SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2025
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IF 4.6
Yuxue Chen,Luyong Wu,Yanyan Niu,Huihui Li,Tingting Sun,Miantai Ye,Lisi Wang,Baoli Wang,Fan Shi,Yucen Yao,Wei Sun
The recurrent proliferation and blooms of Sargassum have emerged as a major environmental challenge in tropical and temperate coastal regions, with profound implications for ecological balance, economic stability, and societal well-being. Levofloxacin (LVF), a fluoroquinolone antibiotic, is physiologically toxic and its residues and accumulation in the aquatic environment have become a serious threat to ecosystems and human health. This work presents a novel approach for the fluorescent detection of LVF, a common antibiotic in environmental waters, using carbon dots derived from the abundant invasive seaweed Sargassum aquifolium (Turner) C. Agardh. The Sargassum carbon dots (SACD) is prepared by a simple one-step hydrothermal method and can reduce the internal filtering effect (IFE) of LVF, thereby facilitating fluorescence detection of high-concentrations of LVF. SEM and TEM were used to characterize the structure, and SACD exhibited a spherical amorphous carbon with a partial lattice structure. The composition of SACD was further analyzed by using FTIR and XPS after synthesis. This method offers a wide detection range (1 μM–100 μM, R 2 = 0.9984) and low detection limit (0.3 μM) for LVF analysis, exhibiting high recovery rates (103.4 %–113.9 %) in spiked real environmental water samples, demonstrating its potential application performance. The SACD can selectively detect LVF in the presence of the common interfering substances, which SACD has promising applications in environmental pollutant detection. This study proposes a sustainable approach to utilizing and mitigating the impact of invasive seaweeds, highlighting the potential for converting biological waste into valuable resources for environmental monitoring and protection.
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PubMed
高影响因子
PHYTOMEDICINE
·
2025
·
IF 8.3
Xiaohan Li,Yue Zhang,Chunxiao Yu,Xu Guo,Xiangxiang Fu,Shiqi Chen,Yanguo Gao,Yu Zhang,Qin Xiang,Wei Lu,Yonghong Zhang,Qibin Wang,Li Chen,Tao Zheng
Background Scrophularia ningpoensis Hemsl. (SN) is a traditional herbal medicine used for treating diabetes mellitus (DM). Previous studies indicated that the aqueous extract of SN (AESN) improves type 2 DM (T2DM) by activating AMPK, but the active components were unclear. Purpose This study aimed to identify the compound in AESN responsible for AMPK activation and to verify its therapeutic effects on T2DM. Methods Rats were administered AESN intragastrically. The absorbed compounds in serum samples were analyzed using LC-MS/MS and subjected to molecular docking with AMPK. The compound with the highest docking score was further verified using SPR, CETSA, and TR-FRET to confirm its effects on AMPK activation. Primary mouse hepatocytes were used to examine the effects of ANC on AMPK activity, Akt/GSK3β signaling, NLRP3 inflammasome activation, and lipid accumulation. An AMPK inhibitor was used to determine whether the effects were AMPK-dependent. In type 2 diabetic db/db mice, various dosages of ANC were administered intragastrically to observe its therapeutic effects. Results Among the 17 absorbed prototype compounds, ANC exhibited the strongest binding ability to AMPK. SPR, CETSA, and TR-FRET assays confirmed that ANC binds to and activates AMPK. In hepatocytes, ANC activated the Akt/GSK3β signaling, suppressed NLRP3 inflammasome activation, and inhibited lipid accumulation in an AMPK-dependent manner. In db/db mice, ANC intervention improved glucose and lipid metabolic disorders, insulin resistance, and histopathological abnormalities in a dose-dependent manner, while activating AMPK and alleviating lipid metabolic disorders and metabolic inflammatory responses. Conclusion ANC can treat T2DM by directly binding to and activating AMPK.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Liang Wang,Fengshuo Xi,Jie Yu,Shaoyuan Li,Jijun Lu,Zhongqiu Tong,Xiuhua Chen,Kuixian Wei,Wenhui Ma
The trend of large-scale wafer thinning has led to increased surface activity, oxidation, and uneven oxidation interfaces in photovoltaic silicon cutting waste (SCW) produced by diamond wire cutting, posing significant challenges for its use as a silicon–carbon anode material. To address these issues, we propose a green recycling method that utilizes alkaline solutions to recover silicates from etched SCWs, avoiding the highly corrosive HF acid. By combining inexpensive chitosan (CTS) as a soft template, we achieve controllable reshaping of silicates into amorphous oxide layers (1 to 16 nm) on submicron SCW surfaces. This process involves a one-step method in a vacuum autoclave, which simultaneously eliminates the chitosan template and forms both the oxide layer and the phenolic resin. Unlike self-crystallizing oxide layers, the amorphous layers ensure uniform expansion and contraction, facilitate Li+ transfer, and introduce structural defects, enhancing lithium storage performance. The resulting Si@SiOx@C composite with a 5 nm thick oxide interface significantly improves the cycling performance, coulombic efficiency, and rate capability of the silicon–carbon material, achieving a reversible capacity of over 1000 mAh g–1 after 200 cycles at 1 A g–1. This work demonstrates the value-added utilization of submicron SCWs in the commercial production of high-performance silicon-based lithium-ion battery anodes.
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高影响因子
JOURNAL OF CATALYSIS
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2025
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IF 6.5
Huacheng Ying,Zeyu Wen,Jia Yao,Mowei Zhou,Yongtao Wang,Haoran Li
Constructing N−O bond in amines via aerobic oxidation is of high interest for producing cyclohexanone oxime; however, the mechanism remains disputed. Concerning TiO 2 /NHPI co-catalyzed aerobic oxidation of cyclohexylamine, here a convincing mechanism involving α-C radical and oxaziridine as key intermediates is demonstrated. All the evidences from electron paramagnetic resonance, mass spectrometry, and product analysis with methylated substrates lead to the same story about the mechanism, where both radical translocation of cyclohexylamino radical and epoxidation of 1-hydroperoxycyclohexylamine are mediated by double proton transfer and are the key to convert amine into oxime. Near IR analysis indicate that surface hydroxyl groups on TiO 2 facilitate the double proton transfer process. Here the unveiled role of surface hydroxyl on TiO 2 highlights its potential for broader applications in amine activation. Additionally, the well-established radical mechanism provides valuable insight into the construction of N−O bonds in amines.
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高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2025
·
IF 5.4
Jia Li,Ying Zhang,Zhe Su,Tangxiaoxiao He,Ze Chen,Zhiwei Pan,Chao Ding,Zhichao Yu,Lei Bi
Ethnopharmacological relevance With a prevalence reaching 80% in terminal cancer patients,Cancer cachexia (CC) manifests as irreversible skeletal muscle wasting. Presently, there exists no effective therapeutic strategy for managing cancer cachexia. Traditional Chinese medicine (TCM) contributes significantly to the management of CC, enhancing quality of life and potentially prolonging survival in affected patients. Bu-zhong-yi-qi decoction (BYD), a classical Chinese formulation, demonstrates therapeutic potential for tumor-associated conditions and muscle-related disorders. However, its precise pharmacological mechanisms remain to be fully elucidated. Aim of the study To systematically investigate the therapeutic effects and underlying mechanisms of BYD on muscle atrophy caused by CC through an integrated approach combining network pharmacology analysis with comprehensive in vivo and in vitro experimental validation. Materials and methods Network pharmacology analysis was employed to recognize bioactive components, potential therapeutic targets, and associated pathways of BYD. Molecular docking simulations were subsequently performed to evaluate the binding affinity between BYD constituents and key target proteins. The skeletal muscle atrophy model of CC in vivo was established by subcutaneous injection of Lewis lung cancer (LLC) cells. The therapeutic efficacy of BYD was systematically evaluated through a comprehensive assessment of multiple parameters, including carcass weight, gastrocnemius muscle mass, histopathological alterations, the cross-sectional area (CSA) of muscle fibers and inflammatory markers. The muscle atrophy model in vitro was established by C2C12 mouse myoblasts and LLC cells to investigate the underlying mechanisms of BYD. qRT-PCR and Western blot analysis were employed to evaluate the regulatory effects of BYD on both mRNA and protein expression levels of MuRF-1, Atrogin-1 and key molecular components of the JNK/c-JUN signaling pathway. Results Network pharmacology analysis identified 146 bioactive components and 331 corresponding potential targets of BYD. KEGG pathway enrichment analysis revealed significant enrichment of BYD component targets in the MAPK signaling pathway. Molecular docking simulations revealed strong binding affinities between BYD's bioactive components and JUN protein. Experiments in vivo demonstrated that BYD could increase the carcass weight, gastrocnemius muscle mass and CSA of muscle fibers in mice with cachexia. Meanwhile, it could increase C2C12 myotube diameters in vitro . Additionally, BYD down-regulated the mRNA and protein expressions of MuRF-1, Atrogin-1 and JNK/c-JUN signaling pathway in vivo . Conclusions BYD might contribute to ameliorate muscle atrophy induced by CC through suppression of JNK/c-JUN signaling pathway and downregulation of muscle atrophy markers MuRF-1 and Atrogin-1. These findings suggested BYD as a potential therapeutic intervention for CC.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
YuChen Wu,JiaJia Li,ZhiTeng Wang,Chao Wan,Zhiqiang Liu,Zhenhe Zhu,HuiXin Lan,Hui Li
Tin-based anodes exhibit high capacities, rendering them suitable for lithium-ion batteries (LIBs). However, their practical use is hindered by their extreme swelling and rapid fading. Moreover, traditional synthesis methods for SnP 2 O 7 , which is a promising tin-based system, involve several limitations such as toxic solvents, complex procedure, high energy consumption, and hazardous phosphorus reagents. Herein, we overcame these limitations using a simple method involving a deep eutectic solvent based on polyethylene glycol and SnCl 4 ·5 H 2 O. Phytic acid serves as a benign phosphorus source and a chelating agent that locks Sn 2 + /Sn 4+ into a rigid Sn–O–P scaffold. The special properties of the material mitigate the structural damage caused by lithium-ion deintercalation during charging and discharging. SnP 2 O 7 /C retains 729 mAh g −1 after 300 cycles at 0.2 A g −1 (retention = 99.4 %) and 515 mAh g −1 after 1000 cycles at 1 A g −1 , considerably surpassing those of SnO 2 /C and SSS/C(Sn 3 (PO 4 ) 2 / SnP 2 O 7 / SnO 2 ). The proposed synthesis method is cost-effective, scalable, and green. Moreover, the main mechanism of this route, i.e., phytic acid chelation, offers a long-lasting solution to the long-standing problems of tin-based anode materials for LIBs.
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高影响因子
APPLIED SURFACE SCIENCE
·
2025
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IF 6.9
An-Min Fei,Liang Wu,Mei-Tong Wei,Wen-Hua Shi,Zhi Qian,Zong-Bu Qin,Hemdan S.H. Mohamed,Zhi-Yi Hu,Jing Liu,Yu Li,Bao-Lian Su
The silicon (Si) anode boasts an exceptionally high theoretical capacity (4200 mAh g −1 ), making it an attractive candidate for advanced lithium-ion batteries (LIBs). However, its practical application is limited by poor electrical conductivity and disastrous volume expansion. In this work, we have successfully synthesized a yolk-shell composite material (Si@H-CoNPSC) consisting of N, P, S co-doped carbon encapsulated silicon nanoparticles (SiNPs) via a self-template method based on the Kirkendall effect. The Si@H-CoNPSC anode exhibits excellent electrochemical performance, after 300 cycles, keeping a specific capacity of 872.8 mAh g −1 at 1 A g −1 . Additionally, after 150 cycles, it retains 1305.8 mAh g −1 at 0.5 A g −1 , with a capacity retention of 91.1 %. These outstanding results are mainly due to the co-doped hollow carbon shell, which improves the anode’s conductivity and reduces volume changes during cycling. This study provides new insights for the designing of silicon-carbon anode structures for high-performance LIBs.
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MOLECULES
·
2025
·Vol. 30
·期 8
·1709
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IF 4.6
Junyong Chen,Defang Pan
The inherent brittleness of silica aerogels has hindered their application in thermal protection systems. To overcome this limitation, we developed a silica/polyimide composite aerogel with a bio-inspired “pomegranate-like” structure through in situ gelation. The strategic integration of polyimide nanofibers into the silica matrix created an interlocking network that immobilized silica particles, effectively resolving the mechanical fragility. By modulating the polyimide precursor (polyamic acid) concentration to 0.08 g/cm3through polyimide nanofiber reinforcement, the compressive strength reached 2.86 MPa—12 times greater than that of unmodified silica aerogel. The material demonstrated multifunctional performance: exceptional flame resistance (withstanding 1300 °C flame for 20 min with self-extinguishing behavior), high hydrophobicity (123° water contact angle), and ultralow thermal conductivity (0.035 W/(m·K)). This synergistic combination of tunable mechanics, thermal stability, and insulation properties positions the composite as an advanced solution for next-generation thermal protection materials.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 45
·20762-20769
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IF 3.3
Yunxiao Zhang,Wenhua Xiao,Jingqiang Zhang,Tiantian Hu,Shanxia Hu,Minjie Zhou,Zhaohui Hou,Yu Liu,Binhong He
The currently leading oxygen reduction reaction (ORR) catalysts are non-precious metal electrocatalysts. However, porous structure engineering and accessibility of Fe–N–C sites still remain a huge challenge. Here, we developed hierarchically porous Fe–N–C catalysts for cathodes of Zn–air batteries using a gas diffusion strategy, which has dense active Fe–Nx moieties. The Fe-NCNF-120 catalyst provided high kinetic current density and mass activity towards the ORR, as well as a more positive initial potential and half-wave potential (Eonset = 1.00 V, E1/2 = 0.90 V). According to experiments, the outstanding ORR activity can be attributed to the organized micro- and mesoporous structure, enhanced intrinsic activity of dense and accessible active sites Fe–Nx, and the facilitated mass and electron transport by 3D interconnected pores. As the cathode for Zn–air batteries, Fe-NCNF-120 demonstrated high power density, a high open-circuit voltage, and excellent stability. The combination of inherent activity with dense and accessible spots in this work opens up new possibilities for the design and synthesis of effective electrocatalysts for energy storage and conversion.
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Water
·
2025
·Vol. 17
·期 9
·1309
·
IF 3
Xiaoyan Ma,Rongbin Quan,Wenqing Cao,Weijie Zhang,Su Jiang,Jiao Feng,Jiulong Wang,Stefanos Giannakis
Electrochemical reduction is a promising strategy for the dechlorination of halogenated organic compounds, offering advantages such as enhanced electron transfer efficiency and increased hydrogen atom concentration. It has garnered significant attention for application in mitigating halogenated disinfection by-products (DBPs) in drinking water, owing to its high efficiency and simple operation. In this study, trichloroacetic acid (TCAA), a representative DBP, was selected as the target contaminant. A novel composite cathode comprising a metal–organic framework MIL-53(Fe)@C supported on an Nd magnet (MIL-53(Fe)@C-MAG) and its dechlorination performance for TCAA were systematically investigated. The innovative aspect of this study is the magnetic attachment of the MOF catalyst to the carbonized cathode surface treated through carbonization, which fundamentally differs from conventional solvent-based adhesion methods. Compared to the bare electrode, the MIL-53(Fe)@C-MAG achieved a TCAA removal efficiency exceeding 96.03% within 8 h of contact time. The structural characterization revealed that the α-Fe0crystalline phase serves as the primary active center within the MIL-53(Fe)@C catalyst, facilitating efficient electron transfer and TCAA degradation. The scavenger experiments revealed that TCAA reduction involves a dual pathway: direct electron transfer and atomic hydrogen generation. The modified MIL-53(Fe)@C-MAG electrode exhibited robust electrolytic performance over a broad pH range of 3–7, with TCAA removal efficiency showing a positive correlation with current density within the range of 10–50 mA/cm2. Furthermore, the electrode maintained exceptional stability, retaining more than 90% removal efficiency after five consecutive operational cycles. The versatility of the system was further validated by the rapid and efficient dechlorination of various chlorinated DBPs, demonstrating the broad applicability of the electrode. The innovative magnetic composite electrode demonstrates a significant advancement in electrochemical dechlorination technology, offering a reliable and efficient solution for the purification of drinking water contaminated with diverse halogenated DBPs. These results provide valuable insights into the development of electrolysis for dechlorination in water treatment applications.
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高影响因子
ANALYTICAL SCIENCES
·
2025
·
IF 2
Xia Shaojie,Yang Zhenyuan,Sun Xiaohui,Huang Junjie,Peng Kuan,Wang Yonghong
Ochratoxin A (OTA), a highly toxic mycotoxin, extensively contaminates a wide range of food commodities. Given increasing demands for sensitive and user-friendly detection platforms, we developed a colorimetric OTA biosensor leveraging copper-silver nanoclusters (Cu/Ag NCs), whose peroxidase-like activity is augmented via G/C-rich DNA hybridization. The system employs two tailored DNA strands: a template strand featuring a cytosine-rich domain for NC synthesis flanked by terminal recognition segments and an enhancer strand containing a guanine-rich signal amplification domain and a complementary linker. Upon OTA binding with the aptamer, the apt-template complex dissociates, facilitating template-enhancer hybridization to form G/C-rich double-stranded DNA. This structural transition substantially enhances the peroxidase-like activity of DNA-Cu/Ag NCs, accelerating the oxidation of 3,3′,5,5′-tetramethylbenzidine by H 2 O 2 while simultaneously amplifying the colorimetric signal. Quantitative OTA detection is accomplished by monitoring this dynamic color response. The biosensor demonstrates a semi-log linear detection range from 5.0 nM to 1.0 μM with a detection limit of 5.0 nM. Furthermore, the specific test has high selectivity for other common mycotoxins, and its applicability has been validated through real sample analysis, suggesting that the DNA-Cu/Ag NCs biosensor used for OTA detection holds promising practical applications in food samples. Graphical abstract
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高影响因子
Advanced Electronic Materials
·
2025
·Vol. 11
·期 8
·2400738
·
IF 5.3
Guodong Han,Song Zhao,Sai Sui,Bo Feng,Yudeng Wang,Junxiang Zhou,Zhuolun Li,Xiaoxia Tian,Yuxiang Jia,Jiafu Wang,Shaobo Qu
Metal–Organic-Frameworks (MOFs) are commonly used as microwave-absorbing materials after pyrolysis treatment. Rare researchers treat MOFs as non-conductive materials and use them as absorbing materials directly. In this paper, MOFs@P-C-800 composite materials are prepared adopt to hydrothermal and ultrasonic dispersion methods by regulating the morphological characteristics of MOFs and the content of P-C-800. As for the Co-BDC-P-C-800, the maximum reflection loss reaches −18.4 dB at 14.29 GHz and the effective absorption bandwidth (EAB) achieves 3.87 GHz from 13.5 to 17.37 GHz. After the contents of P-C-800 is adjusted, the Co-BDC-P-C-800 (0.05 g) exhibited excellent microwave absorption performance, the maximum RL value of −60 dB at 13 GHz with a thickness of 2.0 mm, and the EAB achieves 5.91 GHz from 12.02 to 17.93 GHz. This paper not only provides new application direction for MOFs, but also offers a promising direction for the research and development of absorbing materials.
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危险品化学品经营许可证（带存储）