NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 45
·20762-20769
·
IF 3.3
Yunxiao Zhang,Wenhua Xiao,Jingqiang Zhang,Tiantian Hu,Shanxia Hu,Minjie Zhou,Zhaohui Hou,Yu Liu,Binhong He
The currently leading oxygen reduction reaction (ORR) catalysts are non-precious metal electrocatalysts. However, porous structure engineering and accessibility of Fe–N–C sites still remain a huge challenge. Here, we developed hierarchically porous Fe–N–C catalysts for cathodes of Zn–air batteries using a gas diffusion strategy, which has dense active Fe–Nx moieties. The Fe-NCNF-120 catalyst provided high kinetic current density and mass activity towards the ORR, as well as a more positive initial potential and half-wave potential (Eonset = 1.00 V, E1/2 = 0.90 V). According to experiments, the outstanding ORR activity can be attributed to the organized micro- and mesoporous structure, enhanced intrinsic activity of dense and accessible active sites Fe–Nx, and the facilitated mass and electron transport by 3D interconnected pores. As the cathode for Zn–air batteries, Fe-NCNF-120 demonstrated high power density, a high open-circuit voltage, and excellent stability. The combination of inherent activity with dense and accessible spots in this work opens up new possibilities for the design and synthesis of effective electrocatalysts for energy storage and conversion.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
An-Min Fei,Liang Wu,Mei-Tong Wei,Wen-Hua Shi,Zhi Qian,Zong-Bu Qin,Hemdan S.H. Mohamed,Zhi-Yi Hu,Jing Liu,Yu Li,Bao-Lian Su
The silicon (Si) anode boasts an exceptionally high theoretical capacity (4200 mAh g −1 ), making it an attractive candidate for advanced lithium-ion batteries (LIBs). However, its practical application is limited by poor electrical conductivity and disastrous volume expansion. In this work, we have successfully synthesized a yolk-shell composite material (Si@H-CoNPSC) consisting of N, P, S co-doped carbon encapsulated silicon nanoparticles (SiNPs) via a self-template method based on the Kirkendall effect. The Si@H-CoNPSC anode exhibits excellent electrochemical performance, after 300 cycles, keeping a specific capacity of 872.8 mAh g −1 at 1 A g −1 . Additionally, after 150 cycles, it retains 1305.8 mAh g −1 at 0.5 A g −1 , with a capacity retention of 91.1 %. These outstanding results are mainly due to the co-doped hollow carbon shell, which improves the anode’s conductivity and reduces volume changes during cycling. This study provides new insights for the designing of silicon-carbon anode structures for high-performance LIBs.
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MOLECULES
·
2025
·Vol. 30
·期 8
·1709
·
IF 4.6
Junyong Chen,Defang Pan
The inherent brittleness of silica aerogels has hindered their application in thermal protection systems. To overcome this limitation, we developed a silica/polyimide composite aerogel with a bio-inspired “pomegranate-like” structure through in situ gelation. The strategic integration of polyimide nanofibers into the silica matrix created an interlocking network that immobilized silica particles, effectively resolving the mechanical fragility. By modulating the polyimide precursor (polyamic acid) concentration to 0.08 g/cm3through polyimide nanofiber reinforcement, the compressive strength reached 2.86 MPa—12 times greater than that of unmodified silica aerogel. The material demonstrated multifunctional performance: exceptional flame resistance (withstanding 1300 °C flame for 20 min with self-extinguishing behavior), high hydrophobicity (123° water contact angle), and ultralow thermal conductivity (0.035 W/(m·K)). This synergistic combination of tunable mechanics, thermal stability, and insulation properties positions the composite as an advanced solution for next-generation thermal protection materials.
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EXPERIMENTAL EYE RESEARCH
·
2020
·
IF 3.011
Mengliang Wu,Shangfeng Wang,Yan Wang,Fan Zhang,Tingting Shao
Pterygium is a degenerative disease that characterized by excessive fibrovascular proliferation. To reduce the recurrence rate, surgery is the main strategy, in combination with adjacent procedures or adjunctive therapy. One of the most common adjunctive agents, mitomycin C (MMC), is known as an alkylating agent that inhibits fibroblast proliferation but is limitedly applied in pterygium due to various complications. A previous study demonstrated that activated pterygium subconjunctival fibroblasts overexpressed low-density lipoprotein (LDL) receptors. In this study, we designed and synthesized MMC-loaded mesoporous silica nanoparticles conjugated with LDL (MMC@MSNs-LDL) to deliver MMC into activated pterygium fibroblasts in a targeted manner. The MMC loading efficiency was approximately 6%. The cell viability test (CCK-8 assay) revealed no cytotoxicity for the empty carrier MSNs at a concentration of ≤1 mg/ml after administration for 48 h in subconjunctival fibroblasts. Primary pterygium and normal human subconjunctival fibroblasts with or without stimulation by vascular endothelial growth factor (VEGF) were treated as follows: 1) 10 μg/ml MMC@MSNs-LDL for 24 h (MMC concentration: 0.6 μg/ml); 2) 0.2 mg/ml MMC for 5 min then cultured for 24 h after MMC removal; and 3) normal culture without any drug treatment. At 24 h, the anti-proliferative effect of MMC@MSNs-LDL in activated pterygium fibroblasts was similar to that of MMC (cell viability: 46.2 ± 5.5% vs 40.5 ± 1.1%, respectively, P = 0.349). Furthermore, the cytotoxicity of MMC@MSNs-LDL to normal fibroblasts with or without VEGF stimulation was significantly lower than that of traditional MMC (cell viability: 75.6 ± 4.4% vs 36.0 ± 1.5%, respectively, P < 0.001; 84.7 ± 5.5% vs 35.7 ± 1.3%, P < 0.001). The binding of fluorescently labeled MMC@MSNs-LDL in fibroblasts was assessed using confocal fluorescence microscopy . The uptake of targeted nanoparticles in fibroblasts was time dependent and saturated at 6 h. VEGF-activated pterygium fibroblasts showed more uptake of MMC@MSNs-LDL than normal fibroblasts with or without VEGF activation (both P < 0.001). Our data strongly suggest that MMC@MSNs-LDL had an effective antiproliferative role in activated pterygium fibroblasts, with reduced toxicity to normal fibroblasts compared to traditional application of MMC. LDL-mediated drug delivery might have great potential in the management of pterygium recurrence.
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JOURNAL OF ETHNOPHARMACOLOGY
·
2025
·
IF 5.4
Jia Li,Ying Zhang,Zhe Su,Tangxiaoxiao He,Ze Chen,Zhiwei Pan,Chao Ding,Zhichao Yu,Lei Bi
Ethnopharmacological relevance With a prevalence reaching 80% in terminal cancer patients,Cancer cachexia (CC) manifests as irreversible skeletal muscle wasting. Presently, there exists no effective therapeutic strategy for managing cancer cachexia. Traditional Chinese medicine (TCM) contributes significantly to the management of CC, enhancing quality of life and potentially prolonging survival in affected patients. Bu-zhong-yi-qi decoction (BYD), a classical Chinese formulation, demonstrates therapeutic potential for tumor-associated conditions and muscle-related disorders. However, its precise pharmacological mechanisms remain to be fully elucidated. Aim of the study To systematically investigate the therapeutic effects and underlying mechanisms of BYD on muscle atrophy caused by CC through an integrated approach combining network pharmacology analysis with comprehensive in vivo and in vitro experimental validation. Materials and methods Network pharmacology analysis was employed to recognize bioactive components, potential therapeutic targets, and associated pathways of BYD. Molecular docking simulations were subsequently performed to evaluate the binding affinity between BYD constituents and key target proteins. The skeletal muscle atrophy model of CC in vivo was established by subcutaneous injection of Lewis lung cancer (LLC) cells. The therapeutic efficacy of BYD was systematically evaluated through a comprehensive assessment of multiple parameters, including carcass weight, gastrocnemius muscle mass, histopathological alterations, the cross-sectional area (CSA) of muscle fibers and inflammatory markers. The muscle atrophy model in vitro was established by C2C12 mouse myoblasts and LLC cells to investigate the underlying mechanisms of BYD. qRT-PCR and Western blot analysis were employed to evaluate the regulatory effects of BYD on both mRNA and protein expression levels of MuRF-1, Atrogin-1 and key molecular components of the JNK/c-JUN signaling pathway. Results Network pharmacology analysis identified 146 bioactive components and 331 corresponding potential targets of BYD. KEGG pathway enrichment analysis revealed significant enrichment of BYD component targets in the MAPK signaling pathway. Molecular docking simulations revealed strong binding affinities between BYD's bioactive components and JUN protein. Experiments in vivo demonstrated that BYD could increase the carcass weight, gastrocnemius muscle mass and CSA of muscle fibers in mice with cachexia. Meanwhile, it could increase C2C12 myotube diameters in vitro . Additionally, BYD down-regulated the mRNA and protein expressions of MuRF-1, Atrogin-1 and JNK/c-JUN signaling pathway in vivo . Conclusions BYD might contribute to ameliorate muscle atrophy induced by CC through suppression of JNK/c-JUN signaling pathway and downregulation of muscle atrophy markers MuRF-1 and Atrogin-1. These findings suggested BYD as a potential therapeutic intervention for CC.
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PHYTOMEDICINE
·
2025
·
IF 8.3
Xiaohan Li,Yue Zhang,Chunxiao Yu,Xu Guo,Xiangxiang Fu,Shiqi Chen,Yanguo Gao,Yu Zhang,Qin Xiang,Wei Lu,Yonghong Zhang,Qibin Wang,Li Chen,Tao Zheng
Background Scrophularia ningpoensis Hemsl. (SN) is a traditional herbal medicine used for treating diabetes mellitus (DM). Previous studies indicated that the aqueous extract of SN (AESN) improves type 2 DM (T2DM) by activating AMPK, but the active components were unclear. Purpose This study aimed to identify the compound in AESN responsible for AMPK activation and to verify its therapeutic effects on T2DM. Methods Rats were administered AESN intragastrically. The absorbed compounds in serum samples were analyzed using LC-MS/MS and subjected to molecular docking with AMPK. The compound with the highest docking score was further verified using SPR, CETSA, and TR-FRET to confirm its effects on AMPK activation. Primary mouse hepatocytes were used to examine the effects of ANC on AMPK activity, Akt/GSK3β signaling, NLRP3 inflammasome activation, and lipid accumulation. An AMPK inhibitor was used to determine whether the effects were AMPK-dependent. In type 2 diabetic db/db mice, various dosages of ANC were administered intragastrically to observe its therapeutic effects. Results Among the 17 absorbed prototype compounds, ANC exhibited the strongest binding ability to AMPK. SPR, CETSA, and TR-FRET assays confirmed that ANC binds to and activates AMPK. In hepatocytes, ANC activated the Akt/GSK3β signaling, suppressed NLRP3 inflammasome activation, and inhibited lipid accumulation in an AMPK-dependent manner. In db/db mice, ANC intervention improved glucose and lipid metabolic disorders, insulin resistance, and histopathological abnormalities in a dose-dependent manner, while activating AMPK and alleviating lipid metabolic disorders and metabolic inflammatory responses. Conclusion ANC can treat T2DM by directly binding to and activating AMPK.
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Water
·
2025
·Vol. 17
·期 9
·1309
·
IF 3
Xiaoyan Ma,Rongbin Quan,Wenqing Cao,Weijie Zhang,Su Jiang,Jiao Feng,Jiulong Wang,Stefanos Giannakis
Electrochemical reduction is a promising strategy for the dechlorination of halogenated organic compounds, offering advantages such as enhanced electron transfer efficiency and increased hydrogen atom concentration. It has garnered significant attention for application in mitigating halogenated disinfection by-products (DBPs) in drinking water, owing to its high efficiency and simple operation. In this study, trichloroacetic acid (TCAA), a representative DBP, was selected as the target contaminant. A novel composite cathode comprising a metal–organic framework MIL-53(Fe)@C supported on an Nd magnet (MIL-53(Fe)@C-MAG) and its dechlorination performance for TCAA were systematically investigated. The innovative aspect of this study is the magnetic attachment of the MOF catalyst to the carbonized cathode surface treated through carbonization, which fundamentally differs from conventional solvent-based adhesion methods. Compared to the bare electrode, the MIL-53(Fe)@C-MAG achieved a TCAA removal efficiency exceeding 96.03% within 8 h of contact time. The structural characterization revealed that the α-Fe0crystalline phase serves as the primary active center within the MIL-53(Fe)@C catalyst, facilitating efficient electron transfer and TCAA degradation. The scavenger experiments revealed that TCAA reduction involves a dual pathway: direct electron transfer and atomic hydrogen generation. The modified MIL-53(Fe)@C-MAG electrode exhibited robust electrolytic performance over a broad pH range of 3–7, with TCAA removal efficiency showing a positive correlation with current density within the range of 10–50 mA/cm2. Furthermore, the electrode maintained exceptional stability, retaining more than 90% removal efficiency after five consecutive operational cycles. The versatility of the system was further validated by the rapid and efficient dechlorination of various chlorinated DBPs, demonstrating the broad applicability of the electrode. The innovative magnetic composite electrode demonstrates a significant advancement in electrochemical dechlorination technology, offering a reliable and efficient solution for the purification of drinking water contaminated with diverse halogenated DBPs. These results provide valuable insights into the development of electrolysis for dechlorination in water treatment applications.
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2020
·Vol. 104
·期 5
·2205-2216
·
IF 3.53
Wang Feifei,Wang Yongzheng,Cen Congnan,Fu Linglin,Wang Yanbo
Cyclic diguanylate (c-di-GMP) is a second messenger involved in the regulation of various physiological processes in bacteria. However, its function in spoilage bacteria has not yet been addressed. Here, we studied the function of a tandem GGDEF-EAL domain protein, Sbal_3235, in the spoilage bacterium Shewanella baltica OS155. The deletion of sbal_3235 significantly reduced the c-di-GMP level, biofilm formation, and exopolysaccharide, trimethylamine (TMA), and putrescine production; sbal_3235 deletion also downregulated the expression of the torS and speF genes and affected membrane fatty acid composition. Site-directed mutagenesis in conserved GGDEF and EAL motifs abolished diguanylate cyclase (DGC) and phosphodiesterase (PDE) activity, respectively. These data indicate that Sbal_3235 is an essential contributor to the c-di-GMP pool with bifunctional DGC and PDE activity, which is involved in the biofilm formation and spoilage activity of S. baltica OS155. Our findings expand the biochemical role of c-di-GMP and uncover its link to spoilage activities, providing novel targets for food quality and safety controlling.
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Nanoscale Research Letters
·
2020
·Vol. 15
·期 1
·1-10
·
IF 3.578
Wang Shan,Fu Jing,Zhang Fang,Huan Ruirui,Liu Ting,Zeng Xingguo
Abstract A 0D/2D (0-dimensional/2-dimensional) nanostructure was designed by self-assembly of N–C QDs and carboxylated g-C 3 N 4 nanosheets and used as a fluorescence resonance energy transfer (FRET) fluorescent sensor. The N–C QDs/g-C 3 N 4 nanosheets were synthesized via the amino group on the N–C QD surface and the –COOH of the carboxylated g-C 3 N 4 nanosheets. The mechanism of detection of metronidazole (MNZ) by N–C QDs/g-C 3 N 4 nanocomposites is based on FRET between negatively charged N–QDs and positively charged carboxylated g-C 3 N 4 nanoparticles. N–C QDs/g-C 3 N 4 nanostructures displayed good responses for the detection of MNZ at normal temperature and pressure. The decrease in the fluorescence intensity showed a good linear relationship to MNZ concentration within 0–2.6 × 10 −5 mol/L, and the detection limit was 0.66 μM. The novel FRET sensor will have a great potential in clinical analysis and biological studies. Graphical Abstract
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ChemSusChem
·
2015
·Vol. 8
·期 12
·2066-2072
·
IF 7.657
Yehong Wang,Jian Zhang,Jing Liu,Chaofeng Zhang,Zhixin Zhang,Jie Xu,Shutao Xu,Fangjun Wang,Feng Wang
Graphical CO 2 -mediated reactions: CO 2 -mediated metathesis reactions between amines and DMF to synthesize formamides are described. The N -formylation of amines to formamides is achieved by activating amines, not DMF, via a C N and N H bond metathesis reaction. Using this method, primary, secondary, aromatic, and heterocyclic amines as well as diamines can be obtained with good to excellent formamide yields. Herein, we report CO 2 -mediated metathesis reactions between amines and DMF to synthesize formamides. More than 20 amines, including primary, secondary, aromatic, and heterocyclic amines, diamines, and amino acids, are converted to the corresponding formamides with good-to-excellent conversions and selectivities under mild conditions. This strategy employs CO 2 as a mediator to activate the amine under metal-free conditions. The experimental data and in situ NMR and attenuated total reflectance IR spectroscopy measurements support the formation of the N -carbamic acid as an intermediate through the weak acid–base interaction between CO 2 and the amine. The metathesis reaction is driven by the formation of a stable carbamate, and a reaction mechanism is proposed.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Bowen Luo,Rongxuan Li,Riyang Shu,Chao Wang,Jingtao Zhang,Ying Chen
Simple and efficient catalytic routes have been explored to upgrade the raw lignin oil. Though homogeneous catalysis is easy to operate and possesses a high reaction rate, it also suffers from the difficulty of product separation. In this work, we used H3BO3 as a novel homogeneous catalyst coupled with Ru/C to overcome the separation problem and carry out the hydrodeoxygenation (HDO) of phenolic compounds and raw lignin oil. H3BO3 showed an outstanding performance over the liquid organic and mineral acids, with a good catalyst recyclability. Phenolic model compounds including monomers and dimers can be efficiently converted into cycloalkanes with yields close to 100%. Moreover, the raw lignin oil also had a good HDO result by using this bifunctional catalyst (H3BO3 and Ru/C). The content of hydrocarbons increased from 7.9% to 93.1% at 260 °C, which promoted the upgraded lignin oil capable to be used as fuel directly.
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TALANTA
·
2013
·
IF 3.498
Xian Wang,Yingzhi Liu,Haidong Wang
The study of noncovalent interactions between pharmaceutical molecules and proteins is essential for understanding molecular mechanisms of protein function, and provides foundations for de novo therapeutic agent design. Electrospray ionization mass spectrometry (ESI-MS) has nowadays become a popular tool for analyzing the noncovalent protein complexes, however it usually has difficulty in determining the interaction sites and binding mechanisms. In this work, a new structure-differential binding (SDB) method, combined with ESI-MS and molecular docking (MD) techniques (SDB–ESIMS–MD), was developed and applied to a study of the binding interactions in noncovalent protein–small drug molecule complexes for the characterization of binding sites and binding modes. Using this developed method, protein complexes of flavonoid and flavonoid glycoside ligands and cytochrome-c (Cyt-c) were studied in detail. ESI-MS was used to determine the relative binding affinities and dissociation constants of flavonoid–Cyt-c complexes, and to measure the changes in the stability of the protein complexes with the structural modifications of the ligands for identifying effective binding functional groups. Molecular docking simulations complemented ESI-MS experiments by providing the protein–ligand interaction profile of each complex and displaying the binding mode for each interaction. This SDB–ESIMS–MD method can be applied to a broad range of protein–drug interactions and used to guide further research in the study of structure–binding relationship between drug molecules and targeted biomacromolecules.
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