MICROPOROUS AND MESOPOROUS MATERIALS
·
2018
·
IF 3.649
Chao Chen,Lei Cai,Liang Li,Lixia Bao,Zhengguo Lin,Guoqiang Wu
In order to develop an efficient and environmental friendly approach for epoxidation of soybean oil (SO), a series of hetero-catalysts, titanium silicalite-1 (TS-1) with different Si/Ti ratio (TS-1- x , x = 40, 70, 80), mesoporous TS-1-40 (MTS-1-40) and anatase TiO 2 , were prepared under controlled conditions. These different catalysts were characterized by various characterization methods like XRD , IR, UV–Vis, TGA , ICP , SEM, TEM and N 2 -adsorption, respectively, and the catalytic reaction experiments of the SO epoxidation were studied systematically using hydrogen peroxide (H 2 O 2 ) as clean oxidant over the different catalysts. The results reveal that the TS-1- x catalysts exhibit higher epoxidation catalytic activity and less consumption of H 2 O 2 than anatase TiO 2 , and the number of framework Ti sites in TS-1 structure played a very important role in their catalytic performance of the epoxidation reaction, which is attributed to the unique nature and coordination geometry of the Ti sites in TS-1 framework. Furthermore, the reusability and regeneration behaviors of TS-1-40 catalyst were also studied.
研究领域:
催化化学
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绿色化学
·
材料科学
·
工业化学
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有机合成
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环境友好工艺
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能源与资源工程
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DOI
高影响因子
JOURNAL OF GENERAL VIROLOGY
·
2021
·Vol. 102
·期 12
·001710
·
IF 3.891
Jian Yang,Jia Wang,Xiaowei Peng,Chengfeng Lei,Xiulian Sun,Jia Hu
Dendrolimus punctatuscauses great damage to pine forests worldwide. Dendrolimus punctatus cypovirus 1 (DpCPV-1) is an important pathogen ofD. punctatus. However, the mechanism of DpCPV-1 cell entry has not been elucidated. In this study, we revealed that both GTase and MTase domains of VP3 (B-spike) and VP4 (A-spike) of DpCPV-1 interacted with the midgut proteins ofBombyx mori. Binding and competition assays revealed that GTase, MTase and VP4 played roles as viral attachment proteins. Far-Western blotting and LC-MS/MS analyses identified that heat shock protein 70 (BmHSP70), glutamate dehydrogenase (BmGDH), and angiotensin-converting enzyme (BmACE) in the midgut proteins as ligand candidates of the viral attachment proteins, and this was further verified by co-immunoprecipitation and fluorescence co-localization assays. Viral binding to the host midgutin vitrowas inhibited by pre-treatingB. morimidgut proteins with anti-BmHSP70, anti-BmGDH, anti-BmACE antibodies singly and in combination. Incubating DpCPV-1 virions with prokaryotically expressed BmHSP70, BmGDH, and BmACE also decreased viral attachment to the host midgut.In vivobioassays revealed that viral infection inHelicoverpa armigerawas partially neutralized by BmHSP70, BmGDH, and BmACE. Taking together, we concluded that HSP70, GDH, and ACE mediate DpCPV attachment and entry via binding to the viral attachment proteins, VP3 and VP4. The findings provide foundation for further understanding the entry mechanisms of cypoviruses.
研究领域:
病毒学
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昆虫学
·
分子生物学
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DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Xiushuai Guan,Xiaochao Zhang,Changming Zhang,Rui Li,Jianxin Liu,Yunfang Wang,Yawen Wang,Caimei Fan,Zhong Li
Photocatalysis CO 2 reduction into high-value-added chemical feedstocks is desirable for simultaneously addressing the solar energy storage, CO 2 excess and energy shortage issues. In this work, a kind of original S-scheme BiOBr-(0 0 1)/Bi 2 SiO 5 /Bi (OSB) heterostructure photocatalyst with rich oxygen vacancies is in-situ synthesized, which significantly promotes the photocatalytic CO 2 reduction performance. Interestingly, the lower formation energy of oxygen vacancy exhibits the easy feasibility on the BiOBr-(0 0 1) surface via the assistant of ultrasound. There exists the highest photocatalytic CO 2 reduction activity to CO of 234.05 μmol g -1 h −1 for OSB-20 sample (ultrasound time: 20 min), higher 3.3 times than OSB-0 sample (without ultrasound). Combined with experimental and calculated results, the significative formation mechanism, widened light-response range, highly-efficient separation/transfer paths and improved redox-reduction abilities of photogenerated electron-hole pairs for S-scheme OSB-20 heterostructure are investigated and proposed. Our findings provide new insights for the construction and synthesis of the S-scheme Bi-based heterojunction photocatalyst system.
研究领域:
材料科学
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环境科学
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化学工程
·
光化学
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DOI
PubMed
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2020
·
IF 4.335
Lin Chen,Jin He
A novel Michael/alkylation cascade reaction of N-unprotected 3-bromooxindoles with α,β-unsaturated acyl phosphonates using DABCO as a robust catalyst followed by the derivatization of the acyl phosphonate intermediates in situ has been developed. This scenario enables rapid access to a diverse set of highly functionalized spirocyclopropyl oxindoles in moderate yields with good to excellent diastereoselectivities, which are analogues of a high active non-nucleoside reverse transcriptase inhibitor against HIV-1. The synthetic potential of this tactic has been highlighted by a gram-scale reaction and Suzuki cross-coupling reactions of the product. Moreover, the reaction mechanism has been tentatively elucidated by control experiments and dynamic high-resolution mass spectrometry studies, which indicates that the Michael/alkylation cascade reaction involves DABCO-derived α-substituted ammonium ylides.
研究领域:
有机化学
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药物化学
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抗病毒研究
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DOI
PubMed
高影响因子
ACS Nano
·
2024
·
IF 15.8
Jiayin Fu,Ning Zhang,Changfu Xu,Meng Zhao,Shaofei Wu,Shihui Xu,Xulin Hong,Meihui Wang,Guosheng Fu
Synthetic vascular grafts are promising conduits for small caliber arteries. However, due to restenosis caused by intimal hyperplasia, they cannot keep long patency in vivo. In this work, through single cell RNA sequencing, we found that thrombospondin-1 (THBS1) was highly expressed in the regenerated smooth muscle cells (SMCs) in electrospun polycaprolactone (PCL) vascular grafts. The expression of THBS1 by injured SMCs was confirmed in a balloon-induced vascular injury model. Downregulation of Thbs1 expression maintained contractile phenotypes of SMCs and reduced neointimal hyperplasia after vascular injury via inhibition of FGFR1/EGR1 signaling by decreasing THBS1 expression. THBS1 small interfering RNA (THBS1-siRNA) was then loaded into macrophage membrane (MM) hybrid lipid nanoparticles (Lipid NP@MM), which were used to modify PCL vascular grafts via polydopamine (PDA) coatings. Lipid NP@MM not only protected THBS1-siRNA from degradation but also improved its internalization by SMCs to decrease the level of THBS1 expression. PCL vascular grafts modified with PDA coatings and Thbs1-siRNA-loaded Lipid NP@MM showed significantly reduced intimal hyperplasia. Thus, the downregulation of THBS1 expression in regenerated SMCs in vascular grafts is a promising strategy to inhibit intimal hyperplasia during vascular graft regeneration in vivo.
研究领域:
生物材料
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组织工程
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血管生物学
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分子生物学
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纳米技术
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DOI
PubMed
高影响因子
INFLAMMATION
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2021
·Vol. 44
·期 5
·1993-2005
·
IF 4.092
Wu Yuqin,Fan Lin,Wang Yun,Ding Jing,Wang Rongfu
This study is aimed at exploring the potential of isorhamnetin in protection against diabetes-exacerbated ischemia/reperfusion-induced brain injury and elucidating its action mechanism. After establishment of the model of high glucose (HG)-aggravated oxygen-glucose deprivation and reoxygenation (OGD/R), HT22 cell viability was detected by CCK-8. Lactate dehydrogenase (LDH) activity, casapase-3 activity, and oxidative stress-related markers in HT22 cells were detected by corresponding commercial kits. The apoptosis of HG-treated HT22 cells following OGD/R was observed with TUNEL staining. The level of pro-inflammatory cytokines was examined by ELISA. The expression of Akt/SIRT1/Nrf2/HO-1 signaling-related proteins was assayed by Western blot. The results showed that HG noticeably worsened the OGD/R-induced apoptosis of HT22 cells. Isorhamnetin relieved the HG-aggravated OGD/R-induced apoptosis, inflammatory response, and oxidative stress of HT22 cells. Isorhamnetin alleviated the HG-aggravated OGD/R injury in HT22 cells through Akt/SIRT1/Nrf2/HO-1 signaling pathway. Meanwhile, treatment with Akt inhibitor LY294002 reversed the protective effects of isorhamnetin against HG-aggravated OGD/R injury in HT22 cells. In a conclusion, Isorhamnetin alleviates HG-aggravated OGD/R in HT22 hippocampal neurons through Akt/SIRT1/Nrf2/HO-1 signaling pathway.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2020
·Vol. 31
·期 16
·13111-13117
·
IF 2.22
Chakrabarti Chiranjib,Fu Qingshan,Ali Wajahat,Chen Xinghan,Zheng Jia,Qiu Yang,Yuan Songliu
In this investigation, a series of (1 − x ) Bi 1− y Ho y FeO 3 – x Ba 0.8 Ca 0.2 TiO 3 (0.25 ≤ x ≤ 0.4; y = 0.025) ceramic solid solutions were synthesized using a conventional solid-state reaction route. The primary goal of this study was to perceive the significance of substitution on the structural, magnetic, dielectric, and resistive properties of the ceramic solid solution. The investigation suggested the trace of weak ferromagnetism in all of the samples. A methodical XRD-based phase structural study revealed a presence of a morphotropic phase boundary (MPB) in the range of 0.3 ≤ x ≤ 0.35, showing robust dielectric properties in the MPB region, as verified by the dielectric measurements. A room temperature A.C conductivity study and activation energy calculation advocated an improved resistive property in the x = 0.3 sample.
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2016
·
IF 1.78
Zhi-Jian Chen,Ya-Na Chen,Chun-Na Xu,Shan-Shan Zhao,Qi-Yue Cao,Shao-Song Qian,Jie Qin,Hai-Liang Zhu
Three novel mononuclear complexes, [M Ⅱ ( L ) 2 ·2H 2 O], (M = Cu, Ni or Cd; HL = 4-(3,4-dichlorophenyl)piperazine-1-carboxylic acid)were synthesized and structurally determined by single-crystal X-ray diffraction. Molecular docking study preliminarily revealed that complex 1 had potential urease inhibitory activity. In accordance with the result of calculation, in vitro tests of the inhibitory activities of complexes 1–3 against jack bean urease showed complex 1 (IC 50 = 8.17 ± 0.91 μ M) had better inhibitory activities than the positive reference acetohydroxamic acid (AHA) (IC 50 = 26.99 ± 1.43 μ M), while complexes 2 and 3 showed no inhibitory activities., kinetics study was carried out to explore the mechanism of the inhibiting of the enzyme , and the result indicated that complex 1 was a competitive inhibitor of urease. Albumin binding experiment and in vitro toxicity evaluation of complex 1 were implemented to explore its Pharmacological properties .
研究领域:
生物无机化学
·
药物化学
·
酶学
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DOI
高影响因子
FUEL
·
2025
·
IF 7.5
Xinglin Wen,Yonglu Yang,Yong Pan,Jitao Hu,Xiaoyue Wan,Yanhui Yang,Sébastien Leveneur,Juncheng Jiang
The hydrogenation of 2,4-dinitrotoluene (2,4-DNT) into 1-methyl-2,4-cyclohexanediamine (2,4-MCHD), a significant yet underutilized raw material for the synthesis of methylcyclohexane diisocyanate (HTDI) with exceptional properties, represents one of the most promising reactions for the development of diisocyanate chemical processes. In this study, we developed a highly efficient and stable heterogeneous catalytic system for the direct hydrogenation of 2,4-DNT to 2,4-MCHD using Li-modified γ-Al 2 O 3 supported Ru nanoclusters (Li-modified-Ru/γ-Al 2 O 3 ). Under mild reaction conditions, we successfully inhibited side reactions, such as deamination, achieving a selectivity exceeding 95% for 2,4-MCHD, while the conversion of 2,4-DNT surpassed 99%. Kinetic studies revealed that the hydrogenation of 2,4-DNT in this system occurs as a tandem reaction, with the hydrogenation of the benzene ring identified as the rate-determining step. Investigations into the structure–activity relationship indicated that the valence state of the Ru nanocluster, the acid-base properties of the catalyst, the modification by Li, and the synergistic effects of various elements within the catalyst are critical factors contributing to the high activity and stability of the Li-modified-Ru/γ-Al 2 O 3 catalyst for the hydrogenation of 2,4-DNT to produce 2,4-MCHD. This work represents the first example of the direct hydrogenation of dinitroaromatic compounds to yield diamino aliphatic compounds and provides a solid foundation for understanding such reaction systems.
研究领域:
化学工程
·
催化材料科学
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2021
·
IF 3.178
Hao Wang,Nianzu Zhang,Xiaopo Wang
In this work, the density and viscosity data for binary mixtures of dimethyl carbonate with 1-heptanol, 1-octanol, 1-nonanol, and 1-decanol were presented from 303.15 K to 333.15 K at atmospheric pressure over different concentration ranges. The density and viscosity measurement was carried out based on the vibrating-tube densimeter and Ubbelohde capillary viscometer, respectively. Derived properties, such as excess molar volumes and viscosity deviations, were calculated from the experimental values, and were correlated based on the Redlich-Kister equation. In addition, excess molar volumes and viscosity deviations of the studied mixtures were analyzed and compared with other DMC/1-alcohols mixtures reported in the literatures.
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高影响因子
Analytical Methods
·
2016
·Vol. 8
·期 24
·4926-4933
·
IF 1.915
Dejiang Rao,Qinglin Sheng,Jianbin Zheng
Herein, we report a simple and attractive self-assembly strategy for preparing graphene oxide–multiwalled carbon nanotube–(1-pyrenemethylamine)–gold (GO–MWCNT–PMA–Au) nanocomposites using 1-pyrenemethylamine (PMA) as a coupling agent. The morphology and composition of the nanocomposites were characterized by transmission electron microscopy (TEM), X-ray powder diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDS). Further, a non-enzymatic nitrite sensor was fabricated by immobilizing GO–MWCNT–PMA–Au nanocomposites on a glassy carbon electrode (GCE). To obtain the optimal electrochemical experimental conditions, the effects of pH value and the volume of the as-prepared Au nanoparticle suspension were carefully investigated. Its electrochemical sensing properties were studied by cyclic voltammetry and differential pulse voltammetry. The electrochemical investigation showed that the GO–MWCNT–PMA–Au nanocomposites exhibited good catalytic performance for the oxidation of nitrite. The nitrite electrochemical sensor presented a wide linear range from 2.0 × 10−6 to 1.0 × 10−2 mol L−1, a high sensitivity of 483.51 μA mM−1 cm−2 and a low detection limit of 0.67 μmol L−1 at a signal-to-noise ratio of 3 (S/N = 3). It also exhibited good anti-interference capability and stability. This paper provides a self-assembly strategy for preparing nanocomposites which are used to construct improved electrochemical sensors.
研究领域:
分析化学
·
纳米生物技术
·
电化学传感
·
环境监测
·
食品安全
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DOI
高影响因子
CHEMICAL PHYSICS
·
2025
·
IF 2.4
Mengyu Lin,Jiumei Chu,Dianjun Dong,Xue Yang,Dianquan Dong
Spinel-type titanium-based lithium-ion sieve H 4 Ti 5 O 12 has excellent theoretical adsorption capacity and selectivity. Still, spinel-type lithium adsorbents prepared in existing studies have poor adsorption, poor recyclability, and difficulty in recovery. To solve the above problems, composite mesoporous ion sieves, Polyvinyl Butyral-H 4 Ti 5 O 12 –1 (PVB-HTO-1) modified with dual surfactants, were synthesized for the first time in this paper. Hydrophilic lithium-ion sieve HTO-1 with a mesoporous structure was synthesized by adding two surfactants, CTAB and F127. Then the modified ion sieve was composited with PVB to make a fine rod-like composite material, PVB-HTO-1, with a diameter of no more than 0.5 mm, to solve the limitation of the industrial application that the recycling of powdered ion sieve is difficult. The bi-component surfactant-derived ion sieve, PVB-HTO-1, exhibits superior hydrophilicity and possesses a porous mesoporous framework that facilitates ion exchange processes, achieving adsorption equilibrium within a timeframe of three hours. It demonstrates a remarkable maximum adsorption capacity of 53.25 mg/g. Even after undergoing five cycles of adsorption and desorption, the material's adsorption capacity remains at over 90 % of its initial value, indicative of its robust cyclic stability. The uptake of Li + ions by PVB-HTO-1 aligns with the pseudo-second-order kinetic model and conforms to the Langmuir isothermal adsorption model.
研究领域:
材料科学
·
化学工程
·
环境科学
·
纳米技术
·
分离技术
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）