JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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2024
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IF 3.1
Baoyan Ding,Wei Meng,Xiaoling Zang,Zhihua Lv
A small molecule, (S)-ethyl 1-(3-(4-chlorophenoxy)-2-hydroxypropyl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylate (SEC), has been reported to be capable of suppressing metastasis of prostate cancer (PCa) cells. In this study, SEC was used to study the metabolic responses of PCa cell lines (LNCaP, PC3, and DU145) with different metastatic potential and the alterations of mTOR, p-mTOR, AMPK, and p-AMPK levels, when the PCa cells were inhibited. The ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS)-based analysis showed that SEC induced the decreases of intracellular metabolites including glutamic acid, glutamine, and histidine (LNCaP); creatinine, citric acid/isocitric acid, and aspartic acid (PC3); and spermidine, S-hydroxymethylglutathione, LPE (20:3), and palmitic amide (DU145), and the increases of intracellular LPC (18:0) (LNCaP); tyrosine, pyroglutamic acid/pyrroline hydroxycarboxylic acid (PC3); and tyrosine, phenylalanine, phenylacetylglycine, spermine, histidine, and choline (DU145). SEC also caused the decrease of extracellular N1-acetylspermidine (LNCaP), erythronic acid/threonic acid (PC3 and DU145), and nicotinic acid/picolinic acid (DU145), and the increase of extracellular 5’-methylthioadenosine (DU145). High metastatic PC3 and DU145 cells exhibited changes in aromatic amino acid metabolism including tyrosine metabolism, phenylalanine, tyrosine, and tryptophan metabolism, and phenylalanine metabolism (PC3 and DU145), TCA cycle (PC3), arginine and proline metabolism, and glycerophospholipid metabolism (DU145), different from the low metastatic LNCaP cells, which had changes in alanine, aspartate, and glutamate metabolism, and arginine biosynthesis. In addition, the levels of p-mTOR and p-AMPK were shown to be obviously downregulated and upregulated, respectively, in high metastatic PC3 and DU145 cells upon SEC inhibition, while this behavior was not detected in LNCaP cells.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
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IF 9
Chunhua Li,Xiaoyu Hu,Zhenghao Chen,Zilun Ding
The excessive use of imidacloprid (IMD) poses a severe threat to human health and ecological stability. This study uniformly anchors MOF808 to the edges of Zn 3 In 2 S 6 nanosheets with sulfur vacancies by introducing EDTA ligands onto MOF808, successfully constructing a MOF808-EDTA/S-Zn 3 In 2 S 6 (MEZ) Z-scheme heterojunction for the efficient degradation of IMD. The presence of sulfur vacancies and interfacial In-O bonds in MEZ facilitates the enrichment of electrons on the S-Zn 3 In 2 S 6 side, thereby enhancing its ability to adsorb and activate oxygen and endowing MEZ with excellent photocatalytic activity. The optimized MEZ achieves a degradation rate of 98.4 % for IMD, with rate constants 5.0 and 76 times higher than those of S-Zn 3 In 2 S 6 and MOF808, respectively. After five photocatalytic cycles, MEZ still retains over 90 % photocatalytic activity, demonstrating the excellent stability of the surface catalyst, which can be successfully applied to the degradation of IMD in actual water. Singlet oxygen, superoxide radicals, and hydroxyl radicals preferentially attack the C7, C9, and N14 sites of IMD, leading to hydroxylation, denitration, ring-opening reactions, and dealkylation. These reactions decompose IMD into smaller products and significantly reduce IMD’s environmental risks. This study proposes an effective strategy to regulate the distribution of metal–organic frameworks on semiconductor surfaces and offers new insights for rationally developing Z-scheme photocatalysts to remove emerging pollutants in environmental remediation.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2024
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IF 2.8
Fei Yang,Yi-Yi Cao,Jing Xi,Yang Luan,Na Li,Xin Dong,Xin-Yu Zhang
1,3-Butadiene (BD) is a carcinogenic air pollutant. N -acetyl- S -(4-hydroxy-2-buten-1-yl)-L-cysteine (MHBMA3 or 4HBeMA), an urinary BD metabolite with unspecified configuration, is considered the most sensitive BD biomarker and has been used in routine biomonitoring since 2012. However, two issues remain unaddressed: why its concentrations are unusually high relative to other urinary BD biomarkers and why some authors reported no detection of the biomarker whereas other authors readily quantitated it. To address the issues, we synthesized and structurally characterized the authentic trans - and cis -isomers of MHBMA3 (designated NE and NZ, respectively), developed an isotope-dilution LC-MS/MS method for their quantification, and examined 67 urine samples from barbecue restaurant personnel (n = 47) and hotel administrative staff (n = 20). The restaurant personnel were exposed to barbecue fumes, which contain relatively high concentrations of BD. The results showed that NE and NZ had highly similar NMR spectra, and were difficult to be well separated chromatographically. The NMR data showed that the MHBMA3 isomer investigated in most previous studies was NE. We did not detect NE and NZ in any samples; however, an interfering peak with varying heights was observed in most samples. Notably, under the chromatographic conditions used in the literature, the peak exhibited indistinguishable retention time from that of NE. Thus, it is highly likely that the interfering peak has been mis-identified as NE in previous studies, providing a reasonable explanation for the high MHBMA3 concentration in urine. The contradiction in the presence of MHBMA3 in urine was also caused by the mis-identification, because the researchers who reported the absence of MHBMA3 were actually detecting NZ. Thus, we clarified the confusion on MHBMA3 in previous studies through correctly identifying the two MHBMA3 isomers. The presence of NE and NZ in human urine warrants further investigations.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
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IF 6.371
Jingjing Liu,Mengsha Cao,Zhengdong Feng,Xiaomeng Ni,Jing Zhang,Jianhua Qiu,Shuai Zhang,Huafei Guo,Ningyi Yuan,Jianning Ding
Chemical bath–deposited cadmium sulfide (CBD-CdS) is the most widely used buffer layer material for antimony selenosulfide (Sb 2 (S,Se) 3 ) photovoltaic devices , but its medium band gap, large band gap offset with transparent conducting oxides , and surface defects must be addressed to improve its applicability. Hexagonal CdS films (60 nm thick) prepared using the thermal evaporation method were used as the buffer layers of Sb 2 (S,Se) 3 photovoltaic devices. Compared with CBD-CdS (60 nm thick), thermal evaporation–deposited CdS (TED-CdS) films have a larger band gap and fewer surface defects. The Sb 2 (S,Se) 3 film deposited on TED-CdS is more compact, and its 1D ribbons are stacked more vertically to the substrate. The band gap offset between CdS and fluorine-doped tin oxide glass decreases from 0.76 eV (CBD-CdS) to 0.60 eV (TED-CdS). Therefore, suppressed electron trap density and charge recombination, as well as improved light harvesting, are achieved. By replacing CBD-CdS with TED-CdS, the best device efficiency increases from 6.14 % to 7.16 %, with the open circuit voltage, short-circuit current density, and fill factor increasing from 0.660 V, 15.96 mA/cm 2 , and 58.37 % to 0.664 V, 17.39 mA/cm 2 , and 62.85 %, respectively. The device stability and reproducibility are also improved.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2025
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IF 8
Xincong Su,Li Kai,Xiaowen Han,Rongzhi Wang,Xiao Yang,Xuedong Wang,Jin Yan,Qiuhui Qian,Zejun Wang,Huili Wang
Bisphenol S (BPS) and Bisphenol F (BPF), as alternatives to bisphenol A (BPA), are recognized for their endocrine-disrupting properties, but their combined immune toxicity mechanisms remain poorly understood. This study systematically evaluates the individual and joint immune toxicity effects of BPS and BPF through ADMET predictions, transgenic zebrafish models, and molecular docking analyses. The results indicate that equal effect concentration BPS and BPF act through distinct immune pathways: BPS primarily targets macrophages to mediate immune responses, while BPF significantly stimulates neutrophil proliferation and induces a stronger inflammatory response through chemokine signaling. Molecular docking studies show that BPF binds more stably to pro-apoptotic protein Mapk8 and oxidative stress-related protein Hsp90aa1, leading to significantly higher levels of apoptosis and reactive oxygen species (ROS) compared to BPS. The similarity of modes of action (MOA)between BPS and BPF based on relevant immune indicators calculated and experimentally is about 0.3; this quantitative result also proves that modes of action differ widely. Nonetheless, most of the indicators showed superimposed effects in the combined experiments, and it is noteworthy that the oxidative stress indicators (SOD, MDA) showed synergistic effects, suggesting that BPS and BPF, which have very different modes of action, are able to be risk assessed using an additive model with respect to immunity, but may exhibit synergistic risks with respect to oxidative stress. This research demonstrates that BPS and BPF induce immune toxicity via different molecular targets and pathways and highlights the need to account for their synergistic effects in risk assessments. These findings provide important insights into the immune toxicity mechanisms of BPA substitutes and the potential risks of combined exposures.
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JOURNAL OF POROUS MATERIALS
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2025
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IF 3.2
Dai Xiaojun,Cheng Yan,Wei Qiang,Zhou Yasong
In the petrochemical industry, a significant method of achieving high-value usage of polycyclic aromatic hydrocarbons in light cycle oil is the moderate hydrocracking of these hydrocarbons into C 6 -C 8 chemical raw materials. In order to prepare NiW-S supported catalysts, the impregnation technique was used to modify the small-crystal Y zeolites with P. The catalytic performance of the catalysts was assessed using naphthalene as the model chemical. The physicochemical characteristics of the catalysts and P-modified Y zeolites were examined in relation to the impacts of P modification. The results show that the introduction of P has a negative effect on the structural characteristics and acidity of Y zeolite, and this negative effect increases with the increase of P content. The introduction of P reduces the reduction temperature of the active metal of the catalyst and improves the reducibility of the active metal of the catalyst. Adding appropriate P species enhances the active phase characteristics of the corresponding Ni-W-S supported catalysts while weakening the metal-support interactions of the corresponding Ni-W-S supported catalysts. However, too much P species has a negative effect on the active phase characteristics of the catalysts. Naphthalene conversion and C 6 -C 8 selectivity were shown to be significantly influenced by the synergistic catalysis of acid sites and metal sites of the catalysts. The catalyst based on 2% P modified Y zeolite exhibited the best selectivity of C 6 -C 8 compounds. The yield of C 6 -C 8 of 2% P modified Y zeolite-based catalyst increased by 22.34% when compared to the unmodified catalyst. It is anticipated to serve as a guide for the high-value use of polycyclic aromatic hydrocarbons in light cycle oil in petrochemical industry.
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CHEMICAL PHYSICS LETTERS
·
2025
·
IF 3.1
Shihui Zhang,Xu Zhang,Wanting Shi,Weiyan He,Caihong Li,Xiaojing Wang
Slow charge transfer and a weak built-in electric field (BIEF) at the heterojunction interface critically hinder the construction of efficient S-scheme heterojunctions. Secondary calcination and ultrasonic treatment of g-C 3 N 4 enhance interfacial contact with MIL-101, shortening carrier migration paths. P and Mn doping increases the Fermi-level difference between g-C 3 N 4(C,S) and MIL-101, strengthening the BIEF to drive directional carrier migration. This facilitates the recombination of carriers with low-redox-potential at the heterojunction interface while spatially separating carriers with high-redox-potential, successfully constructing an S-scheme P-Mn-MCN (C,S) heterojunction. The optimized system delivers remarkable photocatalytic performance, achieving 98 % tetracycline hydrochloride degradation under visible light within 60 min.
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FOOD CONTROL
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2026
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IF 6.3
Yaping Zhong,Kayi Shao,Ruixia Zhang,Linlong Zhang,Dong Wang
Food safety is a key public concern, making the detection of harmful substances in food increasingly urgent. Herein, a multifunctional fluorescence sensing platform was designed utilizing glutathione-derived N, S-co-doped carbon quantum dots (N, S-CDs), capable of sensitively monitoring nitrite (NO 2 - ) and hydrogen sulfide (H 2 S) in both food and living biological cells. The detection relies on Fe 3+ -induced fluorescence quenching of N, S-CDs through inner filter effect and static quenching, combined with the redox reactions of NO 2 - with Fe 2+ and H 2 S with Fe 3+ . The linear ranges and limits of detection (LOD) were as follows: NO 2 - , 1-1000 μM and 0.164 μM; H 2 S, 25-425 μM and 0.114 μM. Thanks to its ideal biocompatibility, N, S-CDs enabled visualization of NO 2 - and H 2 S in living cells. Meanwhile, N, S-CDs paper-based fluorescent sensor was constructed to detect NO 2 - in pickled meat and H 2 S in spoiled meat, demonstrating great potential for biological tracking and portable sensor development.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Xiang Qin,Tiantian Yi,Rong Cao,Junchen Luo,Hui Luo,Lijun Ji
The development of efficient S-scheme heterojunctions was crucial for addressing the limitations of insufficient light absorption and rapid charge recombination in photocatalysis. In this study, a dual-synergistic 0D/2D/0D (001)TiO 2 /Ti 3 C 2 /ZnTCPP S-scheme heterojunction was rationally designed. The matched energy levels between (001)TiO 2 and ZnTCPP metalloporphyrin drove the formation of a robust built-in electric field, serving as the endogenous S-scheme charge separation core that preserved strong redox capacity. Meanwhile, the metallic Ti 3 C 2 MXene acted as an exogenous high-conductivity transport bridge, accelerating directional carrier migration to surface active sites. The composite was successfully fabricated via a hydrothermal method combined with electrostatic self-assembly. Comprehensive characterization by XRD, TEM, and XPS confirmed that (001)TiO 2 nanoparticles and amorphous ZnTCPP were uniformly anchored onto Ti 3 C 2 nanosheets, forming intimate 0D/2D/0D interfacial contacts with strong electronic interactions. The incorporation of ZnTCPP significantly extended the optical absorption into the visible region, while Ti 3 C 2 functioned as an efficient electron mediator and photothermal agent, further boosting reaction kinetics. Under visible-light irradiation, the optimized TTZ-2 composite exhibited exceptional dual-functional performance: a tetracycline degradation rate of 93.4% and a hydrogen evolution rate of 590.2 μmol·g −1 ·h −1 . Mechanistic investigations, supported by Kelvin probe force microscopy (KPFM) and density functional theory (DFT) calculations, revealed that the dual synergy between the endogenous built-in electric field and the exogenous Ti 3 C 2 channel synergistically facilitated the directional migration of photogenerated carriers along the S-scheme pathway, effectively suppressing recombination while preserving strong redox capabilities. This work demonstrated a viable strategy for designing multifunctional MXene-based photocatalysts for environmental remediation and solar energy conversion.
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Nano Energy
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2021
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IF 17.881
Dongdong Li,Qian Zhang,Zhichuan Shen,Kumar Siddharth,Lijuan Chen,Minhua Shao,Zhicong Shi
Rechargeable lithium oxygen batteries (LOBs) are one of the most promising energy storage systems by virtue of their high energy density and environmental amiability. However, the development of LOBs is still hindered by some critical issues. Herein, 3D hexapod-shaped Co-ZIFs-thiourea/dimethyl sulfoxide (H-Co-ZIFs-S) derived Co nanoparticles embedded into nitrogen and sulfur co-doped carbon (H-Co-NSC) are developed, and then low content of ruthenium nanoparticles are decorated on the surface to obtain Ru/H-Co-NSC as efficient catalyst for LOBs. The Ru/H-Co-NSC catalysts exhibits unique structure and catalytic properties , such as accommodating the insoluble discharge product Li 2 O 2 , promoting the transportation of ions/O 2, enhancing the electronic conduction, demonstrating excellent OER/ORR kinetics as well. In addition, the Ru-decorated nanoparticles could effectively suppress some side-reactions caused by the exposed carbon of H-Co-NSC in LOBs. First-principles Density functional theory (DFT) calculations reveal the cooperative effect of multiple active sites in Ru/H-Co-NSC can effectively promote the ORR/OER kinetics in LOBs. Therefore, the LOBs with Ru/H-Co-NSC cathode provide a positive catalytic capacity with low overpotential, large specific capacities, long cycle life and superior reversibility . Our work may pave the way to design more advanced catalysts for metal-air batteries with superior electrochemical performance.
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Nanoscale Advances
·
2020
·Vol. 2
·期 4
·1483-1492
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IF 0
Honggang Yin,Die Gao,Yan Qiu,Gaoyi Yi,Jun Li,Yingying Dong,Kailian Zhang,Zhining Xia,Qifeng Fu
In recent years, photoluminescent (PL) carbon dots (CDs) have attracted enormous attention because of their many fascinating properties. However, the traditional synthesis routes of PL CDs usually suffer from relatively low quantum yields (QYs) and require complicated operation processes as well as lots of externally supplied energy. Herein, we report a room temperature, green, ultrafast and energy-efficient route for large scale synthesis of highly PL N, S-codoped CDs without any external energy supply. The N, S-codoped CDs are prepared through a novel carbon source self-heating strategy, using the sole precursor tetraethylenepentamine (TEPA) simultaneously as the carbon, nitrogen and heat source, triggered by the heat initiator sodium persulfate (Na2S2O8). The large amount of heat released from Na2S2O8-triggered oxidation of TEPA could effectively promote the spontaneous polymerization and carbonization of TEPA precursors themselves as well as the in situ co-doping of sulfur, which had marked synergistic effects on the fluorescence enhancement of CDs, eventually leading to the high-yield (58.0%) preparation of highly fluorescent N, S-codoped CDs (QY 26.4%) at room temperature within 2 min. Moreover, the fluorescence of N, S-codoped CDs could be selectively quenched by Fe3+ ions in the presence of EDTA, in an ultra-wide range of 0.2–600 μM, with a detection limit of 0.10 μM. Ultimately, the fluorescent nanoprobe was successfully used for the quantitative detection of Fe3+ in human serum samples, indicating its great potential for sensing and biomedical applications.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
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IF 6.371
Yongxin Jiao,Shu Wang,Yupu Liu,Xin Li,Wenlong Yang,Shuang Han,Hui Zhang,Jiuxing Jiang
The artificial-photosynthetic semiconductor composites have attracted tremendous attention with respect to their enhanced photocatalytic properties. Herein, we reported the facile synthesis of Zn 0.5 Cd 0.5 S/WO 3 ·H 2 O S-scheme photocatalyst via one-pot in situ hydrothermal strategy. Density Functional Theory (DFT) calculation was employed to reveal the S-scheme photogenerated electron transfer mechanism, and the subsequent experimental characterization further illustrated the path for electron-hole transfer and separation under the effect of S-scheme heterojunction. The mass of WO 3 ·H 2 O accounted for Zn 0.5 Cd 0.5 S/WO 3 ·H 2 O 48 wt% (ZCSW48) was the best high-efficiency S-scheme photocatalyst displayed significant photocatalytic properties on pollution degradation, in detail, with the Cr (VI) photoreduction rate of 2.27 μmol·s −1 ·g −1 cat. and the Rhodamine B (RhB) photooxidation rate of 0.38 μmol·min −1 ·g −1 cat. , respectively. The designed Zn 0.5 Cd 0.5 S/WO 3 ·H 2 O photocatalysts have integrated with the three aspects of photocatalytic efficiencies including the visible light response, prolonged photogenerated carrier lifetime and the sufficient surface active sites due to amount of surface defects , therefore, this work provides more insights into the utilization of green energy for environmental treatment by artificial structured semiconductors.
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