SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
·
2018
·
IF 2.854
Bingshan Zhao,Man He,Beibei Chen,Hongrun Xu,Bin Hu
In this study, poly(1-vinylimidazole) functionalized gold ion imprinted polymer coated magnetic nanoparticles (MNPs@PVIM-Au-IIP) were prepared and characterized. The adsorption behaviors of the prepared MNPs@PVIM-Au-IIP toward gold ions (Au(III)) were studied, it was found that MNPs@PVIM-Au-IIP has good selectivity, high adsorption capacity (185.4 mg g −1 ) and fast adsorption kinetic for Au(III). Based on it, a new method of ion imprinted magnetic solid phase extraction (II-MSPE) coupled with graphite furnace atomic absorption spectrometry (GFAAS) detection was proposed for the analysis of trace Au(III) in real samples with complicated matrix. Factors affecting MSPE including sample pH, desorption reagent, elution concentration and volume, elution time, sample volume and adsorption time were optimized. With high enrichment factor of 100-fold, the detection limit of the proposed method is 7.9 ng L −1 for Au(III) with the relative standard deviation of 7.4% (c = 50 ng L −1 , n = 7). In order to validate the accuracy of the proposed method, the Certified Reference Material of GBW07293 geological sample (platinpalladium ore) was analyzed, and the determined value was in good agreement with the certified value. The proposed II-MSPE-GFAAS method is simple, fast, selective, sensitive and has been successfully applied in the determination of trace Au in ore, sediment, environmental water and human urine samples with satisfactory results.
研究领域:
分析化学
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环境科学
·
材料科学
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2016
·
IF 3.926
Qingxiang Zhou,Man Lei,Jing Li,Kuifu Zhao,Yongli Liu
Magnetic Fe@MgAl-layered double hydroxides (MgAl-LDHs) composite was firstly synthesized by coating MgAl-layered double hydroxides on the surface of the dispersed nanoscale zero valent irons with co-precipitation method and characterized by transmission electron microscopy and X-ray diffraction techniques. The synthesized Fe@MgAl-LDHs nanoparticles were investigated for magnetic solid phase extraction (MSPE) of 1-naphthol and 2-naphthol from the water samples. The elutent containing 1-naphthol and 2-naphthol was analyzed by high performance liquid chromatography with variable wavelength detection (HPLC–UV). Under optimal conditions, there is good linear relationship between the concentration and the peak area in the range of 0.5–200 μg L −1 with the correlation coefficients ( r 2 ) above 0.998 for 1-naphthol and 2-naphthol. The limits of detection were 0.22 μg L −1 and 0.19 μg L −1 for 1-naphthol and 2-naphthol, respectively, and precisions were both below 2.5% ( n = 6). The real water analysis demonstrated that the spiked recoveries were in the range of 79.2–80.9% ( n = 3). All these results indicated that the developed MSPE–HPLC–UV method was proved to be an efficient tool for the analysis of naphthols.
研究领域:
环境科学
·
分析化学
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DOI
高影响因子
Russian Journal of Physical Chemistry A
·
2026
·Vol. 100
·期 7
·1360-1365
·
IF 0.7
Xiaoru Pan,Kong Xiangyan,Li Dan
In this experiment, the viscosities and densities of binary systems consisting of cyclohexene oxide with 1-butanol, 1-pentanol, 1-hexanol, 1-heptanol were measured at different temperatures ranging from 298.15 to 313.15 K. Based on these data, excess molar volumes and viscosity deviations were calculated. The excess properties were correlated using the Redlich–Kister equation.
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Yunfei Wang,Wenjie Sun,Yixiao Li,Xuming Zhuang,Chunyuan Tian,Feng Luan,Xiuli Fu
Human immunodeficiency virus (HIV) is still a significant global health concern. Hence, developing a rapid and sensitive method for the detection of HIV is important in early detection. In this paper, we focus on the preparation of a sensitive electrochemical luminescence (ECL) biosensor that uses Ti 3 C 2 T x modified ZIF-8 as an ECL emitter to detect HIV-1 protein. This ECL biosensor used 0.05 M K 2 S 2 O 8 as the co-reactant and conductive carbon black combined with magnetic nanoparticles as the quenching agent. Under the optimized experimental conditions, the relationship was linear in the range from 1 fM to 1 nM (R 2 = 0.993) and the detection limit was 0.3 fM (S/N = 3). Finally, we used the constructed Ti 3 C 2 T x /ZIF-8 nanocomposites to detect HIV-1 in real serum samples and obtained great recoveries. The results demonstrated that this biosensor, which not only exhibited improved electrical conductivity but also demonstrated an excellent ECL response, could be a promising candidate for HIV-1 detection.
研究领域:
生物传感器
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分析化学
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材料科学
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病毒学
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DOI
高影响因子
JOURNAL OF NEUROTRAUMA
·
2023
·
IF 4.2
Hongxing Tang,Kejun He,Kun Zhao,Chen Zheng,Weichi Wu,Weilin Jin,Lixuan Yang,Baoshu Xie
Hinokitiol (β-thujaplicin, HIK) is a natural monoterpene small molecule compound showing various biological effects including antibacterial, anti- inflammatory and anti-tumor. Ferroptosis, a new form of iron-dependent cell death, has been demonstrated as one of the pathophysiological mechanisms of traumatic brain injury (TBI). However, the effect of hinokitiol on neuronal ferroptosis after traumatic brain injury has not been reported. Here, we show that hinokitiol alleviated excessive glutamate-induced intracellular reactive oxygen species (ROS), lipid peroxidation, and Fe2+ accumulation in HT-22. Moreover, hinokitiol upregulated heme oxygenase-1 (HO-1) expression, promoted nuclear factor-erythroid factor 2-related factor 2 (Nrf2) nuclear translocation, and inhibited the activation of microglia and astrocyte after TBI. Furthermore, hinokitiol remarkably reduced brain tissue lesions, mitigated neuron loss, iron deposition and attenuated neurologic impairment in the CCI-constructed TBI model in vivo. These results suggest that hinokitiol has neuroprotective effects on rescuing cells from TBI-induced neuronal ferroptosis. In summary, we reveal a novel role of hinokitiol in TBI, which has neuroprotective effects on rescuing cells from TBI-induced neuronal ferroptosis. Moreover, hinokitiol through activating the Nrf2/Keap1/HO-1 signaling pathway significantly reduces the neuronal damage, suggesting that it is a potential therapeutic candidate for TBI.
研究领域:
神经科学
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药理学
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细胞生物学
·
分子生物学
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DOI
PubMed
高影响因子
CARBOHYDRATE RESEARCH
·
2026
·
IF 3.4
Yufei Jin,Fangcheng Fu,Xinyuan Zhang,Dawei Zhang,Qian Yu,Chunyan Yan
Immunomodulation plays a key role in maintaining organismal health, and precise molecular mechanisms that control immune activation are key to achieving this balance. Angelica pubescens is in high demand in the Chinese herbal medicine market due to its effective properties in dispelling dampness and relieving pain. Nevertheless, the immunological activity of A. pubescens has not been fully elucidated. This study focuses on exploring the structural characterization and immunomodulatory activities of two homogeneous arabinans (APRP70-1-1 and APRP70-1-2) isolated from A. pubescens . Structural analysis revealed that APRP70-1-1 possesses a higher degree of branching compared to APRP70-1-2. In vitro experiments showed that despite activating macrophages, APRP70-1-2 was less effective than APRP70-1-1 at promoting nitric oxide (NO) release. APRP70-1-1 demonstrated superior immunomodulatory effects, as evidenced by its significantly enhancing macrophage phagocytic capacity and upregulation of tumor necrosis factor -α ( TNF-α ), interleukin -1β ( IL-1β ), and IL-6 mRNA expression. Mechanistic studies indicated that APRP70-1-1 activates the JAK2/STAT3 and NF-κB signaling pathways. In summary, these results indicate that APRP70-1-1 had immunomodulatory activity.
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Weibiao Du,Xiaopo Wang
In this work, the volumetric and viscometric properties of the mixtures of methyl decanoate with 1-propanol, 1-butanol, and 1-pentanol were investigated from 298.15 K to 333.15 K. The density data of the mixtures were obtained based on the vibrating-tube densimeter , and the kinematic viscosities of the mixtures were measured using the Ubbelohde capillary viscometer . Based on the experimental data, the excess molar volumes and viscosity deviations were calculated and correlated with the Redlich–Kister equation. In addition, the McAllister four-body model, Frenkel model, Grunberg-Nissan model, and Heric's model were used to correlate the viscosities of the mixtures.
研究领域:
物理化学
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热力学
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流体性质
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燃料化学
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溶液化学
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DOI
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 4
·1-7
·
IF 5.479
Li Zheng,Mao Guobin,Du Mingyuan,Tian Songbai,Niu Longqing,Ji Xinghu,He Zhike
A fluorometric method is described for the determination of the tumor biomarker mucin 1 (MUC1). It is based on signal amplification of the hybridization chain reaction (HCR), and the interaction between a luminescent ruthenium(II) complex and CdZnTeS quantum dots (QDs). If MUC1 bind to the biotin-labeled aptamer, it will initiate HCR with hairpins H 1 and H 2 to form a long-range dsDNA. The long nucleic acid chains are then linked on the surface of streptavidin-modified magnetic microparticles (MMPs) through streptavidin-biotin interaction. The luminescent ruthenium(II) complex is then embedded in the long dsDNA linked to the MMPs. Hence, there is little Ru complex in the supernatant after magnetic separation, and the fluorescence of the CdZnTeS QDs (best measured at excitation/emission wavelengths of 350/530 nm) is only slightly quenched. In the absence of target, the fluorescence of the CdZnTeS QDs is strongly quenched. Fluorescence increases linearly in the 0.2–100 ng·mL −1 MUC1 concentration range, and the LOD is 0.13 ng·mL −1 (at S/ N = 3). The method was applied to the determination of MUC1 in spiked human serum samples.
A fluorometric turn-on aptasensor for mucin 1 is described that is based on the interaction between a Ru(II) complex and quantum dots (QDs). The detection system includes biotin-labeled aptamer-H 0 , hairpins H 1 and H 2 , streptavidin-modified magnetic microparticles (MMPs), Ru(bpy) 2 (dppx) 2+ and CdZnTeS QDs.
研究领域:
分析化学
·
生物传感器
·
癌症诊断
·
纳米技术
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DOI
PubMed
高影响因子
Journal of Energy Chemistry
·
2025
·
IF 14.9
Jingchi Zhang,Ze Hua,Ziqi Wu,Xinting Cao,Wen Yang,Ruiwen Shao,Yu Bai,Zhenhua Wang,Kening Sun
To satisfy the demands of modern society for high-energy–density sulfide-based all-solid-state lithium batteries (ASSLBs), Ni-rich cathode materials have gained much attention for their high capacity and energy density. However, their practical deployment is hindered by accelerated interface degradation and capacity decay originating from surface oxygen release and lattice oxygen activation during prolonged cycling. In this study, Ti x NbB (1− x ) C 2 was successfully coated on the surface of LiNi 0.94 Co 0.05 Mn 0.01 O 2 . Density functional theory (DFT) calculations first elucidate a “point-to-point” anchoring mechanism where each surface oxygen atom coordinates with single species (Ti/Nb/B) offered by Ti x NbB (1− x ) C 2 , which forms robust O–M bonds and sustain a stable interface structure. The electron energy loss spectroscopy (EELS) reveals the segregation of Ti/Nb toward subsurface layers during cycling, creating an optimized lattice oxygen coordination environment and suppressing oxygen activation. The dual oxygen stabilization mechanism dramatically improves the reversibility of phase transition and the structural stability of the Ni-rich cathode materials. Moreover, Ti x NbB (1− x ) C 2 as the protective layer decreases mechanical strain and suppresses the parasitic reactions. Consequently, the engineered cathode delivers 91% capacity retention after 1000 cycles at 0.3 C, suggesting excellent cycling stability. The research delivers a new design philosophy for the coating layer that can stabilize surface oxygen. Furthermore, the atomistic understanding of the structure–property relationship of the Ni-rich cathode materials provides valuable guidance for the future design of new cathode materials with superior structural stability in ASSLBs.
研究领域:
材料科学
·
电化学
·
储能
·
电池技术
·
计算材料设计
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产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
·
2023
·Vol. 26
·期 20
·e202300278
·
IF 2.8
Yonghang Mu,Zi Wang,Linhua Song,Kun Ma,Yao Chen,Peixun Li,Zifeng Yan
Graphical We report a gram-scale synthesis of sphingosines with different deuterated chains. The synthesis of highly stereoselective chain deuterated sphingosine was accomplished in five steps which started from hydrothermal platinum-catalyzed hydrogen/deuterium (H/D) exchange of protiated fatty acids. The subsequent synthesis of the deuterated-chain derivatives are also described. They were all characterized with deuterated content above 94 %. Sphingosine plays crucial roles in various cellular functions. Deuterated molecules are widely used as the important tools to explore the structure, property, and function of biochemical materials. We here report a gram-scale synthesis of sphingosines with different deuterated chains. The synthesis started from different protiated fatty acids, which underwent hydrothermal platinum-catalyzed hydrogen/deuterium (H/D) exchange to produce the deuterated chains with different length. The Horner–Wadsworth–Emmons (HWE) coupling of a chiral amino acid derivative with the deuterated chains generated the unsaturated ketone precursors. The following stereoselective reduction via cyclic Felkin–Anh transition led to the desired anti- amino alcohol geometry. This efficient protocol enabled the gram-scale synthesis of the chain-deuterated sphingosines. The subsequent synthesis of the chain-deuterated derivatives, i. e. ceramide, sphinganine and sphingosine-1-phosphate, is also described. Their deuterium content was simultaneously characterized by 1 H NMR and high-resolution mass spectrum (HRMS).
研究领域:
有机化学
·
生物化学
·
药学
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DOI
高影响因子
Frontiers in Microbiology
·
2022
·
IF 6.064
Le Su,Feifan Ma,Zaiyong An,Xiuyu Ji,Ping Zhang,Qiulin Yue,Chen Zhao,Xin Sun,Kunlun Li,Baojun Li,Xinli Liu,Lin Zhao
Because of the increased incidence and prevalence, ulcerative colitis (UC) has become a global health issue in the world. Current therapies for UC are not totally effective which result in persistent and recurrent symptom of many patients. Lactobacillus with anti-inflammatory effects might be beneficial to the prevention or treatment for UC. Here, we examined the ameliorative effects of the metabolites of Lactobacillus fermentum F-B9-1 (MLF) in Caco-2 cells and dextran sodium sulfate (DSS)-induced UC model mice. MLF displayed intestinal barrier-protective activities in Caco-2 cells by increasing the expression of Occludin and ZO-1. They also showed anti-inflammatory potential in interleukin (IL)-1β and IL-6. In order to further examine the in vivo anti-inflammatory effect of MLF, the MLF was gavaged in the DSS-induced UC model mice. The intragastric administration of MLF effectively alleviated colitis symptoms of weight loss, diarrhea, colon shortening, and histopathological scores, protected intestinal barrier function by increasing Occludin and ZO-1, and attenuated colonic and systemic inflammation by suppressing production of IL-1β and IL-6. Finally, the use of MLF remodeled the diversity of the gut microbiota and increased the number of beneficial microorganisms. Overall, the results demonstrated that MLF relieved DSS-induced UC in mice. And MLF might be an effective therapy method to UC in the clinic in the future.
研究领域:
胃肠病学
·
微生物学
·
免疫学
·
药理学
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DOI
PubMed
高影响因子
Frontiers in Pharmacology
·
2024
·
IF 4.4
Chencen Lai,Shuo Zhang,Zhiyu Chen,Xiaoyu Fu,Min Zhang,Pengjiao Wang,Xiuli Gao
Pyroptosis induced by oxidative stress is a significant contributor to mental health disorders, including depression (+)-Catechin (CA), a polyphenolic compound prevalent in various food sources, has been substantiated by prior research to exhibit potent antioxidant properties and potential antidepressant effects. Nonetheless, the precise antidepressive mechanisms and effects of CA remain incompletely elucidated. In this study, we employed corticosterone (CORT) and PC12 cells to develop a cellular model of depression, aiming to investigate the protective effects of CA against CORT-induced cellular damage. Our objective was to elucidate the underlying mechanisms of protective action. We utilized transcriptomic analysis to identify differentially expressed genes and employed bioinformatics approaches to predict the potential mechanisms of CA’s protective effects in PC12 cells. These transcriptomic predictions were subsequently validated through western blot analysis. The findings indicated that CA possesses the capacity to mitigate oxidative stress and suppress pyroptosis in PC12 cells via the activation of the PI3K/AKT signaling pathway. This activation subsequently modulates the Nrf2/HO1/NF-κB pathways, thereby providing protection to PC12 cells against damage induced by CORT. Furthermore, we investigated the interaction between CA and the Keap1 protein employing molecular docking and protein thermal shift assays. We propose that CA can activate Nrf2 through two mechanisms to decrease reactive oxygen species (ROS) levels and inhibit pyroptosis: one mechanism involves the activation of the PI3K/AKT signaling pathway, and the other involves direct binding to Keap1, leading to an increase in p-Nrf2.
研究领域:
神经科学
·
药理学
·
细胞生物学
·
分子生物学
·
生物信息学
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DOI
PubMed
高影响因子
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