CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Chong Zhang,Xiaoyi Jiang,Shuai Zhang,Xian Cao,Hui Wang,Takashi Sakamaki,Xianning Li
The polycyclic aromatic hydrocarbons (PAHs) frequently accumulate in sediments, particularly those near industrial sites. The efficacy of microbial electrochemical systems (MESs) in electricity generation and PAHs degradation is intricately linked to the microbiome’s response to high contaminant levels. Metabolomics and metagenomics were applied to elucidate the impact of a high pyrene concentration on the functional structure and metabolic dynamics of sediment microbiomes within MES. In sediment with a high pyrene concentration, both the electrical output of MES and efficiency of their microbiomes in degrading organic substrates and pyrene were markedly reduced. These conditions were associated with the enrichment of PAH-degrading microorganisms, such as Hydrogenophaga and Flavobacterium . Analyses of metabolites and genetic profiles revealed that metabolic pathways were primarily influenced in MES exposed to low pyrene concentrations whereas fewer metabolic pathways were activated in MES exposed to high concentrations; instead, pathways representing functions critical for microbial survival and communication were activated as well. According to enzymatic analyses, low pyrene levels promoted carbohydrate metabolism by sediment microorganisms, whereas high levels had an inhibitory effect. An examination of electron transport enzymes revealed that intracellular electron transfer was facilitated by both low and high concentrations. However, high levels impeded enzymes associated with outer membrane electron transfer, hindering electron movement from intracellular to extracellular electron acceptors and thus negatively affecting the electrical output of MES. Our study provides crucial theoretical insight and mechanistic understanding for addressing the challenges that may be encountered when MES are used to treat pyrene-contaminated sediment near industrial sites.
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DYES AND PIGMENTS
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2024
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IF 4.1
Fengshan Liu,Keao Liu,Chunhui Wang,Yang Xu
The physical damage of engineering materials is challenging to perceive, particularly when they occur with only a slight extent. To present the location of damage to engineering is still difficult to achieve. Mechanical responsive engineering materials are therefore highly desired. Herein, a type of composites comprised of carbon nanoparticles (CNP) and poly(vinyl chloride) (PVC) was prepared via a heating incubation process. Notably, we found that these composites were in a metastable state and exhibited a grinding-stimulated fluorescence enhancement performance. After grinding stimulation, a bright orange-yellow color emission appeared and the fluorescence intensity of the composites exhibited a 75-fold enhancement. It was noted that grinding had no effect on the fluorescence of CNP alone. The fluorescence enhancement may be due to the change in the surface environment of CNP, as grinding facilitates the entry of CNP into PVC. In addition, fluorescence enhancement was also observed in tightening screw experiments using commercialized PVC films, demonstrating the abrasive-stimulated fluorescence enhancement properties of this CNP/PVC. Such remarkable mechanical response property and interesting combination between CNP and PVC will provide avenue to promote the development of smart engineering materials and have considerable potentials in external force response and structure damage surveying.
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Chemosensors
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2024
·Vol. 12
·期 10
·220
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IF 3.7
Ting Hu,Yitao Xia,You Wang,Li Lin,Rong An,Ling Xu,Xiangdong Qing
Polycyclic aromatic hydrocarbons (PAHs) are a group of organic compounds that are both toxic and hazardous to human health and ecological systems. In recent work, a novel analytical strategy based on the chemometric-assisted HPLC-DAD method was proposed for the quantification and source apportionment of eight PAHs in PM10 samples. Compared to traditional chromatographic methods, this approach does not require the purification of complex PM10 samples. Instead, it utilizes a mathematical separation method to extract analytes’ profiles from overlapping chromatographic peaks, enabling precise quantification of PAHs in PM10. Firstly, 40 PM10 samples collected in Loudi city during two sampling periods were used for analysis. Subsequently, the second-order calibration method based on alternating trilinear decomposition (ATLD) was employed to handle the three-way HPLC-DAD data. Finally, the pollution sources of PAHs were analyzed by the feature component analysis method according to the obtained relative concentration matrix. For the validation model, the average recoveries of eight PAHs were between (88.8 ± 7.6)% and (105.6 ± 7.5)%, and the root-mean-square errors of prediction ranged from 0.03 μg mL−1to 0.47 μg mL−1. The obtained limits of quantification for eight PAHs were in the range of 0.0050 μg mL−1to 0.079 μg mL−1. For actual PM10 samples, results of the feature component analysis indicated that the main source of PAHs in PM10 may be traffic emissions and coal combustion. In summary, the proposed method provided a new and rapid analysis method for the accurate determination and source apportionment of PAHs in atmospheric aerosols.
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JOURNAL OF CONTROLLED RELEASE
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2024
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IF 10.5
Xinzi Hu,Guangzhi Li,Chenfan Kong,Lisha Liu,Dashi Deng,Guizhong Xin,Jian Pan,Song Wu,Qifang Lei
Cisplatin-based neoadjuvant chemotherapy is first-line strategy to inhibit progression and metastasis of muscle-invasive bladder cancer (MIBC). However, its clinical efficacy is often limited by drug resistance and severe systemic side effects, highlighting the urgent need for innovative therapeutic approaches. Despite advancements in cisplatin-based regimens, research on intravesical cisplatin delivery systems remains scarce. In this study, we developed an amphiphilic platinum(IV) prodrug micellar platform (Pt (IV)-DI-PEG) capable of efficiently encapsulating sanguinarine (San), which was further coated with fluorinated chitosan (FCS) to construct San@Pt(IV)-DI-PEG@FCS nanoparticles (SPFNPs) for intravesical instillation even targeting MIBC. The resulting SPFNPs demonstrated several advantages: the FCS coating facilitated enhanced trans-epithelial drug delivery by regulating bladder epithelial tight junction proteins, enabling efficient intravesical administration; Second, the glutathione (GSH)-responsive reduction of the Pt(IV) prodrug promoted tumor-targeted release of San and localized accumulation of Pt(II), while simultaneously depleting intracellular GSH. Furthermore, the released San induced reactive oxygen species (ROS) production, oxidative cleavage and inhibit the activation and function of poly (ADP-ribose) polymerase, collectively impairing nucleotide-excision repair and preventing the elimination of Pt-DNA adducts, resulting in persistent DNA damage, cell cycle arrest, and apoptosis in tumor cells. The synergistic effects of San and cisplatin were validated in both orthotopic mouse models and patient-derived orthotopic xenograft, demonstrating robust anti-tumor efficacy. This study underscores the potential of intravesical cisplatin formulations as a promising strategy for MIBC treatment, offering a shift from traditional systemic chemotherapy towards localized, targeted drug delivery systems.
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ATMOSPHERIC ENVIRONMENT
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2024
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IF 4.2
Hongxing Yang,Wangjin Yang,Jiawei Ma,Chong Han
The heterogeneous reactions of SO 2 on organic aerosols (OA) have been proposed as a significant source of sulfates. The photochemical conversion of SO 2 to sulfates on the surface of light-absorbing OA, i.e., brown carbon (BrC), remained slight understanding. Herein, the photochemical uptake of SO 2 on typical BrC species, including aromatic carbonyl compounds (ACs), polycyclic aromatic hydrocarbons (PAHs) and phenols (PHs), was systematically investigated by a flow tube reactor. Light can significantly promote the uptake of SO 2 on all BrC species used here, especially for ACs. The initial and steady-state uptake coefficients (γ i and γ ss ) of SO 2 exhibited positive relationships with the light intensity, whereas they negatively correlated with the initial SO 2 concentration. Significant sulfate formation was clearly observed with in situ attenuated total internal reflection infrared (ATR-IR) spectrometer, and H 2 O and O 2 had obvious enhancement effects on the sulfate production. Photoinduced •OH, which primarily originated from •O 2 − that was generated through an electron transfer process on BrC under irradiation, was determined to be a key driver for the oxidation of SO 2 to sulfates. Finally, SO 2 lifetime and sulfate formation rate were evaluated on the basis of experimental results, highlighting potential contributions of BrC photochemistry to atmospheric SO 2 loss and sulfate sources.
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Frontiers in Microbiology
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2024
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IF 4
Zhou Guoyan,Qiao Hongtao,Liu Yandong,Yu Xiongsheng,Niu Xiang
Microbial remediation has become the most promising technical means for the remediation of polycyclic aromatic hydrocarbons (PAHs) non-point source contaminated soil due to its low cost of treatment, complete degradation of pollutants, and in-situ remediation. In this study, in order to demonstrate the phenanthrene degrading microbial diversity, phenanthrene was chosen as the representative of PAHs and strains capable of degrading phenanthrene were isolated and screened from the sedimentation sludge and the bottom sludge of oil tank trucks, and high throughput sequencing was used to check the dominant strains with a good degrading effect on phenanthrene. Results showed even more than 50% of phenanthrene was degraded in all samples, the composition of PAH-degrading bacteria was diverse, and different environments constructed different functional microbial groups, which resulted in the microbial adapting to the diversity of the environment. Finally, a series of bacterial species with phenanthrene-degrading functions such as Achromobacter, Pseudomonas, Pseudochelatococcus, Bosea was enriched after nine transferring process. Overall, our study offers value information for the enrichment of functional degrading microbes of phenanthrene or other pollutants that more concern should be paid in not only the degradation rate, but also the diversity variation of microbial community composition.
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ANALYTICA CHIMICA ACTA
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2025
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IF 6
Ting Wang,Yuan-Yuan Cui,Cheng-Xiong Yang
Background As a class of boomingly developed porous material, microporous organic networks (MONs) demonstrated great prospects in HPLC because of their unique structures and excellent stabilities. However, the agglomerated, irregular, and sub-micron sized MONs obtained via the traditional synthesis methods inevitably cause high column pressure and low column efficiency, rendering the main obstacles for their applications in HPLC. Monolithic column has the characteristics of continuous porous structure, fast mass transfer rate, excellent permeability, and low column pressure. Therefore, the integration of MONs with monolithic column should be a potential way to extend the widespread applications of MONs in HPLC. Results In this work, we reported the first example of fabricating MON incorporated monolithic columns by employing methacrylic acid as the monomer, ethylene dimethacrylate as the cross-linking agent, and polyethylene glycol-6000 as the porogen for the improved HPLC separation of small organic molecules. Effects of preparation conditions for MON incorporated monolithic column, sample loading mass, column temperature, and mobile phase composition were studied in detail. MON monolithic column after MON incorporation exhibits improved permeability, column efficiency, hydrophobicity, and specific surface area. Diverse small organic molecules such as polycyclic aromatic hydrocarbons, alkylbenzenes, acidic phenols, basic amines, phenylurea herbicides, parabens, phthalates, and flavonoids were successfully separated on MON incorporated monolithic column (50.0 mm length × 4.6 mm i.d.). MON incorporated monolithic column also provided better resolution and selectivity than C18 packed column. Significance This work reported the first combination of MON and monolithic column for efficient HPLC separation of variety small organic compounds with good resolution, selectivity, and precisions based on typical reversed phase mechanism. The experimental results demonstrated the great potential of MON incorporated monolithic column for enhanced HPLC separation of small organic compounds and could extend the new applications of MONs in separation science.
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BIORESOURCE TECHNOLOGY
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2024
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IF 9.7
Xing Zhang,Xiao Liu,Shuhuan Lin,Xiaoli Zhu,Ziye Zhang,Baoshou Shen,Shi Zhou
Immobilization technology is a promising way to improve effectiveness and stability of microbial remediation for polycyclic aromatic hydrocarbons (PAHs), in which carrier material is one of key factors restricting removal efficiency. In this study, fulvic acid-wheat straw biochar (FA/WS) composites were applied for immobilization of an efficient PAHs degrading bacterium Stenotrophomonas maltophilia (SPM). FA/WS&SPM showed superior degradation capacity than free bacteria and biochar-immobilized bacteria, with the removal efficiency of pyrene (20 mg L -1 ) reaching 90.5 % (7 days). Transcriptome analysis revealed that FA in the carrier materials can promote transportation and degradation of pyrene, and cell growth, as well as inhibit cell apoptosis. Enzyme activity and degradation products detection showed that SPM utilized both phthalic acid and salicylic acid metabolic pathways to degrade pyrene. Practicality of FA/WS&SPM for different kinds of PAHs remediation had been verified in contaminated soil, demonstrating a great potential in the field of PAHs polluted sites remediation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Tong Ye,Qile Chen,Shujuan Yang,Haifang Liu,Yan Zhou,Yuhong Feng,Jiacheng Li,Yujuan Wang,Gaobo Yu,Jun Dai
Achieving high bioavailability of dendrobine (DDB) necessitates the development of simplified available and efficient delivery systems. Pickering emulsions (PEs) derived from biomass represent a promising option. However, the physicochemical properties of PEs interfacial films were insufficient to prevent DDB leakage, thereby reducing bioavailability. Herein, a supramolecular host-guest interfacial recognition strategy was proposed in-situ between amphipathic sodium alginate-functionalized cyclodextrin (SAE-CD) and hydrophobic DDB at oil-water interface, further forming the SAE-based supra-amphiphiles to efficient stabilize the high internal phase Pickering emulsions (HIPPEs) with gel-like characteristics. A multiscale methodology was empolyed to investigate the interfacial assembly behavior and emulsification properties of supra-amphiphilic SAE-CD/DDB interfacial system, focusing on molecular interactions, interfacial adsorption, and overall stability. Notably, the SAE-CD/DDB-based supramolecular assembly/disassembly behaviors could be self-adjusted for regulating the aggregation particle size and thickness of interfacial self-assembled films. The SAE-CD/DDB co-stabilized HIPPEs exhibited favorable drug release capabilities, enabling sustained effects of DDB. Overall, the SAE-CD/DDB co-stabilized HIPPEs demonstrated excellent properties in terms of stability, drug loading capacity, and sustained release performance, highlighting their potential for in oral delivery and sustained-release systems.
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CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Yufan Guo,Xiuru Yang,Yihong Zhang,Fazhen Luo,Juan Yang,Xupeng Zhang,Jinxia Mi,Yan Xie
Cancer multidrug resistance (MDR) dramatically hindered the efficiency of standard chemotherapy. Mitochondria are highly involved in the occurrence and development of MDR; thus, inducing its malfunction will be an appealing strategy to treat MDR tumors. In this paper, a natural polysaccharides-based nanoplatform (TDTD@UA/HA micelles) with cell and mitochondria dual-targeting ability was facilely fabricated to co-deliver ursolic acid (UA) and doxorubicin (DOX) for combinatorial MDR therapy. TDTD@UA/HA micelles featured a spherical morphology, narrow size distribution (∼140 nm), as well as favorable drug co-loading capacity (DOX: 8.41 %, UA : 9.06 %). After hyaluronic acid (HA)-mediated endocytosis , the lysosomal hyaluronidase promoted the degradation of HA layer and then the positive triphenylphosphine groups were exposed, which significantly enhanced the mitochondria-accumulation of nano micelles . Subsequently, DOX and UA were specifically released into mitochondria under the trigger of endogenous reactive oxygen species (ROS), followed by severe mitochondrial destruction through generating ROS, exhausting mitochondrial membrane potential, and blocking energy supply, etc. ; ultimately contributing to the susceptibility restoration of MCF-7/ADR cells to chemotherapeutic agents. Importantly, TDTD@UA/HA micelles performed potent anticancer efficacy without distinct toxicity on the MDR tumor-bearing nude mice model. Overall, the versatile nanomedicine represented a new therapeutic paradigm and held great promise in overcoming MDR-related cancer.
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FOOD HYDROCOLLOIDS
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2024
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IF 11
Boxue Xia,Yi Shen,Ru Zhao,Jie Deng,Cuina Wang
Interactions between pea protein isolate (PPI, 1%) and soy lecithin (SL, 0.1%–2%) in bulk phase and the impacts on the emulsifying properties of PPI were investigated. Fluorescence spectra, molecular docking, and infrared spectroscopy verified that PPI and SL formed complexes in aqueous phase via hydrophobic interactions, hydrogen bonds, and electrostatic interactions. CMC of SL was increased to 1% in presence of PPI (1%). Increased particle size, surface charge, and surface hydrophobicity of PPI-SL complexes with increasing SL concentrations were observed. Addition of SL transformed the composition of oil/water interface from pure PPI into a mixture of PPI and SL, which decreased the surface tension and resulted in smaller droplet size of emulsions. The inclusion of all PPI-SL complexes enhanced emulsion stability during storage. Incorporating SL below 1% also showed similar protective effects for curcumin against UV irradiation compared to pure PPI. The study may provide a theoretical basis for the rational non-covalent combination of pea protein and lecithin as complex emulsifiers.
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JOURNAL OF CHROMATOGRAPHY A
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2024
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IF 3.8
Xiaomin Li,Mingxia Sun,Yang Feng,Yanming Liu,Yanli Wang,Juanjuan Feng,Min Sun
A covalent organic framework (COF) was gown on porous silica with 1,3,5-tri(4-aminophenyl)benzene and 2,5-divinyl-1,4-phenyldiformaldehyde as monomers, and two ionic liquids were grafted to COF by a click reaction. The materials before and after the modification of ionic liquids were separately packed into solid-phase extraction columns (10 × 4.6 mm, i.d.), which were coupled with liquid chromatography to construct online analysis systems. The extraction mechanisms of polycyclic aromatic hydrocarbons, bisphenols, diphenylalkanes and benzoic acids were investigated on these materials. There were π-π, hydrogen-bond and electrostatic interactions on ionic liquid-functionalized sorbents. After the comparison among these materials, the best sorbent was used, and the analytical method was established and successfully applied to the detection of some estrogens from actual samples. For the analytical method, the detection limit was as low as 0.005 μg L −1 , linear range was as wide as 0.017–10.0 μg L −1 , and enrichment ratio was as high as 3635. The recoveries in actual samples were 70 %-129 %.
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