JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 3
·1-12
·
IF 2.8
Huang Kai,Que Tao,Guo Xiang,Wang Rui,Ding Xiang,Zhou Hongqing
The advancement of high-density integration and packaging technologies necessitates the development of packaging materials that possess enhanced thermal conductivity and substantial mechanical strength. In this paper, we present a novel type of CaO–B 2 O 3 –SiO 2 /β-Si 3 N 4 composites synthesized through the solid-state reaction. The effects of β-Si 3 N 4 ceramic content on the sinterability, phase structure, microstructure, and properties of the composites were studied. As an excellent structural and functional material, the rod-like β-Si 3 N 4 ceramic not only enhanced the thermal conductivity (λ) and flexural strength of composite materials but also effectively reduced the thermal expansion coefficient (CTE) of the composite and maintained good high-frequency dielectric properties. The composite sample containing 15wt.% β-Si 3 N 4 demonstrated exceptional performance after sintering at 850 ℃ for 30 min, achieving a bulk density of 2.80 g/cm 3 , a relative permittivity of 6.52 with a dielectric loss of 1.94 × 10 –3 (15 GHz), a λ of 3.5 W/(m·K), a CTE value of 6.40 ppm/ ℃, and a flexural strength of 180.1 MPa. Additionally, the EDS line mapping indicates that there was no diffusion of silver at the interface, thereby affirming the favorable compatibility between the composite and the silver electrode. This characteristic positions the CBS/β-Si 3 N 4 composite as a potentially promising candidate for applications in electronic packaging.
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ARCHIVES OF TOXICOLOGY
·
2025
·
IF 6.9
Tang Wei,Zong Shimin,Du Peiyu,Yu Xuan,Li Ting,Liu Bo,Zhong Yu,Lei Wenyang,Yu Wenting,Xiao Hongjun
Cochlear hair cell death is the primary cause of cisplatin-induced ototoxicity, currently lacking widely applicable clinical methods for effective prevention and treatment. In this study, an in vivo cisplatin-induced ototoxicity model was established by intraperitoneal injection of 12 mg/kg cisplatin. We found that ablation of SIRT3 exacerbates cisplatin-induced hearing loss and cochlear hair cell damage. An in vitro cisplatin-induced ototoxicity model was established using 5 µM cisplatin in cochlear explants and OC-1 cells. We found that the absence of SIRT3 impairs cochlear hair cell glycolytic metabolism, leading to excessive accumulation of ROS and significant reduction in MMP levels, thereby promoting apoptosis. In contrast, overexpression of SIRT3 in OC-1 cells promotes cochlear hair cell survival and reduces cochlear hair cell apoptosis. Inhibition of PFKFB3 reduces glycolytic metabolism in OC-1 cells, and the protective effect conferred by SIRT3 overexpression is lost. In summary, the protective effect of SIRT3 may be mediated by the regulation of PFKFB3-dependent glycolysis and the mitigation of cisplatin-induced excessive ROS accumulation.
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MOLECULAR NEUROBIOLOGY
·
2024
·
IF 4.6
Yu Shan,Yang Jinghui,Zhang Rui,Guo Qian,Wang Lu
Systemic inflammatory stimulus is a risk factor for the incidence of ischemic stroke and contributes to poorer clinical outcomes. Solute carrier 15A3 (SLC15A3) is a peptide/histidine transporter that is implicated in regulating inflammatory responses. However, whether SLC15A3 affects the progression of ischemic stroke associated with systemic inflammation is unclear. The transient middle cerebral artery occlusion (tMCAO) mice with LPS administration (LPS/tMCAO) were prepared as an in vivo model, and LPS-induced BV2 cells under oxygen–glucose deprivation (OGD) exposure were utilized as an in vitro model. We found that SLC15A3 was highly expressed in the ischemic penumbra of LPS/tMCAO mice, and its inhibition reduced infarct area, attenuated neurological deficit, recovered motor function, and mitigated apoptotic neurons. Knockdown of SLC15A3 suppressed the proinflammatory M1-type markers and promoted the levels of M2-associated genes. The in vitro results confirmed that SLC15A3 overexpression promoted microglia polarizing towards M1 subtypes, while SLC15A3 inhibition exerted an opposite effect. In addition, we demonstrated that the p65 signaling pathway and HIF1α were activated by LPS/OGD. Luciferase reporter assay showed that inhibiting p65 using its specific inhibitor BAY 11–7082 or silencing HIF1α using siRNAs reduced the transcriptional activity of SLC15A3 in LPS/OGD-induced BV2 cells. Results in NIH 3T3 cells also confirmed that p65 and HIF1α directly bound to the SLC15A3 promoter to activate SLC15A3 transcription. In conclusion, this work shows that SLC15A3 , transcriptionally activated by p65 and HIF1α, contributes to poor outcomes in ischemic stroke associated with systemic inflammation by promoting microglial cells polarizing towards M1 types.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-13
·
IF 14.7
Lin Xiaoyun,Du Xiaowei,Wu Shican,Zhen Shiyu,Liu Wei,Pei Chunlei,Zhang Peng,Zhao Zhi-Jian,Gong Jinlong
Low-cost, efficient catalyst high-throughput screening is crucial for future renewable energy technology. Interpretable machine learning is a powerful method for accelerating catalyst design by extracting physical meaning but faces huge challenges. This paper describes an interpretable descriptor model to unify activity and selectivity prediction for multiple electrocatalytic reactions (i.e., O 2 /CO 2 /N 2 reduction and O 2 evolution reactions), utilizing only easily accessible intrinsic properties. This descriptor, named ARSC, successfully decouples the atomic property (A), reactant (R), synergistic (S), and coordination effects (C) on the d -band shape of dual-atom sites, which is built upon our developed physically meaningful feature engineering and feature selection/sparsification (PFESS) method. Driven by this descriptor, we can rapidly locate optimal catalysts for various products instead of over 50,000 density functional theory calculations. The model’s universality has been validated by abundant reported works and subsequent experiments, where Co-Co/Ir-Qv3 are identified as optimal bifunctional oxygen reduction and evolution electrocatalysts. This work opens the avenue for intelligent catalyst design in high-dimensional systems linked with physical insights.
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Cell Death & Disease
·
2025
·Vol. 16
·期 1
·1-14
·
IF 9.6
Liu Min,Li Yuanyuan,Deng Zhilin,Zhang Ke,Huang Shuying,Xia Jiamin,Feng Yi,Liang Yundan,Sun Chengfu,Liu Xindong,Li Shurong,Su Bingyin,dong Yong,Huang Sizhou
Mutation in genes involved in DNA replication continuously disrupt DNA replication and give rise to genomic instability, a critical driver of oncogenesis. To prevent leukemia, immature T lymphocytes with genomic instability often undergo rapid cell death during development. However, the mechanism by which immature T lymphocytes undergo rapid cell death upon genomic instability has been enigmatic. Here we show that zebrafish mcm5 mutation leads to DNA damage in immature T lymphocytes and the immature T cells sensitively undergo rapid cell death. Detailed analyses demonstrated that the immature T lymphocytes undergo rapid apoptosis via upregulation of tp53 and downregulation of bcl2 transcription in mcm5 mutants. Mechanistically, Mcm5 directly binds to Stat1a and facilitates its phosphorylation to enhance bcl2a expression under the conditions of DNA replication stress. However, in mcm5 mutants, the absence of the Mcm5-Stat1 complex decreases Stat1 phosphorylation and subsequent bcl2a transcription, accelerating apoptosis of immature T lymphocytes with genomic instability. Furthermore, our study shows that the role of Mcm5 in T-cell development is conserved in mice. In conclusion, our work identifies a role of Mcm5 in regulating T cell development via Stat1-Bcl2 cascade besides its role in DNA replication, providing a kind of mechanism by which immature T cells with gene mutation-induced DNA damage are rapidly cleared during T lymphocyte development.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-19
·
IF 14.7
Mao Zhinan,Bi Xuewei,Yu Chunhao,Chen Lei,Shen Jie,Huang Yongcan,Wu Zihong,Qi Hui,Guan Juan,Shu Xiong,Yu Binsheng,Zheng Yufeng
The regeneration of critical-size bone defects, especially those with irregular shapes, remains a clinical challenge. Various biomaterials have been developed to enhance bone regeneration, but the limitations on the shape-adaptive capacity, the complexity of clinical operation, and the unsatisfied osteogenic bioactivity have greatly restricted their clinical application. In this work, we construct a mechanically robust, tailorable and water-responsive shape-memory silk fibroin/magnesium (SF/MgO) composite scaffold, which is able to quickly match irregular defects by simple trimming, thus leading to good interface integration. We demonstrate that the SF/MgO scaffold exhibits excellent mechanical stability and structure retention during the degradative process with the potential for supporting ability in defective areas. This scaffold further promotes the proliferation, adhesion and migration of osteoblasts and the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in vitro. With suitable MgO content, the scaffold exhibits good histocompatibility, low foreign-body reactions (FBRs), significant ectopic mineralisation and angiogenesis. Skull defect experiments on male rats demonstrate that the cell-free SF/MgO scaffold markedly enhances bone regeneration of cranial defects. Taken together, the mechanically robust, personalised and bioactive scaffold with water-responsive shape-memory may be a promising biomaterial for clinical-size and irregular bone defect regeneration.
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JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Ge Jiahao,Zhang Kangjun,Hu Weijian,Zhou Haihua,Wu Xiaokang
Hepatocellular carcinoma (HCC) is a common malignant tumor originating from liver cells, characterized by complex pathogenesis and limited treatment options such as surgery, chemotherapy, and transplantation. Cisplatin, an effective chemotherapeutic agent, disrupts cancer cell DNA but is hindered by side effects and the need for controlled sustained release to optimize efficacy. Metal-organic frameworks (MOFs) have emerged as promising nanocarriers for precise local drug delivery, reducing required doses and mitigating side effects of chemotherapeutic drugs, thus offering a potential avenue for hepatocellular carcinoma (HCC) treatment. In this research, a rectangular channel MOF (Rumgay H, Ferlay J, Martel C, Georges D, Ibrahim AS, Zheng R, Wei W, Lemmens VEPP, Soerjomataram I (2022) Global, regional and national burden of primary liver cancer by subtype. Eur J Cancer 161:108–118) carrier was synthesized using ligand L as the organic linker coordinated with Cu(II) and I(I). The MOF’s structure and fluorescence properties were characterized. Additionally, to enhance substrate biocompatibility, composite carrier materials were prepared by incorporating polylactic acid (PLA) with 1 , utilized for cisplatin loading. To evaluate the inhibitory effect of PLA- 1 @cisplatin on HCC, HepG-2 and Huh-7 HCC cell lines were treated with varying concentrations of the drug for 48 h, and their cell viability was assessed. The results demonstrated a significant dose-dependent reduction in cell viability of both HepG-2 and Huh-7 cells. To explore the potential inhibitory mechanism of PLA- 1 @cisplatin on HCC, the mRNA levels of GADD45A and NACC1 in HepG-2 and Huh-7 cells post-treatment were measured. GADD45A expression, initially low in HCC cells, was significantly upregulated after drug treatment, while NACC1, typically highly expressed in HCC, showed a significant decrease in mRNA levels with increasing concentrations of PLA- 1 @cisplatin. These findings indicate that PLA- 1 @cisplatin effectively upregulates GADD45A expression and downregulates NACC1 expression. Overall, the developed cisplatin-loaded nanoparticle system holds promise for HCC treatment by reducing chemotherapy side effects and enhancing drug efficacy.
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JOURNAL OF THERMAL SPRAY TECHNOLOGY
·
2025
·
IF 3.3
Zhang Jian,Chen Hongxuan,Pang Xiaotong,Liu Shilong,Misra R. D. K.,Sun Junhao
Currently, surface coatings on agricultural machinery are crucial for extending service life. However, achieving coating strength and toughness remains a challenge. In this paper, two types of high-hardness iron-based coatings, referred as S1 and S2, were prepared by modulating the Mo/V ratio in the Fe-C-V-Mo-B system, and their microstructural evolution and property changes were investigated. The results show that the S1 coating primarily consist of martensitic matrix, spherical VC, blocky Mo 2 B, and a small amount of skeleton-like Mo 2 B. In contrast, the S2 coating consist of martensitic matrix, petal-like VC, and skeleton-like Mo 2 B. Compared with S1, the VC volume fraction in S2 increases by 6.5%, and the Mo 2 B volume fraction increases by 16.3%. The average microhardness of S1 and S2 coatings are 737 HV 0.5 and 954 HV 0.5 , respectively, indicating that the S2 coating exhibits a 22.7% higher microhardness compared with S1. The average friction coefficients of S1 and S2 coatings are 0.434 and 0.398, respectively. Furthermore, the wear loss of S2 coating is approximately half that of S1. The fracture toughness of S1 and S2 coatings are 51.9 MPa·m 1/2 and 51.7MPa·m 1/2 , respectively. Fracture analysis reveals that the skeleton-like eutectic structure in S2 can deflect cracks generated by impact, increase the length of propagation path, and improve the toughness of coating. It allows S2 coating to achieve high hardness and wear resistance, while maintaining toughness comparable to S1 coating. This study provides a theoretical basis for the design and development of iron-based coatings with high hardness, high abrasion resistance, and impact resistance for agricultural machinery.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2024
·Vol. 50
·期 6
·2743-2761
·
IF 2.8
Lin Yingzi,Chen Jing,Chen Junjie,Chen Lei,Yang Hong,Sun ShengBo,Sun Ningning,Weng Qixuan,Tian Shiqi
To address the disadvantage of poor degradation effect of Fe 2+ /peroxydisulfate (PDS) system, a co-catalyst was introduced in this study to construct a molybdenum (Mo)/Fe 2+ /PDS system for the degradation of Acid Orange 7 (AO7), and the degradation rate could reach 95.67%. The effects of different parameters (initial pH, Fe 2+ concentration, etc.) on the degradation effect of AO7 in this system were investigated, and the optimal degradation conditions were obtained by combining cost analysis. Cycling experiments showed that Mo had good stability. The co-catalytic mechanism of Mo powder was determined using X-Ray Diffraction, Scanning Electron Microscope, and X-ray Photoelectron Spectroscopy. The effects of different inorganic anions on AO7 were discussed: Cl − and NO 3 − had little effect on degradation, while SO 4 2− and HCO 3 − both inhibited the removal of AO7 from the system to different degrees, with HCO 3 − showing a greater inhibition than SO 4 2− . The main active radicals were identified as sulfate radical (SO 4 ·− ) and hydroxyl radical (·OH). In addition, intermediates were identified, and the attack sites were determined by combining the highest occupied molecular orbital/lowest unoccupied molecular orbital energy levels and the Fukui index to hypothesize the degradation pathways. Toxicity indicators such as the mutagenicity of AO7 and intermediates were evaluated, and the overall trend of toxicity was decreasing. This study is expected to provide an efficient treatment process for dye wastewater.
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MOLECULAR NEUROBIOLOGY
·
2024
·
IF 4.6
Shen Yifen,Zhang Le,Yang Tao,Li Xiaosong,Liu Chao,Li Hongmei,Hu Yanping,Shen Hao,Li Hua,Orlov Yuriy L.,Zhou Shasha,Shen Yihang
Puberty onset through hypothalamic-pituitary-gonad (HPG) axis as an important reproductive event in postnatal development is initiated from hypothalamic arcuate nucleus (ARC). The growing evidence indicates that translational control also plays an essential role in the final expression of gonadotropin genes. To investigate the role of protein translation and behavior of ribosomes in pubertal onset, the global profiles of transcriptome, single ribosome (monosome), polysome, and tandem mass tag proteome were comprehensively investigated in rat hypothalamic ARCs of different pubertal stages using RNA sequencing, polyribo sequencing, and mass spectrum. Transcriptome-wide enrichments of N6-methyladenosine and IGF2BP2 were investigated using meRIP and RIP sequencing. Monosome was robustly enriched on a large proportion of mRNA in early puberty rats (postnatal day (PND)-25) compared to late puberty (PND-35 and PND-45). Monosome-enriched mRNAs, including HPG axis-related genes, had a large number of upstream ORFs (uORF, < 100 nt) and displayed translational repression in early puberty. Furthermore, insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) could particularly interact with and facilitate monosome to bind with mRNA in early puberty. Finally, ectopic over-expression of IGF2BP2 in hypothalamic ARC via lateral ventricle injection in vivo could recruit monosome to aggregate on mRNA and delay puberty onset. We uncovered a novel regulatory mechanism of IGF2BP2 and monosome for translational control in puberty onset, which shed light on the neuroendocrine regulatory network involved in HPG axis activation.
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WATER AIR AND SOIL POLLUTION
·
2024
·Vol. 235
·期 12
·1-15
·
IF 3.8
Yi Junming,Feng Dongsheng,Fu Jiangzhe,Liu Yuxin,Gong Ruihui,Liu Peizu,Guo Jing,Cui Kai,Li Huidong
Nowadays, the use of antibiotics is widespread which is causing great pressure on the ecological environment. Incorporation of nitrogen source in biochar can improve its adsorption performance, which is widely used as an adsorbent due to its high efficiency and low-cost. In this study, municipal sludge and red mud were used as raw materials, urea as nitrogen source and KOH and ammonium oxalate as activators to prepare N-doped sludge-based magnetic biochar (NBC) by co-pyrolysis for adsorption of norfloxacin (NOR) in wastewater. The experiment was conducted using 50 mL of NOR wastewater with a concentration of 100 mg/L. The optimal adsorption conditions were identified as 1.6 g/L dosage, pH 5, and temperature 25 °C. The actual adsorption capacity of NBC reached a maximum of 160.25 mg/g. The maximum adsorption capacity of NBC was 388.82 mg/g, which was measured by Langmuir isothermal modelling. The adsorption kinetics are consistent with a pseudo-second order model, while the adsorption isotherms are consistent with the Langmuir and Freundlich models. The characterization demonstrates that NBC is a rough and porous material, with a specific surface area of 192.8397 m2/g and a surface functional group composition including -OH/NH, C = C, C = N, C-O. The main mechanisms of this research include pore filling, π-π interactions, H-bonding and electrostatic interactions. The introduction of a nitrogen source to sludge-based magnetic biochar (BC) has improved its performance in various aspects of adsorption. This paper demonstrates the excellence of NBC by comparing the adsorption performance of NOR with that of BC, which has great potential for future practical applications. Graphical
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European Journal of Wood and Wood Products
·
2025
·Vol. 83
·期 2
·1-12
·
IF 2.5
Li Peisheng,Xu Jiayu,Pan Anbo,Jiang Mingyue,Xu Yantao,Zhang Xiaochun
With the rapid development of the economy and society, problems such as high resource consumption and serious environmental pollution in traditional reinforced concrete buildings are becoming increasingly prominent. Bamboo scrimber is an effective substitute for green building materials, but there are some problems such as susceptibility to mildew and poor flame retardancy, which limit its application in the building industry. In this study, the alkaline pretreatment process was used to remove some nutrients from bamboo to improve mildew resistance, and phytic acid and magnesium hydroxide were loaded on the surface of the bamboo bundle to enhance the flame retardancy. The results showed that phytic acid and magnesium hydroxide could be effectively loaded on the surface of bamboo bundles, and the mechanical strength, mildew resistance, and flame retardancy of modified bamboo scrimber (M10-PB) have been effectively improved. Compared with unmodified bamboo scrimber, the flexural strength and flexural modulus of M10-PB increased by 33.72% and 36.61% to 155.26 MPa and 14.59 GPa, respectively; the mold infection rate has decreased from 100% at 5 d to below 20% at 28 d; the limiting oxygen index of M10-PB bamboo scrimber increased by 13.2%, and the total smoke emission decreased by 54.4%. This method can effectively improve the mildew resistance, flame retardancy and smoke suppression of bamboo scrimber while maintaining high mechanical strength, which helps to promote the application of bamboo in the construction field.
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