Membranes
·
2022
·Vol. 12
·期 8
·728
·
IF 4.562
Yifan Li,Jing Hu,Joan Papavasiliou,Zhiyong Fu,Li Chen,Haibin Li
This work exhibits an effective approach to enhance the performance of membrane-electrode assembly (MEA) with KH5(PO4)2-doped PBI membrane, by adding phosphoric acid (PA) in the catalyst layer (CL). The ohmic resistance and single-cell performance of the MEA, treated with PA, are reduced by ~80% and improved by ~800%, respectively, compared to that of untreated MEA. Based on the MEA pretreated with PA, the influence of humidity and temperature on the resistance and the single-cell performance are investigated. Under humidified gas conditions, the ohmic resistance of MEA is reduced but the charge transfer resistance is slightly increased. Regarding the effect of temperature, the ohmic resistance of MEA becomes lower as the temperature elevates from 140 to 180 °C, but increases at 200 °C. The maximum peak power density presents at 180 °C and 20% RH with 454 mW cm−2. The peak power density is favored with temperature increase from 140 to 180 °C, but decreases with further increase to 200 °C. Moreover, when dry gas conditions are employed, the output performance is unstable, suggesting that humidification is necessary to inhibit degradation for a long-term stability test.
研究领域:
材料科学
·
能源工程
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Zhenghua Zhang,Jiugang Hu,Yang Hu,Hongmei Wang,Huiping Hu
Ni-rich LiNi x Co y Mn 1−x−y O 2 /graphite batteries with Ni ≥ 0.8 have aroused great interest in high-energy–density Li-ion batteries. However, their practical applications still face huge challenges owing to severe capacity fading on unstable cathodic solid electrolyte interfaces (SEI). Herein, we propose an advanced electrolyte additive , tri(2-furyl)phosphine (FuP), to induce the simultaneous formation of robust SEI films on cathode and anode surfaces. This interphase can significantly improve the cyclability of commercial LiNi 0.8 Co 0.1 Mn 0.1 O 2 /graphite pouch cells at 45 °C and reduce cell impedance during cycling. The capacity retention rate of the cells with the FuP-based electrolyte can reach 90 % after 600 cycles, which is considerably better than that of baseline batteries (70 %). Mechanistic studies indicate that FuP suppresses the formation of fragile Li 2 CO 3 to generate more stable LiF, Li x PO y F z , and additional organic phosphorus species on the electrode surface, thereby preventing cation disorder and irreversible phase transitions. These results provide a facile and efficient strategy for enhancing the performance of Ni-rich Li-ion batteries.
研究领域:
电化学
·
材料科学
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能源存储
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电池技术
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界面化学
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Huajie Lan,Lei Tian,Wenfeng Wang,Yuan Li,Shumin Han,Lu Zhang
The currently used β -Ni(OH) 2 for alkaline nickel batteries are falling short of higher capacity demand. In contrast, α -Ni(OH) 2 with high theoretical capacity can address this need. However, the α -Ni(OH) 2 suffers from poor stability and intrinsic low electrical conductivity. Herein, we designed La/Ce-doped spherical α -Ni(OH) 2 and study the effect of La/Ce on the structure and electrochemical properties of α -Ni(OH) 2 . The increased specific surface area of the α -Ni(OH) 2 with La/Ce doping reduces the electron transfer resistance. The La/Ce-doped α -Ni(OH) 2 with 2 at% La (Ni-La-2) and 3 at% Ce (Ni-Ce-3) doping deliver high capacities of ∼365 mAh g –1 and ∼373 mAh g –1 , respectively, which is only 309 mAh g –1 for the pure α -Ni(OH) 2 . Meanwhile, the La/Ce-doping stabilizes the structural robustness of the α -Ni(OH) 2 during cycling. Notably, Ni-La-2 shows a superior stable cycling life with a capacity retention of ∼95 % after 400 cycles, which is ∼20 % higher than that of pure α -Ni(OH) 2 .
研究领域:
材料科学
·
电化学
·
储能技术
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 26
·12844-12855
·
IF 3.925
Ning Yang,Lixi Xiao,Yuwei Deng,Zhiyu Wu,Hang Yin,Yang Liu,Mengru Li,Yuxuan Ye,Dandan Wang,Qiang Li,Fei Pan,Dongsheng Xia
In this study, a novel catalyst was prepared by loading OMS-2 onto activated carbon fiber (ACF) via a one-step hydrothermal method, which was further adopted for carbamazepine treatment. SEM, TEM and XRD analyses indicate that OMS-2 was successfully loaded on ACF. In the OMS-2@ACF/UV/PMS system, the degradation rate of CBZ (20 mg L−1) was 98.1% and the mineralization rate was 53.3%, which were higher than those of the traditional UV/PMS process. The enhanced performance in the presence of OMS-2@ACF was attributed to the redox cycle between Mn2+/Mn3+/Mn4+, which then accelerated PMS activation to generate more active species. The primary reactive species, including SO4˙−, ˙OH, O2˙− and 1O2, were confirmed through EPR and radical capture experiments. Additionally, the material exhibited excellent reusability even after 5 cycles, and remarkable performance for CBZ degradation was found in real water samples.
研究领域:
环境科学
·
催化材料
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DOI
高影响因子
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
·
2020
·Vol. 97
·期 8
·879-888
·
IF 1.659
Qin Ye,Chaosheng Xia,Xiaohua Nie,Xianghe Meng
2- tert -Butyl-1,4-benzoquinone (TBBQ), the main oxidation product of tert -butyl-hydroquinone (TBHQ) during frying, is cytotoxic and its residual levels in frying oils and foods are unknown. In this study, TBBQ residues have been evaluated during the preparation of french fries. Results showed that frying at 140 °C resulted in the highest TBBQ peak concentration (48.42 mg kg −1 ) compared with frying at 190 or 170 °C. This unexpected finding can be attributed to more extensive hydrolytic reaction when frying at the lower temperature, generating more peroxyl radicals. TBBQ concentrations proved to be independent of the oil type among various unsaturated oils. However, higher TBBQ levels were observed in saturated palm oil and crude soybean oil than in unsaturated oil or refined oil. Continuous frying leads to the accumulation of a large amount of TBBQ in fried food. After frying 1–5 batches, TBBQ levels in both the frying oil and fries were above 10 mg kg −1 , exceeding its critical cytotoxic concentration (IC 50 value of 10.71 mg kg −1 for RAW 246.7 cells in our previous study), warranting concern with respect to the safety of fried food. FTIR has been utilized as an effective tool for visually monitoring the degree of oxidation in the frying medium with respect to its hydrogen peroxide level, which contributes to the increased level of TBBQ derived from TBHQ therein.
研究领域:
食品安全
·
毒理学
·
食品化学
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DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Qiongyu Zhang,Gang Liu,Lingbin Ou
This work reported an electrochemical method for the detection of SARS-CoV-2 major protease (Mpro). Specifically, ferrocene (Fc)-labeled peptide substrates were immobilized on the gold nanoparticles (AuNPs)-modified electrode. Cleavage of the peptides by Mpro led to the release of Fc tags and the decrease of the electrochemical signals. The analytical performance of the biosensor for analysis of Mpro was investigated. Inhibiting the activity of Mpro prevented the cleavage of the peptide substrates. The method was successfully used to evaluate the inhibition efficiency of a well-known inhibitor.
研究领域:
生物化学
·
分析化学
·
病毒学
✓ 已验证
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 8
·1-10
·
IF 6.408
Zhao Tingting,Yan Weizhen,Dong Fengqi,Hu Xinlong,Xu Yanli,Wang Zhenyu,Shen Yating,Wang Wanrong,Zhao Ye,Wei Wenmei
COVID-19 necessitates the development of reliable and convenient diagnostic tools. In this work, a facile 3D-printed smartphone platform was constructed that achieved reliable visual detection of SARS-CoV-2 by eliminating the effect of ambient light and fixing the camera position relative to the sample. The oligonucleotide probe is modified with orange-red-emitting TAMRA working as an internal standard and green-emitting FAM serving as a sensitive sensing agent. Under 365-nm UV excitation, the emission wavelengths of TAMRA and FAM are 580 nm and 518 nm, respectively. When the probes interact with the targets, the green fluorescence gradually restores while the orange-red fluorescence remains stable. Thus, a striking color transition from orange-red to green could be observed by the naked eye. The detection limit of SARS-CoV-2 nucleic acid is 0.23 nM, and the entire process of color change could be completed in 25 min. Furthermore, the RGB value analysis of the sample solution was conducted using a smartphone for reliable and reproducible discrimination of SARS-CoV-2. The proposed smartphone platform might establish a general method for visual detection of SARS-CoV-2 nucleic acid as well as other virus-related diseases. Graphical abstract
研究领域:
生物医学工程
·
分子生物学
·
诊断工具
·
病毒学
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Sustainable Food Systems
·
2025
·
IF 3.1
Chang Ma,Hooi Tin Ong,Hoon Koon Teoh,Yue Ling Wang,Zhong Han Zhu,Yan Liu,Juan Du
Background: T-2 toxin is a highly toxic mycotoxin that poses serious risks to food safety and human health. There is an urgent need for sensitive, selective, and reliable analytical methods for its detection in complex food matrices.Methods: We developed a novel ratiometric fluorescence immunoassay based on gold nanoparticles encapsulated in manganese dioxide nanosheets (AuNP@MnO₂), which exhibit intrinsic oxidase-like activity. The assay utilizes dual-emission fluorescence (at 430 nm and 570 nm) and quantifies T-2 toxin by measuring the fluorescence intensity ratio (F₄₃₀/F₅₇₀), thereby minimizing environmental and instrumental variability.Results: The method demonstrated excellent linearity over a wide concentration range (0.082–60.00 ng/mL) with a low detection limit of 0.068 ng/mL. High specificity was achieved, showing negligible cross-reactivity against common mycotoxins such as aflatoxin B₁, zearalenone, fumonisin B₁, ochratoxin A, and deoxynivalenol. In spiked corn samples, recoveries ranged from 76.94% to 99.48%, confirming good accuracy, stability, and reproducibility.Conclusion: This ratiometric immunoassay significantly enhances detection precision by self-calibrating through an internal fluorescence reference. Its simplicity, sensitivity, and robustness in real food samples make it a promising tool for rapid and reliable monitoring of T-2 toxin in food safety applications.
✓ 已验证
DOI
高影响因子
Polymers
·
2022
·Vol. 14
·期 24
·5466
·
IF 4.967
Changcai Teng,Xiongyan Meng,Yeqin Hu,Hongzhao Mao,Huiting Li,Jing Yang,Tiantian Sun,Shuai Meng,Chengli Zong
Small synthetic TLR7/8-agonists can be used as vaccine adjuvants to enhance cell and humoral-mediated immune responses to specific antigens. Despite their potency, after local injection they can be dispersed to undesired body parts causing high reactogenicity, limiting their clinical applications. Here we describe a vaccination strategy that employs the covalent conjugate of a mannose and TLR7/8 agonist as a vaccine adjuvant to take advantage of mannose binding C-type lectins on dendritic cells to enhance the vaccine’s immunogenicity. The mannose-TLR7/8 agonist conjugate can self-assemble into nanoparticles with the hydrophilic mannose on the outside and hydrophobic TLR7/8 agonist inside. Although its ability to stimulate HEK-BlueTMhTLR7/8 cells dropped, it can efficiently stimulate mouse bone marrow-derived dendritic cells as indicated by the up-regulation of CD80 and CD86, and higher cytokine expression levels of TNF-α, IL6, and IL-12p70 than the native TLR7/8 agonist. In vivo, vaccination using the SARS-CoV-2 RBD trimer as the antigen and the conjugate as the adjuvant induced a significantly higher amount of IgG2a. These results suggest that the mannose-TLR7/8-agonist conjugate can be used as an effective vaccine adjuvant.Keywords:adjuvants;mannose;TLR7/8 agonist;immune responses;cytokines;antibody
研究领域:
免疫学
·
病毒学
·
药学
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2017
·
IF 3.154
Jian Zhang,Lei Zhao,Chun Zhu,Zengxue Wu,Guoping Zhang,Xiuhai Gan,Dengyue Liu,Jianke Pan,Deyu Hu,Baoan Song
A series of vanillin derivatives incorporating a bis(2-hydroxyethyl)dithioacetal moiety was designed and synthesized via a facile method. A plausible reaction pathway was proposed and verified by computational studies. Bioassay results demonstrated that target compounds possessed good to excellent activities against potato virus Y (PVY) and cucumber mosaic virus (CMV), of which, compound 6f incorporating a bis(2-hydroxyethyl)dithioacetal moiety, exhibited the best curative and protection activities against PVY and CMV in vivo, with 50% effective concentration values of 217.6, 205.7 μg/mL and 206.3, 186.2 μg/mL, respectively, better than those of ribavirin (848.0, 808.1 μg/mL and 858.2, 766.5 μg/mL, respectively), dufulin (462.6, 454.8 μg/mL and 471.2, 465.4 μg/mL, respectively), and ningnanmycin (440.5, 425.3 μg/mL and 426.1, 405.3 μg/mL, respectively). Current studies provide support for the application of vanillin derivatives incorporating bis(2-hydroxyethyl)dithioacetal as new antiviral agents.
研究领域:
有机化学
·
植物病理学
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
ACTA MATERIALIA
·
2025
·
IF 9.3
Ziming Zhang,Chen Ming,Qingfeng Song,Lei Wang,Hanbing Chen,Jincheng Liao,Chao Wang,Lidong Chen,Shengqiang Bai
Mg 3 (Sb,Bi) 2 -based Zintl compounds are rising stars with superior features of high thermoelectric (TE) performance, nontoxicity and low cost. However, the poor thermodynamic stability hinders its practical application. Here, we propose a design strategy of modulating the local chemical composition with grain boundary (GB) phase guided by computational phase equilibrium diagrams. By in-situ constructing ZrSb 1- x second phase in the GB regions of Mg 3 (Sb,Bi) 2 -based compounds, the migration of Mg is blocked and the Mg deletion is depressed. Benefit from these, the driving force of Mg diffusion from matrix to GB and Mg migration along GBs is weakened, resulting in an improved thermal stability without degradation of electrical transport properties. The fabricated 8-pair TE module using GB modulated n-type Mg 3.1 Sb 1.5 Bi 0.49 Te 0.01 and p-type Ge 0.89 Cu 0.06 Sb 0.08 Te presents an efficiency of 8.9 % under the temperature difference of 450 K and shows excellent durability in the thermal cycling test. This study provides an effective strategy to improve thermal stability by constructing GB phase, and proves the feasibility of the practical application for Mg 3 Sb 2 -based TE modules.
研究领域:
材料科学
·
热电材料
·
固态化学
·
计算材料学
·
能源材料
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2016
·
IF 0.661
Hui-Long Zhu,Yu-Wei Liu,Wei-Wei Liu,Fu-Jun Yin,Zhi-Ling Cao,Juan Bao,Meng Li,Ling-Yan Qin,Da-Hua Shi
Four 5-benzyl-1,3,4-thiadiazol-2-amine derivatives were synthesised from phenylacetic acid derivatives. The structures of the 5-benzyl-1,3,4-thiadiazole derivatives were characterised by NMR spectroscopy and X-ray crystallography. The acetylcholinesterase-inhibition activities were also tested. Among the four compounds, 5- (4-bromobenzyl)-1,3,4-thiadiazol-2-amine showed the best acetylcholinesterase-inhibition activity with an IC50 of 49.86 μM. The docking study performed with AUTODOCK demonstrated that this compound could interact with the catalytic active site of acetylcholinesterase.
研究领域:
药物化学
·
生物化学
·
结构生物学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）