Nature Communications
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2024
·Vol. 15
·期 1
·1-11
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IF 14.7
Zhu Ruixin,Zhu Dandan,Zheng Zhen,Wang Xinling
Most tough hydrogels are reinforced by introducing energy dissipation mechanisms, but simultaneously realizing a high toughness and low hysteresis is challenging because the energy dissipation structure cannot recover rapidly. In this work, high mechanical performance highly entangled double network hydrogels without energy dissipation structure are fabricated, in which physical entanglements act as the primary effective crosslinking in the first network. This sliding entanglement structure allows the hydrogel network to form a highly uniform oriented structure during stretching, resulting in a high tensile strength of ~3 MPa, a fracture energy of 8340 J m −2 and a strain-stiffening capability of 47.5 in 90% water content. Moreover, almost 100% reversibility is obtained in this hydrogel via energy storage based on entropy loss. The highly entangled double network structure not only overcomes the typical trade-off between the high toughness and low hysteresis of hydrogels, but more importantly, it provides an insight into the application of entanglement structures in high-performance hydrogels.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-13
·
IF 14.7
Gao Changsong,Liu Di,Xu Chenhui,Xie Weidong,Zhang Xianghong,Bai Junhua,Lin Zhixian,Zhang Cheng,Hu Yuanyuan,Guo Tailiang,Chen Huipeng
Reservoir computing has attracted considerable attention due to its low training cost. However, existing neuromorphic hardware, focusing mainly on shallow-reservoir computing, faces challenges in providing adequate spatial and temporal scales characteristic for effective computing. Here, we report an ultra-short channel organic neuromorphic vertical transistor with distributed reservoir states. The carrier dynamics used to map signals are enriched by coupled multivariate physics mechanisms, while the vertical architecture employed greatly increases the feedback intensity of the device. Consequently, the device as a reservoir, effectively mapping sequential signals into distributed reservoir state space with 1152 reservoir states, and the range ratio of temporal and spatial characteristics can simultaneously reach 2640 and 650, respectively. The grouped-reservoir computing based on the device can simultaneously adapt to different spatiotemporal task, achieving recognition accuracy over 94% and prediction correlation over 95%. This work proposes a new strategy for developing high-performance reservoir computing networks.
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JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-20
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IF 10.6
Zeng Youyun,Hu Xiangyu,Cai Zhibin,Qiu Dongchao,Ran Ying,Ding Yiqin,Shi Jiayi,Cai Xiaojun,Pan Yihuai
Background The main issues faced during the treatment of apical periodontitis are the management of bacterial infection and the facilitation of the repair of alveolar bone defects to shorten disease duration. Conventional root canal irrigants are limited in their efficacy and are associated with several side effects. This study introduces a synergistic therapy based on nitric oxide (NO) and antimicrobial photodynamic therapy (aPDT) for the treatment of apical periodontitis. Results This research developed a multifunctional nanoparticle, CGP, utilizing guanidinylated poly (ethylene glycol)-poly (ε-Caprolactone) polymer as a carrier, internally loaded with the photosensitizer chlorin e6. During root canal irrigation, the guanidino groups on the surface of CGP enabled effective biofilm penetration. These groups undergo oxidation by hydrogen peroxide in the aPDT process, triggering the release of NO without hindering the production of singlet oxygen. The generated NO significantly enhanced the antimicrobial capability and biofilm eradication efficacy of aPDT. Furthermore, CGP not only outperforms conventional aPDT in eradicating biofilms but also effectively promotes the repair of alveolar bone defects post-eradication. Importantly, our findings reveal that CGP exhibits significantly higher biosafety compared to sodium hypochlorite, alongside superior therapeutic efficacy in a rat model of apical periodontitis. Conclusions This study demonstrates that CGP, an effective root irrigation system based on aPDT and NO, has a promising application in root canal therapy.
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Communications Biology
·
2025
·Vol. 8
·期 1
·1-14
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IF 5.1
Sun Wei,Zhao Bo,He Zhong,Chang Lihua,Song Wei,Chen Yingying
Idiopathic pulmonary fibrosis (IPF) is an irreversible lung condition that progresses over time, which ultimately results in respiratory failure and mortality. In this study, we found that PLAC8 was downregulated in the lungs of IPF patients based on GEO data, in bleomycin (BLM)-induced lungs of mice, and in primary murine alveolar epithelial type II (pmATII) cells and human lung epithelial cell A549 cells. Overexpression of PLAC8 facilitated autophagy and inhibited apoptosis of pmATII cells and A549 cells in vitro. Moreover, inhibition of autophagy or overexpression of p53 partially abolished the effects of PLAC8 on cell apoptosis. ATII cell-specific overexpression of PLAC8 alleviated BLM-induced pulmonary fibrosis in mice. Mechanistically, PLAC8 interacts with VCP-UFD1-NPLOC4 complex to promote p53 degradation and facilitate autophagy, resulting in inhibiting apoptosis of alveolar epithelial cells and attenuating pulmonary fibrosis. In summary, these findings indicate that PLAC8 may be a key target for therapeutic interventions in pulmonary fibrosis.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2024
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IF 3.8
Wang Qian,Meng Song,Zhou Gang,Shi Qingshan,Xu Ziqiang,Xie Xiaobao
Nanoceria have demonstrated a wide array of catalytic activity similar to natural enzymes, holding considerable significance in the colorimetric detection of alkaline phosphatase (ALP), which is a biomarker of various biological disorders. However, the issues of physiological stability and formation of protein corona, which are strongly related to their surface chemistry, limit their practical application. In this work, CeO 2 nanoparticles characterized by enhanced dimensional uniformity and specific surface area were synthesized, followed by encapsulation with various polymers to further increase catalytic activity and physiological stability. Notably, the CeO 2 nanoparticles encapsulated within each polymer exhibited improved catalytic characteristics, with PAA-capped CeO 2 exhibiting the highest performance. We further demonstrated that the PAA-CeO 2 obtained with enhanced catalytic activity was attributed to an increase in surface negative charge. PAA-CeO 2 enabled the quantitative assessment of AA activity within a wide concentration range of 10 to 60 μM, with a detection limit of 0.111 μM. Similarly, it allowed for the evaluation of alkaline phosphatase activity throughout a broad range of 10 to 80 U/L, with a detection limit of 0.12 U/L. These detection limits provided adequate sensitivity for the practical detection of ALP in human serum.
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WATER AIR AND SOIL POLLUTION
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2024
·Vol. 235
·期 12
·1-15
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IF 3.8
Yi Junming,Feng Dongsheng,Fu Jiangzhe,Liu Yuxin,Gong Ruihui,Liu Peizu,Guo Jing,Cui Kai,Li Huidong
Nowadays, the use of antibiotics is widespread which is causing great pressure on the ecological environment. Incorporation of nitrogen source in biochar can improve its adsorption performance, which is widely used as an adsorbent due to its high efficiency and low-cost. In this study, municipal sludge and red mud were used as raw materials, urea as nitrogen source and KOH and ammonium oxalate as activators to prepare N-doped sludge-based magnetic biochar (NBC) by co-pyrolysis for adsorption of norfloxacin (NOR) in wastewater. The experiment was conducted using 50 mL of NOR wastewater with a concentration of 100 mg/L. The optimal adsorption conditions were identified as 1.6 g/L dosage, pH 5, and temperature 25 °C. The actual adsorption capacity of NBC reached a maximum of 160.25 mg/g. The maximum adsorption capacity of NBC was 388.82 mg/g, which was measured by Langmuir isothermal modelling. The adsorption kinetics are consistent with a pseudo-second order model, while the adsorption isotherms are consistent with the Langmuir and Freundlich models. The characterization demonstrates that NBC is a rough and porous material, with a specific surface area of 192.8397 m2/g and a surface functional group composition including -OH/NH, C = C, C = N, C-O. The main mechanisms of this research include pore filling, π-π interactions, H-bonding and electrostatic interactions. The introduction of a nitrogen source to sludge-based magnetic biochar (BC) has improved its performance in various aspects of adsorption. This paper demonstrates the excellence of NBC by comparing the adsorption performance of NOR with that of BC, which has great potential for future practical applications. Graphical
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European Journal of Wood and Wood Products
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2025
·Vol. 83
·期 2
·1-12
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IF 2.5
Li Peisheng,Xu Jiayu,Pan Anbo,Jiang Mingyue,Xu Yantao,Zhang Xiaochun
With the rapid development of the economy and society, problems such as high resource consumption and serious environmental pollution in traditional reinforced concrete buildings are becoming increasingly prominent. Bamboo scrimber is an effective substitute for green building materials, but there are some problems such as susceptibility to mildew and poor flame retardancy, which limit its application in the building industry. In this study, the alkaline pretreatment process was used to remove some nutrients from bamboo to improve mildew resistance, and phytic acid and magnesium hydroxide were loaded on the surface of the bamboo bundle to enhance the flame retardancy. The results showed that phytic acid and magnesium hydroxide could be effectively loaded on the surface of bamboo bundles, and the mechanical strength, mildew resistance, and flame retardancy of modified bamboo scrimber (M10-PB) have been effectively improved. Compared with unmodified bamboo scrimber, the flexural strength and flexural modulus of M10-PB increased by 33.72% and 36.61% to 155.26 MPa and 14.59 GPa, respectively; the mold infection rate has decreased from 100% at 5 d to below 20% at 28 d; the limiting oxygen index of M10-PB bamboo scrimber increased by 13.2%, and the total smoke emission decreased by 54.4%. This method can effectively improve the mildew resistance, flame retardancy and smoke suppression of bamboo scrimber while maintaining high mechanical strength, which helps to promote the application of bamboo in the construction field.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2024
·
IF 4.7
Song Jie,Yu Shuang,Han Jiaxuan,Zhang Rong,Ma Xiaoyan
To improve the performance of biodegradable materials and endow them with antimicrobial properties, herein, pyridine-3,5-dicarboxylic acid was introduced as a third monomer into the molecular chain of polybutylene succinate (PBS) via copolymerization, followed by introduction of pyridine quaternary ammonium into the PBS branched chain through nucleophilic substitution to afford antimicrobial PBS-BD, which was then comingled with polylactic acid (PLA) to prepare PBS-BD/PLA composites. X-ray diffraction analysis revealed that the introduction of pyridine-3,5-dicarboxylic acid caused a small shift in the diffraction peaks of PBS and a decrease in crystallinity, which was further decreased upon blending with PLA. PBS-BD and PLA were bound together by intermolecular forces. When the PBS-BD/PLA ratio was 8:2, the melting points of the two phases were the closest, the compatibility was the best, and the thermal and antimicrobial properties were optimal. The antimicrobial properties of the composites were gradually enhanced with increasing PBS-BD content, reaching optimal values for application as antimicrobial materials. The composites were degraded in soil supernatant for 6 months at a rate of 31.52%. After 42 d of enzymatic degradation, the degradation rate reached 23.24%. The PBS-BD/PLA composites promoted the growth of green vegetables to a certain extent and enhanced their nutritional value, reaching the highest chlorophyll content and vitamin C content after 45 d of growth in the presence of the composites.
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Food and Bioprocess Technology
·
2024
·
IF 5.3
Cao Zhaoxin,Su Jingyi,Luo Yali,Wang Xinyu,Liu Zhiming,Chen Yanqi,Zou Yijing,Shen Wen,Ge Xuemei
Carvacrol essential oil has broad-spectrum antibacterial properties, but the essential oil is volatile and unstable for long-term storage and use. In order to improve the relevant properties of carvacrol, in the present study, carvacrol was encapsulated with β-cyclodextrin (β-CD) using the saturated aqueous solution method, and response surface analysis was carried out, which gave a high encapsulation rate (63.58 ± 3.74%). The success encapsulation of carvacrol was confirmed by scanning electron microscopy (SEM), Fourier infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The release performance of the encapsulants was also tested at different temperature and humidity levels. In addition, polyethylene glycol (PEG) composite carvacrol-inclusive preservation paper prepared by these anhydrous conditions showed high antibacterial activity against Streptomyces fructus Monilinia fructicola , the main pathogen of peaches. Also, PEG was used to form the film in the anhydrous condition with the inclusion compound and ethylene inhibitor 1-methylcyclopropene (1-MCP) to obtain the film coated paper, and its effect on postharvest preservation quality of peach was studied. The results showed that PEG + Carvacrol-β-CD + 1-MCP-α-CD inclusion complexes (ICs) effectively prolonged the storage time and improved the fruit quality and enzyme activity of peach. This study provides a solution for the preparation of controlled-release coated paper with essential oils and 1-MCP bioactives to extend the shelf life of fruits and vegetables. Graphical Abstract
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 8
·1-13
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IF 5.3
Xu Ruijie,Liu Zhenkang,Kong Zhibo,Ma Xinyu,Peng Xiaolun,Wang Yazhen
CoFe@C was first prepared by calcining the precursor of CoFe-metal–organic framework-74 (CoFe-MOF-74), then an electrochemical sensor for the determination of neohesperidin dihydrochalcone (NHDC) was constructed, which was stemmed from the novel CoFe@C/Nafion composite film modified glassy carbon electrode (GCE). The CoFe@C/Nafion composite was verified by field-emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM). Electrochemical impedance spectroscopy (EIS) was used to evaluate its electrical properties as a modified material for an electrochemical sensor. Compared with CoFe-MOF-74 precursor modified electrode, CoFe@C/Nafion electrode exhibited a great synergic catalytic effect and extremely increased the oxidation peak signal of NHDC. The effects of various experimental conditions on the oxidation of NHDC were investigated and the calibration plot was tested. The results bespoken that CoFe@C/Nafion GCE has good reproducibility and anti-interference under the optimal experimental conditions. In addition, the differential pulse current response of NHDC was linear with its concentration within the range 0.08 ~ 20 µmol/L, and the linear regression coefficient was 0.9957. The detection limit was as low as 14.2 nmol/L (S/N = 3). In order to further verify the feasibility of the method, it was successfully used to determine the content of NHDC in Chinese medicine, with a satisfactory result, good in accordance with that of high performance liquid chromatography (HPLC). Graphical Abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
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IF 15.7
He Shuai,Lin Weixi,Yu De,Shi Junwei,Yin Zhen,Sun Changjiu,Liu Haoliang,Zhang Chen,Yuan Jianyu,Bai Sai,Xiao Shumin,Long Guankui,Yuan Mingjian,Jiang Yuanzhi,Chen Yimu,Song Qinghai
Realizing high electroluminescence dissymmetric factor and high external quantum efficiency at the same time is challenging in light-emitting diodes with direct circularly polarized emission. Here, we show that high electroluminescence dissymmetric factor and high external quantum efficiency can be simultaneously achieved in light-emitting diodes based on chiral perovskite quantum dots. Specifically, chiral perovskite quantum dots with chiral-induced spin selectivity can concurrently serve as localized radiative recombination centers of spin-polarized carriers for circularly polarized emission, thereby suppressing the relaxation of spins, Meanwhile, improving the chiral ligand exchange efficiency is found to synergistically promote their spin selectivity and optoelectronic properties so that chiroptoelectronic performance of resulting devices can be facilitated. Our device simultaneously exhibits high electroluminescence dissymmetric factor ( R : 0.285 and S : 0.251) and high external quantum efficiency ( R : 16.8% and S : 16%), demonstrating their potential in constructing high-performance chiral light sources.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 3
·1-13
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IF 2.8
Liang Caiying,Lan Pei,Feng Shuhuan,Xu Tengfei,Dong Liubing,Zhao Jianhao,Rong Jianhua
Integrated hydrogel supercapacitors have attracted increasing attention owing to their low interfacial contact resistance and excellent electrochemical performance even under folding and bending. Herein, phosphomolybdic acid-doped polypyrrole (PPy) was deposited in situ on the surface of a hydroxypropyl cellulose/polyvinyl alcohol (HPC/PVA) hydrogel to fabricate integrated hydrogel supercapacitors. The negatively charged phosphomolybdic acid (PMo 12 ) was anchored onto the positively charged PPy chain to prevent its dissolution in the electrolyte thereby enhancing its pseudocapacitive performance. PMo 12 also can dope and modify PPy, providing additional pseudocapacitance and thereby improving the energy storage capacity of the supercapacitor. The supercapacitor achieved a high areal specific capacitance (350 mF cm −2 at 0.5 mA cm −2 ) and demonstrated a remarkable energy density (24.0 \(\upmu\) Wh cm −2 at 1000 \(\upmu\) W cm −2 ). After 1000 galvanostatic charge–discharge cycles at a high current density of 10 mA cm −2 , it retained 71.3% of its initial capacitance and maintained 98% Coulombic efficiency.
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