong Sui,Xueyan Dai,Qiangsheng Fang,Haofei Sima,Chunling Zhang
Dynamic hydrogels constructed with dynamic chemical bonds often have mechanical strength and self-healing properties. In this paper, tannic acid is combined with lysine-containing F127 through Schiff base. A series of FLaT hydrogels cross-linked by hydrogen bonds and dynamic chemical bonds is prepared, and the influence of Schiff base amount on the performance is discussed. The FLaT hydrogel exhibits reversible sol–gel transition, self-healing, injectability, and pH sensitivity. Increasing the amount of Schiff base can improve the strength, stability, and self-healing ability of the hydrogel. Owing to their low cytotoxicity, linear release pattern, and pH-controlled release rate, the FLaT hydrogels show potential use in drug delivery systems for cancer treatment.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Wang Zhiheng,Dai Yimin,Fang Chengqian,Chen Ling,Lu Qi,Li Yaqi,Cai Ling,Liu Bo,Zhang Yue-Fei,Li Yan,Wan Li
Smart oil-water separation materials with stimuli-responsive wettability surfaces have attracted wide attention. In this paper, a novel, simple and low-cost method is developed to prepare a pH-responsive melamine sponge (MS) with switchable wettability . This approach involves the hydrophobic modification of hexadecyltrimethoxysilane (HDTMS) on the MS surface modified by polydopamine (PDA) and the Michael addition reaction and Schiff base reaction between 12-aminododecanoic acid (NH 2 (CH 2 ) 11 COOH) and PDA. Hydrophobic/oleophilic HDTMS and pH-triggered NH 2 (CH 2 ) 11 COOH enable the functionalized sponge to repeatedly switch between the two extreme wettability under different pH environments. Benefiting from the excellent 3D porous surface structure and smart wettability, the as-prepared sponge can be applied in the on-demand separation of various oil-water mixtures by adsorption or filtration with a separation efficiency over 98.5% and high absorption capacity of 72.7–161.3 g·g −1 . With the assistance of pump-driven, continuous adsorption separation can be achieved in two cases by utilizing the wettability transformation. Moreover, in an alkaline solution, the sponge can quickly release most of the absorbed oil, showing a controllable desorption process. This smart wettability material with simple preparation and green has application potential in controllable oil-water separation and on-demand oil-spills treatment.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Anqi Yang,Yan Huang,Songbao Fu,Haodong Zhang,Sailing He
A high-precision pH monitoring system over a wide pH range is introduced. The system comprises a cavity-enhancement module constructed by two high-reflectivity mirrors, a microfluidic pH sensing chip based on a binary-indicator membrane of Congo red and m-cresol purple, and a hyperspectral transmission module. This structure extends the effective absorption optical path of the sensing chip, significantly amplifying the spectral differences at various pH values. The spectrum of the transmitted light is recorded by a self-developed hyperspectral module and then converted to broadband cavity-enhanced absorption spectrum (BBCEAS) via the Beer-Lambert law. An artificial neural network (ANN) is employed to predict pH values of the solution. With such a design, this system exhibits a wide detecting range of 2 M [H + ] − 2 M [OH – ] (corresponding to pH −0.3–14.3) with a response time of about 120 s. The system can achieve a higher detection accuracy with root mean square error (RMSE) of 0.073, as compared to 0.137 without the cavity enhancement. The system also possesses good properties of repeatability, long-term stability, ion resistance, and organic corrosion resistance. These excellent properties make the proposed system a promising candidate technology for harsh environments, such as seawater acidification warning, chemical plant sewage monitoring, and biological sample detection.
研究领域:
分析化学
·
环境科学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 48
·42589-42595
·
IF 3.289
W. Li,X. N. Tan,T. Luo,X. Huang,Q. Wang,Y. J. Yang,M. J. Wang,L. F. Liu
A novel polyethylene oxide (PEO) nanofibrous membrane, which contains chitosan (CS)/sodium alginate (SA) or CS nanocapsules formed by vesicles as a template, has been designed as a pH-responsive drug-delivery system and fabricated via an electrospinning process. Three different vesicle systems, including didodecyldimethylammonium bromide (DDAB), cetyl trimethyl ammonium bromide (CTAB)/sodium dodecyl benzene sulfonate (SDBS) (7/3) and CTAB/SDBS (3/7), were employed as the templates to construct the nanocapsules and 5-fluoro-2,4(1H,3H)pyrimidinedione (5-Fu) was selected as the model drug to be loaded within the drug delivery system. Structural characterization of the composites was obtained by means of zeta potential and a digital microscope image. The pH-responsive behaviors of the nanocapsules made from three different surfactant systems were detected by fluorescence spectroscopy. Drug release from the electrospun nanofibers with nanocapsules made from these different systems was investigated by a UV-visible spectrophotometer. The result showed that these different drug-delivery systems exhibit different release rates and pH-responsive behaviors. They can be good candidates for anticancer therapy in the organism, especially in wound healing dressing used after surgical procedures to improve the therapeutic value and reduce the local toxicity of medicinal drugs in clinical practice.
研究领域:
生物医学工程
·
药剂学
✓ 已验证
DOI
高影响因子
Journal of Physical Chemistry C
·
2011
·
IF 4.524
Li Yuan,Qianqian Tang,Dong Yang,Jin Zhong Zhang,Fayong Zhang,Jianhua Hu
Poly(acrylic acid) grafted mesoporous silica nanoparticles (PAA-MSNs) were prepared by a facile graft-onto strategy, i.e., the amidation between PAA homopolymer and amino group functionalized MSNs. The resultant PAA-MSNs were uniform spherical nanoparticles with a mean diameter of approximately 150 nm, and the graft amount of PAA evaluated by thermogravimetric analysis (TGA) was about 12 wt %. Due to the covalent graft of hydrophilic and pH-responsive PAA, the PAA-MSNs could be well dispersed in aqueous solution, which is favorable to be utilized as drug carriers to construct a pH-responsive controlled drug delivery system. N2 adsorption–desorption isotherm results demonstrated that doxorubicin hydrochloride (DOX), a well-known anticancer drug, could be effectively loaded into the channels of PAA-MSNs through the electrostatic interaction. The loading content and the entrapment efficiency of DOX could reach up to 48% and 95%, respectively. The drug release rate of DOX@PAA-MSN was pH dependent and increased with the decrease of pH. The in vitro cytotoxicity test indicated that PAA-MSNs were highly biocompatible and suitable to use as drug carriers. The drug-loaded DOX@PAA-MSNs were distinctly cytotoxic to HeLa cells, due to the sustained release of drug, and showed higher clinical effects than free DOX. These results imply that the PAA-MSNs are promising platforms to construct pH-responsive controlled drug delivery systems for cancer therapy.
研究领域:
纳米医学
·
肿瘤学
·
药剂学
·
生物材料
·
分子药理学
·
转化医学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2019
·Vol. 11
·期 10
·1362-1368
·
IF 1.158
Liu Mengna,Wu Jun,Wang Kaili,Yuan Dehao,Wang Yinan,Cheng Haoran,Zhao Feng,Fan Huaying,Xu Hui,Chen Daquan
In this paper, for the sake of improving the bioavailability and tumor targeting ability of curcumin (cur), we reported a nanoplatform self-assembled from Folic acid-Adipic dihydrazide-oligomeric hyaluronic acid (FA-ADH-oHA) as drug carrier, curcumin and β-elemene as loaded
model drug for dual targeting to breast cancer cells. We used pH sensitive Folic acid-Adipic dihydrazide (FA-ADH) as hydrophobic moieties, HA as the target of cancer stem cells CD44 receptor. The structure characteristic of this smart multifunctional dual targeting nano-sized carrier was measured
by 1H-NMR. Cur, an anticancer drug, was successfully loaded into FA-ADH-oHA micelles by self-assembly with a hydrodynamic diameter of 216.4 ± 0.5 nm. Triggered by faintly acidic tumor microenvironment, more encapsulated curcumin and β-elemene could be released
from the FA-ADH-oHA micelles in tumor environment than in the pH 7.3 environment. To sum up, the novel polymeric carrier based on pH sensitive and dual drug-targeting strategies was a prospective delivery platform to enhance therapeutic efficiency and decrease toxic side effect in breast cancer
therapy.
研究领域:
药学
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2022
·Vol. 13
·期 19
·2791-2802
·
IF 5.364
Rang Chen,Xue Jiang,Guolin Lu,Wenbin Liu,Weize Jin,Guojian Tian,Xiaoyu Huang
Graft copolymers have extensive applications in material science because of the tunable nature of their backbones and side chains and the diverse morphologies of their aggregates. Recent studies have mainly focused on amphiphilic graft copolymers containing hydrophobic backbones and hydrophilic side chains. To the best of our knowledge, no studies have reported amphiphilic graft copolymers bearing pyridine-containing hydrophilic backbones. Based on the design of functional monomers, a new trifunctional acrylate monomer, PyMCIBMA, was prepared in two steps via a Morita–Baylis–Hillman reaction, followed by reaction with 2-chloroisobutyryl chloride. Reversible addition–fragmentation chain transfer (RAFT) polymerization of PyMCIBMA monomer was performed to generate a well-defined poly(PyMCIBMA) homopolymer possessing a Cl-containing ATRP initiating group in each repeat unit. Next, a series of well-defined double hydrophilic graft copolymers bearing densely distributed poly(N-isopropyl acrylamide) (PNIPAM) side chains along the backbone on every unit, PPyMA-g-PNIPAM, was synthesized via atom transfer radical polymerization (ATRP) initiated by poly(PyMCIBMA) homopolymer. The resulting graft copolymers exhibited intriguing dual temperature- and pH-sensitive behavior, signifying their potential applications in controlled delivery as polymer–drug nanocarrier.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）