JOURNAL OF POLYMER RESEARCH
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2014
·Vol. 21
·期 12
·1-8
·
IF 1.897
Sun F. M.,Xu W. F.,Chen M. S.,Zhang F. A.
A series of polymerized high internal phase emulsions (polyHIPEs) with different cavities and windows (named PSD) were used as microreactors. Then methyl methacrylate (MMA) was polymerized in the spaces of the polyHIPE by reverse atom transfer radical polymerization (RATRP). The resulting materials and PMMA in the polyHIPEs were characterized by scanning electron microscopy, gel permeation chromatography, Fourier transform infrared spectroscopy, thermogravimetry, hydrogen nuclear magnetic resonance and differential scanning calorimetry. The results suggest that the monomer MMA is polymerized in the PSDs by RATRP. The confinement effect of the different cavities and pores is obvious but it weakens with the increase of the pore size. Compared with the conventional PMMA by RATRP, the number-average molecular weight and temperature of the initial decomposition of the PMMA obtained from PSDs is significantly high, which suggests that the confined space in the PSDs plays an active role in RATRP.
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Nanoscale
·
2015
·Vol. 7
·期 25
·11048-11054
·
IF 7.394
Jintao Kong,Wei Zheng,Yongsheng Liu,Renfu Li,En Ma,Haomiao Zhu,Xueyuan Chen
Persistent luminescence phosphors, which are capable of emitting light for a long time after ceasing excitation, have shown great promise in diverse areas as bioprobes, lighting and displays. Exploring new materials to realize efficient persistent luminescence is a goal of general concern. Herein, we report a novel persistent luminescence phosphor based on Eu3+-doped SnO2 nanoparticles (NPs). The afterglow decay behaviour, the trap depth distribution as well as the underlying mechanism for persistent luminescence of the NPs were comprehensively surveyed by means of thermoluminescence and temperature-dependent afterglow decay measurements. It was found that the thermal activation mechanism is responsible for the afterglow decay of the NPs with an inverse power-law exponent of 1.0 (or 1.7) in the temperature region below (or above) 220 K. In particular, the co-existence of uniform and exponential distributions in trap depths may result in such a unique afterglow decay behaviour. These results reveal the great potential of SnO2 NPs as an excellent host material for Eu3+ doping for the generation of efficient persistent luminescence.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2013
·
IF 1.977
Renping Cao,Kaniyarakkal N. Sharafudeen,Jianrong Qiu
Red-emitting SrMgAl x O 17±δ : y Mn 4+ composite phosphors ( x = 10–100; y = 0.05–4.0 mol%) are synthesized by solid-state reaction method in air. Addition of Al 2 O 3 leads to the formation of two concomitant phases, i.e., SrMgAl 10 O 17 and Al 2 O 3 phases in the composite phosphor. Red emission from Mn 4+ ions in the composite phosphors is greatly enhanced due to multiple scattering and absorption of excitation light between SrMgAl 10 O 17 and Al 2 O 3 phases. SrMgAl x O 17±δ : y Mn 4+ composite phosphors would be a promising candidate as red phosphor in the application of a 397 nm near UV-based W-LED.
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APPLIED CLAY SCIENCE
·
2016
·
IF 2.586
Jiang Guancheng,Qi Yourong,An Yuxiu,Huang Xianbin,Ren Yanjun
In this paper, the inhibition property of polyethyleneimine (PEI) in drilling fluid was studied. The inhibition property was evaluated by linear swell test and roll recovery. The addition of PEI 70000 resulted in the lowest swelling height, compared with the others inhibitor. Especially PEI was environmental and friendly. The inhibition mechanism was investigated by Fourier transform infrared spectroscopy , X-ray diffraction, X-ray photoelectron spectroscopy, Scanning electron microscopy, Zeta potential and Surface area analyzer. The negative charge in the surface of montmorillonite (Mt) was neutralized by the positive charge of PEI. PEI was adsorbed in the surface of Mt and intercalated into the interlayer of Mt, which reduced the hydration repulsion of diffuse electric double layer and leaded to inhibit the hydration of clay. Hydrogen bonding between amino groups in PEI and hydroxyl in the surface of Mt can be formed in the process. The coordination of electrostatic interaction and hydrogen bonding presented water molecules from the interlayer space of Mt, which resulted from the adsorption and intercalation of PEI in the surface and interlayer space of Mt. There was an amount of nitrogen in the backbone and side of PEI, leading to more positive ion than chitosan quaternary ammonium salt (HTCC). The more positive ion resulted in the stronger force between inhibitor and clay due to the protonation of nitrogen in water. The molecular weight of PEI has great influence on inhibition property. The larger molecular weight of PEI performed the better inhibition property except for PEI 1800 . Indicating the molecular weight of PEI was not the sole factor to control the inhibition property. What was more, the larger molecular weight of PEI leaded to the worse water-solubility.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2016
·
IF 1.835
Peipei Zhu,Yanxin Chen,Yanan Zhou,Yan Xiao,Jinbo Ouyang,Xin Huang,Gaohong He,Baohong Hou,Wei Chen
In this work, solubility data of 1,3-dimethylurea (DMU) in methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, 1-heptanol, and 1-octanol were measured by synthetic method from T = 288.15 to 328.15 K at ordinary pressure. It turned out that the solubility data increased as temperature and solvent polarity increased. The molecular interactions in solution have been studied by the linear energy relationship. Furthermore, based on two thermodynamic models (i.e., modified Apelblat and Wilson), the experimental results were fitted and analyzed. Finally, the thermodynamic properties of solution, including entropy, enthalpy, and Gibbs energy were calculated. These results indicate that in all selected solvents the dissolution behavior were endothermic, entropy-driven, and not spontaneous.
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CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
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2017
·Vol. 43
·期 2
·626-635
·
IF 5.104
Zhang Yan-Yan,Yi Minhan,Huang Yong-Pan
Background/Aims: Doxorubicin-induced cardiac toxicity has been a major concern of oncologists and is considered the main restriction on its clinical application. Oxymatrine has shown potent anti-cancer, anti-fibrosis, and anti-oxidative effects. Recently, it has been reported that oxymatrine is protective against some cardiovascular diseases. In this study, we aimed to investigate the effects of oxymatrine on doxorubicin-induced cardiotoxicity in rat hearts and H9c2 cells. Methods: Creatine Kinase - MB (CK-MB) and Lactate Dehydrogenase (LDH) levels were determined using commercial kits. Biochemical indices reflecting oxidative stress, such as catalase (CAT), malonyldialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were also analyzed with commercial kits. Mitochondrial reactive oxygen species (ROS) 2’,7’-dichlorofluorescin diacetate (DCFH-DA) was measured by fluorescence microscopy. Histological analyses were conducted to observe morphological changes, and apoptosis was measured using a commercial kit. Western blots were used to detect the level of expression of cleaved caspase-3. Results: Doxorubicin treatment significantly increased oxidative stress levels, as indicated by catalase, malonyldialdehyde, superoxide dismutase, glutathione peroxidase and reactive oxygen species. Doxorubicin also increased pathological damage in myocardial tissue, myocardial ROS levels, and malonyldialdehyde levels, and induced apoptosis in myocardial tissues and H9c2 cells. All of these doxorubicin-induced effects were attenuated by oxymatrine. Conclusion: These in vitro and in vivo findings indicate that oxymatrine may be a promising cardioprotective agent against doxorubicin-induced cardiotoxicity, at least in part mediated through oxymatrine’s inhibition of cardiac apoptosis and oxidative stress
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Zijie Zhou,Yan Zhang,Yan Liu,Quanshu Wang,Shouhai Jiao,Shuping Zhang,Xiaolu Li,Li Sun
Maternal anemia has been identified as a contributing factor to adverse reproductive outcomes associated with cadmium (Cd) exposure, a common heavy metal. Our recent findings suggest that inhibited erythroid differentiation and enucleation also play significant roles in the direct embryonic toxicity resulting from maternal Cd exposure. However, the effects of Cd exposure on lipid metabolism remodeling, which is essential for physiological erythropoiesis, remain poorly understood. In the present study, pregnant mice were administered low doses of CdCl 2 via oral exposure from early to late gestation to mitigate Cd-induced maternal anemia. Compared to vehicle-treated controls, embryos from Cd-treated mice exhibited a slight decrease in weight, though without signs of atrophy. Consistent with our previous observations, fetal livers from Cd-exposed embryos demonstrated a dose-dependent inhibition of erythroid differentiation, as confirmed by ex vivo analysis. Notably, an intrinsic decrease in lipid peroxidation during erythroid differentiation was observed in the bone marrow and fetal livers of vehicle-treated mice, attributed to diminished lipid content. In contrast, this decrease in lipid peroxidation was absent in fetal liver erythroblasts from Cd-treated mice, where an increase in lipid peroxidation was instead noted. These findings elucidate a potential mechanism, lipid peroxidation, underlying Cd-induced embryonic toxicity.
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ACS Catalysis
·
2017
·
IF 10.614
Pan Li,Haobo Li,Xiulian Pan,Kai Tie,Tingting Cui,Minzheng Ding,Xinhe Bao
This study presents the discovery that porous boron nitride (p-BN) is active in acetylene hydrochlorination, although boron nitride (BN) is generally considered chemically inert. An acetylene conversion of 99% is achieved with a vinyl chloride selectivity over 99% at 280 °C at a gas hourly space velocity (GHSV) of 1.32 mL min–1 g–1. By contrast, the commercially available crystallized hexagonal BN (h-BN) exhibits no catalytic activity. Furthermore, this p-BN is rather durable as demonstrated by a 1000 h lifetime test. Catalytic tests, spectroscopic characterization, and theoretical calculations indicate that the activity likely originates from the defects and edge sites. Particularly, the armchair edges of BN can polarize and activate acetylene, which then reacts with gaseous HCl giving vinyl chloride as the product.
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Chemical Science
·
2024
·Vol. 15
·期 23
·8922-8933
·
IF 7.6
Hao-Hua Deng,Kai-Yuan Huang,Yu Zhong,Ye Li,Hong-Xiang Huang,Xiang-Yu Fang,Wei-Ming Sun,Qiaofeng Yao,Wei Chen,Jianping Xie
Surface-protecting ligands, as a major component of metal nanoclusters (MNCs), can dominate molecular characteristics, performance behaviors, and biological properties of MNCs, which brings diversity and flexibility to the nanoclusters and largely promotes their applications in optics, electricity, magnetism, catalysis, biology, and other fields. We report herein the design of a new kind of water-soluble luminescent gold nanoclusters (AuNCs) for enzyme-activatable charge transfer (CT) based on the ligand engineering of AuNCs with 6-mercaptopurine ribonucleoside (MPR). This elaborately designed cluster, Au5(MPR)2, can form a stable intramolecular CT state after light excitation, and exhibits long-lived color-tunable phosphorescence. After the cleavage by purine nucleoside phosphorylase (PNP), the CT triplet state can be easily directed to a low-lying energy level, leading to a bathochromic shift of the emission band accompanied by weaker and shorter-lived luminescence. Remarkably, these ligand-engineered AuNCs show high affinity towards PNP as well as decent performance for analyzing and visualizing enzyme activity and related drugs. The work of this paper provides a good example for diversifying physicochemical properties and application scenarios of MNCs by rational ligand engineering, which will facilitate future interest and new strategies to precisely engineer solution-based nanocluster materials.
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Frontiers in Pharmacology
·
2024
·
IF 4.4
Wubuli Abudukahaer,Chai Junwei,Liu Haoqiang,Nijat Dilaram,Li Jianmin,Xia Guoyu,Cao Qi,Zhang Saidan,Huang Weidong,Aipire Adila,Li Jinyao
Glycyrrhiza uralensis polysaccharides (GUPS) are widely applied in biomedicine and functional food due to their multiple pharmacological activities and low toxicity. Despite their widespread use, the in vivo metabolic profile of GUPS remains poorly understood. To address this gap, we developed a quantitative analysis method that involves labeling GUPS with visible fluorescein (5-DTAF) and near-infrared (NIR) fluorescein (Cy7), resulting in stable conjugates with substitution degrees of 0.81% for 5-DTAF and 0.39% for Cy7. The pharmacokinetic studies showed a biphasic elimination pattern in the blood concentration-time curve following both intravenous and oral administration, consistent with a two-compartment model. Using fluorescence quantification and NIR imaging, we observed that GUPS was distributed to various tissues, exhibiting higher concentrations particularly in liver, kidney and lung. Excretion studies indicated that feces were the major excretion pathway of GUPS after oral administration (60.98%), whereas urine was the main pathway after intravenous administration (31.16%). Notably, GUPS could be absorbed rapidly by gut (Tmax 1 ± 0.61 h) and showed a biological half-time t1/2 26.4 ± 7.72 h after oral administration. Furthermore, the Caco-2 cells uptake studies illustrated that macropinocytosis and clathrin-mediated endocytosis were participated in the transport of GUPS in intestine epithelium. This comprehensive analysis of the in vivo pharmacokinetics of GUPS not only enhances our understanding of its metabolic pathways but also establishes a foundational basis for its clinical application, optimizing its therapeutic potential and safety profile.
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WATER RESEARCH
·
2024
·
IF 11.4
Jie Chen,Peizeng Yang,Jing Chen,Bin Gao,Junhe Lu
This study investigated the expediated transformation of halophenols in the presence of nitrite (NO 2 − ) under slightly acidic conditions in ice, whereas such transformation was negligible in liquid water at 4 °C. We proposed that this phenomenon was attributed to the freeze-concentration effect, incurring a pH drop and the aggregation of NO 2 − and halophenols within the liquid-like grain boundary layer amid ice crystals. Within this micro-environment, NO 2 − underwent protonation to generate reactive nitrous acid (HNO 2 ) and nitrosonium ions (NO + ) that facilitate the nitration and oxidation of halophenols. When 10 μМ halophenol was treated by freezing in the presence of 5 μМ NO 2 − , the total yields of nitrated products reached 2.4 μМ and 1.4 μМ within 12 h for 2-chlorophenol (2CP) and 2-bromophenol (2BP), respectively. NO + drove oxidative coupling reactions, generating hydroxyl polyhalogenated diphenyl ethers (OH-PBDEs) and hydroxyl polyhalogenated diphenyls via C-O or C-C coupling. These two pathways were intricately intertwined. The presence of natural organic matter (NOM) mitigated the formation of nitrated products and completely suppressed the coupling products. This study offers valuable insights into the fate of halophenols in ice and suggests potential pathways for the formation of nitrophenolic compounds and OH-PBDEs in natural cold environments. These findings also open up a new avenue in environmental chemistry research.
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Cell and Bioscience
·
2024
·Vol. 14
·期 1
·1-18
·
IF 6.1
Maimaiti Yasenjiang,Su Ting,Zhang Zhanying,Ma Lingling,Zhang Yuan,Xu Hong
This study investigates NADPH oxidase 4 (NOX4) involvement in iron-mediated astrocyte cell death in Alzheimer’s Disease (AD) using single-cell sequencing data and transcriptomes. We analyzed AD single-cell RNA sequencing data, identified astrocyte marker genes, and explored biological processes in astrocytes. We integrated AD-related chip data with ferroptosis-related genes, highlighting NOX4. We validated NOX4’s role in ferroptosis and AD in vitro and in vivo. Astrocyte marker genes were enriched in AD, emphasizing their role. NOX4 emerged as a crucial player in astrocytic ferroptosis in AD. Silencing NOX4 mitigated ferroptosis, improved cognition, reduced Aβ and p-Tau levels, and alleviated mitochondrial abnormalities. NOX4 promotes astrocytic ferroptosis, underscoring its significance in AD progression.
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