World Journal of Cardiology
·
2025
·Vol. 17
·期 12
·112062
·
IF 2.8
Yu-Bao Zhao,Zhi-Hong Bao,Ya Tu,Xia Qiu,Yin-Lan Bao,Min Su,Hai-Jun Qi,Quan Wan
BACKGROUND Myocardial infarction (MI) occupies a very high mortality and morbidity rate, and the search for effective pharmacological treatments has far-reaching implications for clinical research. AIM To explore the protective effects of Mongolian medicine Agari-5 on rats with MI. METHODS Sprague-Dawley rats were used, and both the Agari-5 and model groups had their coronary arteries clamped to induce MI. Proteomics was used to research the potential mechanism of action while ELISA, hematoxylin and eosin, and Masson’s staining were used to preliminarily investigate the protective impact of Agari-5 on rats with MI. RESULTS The current study has shown that Agari-5 might enhance cardiac function indicators, including echocardiography results of rats and creatine kinase, creatine kinase isoenzyme, and lactate dehydrogenase, in rats that had MI. According to the results of pathological staining, Agari-5 may lessen inflammatory cell infiltration and cardiomyocyte fibrosis, among other things. The proteome analysis revealed that there were 60 distinct proteins in total, four of which were associated with the heart. The expression of PSAT1, PDK1, SMAD4, and SDF2 proteins may be linked to the mechanism of their protective effects. CONCLUSION Potential therapeutic effects of Agari-5 for MI and its mechanism of action may be related to PSAT1, PDK1, SMAD4, and SDF2.
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PubMed
高影响因子
Catalysis Science & Technology
·
2022
·Vol. 12
·期 21
·6437-6443
·
IF 6.177
Xingyu Lu,Ke Qi,Di Wang,Xueya Dai,Wei Qi
2,5-Furandicarboxylic acid (FDCA) is a high-value platform molecule that can replace the fossil derivative terephthalic acid in the synthesis of important chemicals. FDCA can be synthesized from the oxidation of the biomass derivative 5-hydroxymethylfurfural (HMF). In this study, we loaded Cu-based catalysts with different morphologies and chemical states on carbon paper, and it was found that the Cu nanocrystalline/carbon paper catalyst with a thin and scattered dendrite structure (Cu(NSD)/CP) exhibits the best performance for the electrooxidation of HMF (96% yield and 100% selectivity for FDCA), which is attributed to the fact that the Cu0 and Cu1+ species in the catalyst are easily oxidized in situ to Cu2+ species, showing high catalytic activity during the reaction process. This paper highlights the importance of the identification of active sites and the rational design of catalysts based on structure–function relations.
研究领域:
催化化学
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电化学
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材料科学
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高影响因子
RSC Advances
·
2017
·Vol. 7
·期 75
·47435-47447
·
IF 3.108
Donglin He,Huiping Zhang,Ying Yan
CuO over ZSM-5 zeolite membrane was prepared by chemical vapor deposition (CVD) for catalytic wet peroxide oxidation (CWPO) of phenol in a fixed bed reactor. Firstly, Cu-ZSM-5/PSSFs catalysts with Cu loading of 2 wt%, 4 wt% and 6 wt% were prepared and characterized by XRD, XPS, SEM, EDS, N2 adsorption–desorption and TPR (H2), respectively. Compared with CuO deposited directly onto PSSFs, the CuO supported on ZSM-5/PSSFs tended to be more regular with smaller crystal size. Then, several parameters affecting H2O2 consumption and phenol oxidation such as reaction temperature, Cu loading, and different supports were investigated in the CWPO of phenol with a high concentration (1 g L−1 phenol and 5.1 g L−1 H2O2). Experimental results revealed that Cu-ZSM-5/PSSFs (6%) showed better activity for the oxidation of phenol than Cu-ZSM-5/PSSFs catalysts with lower Cu loading and CuO/PSSFs with same theoretical loading. A complete reduction of phenol and a high TOC removal around 60% had been achieved over Cu-ZSM-5/PSSFs (6%) at the temperature of 80 °C, feed flow rate of 2 mL min−1 and catalyst bed height of 2 cm. Finally, the possible oxidation pathway of phenol was studied based on the by-products detected by high-performance liquid chromatography (HPLC).
研究领域:
环境科学
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化学工程
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材料科学
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Shuxing Zhang,Xiaoshu Ding,Yanji Wang
5-Amino-1-pentanol is an important pharmaceutical intermediate used in the synthesis of anti-inflammatory and anticancer drugs. The direct hydrogenolysis of furfurylamine to 5-amino-1-pentanol has the advantages of a simple process route and high atom utilization. In this paper, for Pt/ZrO2 catalysts, the effects of different Pt loading and calcination temperatures on catalyst activity, selectivity, and surface properties such as Pt nanoparticle size, acidity and alkalinity, and the ratio of Pt0/(Pt0+Pt2+) were investigated. Through the study of the relationship between catalyst preparation conditions, furfurylamine hydrogenolysis reaction performance, and surface properties, it was found that moderate Pt nanoparticle size, higher Pt0/(Pt0+Pt2+) ratio, and more acidic sites favored furfurylamine hydrogenolysis. The higher number of basic sites favors the dispersion of Pt metal. The results of in situ FTIR show that the amino group of furfurylamine is adsorbed on the acidic site of Pt/ZrO2, and the furan ring is adsorbed on Pt nanoparticles, which is beneficial to the hydrogenolysis of furfurylamine.
研究领域:
催化化学
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药物合成
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高影响因子
MOLECULES
·
2025
·Vol. 30
·期 7
·1643
·
IF 4.6
Dongmei Gao,Lele Shi,Yuhang Huang,Yingmei Lv,Xuan Yang,Zhenting Du
The thiazole heterocycle is one of the most common moieties found in various drugs. Using 2-aminothiazole as the core structure, the amino group was functionalized with an amide. As a result, 30 trisubstituted 2-amino-4, 5-diarylthiazole derivatives were synthesized, with different substitutions introduced at the C2, C4, and C5 positions. The anti-Candida albicansbiological activities of these synthetic compounds on five kinds ofCandida albicansat different concentrations were detected by the microdilution method. In the first round, four derivatives of 2-amino-4, 5-diarylthiazole exhibited moderate anti-Candida albicansactivity. Among them,4a8was chosen to be subjected to a demethylation process. Thus,5a8was synthesized successfully, giving anti-Candida albicansactivity (MIC80= 9 μM) similar to that of a typical antifungal drug, fluconazole. To understand the mechanism of anti-Candida albicans, molecular docking of the most active5a8against four target proteins of anti-Candida albicans,such as glutamine-fructose-6-phosphoamidamitransferase (GFAT), protein kinase (Yck2), heat-shock protein 90 (Hsp90), and lanosterol 14a-demethylase (CYP51) was carried out. Our research will provide an experimental basis and theoretical guidance for the further design of a new aminothiazole-leading pharmaceutical molecule.
研究领域:
药理学
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药物化学
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微生物学
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PubMed
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Yiheng Wu,Yangping Lv,Ruipu Wang,Lixia Bao,Zhongdong Zhang,Dejun Shi,Anlv Zhang,Yaoyuan Zhang,Qi Liu,Qin Wu,Daxin Shi,Kangcheng Chen,Guiyuan Jiang,Hansheng Li
The aromatization of light alkane is an important process for increasing the aromatic production and utilization efficiency of light alkane resources simultaneously. Herein, Ga-modified HZSM-5 catalysts were prepared and investigated by a series of characterization techniques such as X-ray diffraction, nuclear magnetic resonance spectroscopy, transmission electron microscopy, N2 adsorption–desorption, and NH3 temperature-programmed desorption to study their physicochemical properties. The catalytic performance in propane aromatization was also tested. Importantly, the structure–activity relationship, reaction pathway, and coke formation mechanism in propane aromatization were systematically explored. It was found that different Ga introduction methods would affect the amounts of Brønsted and Lewis acid sites, and Ga-HZSM-5 prepared by the hydrothermal method exhibited higher amounts of Brønsted and Lewis acid sites but a lower B/L ratio. As a result, Ga-HZSM-5 showed higher propane conversion and benzene, toluene, and xylene yield compared with that of Ga2O3/HZSM-5. The propane aromatization reaction pathway indicated that propane dehydrogenation to propene was a crucial step for aromatic formation. The increase of the Lewis acid density in Ga-HZSM-5 can effectively improve the dehydrogenation rate and promote the aromatization reaction. Furthermore, the formation of coke species was studied by thermogravimetry–mass spectrometry and Raman approaches, the results of which indicated that the graphitization degree of coke formed over spent Ga-HZSM-5 is lower, resulting in enhanced anticoking stability.
研究领域:
催化
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化学工程
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材料科学
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2020
·
IF 5.774
Deyu Si,Meihua Zhu,Xinmei Sun,Miao Xue,Yuqin Li,Ting Wu,Tian Gui,Izumi Kumakiri,Xiangshu Chen,Hidetoshi Kita
The formation progress of the high aluminum ZSM-5 zeolite membrane was investigated and characterized with the organic template-free and fluoride-containing initial synthesis gel. The nano spherical Silicalite-1 seed crystals were dissolved into amorphous by the fluoride-containing precursor synthesis gel. The amorphous contained elementary structural units (TO 4 ) and isolated five-membered ring structure of MFI zeolites. These were retained to provide the nucleation sites for high aluminum ZSM-5 zeolite. The ZSM-5 zeolite nucleus was grown into fine needle-like ZSM-5 zeolites, which were gradually grown into twin crystals, aggregation and compact ZSM-5 zeolites layer on the support without the organic template initial synthesis gel. In addition, the high aluminum ZSM-5 zeolite membranes kept the identical morphology and structure for separation of high concentration acetic acid (H 2 O/HAc) or inorganic acid (1 M H 2 SO 4 ) aqueous mixtures by XRD, SEM and NMR characterization. Furthermore, the membrane had a good dehydration performance and acid-stability by pervaporation. The flux and separation factor of the membrane for 10 wt% H 2 O/HAc mixtures were 0.98 kg∙m −2 ∙h −1 and 3200 at 348 K, respectively.
研究领域:
材料科学
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化学工程
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高影响因子
CATALYSIS SURVEYS FROM ASIA
·
2018
·Vol. 22
·期 3
·129-135
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IF 3.081
Zhang Di,Zhao Yun-Peng,Fan Xing,Liu Zhong-Qiu,Wang Rui-Yu,Wei Xian-Yong
A series of Ni/HZSM-5 catalysts with different Ni-loadings and Si/Al ratios were prepared by incipient wetness impregnation and employed for catalytic hydrogenation of levulinic acid (LA) to gamma-valerolactone (GVL). Their physicochemical properties were characterized by X-ray diffraction, nitrogen adsorption–desorption, X-ray photoelectron spectrometer, temperature-programmed desorption of ammonia,transmission electron microscopy, temperature-programmed reduction of hydrogen, and pyridine-adsorbed infrared spectroscopy. The diffraction peaks assigned to Ni phase were not observed, implying that nickel particles were small and had a high dispersion on the supports. The catalysts with a strong acidity and the appropriate ratio of Brönsted (B) acid sites to Lewis (L) acid sites (B/L = 4.9) show an excellent activity and selectivity for the hydrogenation of LA to GVL. High conversion of LA and selectivity towards GVL were achieved over 5 wt% Ni/HZSM-5-50. The maximum GVL yield of 100% over 5 wt% Ni/HZSM-5-50 was obtained under the optimized reaction conditions of 210 °C, 2 h, and 3 MPa initial hydrogen pressure.
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高影响因子
CATALYSIS LETTERS
·
2020
·Vol. 150
·期 12
·3505-3513
·
IF 2.482
Zhang Huifa,Geng Tong,Zhang Huixian,Cao Fahai
Abstract 5-Hydroxymethylfurfural (HMF) is mainly produced by dehydration of hexasaccharides which were limited by the source availability and low yield of the process. Accounting to this, the current study was thus designed to first identify the mesoporous niobium phosphate was a tailored catalyst and further to develop a suitable reaction system for hydroxymethylation of furfural to HMF. The mesoporous niobium phosphate was prepared by a two-step sol–gel hydrothermal method used to catalyze this hydroxymethylation reaction either in a pure water solvent or in an aqueous organic solvent system. Detailed investigation on reaction activity and HMF selectivity was carried out by varying reaction conditions. A highest HMF yield of 51.1% was obtained with a 79.2% furfural conversion under the aqueous dimethyl sulfoxide (DMSO) at 90 °C for 20 h over the current catalyst. Moreover, the mesoporous niobium phosphate could be recovered and reused at least for 6 runs without obvious loss in catalytic activity. Grpahic Abstract Mesoporous niobium phosphate was synthesized by a two-step sol–gel hydrothermal method and firstly investigated for the catalytic hydroxymethylation of furfural to HMF. The results suggest that mesoporous niobium phosphate shows a superior activity and selectivity. The highest yield of 51.1% of HMF was obtained with a 79.2% furfural conversion. The excellent catalytic performance could be attributed to attributed to the strong acid sites and larger porous structure in the catalyst.
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高影响因子
JOURNAL OF POROUS MATERIALS
·
2015
·Vol. 22
·期 3
·577-584
·
IF 1.108
Zhao Xinhong,Wen Juanjuan,Zhao Jiangbo,Li An,Li Guixian,Wang Xiaolai
Hierarchically structured SAPO-5 molecular sieve was synthesized by microwave-assisted ionothermal method in eutectic mixture solvent. Their porous texture and acid properties were characterized by nitrogen physisorption, SEM, TEM and NH 3 -TPD. The results show that the mesoporous volume of SAPO-5 can be tuned via simply varying the degree of supersaturation, the type of mineralizer or replacing partly succinic acid with sebacic acid. A lower degree of supersaturation and using ammonium fluoride as a mineralizer favor the synthesis of SAPO-5 with large mesoporous volume. Notably, the introduction of sebacic acid can lead to three-level micro-meso-macroporous structure (sample C1). Five typical samples were selected as catalysts and tested in the alkylation of benzene with benzyl alcohol. Among all catalysts, the sample C1, whose aspect ratio is the lowest, exhibited the best catalytic activity, giving a 91 % benzyl alcohol conversion. The diffraction peak intensity ratio of I 002 /I 100 was proposed to be a good indicator in fabricating a highly active SAPO-5 catalyst for this reaction.
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高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2023
·
IF 4.7
Xinhui Liu,Chen Yan,Yilin Wang,Peng Zhang,Siyan Yan,Hanbin Wang,Jianguo Zhuang,Yitao Zhao,Yuchen Wang,Yijun Yu,Qichao Zhao,Xuedong Zhu,Fan Yang
A series of Zn loaded ZSM-5 (Zn/ZSM-5) zeolites were prepared utilizing either Zn(NO 3 ) 2 or Zn-based MOFs (ZIF-61, ZIF-8 and ZIF-14) as Zn sources to explore their effects on the catalysts’ physiochemical properties through characterizations and simulations. Results revealed that hierarchical structures containing meso - to macro- pores of 10 ∼ 80 nm aside from the intrinsic micropores were constructed profiting from the use of Zn-based MOFs. On the other side, lager proportions of medium acid and Lewis acid sites were generated by more Zn(OH) + , whose content was proven to be inextricably linked to the binding energy between Zn and ligand as well as local charge valence state of Zn. Benefitting from hierarchical structures and balanced acidities, Zn/Z5(ZIF-14) employing ZIF-14 as Zn source demonstrated higher aromatic selectivity and longer catalyst lifetime (50.9 % and 26 h) than the microporous counterpart synthesized from zinc nitrate hexahydrate (42.1 % and 20 h) in methanol to aromatics (MTA) reaction.
研究领域:
催化化学
·
材料科学
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高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Wanzhen Zhu,Yu Meng,Chaoxin Yang,Jun Zhao,Hongliang Wang,Wei Hu,Guangqiang Lv,Yingxiong Wang,Tiansheng Deng,Xianglin Hou
As the frontier in heterogeneous catalyst, a monomer and positively charged active sites in the single-atom catalyst (SAC), anchored by high electronegative N, O, S, P, etc., atoms, may not be active for the multispecies (O2, substrates, intermediates, solvent etc.) involved liquid-phase aerobic oxidation. Here, with catalytic, aerobic oxidation of 5-hydroxymethylfurfural as an example, Pt SAC (Pt1-N4) was synthesized and tested first. With commercial Pt/C (Pt loading of 5 wt %) as a benchmark, 2,5-furandicarboxylic acid (FDCA) yield of 97.6% was obtained. Pt SAC (0.56 wt %) gave a much lower FDCA yield (28.8%). By changing the coordination atoms from highly electronegative N to low electronegative Co atoms, the prepared Pt single-atom alloy (SAA, Pt1-Co3) catalyst with ultralow Pt loading (0.06 wt %) gave a much high FDCA yield (99.6%). Density functional theory (DFT) calculations indicated that positively charged Pt sites (+0.712e) in Pt1-N4 almost lost the capability for oxygen adsorption and activation, as well as the adsorption for the key intermediate. In Pt1-Co3 SAA, the central negatively charged Pt atom (−0.446e) facilitated the adsorption of the key intermediate; meanwhile, the nearby Co atoms around the Pt atom constituted the O2-preferred adsorption/activation sites. This work shows the difference between the SAC with NPs and the SAA during liquid-phase oxidation of HMF and gives a useful guide in the future single-atom catalyst design in other related reactions.
研究领域:
催化化学
·
材料科学
·
理论计算化学
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高影响因子
危险品化学品经营许可证（带存储）