ACS Applied Nano Materials
·
2023
·
IF 5.9
Guangli Li,Xuan Wan,Yonghui Xia,Du Tuo,Xiaoman Qi,Tianyu Wang,Mohammad Mehmandoust,Nevin Erk,Quanguo He,Qing Li
The excessive use of levofloxacin (LEV) can lead to significant environmental pollution, while also damaging human health. The accurate detection of its concentration is therefore essential to protect both the environment and human health. Herein, we report the simple synthesis of α-zirconium phosphate supported on nitrogen-doped graphene nanosheets (α-ZrP/NG) and its application in the voltammetric determination of trace LEV in real samples. The surface morphology, microstructure, and electrochemical properties of α-ZrP/NG were investigated by microscopic and spectroscopic techniques. The analytical parameters, including the accumulation potential, accumulation time, loading volume, and buffer pH, were optimized to improve the electrocatalytic sensing performance of α-ZrP/NG. Owing to the synergetic interaction between α-ZrP and NG, the proposed sensor exhibited an excellent electrocatalytic activity for the electrical oxidation of LEV. In the range of 0.01–5.0 μM, the anodic peak current of LEV increased linearly with an increase in the LEV concentration, and the limit of detection was 2.6 nmol L–1. Finally, the LEV levels in wastewater, human serum, milk, and eye drop samples were determined by using the α-ZrP/NG system combined with a glassy carbon electrode to give satisfactory recoveries (98.48–103.2%), indicating that the prepared sensor demonstrates promise for use in environmental, food, and drug monitoring applications.
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高影响因子
ANALYST
·
2023
·Vol. 148
·期 20
·5210-5220
·
IF 4.2
Huiyang Xu,Chuang Guo,Weijian Yuan,Wenna Zhang,Qiu Sun,Jianfeng Wu,Xuelin Zhang
In this study, a simple and portable electrochemical sensor based on laser-induced graphene (LIG) has been developed to systematically investigate the feasibility of LIG as an electrode to detect organophosphorus pesticides (OPs). It proves that the LIG-based electrode has a relatively high electrochemically active surface area (ECSA) and heterogeneous electron transfer (HET) of 0.100 cm2 and 0.000825 cm s−1, respectively. In addition, zirconium dioxide nanoparticles (ZrO2 NPs) have been modified on the electrode with three different binders, β-cyclodextrin (β-CD), chitosan (CS) and Nafion, to improve the adsorption capacity of the electrode toward OPs, and the effect of the binders on the performance of the as-fabricated sensor has been investigated in detail. The results show that β-CD increases not only the electrochemically active surface area of the electrode but also the redox peak current of methyl parathion (MP). To evaluate the sensitivity of the sensor, differential pulse voltammetry (DPV) curves have been tested in solutions containing different concentrations of MP using ZrO2-β-CD/LIG as an electrode, which shows a detection range of 5–200 ng ml−1 and a detection limit of 0.89 ng ml−1. In summary, the LIG-based sensor has a low detection limit, high sensitivity and good interference resistance, and thus has tremendous potential for the detection of pesticides in the environment.
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高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Huanan Guan,Bolin Han,Bo Peng,Hua Ye,Qi Zhang,Dongxu Wang
Herein, the turn-off colorimetric system based on magnetic supported gold-copper bimetallic organic framework (Fe 3 O 4 @Au/Cu-MOF) nanozyme catalytic reaction has developed for the high sensitivity spectrophotometric determination of glutathione (GSH). Fe 3 O 4 is embedded into Cu-MOF to reduse aggregation, exposing more active metal sites. The uniform size, high dispersity of Au and the 2D Cu-MOF structure with coordinatively unsaturated metal sites enhances the host–guest electron transfer. The intrinsic catalytic activity of each site was enhanced due to the synergistic interaction between the three metals. Meanwhile, the Fe 3 O 4 @Au/Cu-MOF was recyclable, maintaining a relative activity of more than 87.4% after 10 cycles, and the catalytic activity remained stable at pH 3–11 and temperature ranging from 5 to 70 °C. Fe 3 O 4 @Au/Cu-MOF nanocomposites displayed higher peroxidase activity than their individual components, which can be utilized in catalysis to oxidise the peroxidase substrate 2,2′-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) into a green-colored product in the presence of H 2 O 2. After the introduction of GSH, the green color ABTS •+ was gradually fading owing to the free radical scavenging effect. The novel colorimetric sensing platform demonstrated excellent performance for GSH detection in real samples with a detection limits of 0.033 μmol/L, the detection time of only 3 min. The suggested bioassay is user-friendly, economical, and applicable to both food analysis and medical diagnostics.
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PHARMACOLOGICAL RESEARCH
·
2023
·
IF 9.3
Depeng Li,Meihong Zhang,A.La Teng Zhu La,Zhengtian Lyu,Xin Li,Yuqing Feng,Dan Liu,Yuming Guo,Yongfei Hu
The development of hyperuricemia (HUA) and gout is associated with dysbiosis of the gut microbiota. Quercetin can reduce serum uric acid levels and thus alleviate HUA by modulating the gut microbiota. However, the detailed mechanisms involved in this process are not fully understood. Here, we showed that quercetin significantly reduced the serum uric acid level in a chicken HUA model by altering the chicken cecal microbiota structure and function and increasing the abundance of Lactobacillus aviarius . An L. aviarius strain, CML180, was isolated from the quercetin-treated chicken gut microbiota. Strain characterization indicated that quercetin promoted the growth of L. aviarius CML180 and increased its adhesion, hydrophobicity, and co-aggregation abilities. Gavage of live L. aviarius CML180 to a mouse model of HUA—established by adenosine and potassium oxonate—reduced the serum uric acid level and alleviated HUA. The ability of L. aviarius CML180 to decrease the level of uric acid was due to its degradation of purine nucleosides, which are the precursors for uric acid production. A nucleoside hydrolase gene, nhy69 , was identified from the genome of L. aviarius CML180, and the resulting protein, Nhy69, exhibited strong purine nucleoside-hydrolyzing activity at mesophilic temperature and neutral pH conditions. These findings provide mechanistic insights into the potential of quercetin to treat HUA or gout diseases via a specific gut microbe.
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高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Shichao Ma,Xichen Yuan,Xu Yin,Yang Yang,Li Ren
Glucose redox is the indispensable method for biological energy supply, and its concentration in the organism is one of the most vital determinants of its health status. Nevertheless, nearly 10,000 organic substances that coexist with glucose in the blood hinder the glucose detection. As a result, developing a detection method that can feature high sensitivity and selectivity is extremely indispensable. In this work, a silver nanowire aerogel (AgNW-gel) was prepared for non-enzymatic glucose detection. The unique porous structure of aerogel and the high electrical conductivity of silver guarantee rapid electron transport and transfer. Furthermore, the presence of massive mesopores in AgNW-gel imparts high specific surface area which provides a large number of active sites. Compared to enzymatic glucose methods, the AgNW-gel, which is a non-enzymatic assay, has a lower environmental dependence. With the help of these characteristics, the glucose non-enzymatic sensor exhibits a high sensitivity of 1940 μA·mM −1 · cm −2 , a wide linear range from 1.0 to 3.5 mM, and a detection limit of 0.8 mM· cm 2 . In addition, the largest interference signal was only 4.4% of the glucose signal in the interference test for the five common interferents in blood.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Ciyang Zhang,Keren Lu,Linrui Li,Wu Lei,Mingzhu Xia,Fengyun Wang
Oxytetracycline hydrochloride (OTC) is a commonly used over-the-counter antibiotic, valued for its potent antibacterial properties. However, the inappropriate and excessive use of OTC can result in the accumulation of the drug in both the environment and human body, causing significant harm to ecosystems and human health. Therefore, the development of a fast and sensitive method for detecting OTC is of great significance. Lanthanide metal–organic frameworks (LnMOFs) can effectively excite lanthanide metals to emit long-lifetime, narrow and stable fluorescence based on the antenna effect, but their application in fluorescence sensing is rarely reported. In this work, a strongly fluorescent material Tb-MOF was synthesized by a facile solvothermal method using 1,2,4,5-phenylenetetracarboxylic acid (H 4 btec) and 1,10-phenanthroline (1,10-phen) as organic ligands and lanthanide metal Tb as the luminescent center. Tb-MOF is a stable material in water and shows excellent linearity with OTC in the concentration range of 0 ∼ 70 μM, with low detection limit (0.12 μM) and luminescence color transition from bright green to dark green during the detection process. X-ray diffraction, UV–vis absorption and fluorescence lifetime analyses revealed that the fluorescence quenching of Tb-MOF by OTC is caused by the inner filter effect in static quenching. Test strips for OTC detection were successfully prepared using Tb-MOF. These strips are not only low cost and easy to prepare but can also be used as portable sensing devices that can be easily distinguished by the naked eye during OTC testing. This study not only presents a fluorescent probe for the detection of OTC in water but also offers a practical method for converting fluorescent luminescent materials into functional devices for OTC detection.
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Analytical Methods
·
2017
·Vol. 9
·期 19
·2812-2820
·
IF 1.9
Yanyi Fu,Qinglin Sheng,Jianbin Zheng
Au nanoparticles supported on nickel hydroxide nanowires with multiple cavities (Au/m-Ni(OH)2) were synthesized and used for the enhanced electrochemical sensing of dopamine (DA). m-Ni(OH)2 nanowires were first fabricated based on an anion exchange strategy and then chosen as supports for Au nanoparticles without an additional stabilizer and surfactant. The morphology and composition of the nanocomposites were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDS). TEM observations revealed that Au nanoparticles were uniformly embedded in the cavities of m-Ni(OH)2 nanowires, with a high dispersion and a narrow size of 2 nm. Electrochemical investigations indicated that the as-prepared sensor exhibited fascinating performance towards the oxidation of DA. The linear range for DA detection was 0.45 μM to 1.78 mM with a low detection limit of 0.09 μM (S/N = 3). Additionally, the DA sensor possessed an excellent selectivity in the presence of potentially interfering substances such as ascorbic acid (AA), uric acid (UA) and glucose (Glu). Therefore, it is expected that Au/m-Ni(OH)2 nanocomposites could be used as electroactive materials for developing DA sensors.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2017
·Vol. 41
·期 24
·15439-15446
·
IF 3.269
Yanyi Fu,Qinglin Sheng,Jianbin Zheng
Herein, a novel dopamine (DA) electrochemical sensor was developed by combining carbon nanospheres (CNSs) and sulfonated polyaniline (SPANI) with their own excellent characteristics. The sensing materials SPANI/CNSs were prepared through a green and economical approach under hydrothermal treatment, in situ chemical oxidative polymerization, and sulfonation. Scanning electron microscopy and Fourier transform infrared spectroscopy were employed to characterize the morphology and composition of the nanocomposites. Moreover, electrochemical activities of the sensor were investigated by cyclic voltammetry, differential pulse voltammetry, and amperometry. Investigation of the sensor indicated that it had excellent properties towards DA oxidation, with a linear range from 0.50 μM to 1.78 mM, a detection limit of 0.0152 μM (S/N = 3), and a sensitivity of 113.9 μA mM−1 cm−2. Moreover, the sensor exhibited intriguing anti-interference to co-existing substances such as ascorbic acid (AA), uric acid (UA), and glucose (Glu). These electrochemical results could be attributed to the enhanced electron transfer rates and abundant functional groups with negative charges possessed by the nanocomposites. Therefore, the SPANI/CNS nanocomposites showed great application potential for the construction of a DA sensor.
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高影响因子
MICROCHEMICAL JOURNAL
·
2019
·
IF 3.206
Xiaoli Liu,Yanyi Fu,Qinglin Sheng,Jianbin Zheng
Herein, a simple electrochemical sensor for dopamine (DA) detection was developed based on Ag@C core-shell structure and Au nanocomposites (Ag@C/Au). The Ag@C core-shell nanoparticles were synthesized by one-pot hydrothermal method , which were supported on Au nanoparticles in situ reduction process. The as-prepared nanocomposites were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and UV–vis absorption spectra. The electrochemical investigations indicated that Ag@C/Au nanocomposites possessed intriguing properties towards DA. These results could be attributed to the synergistic effect of Ag@C with enhanced substrate accessibility and conductivity, Au nanoparticles with surface of negative charges. Under the optimum experimental conditions, the liner range was 0.5 μM to 27.5 μM, 27.5 μM to 0.2775 mM and 0.2775 mM to 4.278 mM. The detection limit was 0.21 μM (S/N = 3). Furthermore, the electrochemical sensor showed favorable selectivity in the presence of interferents such as ascorbic acid (AA) and uric acid (UA). In general, the work could provide a promising possibility to develop excellent electrochemical sensors for DA detection.
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高影响因子
MICROCHIMICA ACTA
·
2023
·Vol. 191
·期 1
·1-12
·
IF 5.7
Zhang Mingxia,Tan Wei,Wu Xiaodan,Wan Chengan,Wen Chen,Feng Lei,Zhang Feng,Qu Fengyu
The present study selected 5, 5′-((6-(ethylamino)-1, 3, 5-triazine-2, 4-diyl) bis(azanediyl))diisophthalic acid (H 4 EATDIA) as ligand and an amino-functionalized cuprum-based MOF (EA-JUC-1000), successfully synthesized by microwave-assisted method, for proton conduction and dopamine sensing applications. In order to enhance the proton-conducting potential of EA-JUC-1000, the Brönsted acid (BA) encapsulated composites (BA@EA-JUC-1000) are dopped into chitosan (CS) to form a series of hybrid membranes (BA@EA-JUC-1000/CS). The impedance results display that the best proton conductivity of CF 3 SO 3 H@EA-JUC-1000/CS-8% reaches up to 1.23 × 10 –3 S∙cm −1 at 338 K and ~ 98% RH, 2.6-fold than that of CS. Moreover, the EA-JUC-1000 is in-situ combined with reduced graphene oxide (rGO) (rGO/EA-JUC-1000), which makes EA-JUC-1000 have a wide detection range (0.1 ~ 500 μM) and a low limit of detection (50 nM), together with good anti-interference performance, reproducibility and repeatability. In addition, the electrochemical sensing method has been successfully applied to detect DA in bovine serum samples. The dual-functional MOF-based hybrid membrane and composites including proton conduction and DA sensing would provide an example of practical application for MOFs. Graphical abstract
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2021
·
IF 4.464
Haitao Wang,Juan He,Lei Ge,Zhi Xu,Wei Zhou,Zongping Shao
Although many metal-based compounds demonstrate the ability to detect glucose, limited metal compounds have the desired high conductivity. Metal nitrides with different states of metal elements (M), such as M 0 and M 2+/3+ , can perform excellent conductivity and catalytic activity. In this work, self-supported non-enzymatic electrochemical sensors supported by carbon paper (CP) were synthesized for monitoring glucose in alkaline solutions. The antiperovskites FeNNi 2 Co and FeNNi 3 as electrocatalysts are first reported in the field of the electrochemical sensor, displaying outstanding catalytic activity and high electrical conductivity. Electrochemical tests suggest that the FeNNi 2 Co/CP and FeNNi 3 /CP electrodes perform outstanding sensing abilities toward rapid glucose determination. In addition, the FeNNi 2 Co with multi-metals can display the trimetallic synergic effect and superior performance than the original material of FeNNi 3 . The sensitivity of FeNNi 2 Co/CP electrode can reach level of 3621 and 1141 μA mM −1 cm −2 in the concentration ranges of 2–2789 μM and 2789–7444 μM, respectively. The repeatability of the glucose concentration in the glucose drink measured by the FeNNi 2 Co/CP electrode can achieve 96.2%.
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高影响因子
Bioengineered
·
2021
·
IF 3.269
Xia Zhao,Jing Wang,Liying Tang,Pei Li,Jing Ru,Yuzhi Bai
The study was designed to explore the effects of Withaferin A (WFA) on hyperuricemia-induced kidney injury and its action mechanism. Potassium oxonate (PO) was employed to establish the hyperuricemic mouse model. The pathological changes of renal tissue were evaluated by hematoxylin-eosin and masson trichrome staining. The levels of creatinine, blood urea nitrogen (BUN), uric acid (UA) and xanthine oxidase (XOD) were detected using corresponding commercial kits. Expressions of collagen-related and apoptosis-associated proteins in renal tissues were, respectively, evaluated by immunofluorescence and western blotting. Cell apoptosis was detected by TUNEL assay, and transporter expressions using western blotting. Followed by WFA, NRK-52E cells were treated with UA before evaluation of apoptosis and fibrosis. Results indicated that WFA ameliorated renal damage, improved kidney function, and decreased levels of creatinine, BUN, UA, and XOD in PO-induced hyperuricemic mice. Furthermore, WFA significantly prevented renal fibrosis and increased the expression of collagen-related proteins. Similarly, WFA markedly inhibited renal apoptosis, accompanied by changes of apoptosis-related proteins. Importantly, expression of transporters responsible for the secretion of organic anion transporter 1 (OAT1), OAT3, ATP-binding cassette subfamily G member 2 (ABCG2) was remarkably enhanced whereas that of urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) was reduced in renal tissues of mice with hyperuricemia. In vitro study revealed that WFA notably ameliorated UA-induced cell fibrosis and apoptosis. Taken together, WFA improves kidney function by decreasing UA via regulation of XOD and transporter genes in renal tubular cells.
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