JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Kunpeng Liu,Binbin Jiao,Guan Zhang,Zhihua Gan,Shicong Lai,Zhenshan Ding,Qingsong Yu
Bladder cancer remains a significant clinical challenge, necessitating the development of innovative therapeutic strategies. Recent advancements have highlighted the potential of reactive oxygen species (ROS)-responsive drug delivery systems in cancer therapy. In this study, we introduce a novel treatment approach utilizing a ROS-responsive camptothecin (CPT) prodrug encapsulated within a chitosan nanocarrier, named CACPT. Cinnamaldehyde (CA), acting as a ROS generator, forms thioketal bonds with CPT to create a prodrug that responds selectively to the elevated ROS levels within the tumor microenvironment. Upon exposure to high ROS conditions, these thioketal bonds are cleaved, resulting in the simultaneous release of CPT and CA. The liberated CA further enhances ROS production, establishing a positive feedback loop that amplifies the therapeutic effect. The use of amphiphilic chitosan nanocarriers enhances the retention and penetration of the prodrug within bladder tissue, optimizing its therapeutic potential. Our experimental findings demonstrate that this self-enhanced ROS-responsive release promotes increased cellular uptake and significantly enhances the anticancer efficacy of CACPT. These results position CACPT as a promising candidate for intravesical therapy in bladder cancer, potentially overcoming current limitations in treatment options. The innovative combination of ROS-responsive mechanisms and chitosan nanocarriers represents a paradigm shift in bladder cancer therapeutics, offering a multifaceted approach with substantial promise for clinical translation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-17
·
IF 12.6
Jiang Kai,Lin Zhenyi,Cheng Mingrui,Chen Yanmin,Jiang Yiru,Xu Changhua,Zhu Lijuan,Gong Bo,Zhang Chuan,Hong Jiaxu
Dry eye disease (DED) is a prevalent ocular surface disorder characterized by chronic inflammation and oxidative stress, significantly impacting vision and quality of life. Although reactive oxygen species (ROS) serve as a key upstream regulator that initiate and perpetuate inflammatory cascades in DED, current clinical therapies predominantly target downstream inflammatory pathways, leading to suboptimal treatment outcomes. To address this limitation, we developed a novel mucin-1 (MUC1)-targeted nanotherapeutic platform (tFNA-IM) by integrating the dual antioxidant and anti-inflammatory agent itaconate (ITA) with ROS-scavenging tetrahedral framework nucleic acids (tFNA) for efficient DED treatment. The engineered tFNA-IM exhibits uniform nanostructure and optimal size distribution, enabling deep penetration into ocular tissues, while the conjugated MUC1 aptamer significantly enhances cellular internalization in human corneal epithelial cells (HCECs), as demonstrated by confocal microscopy and flow cytometry analyses. Functionally, tFNA-IM effectively neutralizes ROS, reduces apoptosis, and downregulates pro-inflammatory cytokines in vitro, demonstrating potent anti-oxidative and anti-inflammatory capabilities. In a murine DED model, tFNA-IM exhibits prolonged ocular retention and superior therapeutic efficacy, markedly improving corneal epithelial integrity and suppressing inflammatory responses. These findings establish aptamer-functionalized tFNA as a precision nanoplatform for ocular drug delivery, offering a synergistic therapeutic strategy to disrupt the ROS-inflammatory vicious cycle in DED. Graphical MUC1-aptamer–guided tetrahedral DNA (tFNA-IM) delivers itaconate to the cornea, simultaneously scavenging ROS and suppressing cytokine cascades to break the ROS–inflammation loop and restore epithelial integrity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Muhammad Shoaib,Shengyuan Xu,Haocheng Zhai,Qihui Sun,Shahab Ahmad,Maysam alsharawneh,Yifan Liu,Yang Guo,Xinyu Mu,Wei Tian,Xian Jian
An ideal and distinctive microwave-absorbing carbon-based material feature an eco-friendly, low-cost fabrication process combined with high loss efficiency and strong absorption potential. Here we design an innovative nanohybrids with carbon nano onion (CNO) from paraffin ultra-pure lamp oil by flame method awning unique structure to boost up the dielectric loss. And TiO 2 is introduced for efficient microwave absorption loss through an in-situ process using C 7 H 8 O and TiCl 4 , while SiO 2 plays a critical role in controlling the dielectric constant through the use of tetraethyl orthosilicate (TEOS). To boost up the nanohybrids effective loss mechanism the material is exposed to a carbon capsule (CC) utilizing acetylene (C 2 H 2 ) as a carbon source for 5 minutes under argon to prepare CNO/TiO 2 /SiO 2 /CC nanohybrids. The nearby dual-nanocarbon forms multi-level interfaces enhancing the multi-level rebound and microwave absorption of the microwave interfaces. The as-designed CNO/TiO 2 /SiO 2 /CC has effective minimum reflection loss (RL min ) value of -54.4 dB and the maximum effective absorption bandwidth (EAB max ) of 5.5 GHz at a thickness of 1.9 mm. It also has good thermal conductivity. Hence, this work confirms that high-performance nanohybrids derived from paraffin ultra-pure lamp oil are promising candidates, providing a novel approach for the design and development of carbon-based microwave absorbers.
✓ 已验证
产品关联
DOI
高影响因子
ENERGY & FUELS
·
2025
·
IF 5.3
Shengqi Lin,Hailong Huang,Jieyi Fan,Chunhe Li,Kuankuan Ren,Weidong Dou
Photocatalytic conversion of biomass-derived compounds into value-added chemicals coupled with hydrogen production presents a promising strategy to address energy and environmental challenges. In this study, a series of NiB/ZnIn2S4 nanocomposites were synthesized via a facile two-step hydrothermal approach. The designed system enables the simultaneous utilization of photoexcited electrons and holes in redox reactions, achieving efficient benzyl alcohol oxidation and hydrogen evolution. The optimized 3%-NiB/ZnIn2S4 nanocomposite demonstrates exceptional photocatalytic performance, exhibiting a hydrogen evolution rate of 7223.2 μmol g–1 h–1 in 1.50 vol % benzyl alcohol solution, representing 2889.3-fold and 4.8-fold enhancements over pristine NiB and ZnIn2S4, respectively. Furthermore, the system maintains robust stability over 14 photocatalytic cycles, achieving 71.7% conversion efficiency and 86.8% selectivity toward benzaldehyde production. The enhanced performance originates from the formation of Z-scheme heterojunctions between NiB and ZnIn2S4, which facilitates efficient charge carrier separation and transport, as evidenced by improved photocurrent response and reduced electrochemical impedance. This work provides valuable insights into the photocatalytic valorization of biomass-derived platform chemicals under visible light irradiation.
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Yuda Lin,Kaihui Lin,Xiaohui Xu,Junjie Chen
In this paper, a new composites material Zn 3 V 3 O 8 /VO 2 @Nitrogen graphene (ZnVO/VO 2 @NG) was synthesized, and its structural features and electrochemical properties were systematically characterized. The electrochemical analysis reveals that the electrode exhibits fast electron/lithium ion transport kinetics, and its pseudocapacitive behavior storage characteristics can achieve ultra-fast dynamic response. The ZnVO/VO 2 @NG electrode maintains a high reversible specific capacity of 995 mAh g -1 after 700 cycles at 1 A g -1 , and an impressive rate capability of 540 mAh -1 at 5 A g -1 . In addition, first-principles calculation reveals that ZnVO/VO 2 @NG exhibits zero-bandgap metallic properties with excellent electrical conductivity. Meanwhile, differential charge density and adsorption energy calculations further demonstrates that Li-ions at the interface of ZnVO and NG have a charge transfer as high as 1.71 eV, and a corresponding adsorption energy of -5.46 eV, which suggests the existence of strong lithium interactions at this interface. These findings provide an important theoretical basis for a deeper understanding of the lithium ion storage properties at the heterogeneous interface.
✓ 已验证
产品关联
DOI
高影响因子
Food & Function
·
2020
·Vol. 12
·期 4
·1626-1638
·
IF 4.171
Xu-Hui Huang,Yu-Ying Zhang,Ming Zhu,Da-Yong Zhou,Ming Du,Bei-Wei Zhu,Xiu-Ping Dong,Ian Fisk,Lei Qin
Clam is a kind of nutritious, delicious and economical aquatic food around the world and is famous for its unique aroma. Instrumental analysis, sensory analysis, and comprehensive statistical analysis were performed to explain the relationship between aroma and odorants in clam soup. Six extraction methods combined with GC-MS and sniffing were utilized to obtain the aroma fingerprints of clam soup and to analyze the correlation with aroma perception. Solvent extraction methods were more effective than headspace extraction methods for the volatiles of clam soup. SAFE was the best method to obtain the most comprehensive information of volatiles of clam soup. The sequence of a combination of different extraction methods and SAFE would also affect the results of volatiles extracted from clam soup. Volatiles extracted via SDE, P&T, and SPME would add further information to the result of SAFE. A total of 119 volatile compounds were identified from clam soup by summarising the results of different extraction methods. The significant effect of 14 key odorants in clam soup on aroma perception was verified by aroma recombination and odorant omission tests. A neural network diagram of the aroma profile was designed to visualize the information of odor perception. Furthermore, the results would be beneficial for aroma research studies of aquatic food and the processing of clam products.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Fuxin Wang,Guojun Lv,Jiande Hu,Zixiang Li,Xupeng Yang,Shengnan Xu
Heterogenization of Co-based catalyst can effectively solve the catalyst recovery problem encountered by homogenous catalyst Co(OAc) 2 , but there may generate an obvious performance decrease for the heterogenized cobalt site ascribed to the increased mass transfer resistance. Hence, how to alleviate or eliminate the performance decline for Co-based heterogeneous catalyst is an intriguing scientific question. In this study, we reported the application of crystal engineering strategy on Co 3 O 4 to bridge the performance gap between homogeneous catalyst and heterogeneous catalyst in the selective oxidation of toluene into benzaldehyde. Four distinct spinel Co 3 O 4 catalysts, predominantly exposing the {220}, {222}, {440}, and {311} crystal facets respectively, were prepared and utilized as heterogeneous catalysts. The Co 3 O 4 -P sample predominantly exposing the {220} facets exhibited the optimal catalytic activity for toluene oxidation, achieving a toluene conversion of 56.1 % and a benzaldehyde selectivity of 67.6 %, which was significantly superior to that of homogenous catalyst Co(OAc) 2 . The enhanced performance of this material is primarily attributed to the abundant reversible Co 2+ /Co 3+ redox couples on its surface, which maintains sufficient Co 2+ active sites throughout the catalytic process and facilitates toluene oxidation reactions. In addition, Co 3 O 4 -P also exhibited the maximum specific surface area, the highest Co 2+ /Co 3+ ratio, and the greatest oxygen vacancy density, which together give rise to its best catalytic performance. Density functional theory (DFT) calculations further corroborated these findings. According to quenching experiments and in-situ FTIR characterizations, the possible selective toluene oxidation mechanism over Co 3 O 4 -P catalyst was proposed. Moreover, the recycled Co 3 O 4 -P sample could be reused for more than five consecutive reactions, demonstrating its eminent re-usability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CATALYSIS
·
2025
·
IF 6.5
Xiangyu Jia,Xiaoming Li,Shiying Li,Kai Yuan,Xiaoqing Gao,Shanhui Zhu,Mei Dong,Weibin Fan
Metals embedded nitrogen-doped carbon (M/NC) materials have garnered substantial attention due to the catalytic active centers provided by their transition metals. Here, the ZIF-67 derived Co/NC hollow structure catalyst (Co/NHC-4) exhibited remarkable performance in the hydrogenation of biomass-based 5-hydroxymethylfurfural (HMF) to valuable 2,5-dihydroxymethylfuran (DHMF). Under mild conditions of 60 °C and 2 MPa H 2 , the conversion of HMF reached nearly 100 %, with DHMF selectivity >99 %. Through the integration of advanced characterization techniques, such as TEM, XPS, XAFS, Raman spectroscopy, vapor adsorption curve, H 2 -TPD and in situ FTIR spectroscopy, it was demonstrated that the superior hydrogenation performance of hollow-structured catalysts primarily stems from unique morphology. Specifically, the hollow morphology facilitates the adsorption and diffusion of HMF on Co surface, which substantially enhances the hydrogenation efficiency. DFT calculation reveals the preferential parallel adsorption geometry of HMF and the energetically favorable hydrogenation pathway.
✓ 已验证
产品关联
DOI
高影响因子
AICHE JOURNAL
·
2025
·
IF 4
Qi Liu,Yan Ouyang,Tong Luo,Qinlan Luo,Min Xiao,Hongxia Gao,Zhiwu Liang
Blending is a common method to improve the performance of amine solution for CO 2 capture. While the amine will degrade at elevated temperatures or so-called thermal degradation, the mixing of multiple amines could change the thermal degradation behavior and it is critical to reveal them before implementing the CO 2 capture at large scale. Herein, the thermal degradation performance of blended amines was studied via experimental and computational methods. In comparison with single amine solution, the effect of an additional tertiary amine N,N -dimethylethanolamine (DMEA) was analyzed. The thermal degradation experiments were carried out at multiple temperatures. The temperature threshold was identified for the blended solution after which the degradation rate increases dramatically. Based on the obtained degradation products, the degradation mechanism of the blended amine is proposed. The energy barrier of key reactions in thermal degradation was obtained and the interaction of primary amine and tertiary amine is clarified.
✓ 已验证
产品关联
DOI
高影响因子
ACS Sensors
·
2025
·
IF 9.1
Changle Pei,Muhammad Hamza Nadeem,Nan Li,Jun Fu,Nan Xu,You Wang,Adrian Carl Stevenson,Guang Li,Ruifen Hu
The complexity of in situ volatile organic compounds (VOCs) detection demands high selectivity and anti-interference capability of electronic noses (E-noses). Multivariant virtual sensor array (VSA) is a new generation of E-noses under research to overcome the insufficient VOCs selectivity limitation of existing electronic noses and alleviate the issue of sensor drifts. In this paper, a frequency-amplitude dual-parameter modulation strategy is presented on a wireless electrodeless quartz crystal microbalance with dissipation (WE-QCM-D) to realize the recognition and analysis of VOC mixtures and complex real-world analytes with a single multivariant VSA E-nose, by probing the gas dynamic sorption in a sensitive film at various scales of oscillating shear displacements and obtaining multiple partially independent responses to VOCs. Ten VOC analytes from alcohols, esters, and aromatic hydrocarbons were classified with accuracies of above 95% for both interclass and intraclass discriminations. Additionally, a discriminating accuracy of 95% has been achieved on VOC mixtures, and their component concentrations were predicted with coefficients of determination above 0.9. For practical testing, the system was exposed to the headspace VOCs of banana, pineapple, and mango under different concentrations. It recognized different fruits and identified the ripen state of bananas based on the detection of their volatiles. The dual-parameter modulated WE-QCM-D paves a promising multivariant way to realize online real-time VOCs monitoring with high performance on selectivity and quantitative analysis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CATALYSIS
·
2025
·
IF 17.7
Hao Wu,Xian Jiang,Jingyu Lu,Yibo Li,Xinyan Li,Guidong Ju,Rengui Li,Jing Zhang
The hydrogen evolution reaction (HER) in alkaline water electrolysis faces significant kinetic and thermodynamic challenges that hinder its efficiency and scalability for sustainable hydrogen production. Herein, we employed an in-situ synthesis strategy to incorporate H atoms into the PdRu alloy lattice to form H Inc -PdRu electrocatalyst, thereby modulating its electronic structure and enhancing its alkaline HER performance. We demonstrate that the incorporation of H atoms significantly improves electrocatalytic activity, achieving a remarkably low overpotential of 25 mV at 10 mA cm –2 compared with the Pd, Ru and PdRu catalysts while maintaining robust catalyst stability. Operando spectroscopic analysis indicates that H insertion into the H Inc -PdRu electrocatalyst enhances the availability of H 2 O* at the surface, promoting water dissociation at the active sites. Theoretical calculations proposed that the co-incorporating H and Ru atoms induces s-d orbital coupling within the Pd lattices, effectively weakening hydrogen adsorption strength and optimizing the alkaline HER energetics. This work presents a facile approach for the rational design of bimetallic electrocatalysts for efficient and stable alkaline water electrolysis for renewable hydrogen production.
✓ 已验证
产品关联
DOI
高影响因子
Catalysts
·
2025
·Vol. 15
·期 5
·442
·
IF 4
Zhe Wang,Xiaoliang Li
A series of Pd/g-C3N4catalysts were synthesized using different graphitic carbon nitride precursors, and were found to exhibit significant variations in catalytic performance for solvent-free selective catalytic oxidation of benzyl alcohol. Through comprehensive characterization (XRD, N2-BET, ICP-AES, TEM, and XPS), the experimental results found that the nitrogen chemical configuration and surface Pd2+concentration critically determined the catalytic efficiency. Among the various nitrogen species, N-(C)3-type nitrogen demonstrated the strongest influence on catalytic activity, which was positively correlated with its abundance in g-C3N4matrices. In particular, g-C3N4derived from dicyandiamide contained the highest N-(C)3type nitrogen content. When serving as Pd nanoparticle support, this material simultaneously achieved the best Pd2+surface concentration and catalytic performance compared to the other g-C3N4-supported catalysts.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）