JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2019
·
IF 2.121
Li Zhang,Chunxia Zhang,Wenwen Zhang,Honghong Zhang,Zhaosheng Hou
In this article, a series of medical poly(ester-urethane)s (PEUs) with varying uniform-size hard segment content were prepared via one-step chain extension of poly(ε-caprolactone)s with aliphatic urethane diisocyanate, and the corresponding films were obtained by solvent evaporation technique. The chemical structures of polymers were confirmed by 1H NMR, FT-IR and GPC. The effect of uniform-size hard segment content on the physicochemical properties of PEU films, including thermal properties, mechanical properties, crystallization behavior, water-swelling behavior and in vitro degradability, was extensively researched. The PEU films exhibiting similar thermal transition and thermal stability indicated that the uniform-size hard segment content had little effect on the thermal properties. Two obvious glass transition temperatures observed in DSC curves manifested a microphase separation structure, which endowed the PEU films excellent mechanical properties with ultimate stress of 34.6–51.2 MPa and strain at break of 898–1485%. And with the increase of uniform-size hard segment content, the initial modulus and ultimate stress increased, while the strain at break decreased. Due to the compact physical-linking network structure formed by the denser hydrogen bonds, the PEU films exhibited low water-swellability of less than 1.5 wt% and low degradation rate in vitro. The weight loss of the PEU films in degradation test was less than 1 wt% at the first four months and the time of films becoming fragments was more than 15 months. Cytotoxicity test of film extracts was conducted with L929 mouse fibroblasts, and the relative growth rate approached or exceeded 75%, indicating an acceptable cytocompatibility. For the excellent mechanical properties, slow biodegradability, non-toxic degradation products and adequate cytocompatibility, the PEUs containing uniform-size hard segments possess a high potential to be applied as long-term implant biomaterials.
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高影响因子
STEROIDS
·
2013
·
IF 2.803
Shu-Xiao Feng,Ya-Dong Zhang
One-pot synthesis of an 18-norsteroid compound, 13( R ),14( R )-epoxy-17β-methyl-20( S )-hydroxyl-18-nor-pregna-4-en-3-one has been achieved with peracetic acid/acetic acid under a mild condition, via a proved tandem epoxidation-rearrangement-epoxidation sequence. Its structure was designated on the basis of NMR and X-ray crystallography data.
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JOURNAL OF ORGANIC CHEMISTRY
·
2019
·
IF 4.745
Yong-Long Zhao,Xing-Hai Fei,Yong-Qin Tang,Peng-Fei Xu,Fen-Fen Yang,Bin He,Xiao-Zhong Fu,Yuan-Yong Yang,Meng Zhou,Yuan-Hu Mao,Yong-Xi Dong,Chun Li
An organocatalytic asymmetric α-sulfenylation of 2-substituted indolin-3-ones with N-(alkylthio or arylthio)succinimides has been developed for the first time using Cinchona-derived squaramide as the catalyst. Various chiral 2,2-disubstituted indole-3-ones with S- and N-containing heteroquaternary carbon stereocenters were obtained with up to 98% yield and 99% ee.
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ELECTROCHIMICA ACTA
·
2022
·
IF 7.336
Somaye Ebrahimi,Abbas Afkhami,Tayyebeh Madrakian,Zahra Amouzegar
To investigate heteroatom-doped carbon nitride (C 3 N 4 ) materials as supports, Au nanoparticles anchored on sulfur-doped carbon nitride nanosheets (AuNPs@SCNN) was prepared and used as a catalyst for arsenic electroreduction. Novel SCNN was synthesized for the first time via a simple thermally induced copolymerization route using ammonium persulfate (APS) as a low-cost sulfur source. Thereafter, the SCNN was used to integrate with AuNPs for the benefit of enhancing the quality of assembly and interface between SCNN and AuNPs and improving the catalytic activity of the AuNPs@SCNN nanocatalyst. This optimized assembly was characterized by different techniques, morphologically favorable heterojunction formation between SCNN and AuNPs. More importantly, it was confirmed that the addition of APS during the polymerization of urea not only afforded a significant morphological change from a layered material to a porous structure with many in-plane holes, but also resulted in a higher yield than urea. The electrocatalytic reduction of arsenic was considered at a glassy carbon electrode modified by the composite (AuNPs@SCNN/GCE), which exhibited enhanced electrochemical responses in a wide range of pH conditions with minimal interference of Cu. More distinctly, this robust and repeatable detection method exhibits a linearity range of 0.2–30.0 ppb and a detection limit of 0.07 ppb. The successful determination of arsenic concentration in real water samples also underpins its practical applications in the real world. This promotes innovative design for the synthesis of novel functional nanocomposites.
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2023
·
IF 3.4
Yao Wang,Yuhan Liu,Yutong Sha,Jia Li,Luyao Han,Huili Chen,Shengdi Su,Ning Li,Xijing Chen,Di Zhao
A chiral UPLC-MS/MS method was developed and validated to determine oxiracetam enantiomers in human plasma, urine, and feces. The R-Oxiracetam and S-Oxiracetam were quantified using a CHIRALPAK ®AD3 column at 25 ℃, and the resolution was greater than 3.2. The S-Oxiracetam is the eutome r that isresponsible for the treatment of various brain damage. Isocratic elution was conducted at a flow rate of 0.9 mL/min for 6 min using the mixture of methanol and acetonitrile (methanol:acetonitrile, 15:85) containing 0.3‰ formic acid . The methods showed linearity at the range of 0.5–100 µg/mL for each oxiracetam enantiomer. A comprehensive validation process was carried out, covering aspects including linearity, selectivity, carryover, accuracy, precision, interferences, matrix effect, recovery, dilution integrity and stability in matrix and solution. The validated methods were successfully applied to quantifying R-Oxiracetam and S-Oxiracetam in human plasma, urine, and feces of 12 healthy subjects treated with either a single dose of 2 g S-Oxiracetam injection or 4 g Oxiracetam injection in a phase-I clinical trial . There was no significant difference for plasma pharmacokinetic parameters of S-Oxiracetam between the two regimens ( P＞0.05 ). The S-Oxiracetam and Oxiracetam were primarily eliminated through urine in their original form, with cumulative excretion rates of 92.16% and 85.92%, respectively, within 24 h after administration. Enantiomers interconversion was not observed in the plasma, urine, or feces. The results of this study suggest that replacing 4 g Oxiracetam injection with 2 g S-Oxiracetam injection could offer clinical benefits by lowering the dosage and mitigating potential risks, based on the pharmacokinetic characteristics.
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高影响因子
MACROMOLECULES
·
2017
·
IF 5.835
Wen-Ming Wan,Shun-Shun Li,Dong-Ming Liu,Xin-Hu Lv,Xiao-Li Sun
Electron-deficient borinic acid monomers and corresponding polymers were synthesized with different substituents via a one-pot reaction of Grignard reagents with trimethoxyborane and reversible addition–fragmentation chain transfer polymerization, respectively. Further investigations of substituent effects of borinic acid polymers (PBAs) were carried out, indicating that the thermoresponsive properties of PBAs benefit from the increase of steric hindrance of PBA substituent, while the binding affinity of PBAs with Alizarin Red S, 8-hydroxyquinoline (HQ), and fluoride ion decreases with the increase of steric hindrance of substituent. Attributed to the strong dative N → B bond and the strongly luminescent boron quinolate, the application of phenyl PBA for fluorescence detection of HQ is realized with high sensitivity at the ppm level. These results therefore confirm that borinic acid-containing polymer is a new type of stimuli-responsive polymer in the field of thermoresponsiveness over a wide temperature range and chemical sensor for diol and electron-rich compounds.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Xinyue Duan,Yingqing Zhan,Hongshan Jia,Jie Liu,Yajie Lei,Jing Yang,Yuxing Han
MXene nanosheets based membrane materials encounter challenges in the field of oil-water separation, including narrow interlayer spacing, insufficient stability, and limited photocatalytic self-cleaning efficiency. To address the aforementioned issues, the 2D/2D MXene nanosheets based heterojunction was constructed through in situ growth of porous ZnIn 2 S 4 and freely assembled onto a PAN fibrous membrane with via vacuum-assisted self-assembly technology. The resulting MXene/ZnIn 2 S 4 @PAN fibrous composite membrane (FCM) exhibited high flux and exceptional photocatalytic self-cleaning property. On the one hand, the porous petal-like structure and intrinsic hydrophilic nature of MXene/ZnIn 2 S 4 heterojunction offered the remarkable nanochannel modulation capability, enabling the composite membrane to achieve high permeability (5471.13 -6732.57 L m -2 h -1 ) compared with the conventional MXene based composite membranes with compacted lamellar structure. On the other hand, the heterojunction formed between MXene and ZnIn 2 S 4 significantly improved electron conduction efficiency and effectively regulated the energy band structure, as confirmed by electrochemical impedance spectrum and UV–visible near infrared diffuse reflection test. This imparted the composite membrane with exceptional photocatalytic self-cleaning capability for the degradation of organic dyes, with the degradation efficiency reaching as high as 92.15%. Besides, the rational photocatalytic mechanism was proposed on the basis of free radical quenching and EPR experiments. Such high-flux and enhanced self-cleaning PAN FCM showed the potential in dealing with complicated membrane fouling issues and separating emulsified oily wastewater.
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PLANT CELL AND ENVIRONMENT
·
2024
·Vol. 47
·期 3
·913-927
·
IF 6
Guanhua Liu,Qian Wang,Hui Chen,Yuxi Wang,Xiaogui Zhou,Demeng Bao,Nuo Wang,Juan Sun,Fuyin Huang,Mei Yang,Han Zhang,Peng Yan,Xin Li,Jiang Shi,Jianyu Fu
Insect-induced plant volatile organic compounds (VOCs) may function as either direct defence molecules to deter insects or indirect defence signals to attract the natural enemies of the invading insects. Tea ( Camellia sinensis L.), an important leaf-based beverage crop, is mainly infested by Ectropis obliqua which causes the most serious damage. Here, we report a mechanistic investigation of tea plant-derived VOCs in an indirect defence mechanism against E. obliqua . Parasitoid wasp Parapanteles hyposidrae , a natural enemy of E. obliqua , showed strong electrophysiological response and selection behaviour towards S -linalool and β-ocimene, two monoterpenes with elevated emission from E. obliqua -damaged tea plants. Larvae frass of E. obliqua , which also released S -linalool and β-ocimene, was found to attract both mated female or male Pa. hyposidrae according to gas chromatography-electroantennogram detection and Y-tube olfactometer assays. In a field setting, both S -linalool and β-ocimene were effective in recruiting both female and male Pa. hyposidrae wasps. To understand the molecular mechanism of monoterpenes-mediated indirect defence in tea plants, two novel monoterpene synthase genes, CsLIS and CsOCS-SCZ , involved in the biosynthesis of S -linalool or β-ocimene, respectively, were identified and biochemically characterised. When the expression of these two genes in tea plants was inhibited by antisense oligodeoxynucleotide, both volatile emission and attraction of wasps were reduced. Furthermore, gene expression analysis suggested that the expression of CsLIS and CsOCS-SCZ is regulated by the jasmonic acid signalling pathway in the tea plant.
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WASTE MANAGEMENT
·
2025
·
IF 7.1
Dongping Song,Tao Huang,Xiaolong Sun,Yun Xia,Chong Luo,Jialin Cui,Kai Chen,Weihua Liu,Jie Ren
The poor pozzolanic activity and high alkalinity of municipal solid waste incineration fly ashes (MSWI-FA) would deteriorate the stability of the MgO-SiO 2 -H 2 O (M−S−H) binder system, further inhibiting the treatment capacity of cement to wastes. In this study, sulfhydryl-functionalized graphene oxide nanoparticles (SFG) were synthesized and incorporated into the MSWI-FA-blended M−S−H (MSH-MSWI-FA) system to strengthen the solidification/stabilization (S/S) of both heavy metals (HMs) and chloride salts in the matrix and mechanical stability of cement. The linear increases in nanomaterials (from 0.5 % to 2.5 %) and MSH (from 40 % to 80 %) both decreased the concentrations of HMs and Cl anions leached from the solidified cubes in the MSH-MSWI-FA cementation. The least leaching concentration of Zn, Cu, Pb, Cd, Cr, and Cl were 0.0046 mg/L, 0.0032 mg/L, 0.014 mg/L, 0.00068 mg/L, 0.030 mg/L, and 0.36 g/L from the SFG-MSH-MSWI-FA cemented samples, respectively. The incorporation of graphene oxide nanoparticles (NGO) and SFG elevated the residual moieties of HMs, enhanced the mechanical strength and acid resistance, and improved the microstructural properties of MSH-MSWI-FA cementation. SFG played a more dominant role in the enhancement than NGO. Sulfhydryl-functionalization for nanomaterials intensifies the improvement process. The minerals including M−S−H, CaO-SiO 2 -H 2 O (C-S-H), and Phase-5 were formed in the MSH-MSWI-FA cement. Silica fume (SF), lightly burnt magnesia (CC-MgO), and MSWI-FA reacted with each other in a ternary system, which induced the self-alkali-activated cementation of C-S-H, M−S−H, and magnesium oxychloride (MOC) cement.
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Journal of Materials Chemistry A
·
2019
·Vol. 7
·期 25
·15320-15332
·
IF 10.733
Deliang Cheng,Lichun Yang,Jiangwen Liu,Renzong Hu,Jun Liu,Ke Pei,Min Zhu,Renchao Che
The exploitation of high-performance anode materials is one of the key challenges for the development of lithium-ion batteries. Herein, we report a micro-nano structured (SnS–SnS2–S)/FLG (few-layer graphene) composite in which the in situ formed SnS, SnS2 and S nanoparticles are tightly supported by the in situ exfoliated FLG. The multi-phase structure could induce the formation of a high fraction of interfaces, enabling the interface-controlled lithiation/delithiation, which is characterized by large interfacial storage and fast interfacial diffusion, and boosting the electrode performance at high rates greatly. On the other hand, the step-wise lithiation/delithiation of S, SnS2 and SnS can offer nano-spatial confinement effects to accommodate the volume expansion and particle aggregation, and thus enhance the structural stability of the electrode. Meanwhile, the FLG matrix can serve as a robust layer to further maintain the structural integrity of the electrode. As an anode for lithium-ion batteries, the composite exhibits an ultrahigh gravimetric/volumetric capacity (1062.2 mA h g−1/2018 mA h cm−3 at 0.2 A g−1), ultrahigh rate (842/756 mA h g−1 even at 5.0/10.0 A g−1) and ultrastable cyclability (100%/93.6% capacity retention after 1000/2000 cycles at 1.0/10.0 A g−1). Even in full-cells and sodium-ion batteries, superb comprehensive performance is demonstrated. Therefore, the (SnS–SnS2–S)/FLG composite could be a new promising anode material for application in batteries.
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POLYMER DEGRADATION AND STABILITY
·
2026
·
IF 8.1
Haopeng Li,Xinbo Dong,Jiahui Huang,Zheng Zhao,Xigao Jian,Cheng Liu
Conventional toughening of bismaleimide (BMI) resin with linear thermoplastic faces a critical compromise: enhanced toughness often compromises thermal properties and elevates melt viscosity, severely limitations for their application in extreme environments. To overcome this long-standing challenge, a novel strategy was pioneered by designing and synthesizing a unique class of hyperbranched poly(carbazole-type bisphthalazinone sulfone)s (h-PCBPSs) with tailored reactive groups (propenyl or allyl), with the trifunctional monomer 4,4′-(9H-carbazole-2,7-diyl)bis(phthalazin-1(2H)-one) (CZ-BDHPZ) employed as the building block via a two-step procedure for the modification of BMI resin. h-PCBPSs exhibited high thermal resistance, with glass transition temperatures ( T g ) ranging from 308 to 355°C. The rheological behavior of the h-PCBPSs/BMI blends was characterized. The temperature range corresponding to the processing window, defined by a viscosity below 0.2 Pa·s, was broadened up to 140.1-185.5°C. The formation mechanisms of sea-island, single-phase, and star-shaped morphologies were elucidated, and the effects of these three distinct morphological structures on the thermal and mechanical properties of the BMI were systematically analyzed. The T g , unnotched impact strength, and flexural strength reached 293°C, 33.5 kJ/m², and 190 MPa, respectively. Compared with the cured product of the neat BMI, these values increased by 5.4%, 196.5%, and 36.7%, respectively. The thermo-oxidative aging resistance mechanism of BMI modified by h-PCBPS-A was elucidated. After 7 days of aging at 250°C, the impact strength retention rate and flexural strength retention rate of h-PCBPS-A-10phr/BMI reached 36.3% and 88.9%, respectively. This work provides a new design strategy for BMI toughening agents and promotes the application of BMI resin in extreme environments.
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BIORESOURCE TECHNOLOGY
·
2016
·
IF 4.917
Yu-Cai He,Dan-Ping Zhang,Jun-Hua Di,Yin-Qi Wu,Zhi-Cheng Tao,Feng Liu,Zhi-Jun Zhang,Gang-Gang Chong,Yun Ding,Cui-Luan Ma
In this study, sugarcane bagasse (SB) was pretreated with combination pretreatment (e.g., sequential KOH extraction and ionic liquid soaking, sequential KOH extraction and Fenton soaking, or sequential KOH extraction and glycerol soaking). After the enzymatic hydrolysis of pretreated SBs, it was found that all these three concentrated hydrolyzates could be used for the asymmetric bioreduction of ethyl 4-chloro-3-oxobutanoate (COBE) into ethyl ( S )-4-chloro-3-hydroxybutanoate [( S )-CHBE]. Compared with glucose, arabinose and cellobiose couldn’t promote the initial reaction rate, and xylose could increase the intracellular NADH content. Moreover, it was the first report that hydrolyzates could be used for the effective biosynthesis of ( S )-CHBE (∼500 g/L; 98.0% yield) from 3000 COBE by whole cells of Escherichia coli CCZU-K14 in the presence of β-CD (0.4 mol β-CD/mol COBE), l -glutamine (200 mM) and glycine (500 mM). In conclusion, it is a new alternative to utilize bioresource for the synthesis of key chiral intermediate ( S )-CHBE.
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危险品化学品经营许可证（带存储）