EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2021
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IF 6.514
Haoran Xu,Yue Zhao,Xin Gao,Fang Wang,Yueqing Gu
Breast cancer is the most dangerous, among all malignant tumors that threaten women’s lives and health. Surgical resection can effectively prolong the survival time of patients with early breast cancer. Insulin-like growth factor type 1 receptor (IGF1R) is a member of the large family of receptor tyrosine kinases , and it’s significantly overexpressed in breast cancer cells, which make them ideal biomarkers for the diagnosis and surgery navigation of breast cancer. Herein, we developed a series of IGF1R-targeted probes ( YQ-L ) for fluorescent imaging in breast cancer based on the strategy of drug repositioning . YQ-L exhibited specific IGF1R binding both in vitro and in vivo, especially probe 5d exhibited higher tumor uptake with a high tumor/normal ratio in the MCF-7 tumor bearing mouse. The maximum T/N ratio of probe 5d was 4.9, which was about 3 times that of indocyanine green (ICG). Meanwhile, probe 5d displayed more favorable in vivo pharmacokinetic properties than that of ICG with less hepatic and intestinal uptake. Convenient preparation, excellent IGF1R specificity in breast cancer, rapid clearance from normal organs and good biosafety profiles of probe 5d warrant further investigations for clinical translation in detection and surgery navigation of breast cancer.
研究领域:
肿瘤学
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药学
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医学成像
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分子生物学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2021
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IF 9.229
Hongzhong Liu,Yue Feng,Xiang Cao,Binghong Luo,Mingxian Liu
To solve the damage to the environment and human body caused by organic solvent adhesives in the utilization process, chitin nanocrystal (ChNC) suspension is explored as a strong anisotropic adhesive, which is an eco-friendly and water-based adhesive with high adhesive strength. ChNCs extracted from crab shells are rod-like nanoparticles with high aspect ratios, which are mainly employed as reinforcing polymer nanocomposites and biomedicine nanomaterials. ChNC suspension sandwiched between substrates forms a long-range ordered superstructure by a self-assembly process. ChNC nanoglue exhibits high anisotropy adhesion strength, i.e., an in-plane shear strength (5.26 MPa) and an out-of-plane shear strength (0.46 MPa) for glass substrates. Moreover, the ChNC nanoglue is suitable to many substrates, such as glass, plastic, wood, metal, paper, etc. The ChNC nanoglue shows high biocompatibility toward the fibroblast cell and rat skin, proving their excellent biosafety. As an eco-friendly and high-performance adhesive, ChNC nanoglue shows promising applications in daily life and industrial fields.
研究领域:
材料科学
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纳米技术
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胶粘剂技术
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环境科学
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生物医学工程
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DOI
PubMed
高影响因子
Scientific Reports
·
2021
·Vol. 11
·期 1
·1-9
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IF 4.38
Yue Song,Sun Kexin,Li Siyuan,Liu Yi,Zhu Qihao,Chen Yiyu,Yuan Dong,Wen Tao,Ge Mingjian,Yu Qiubo
In this paper, we first synthesis three-dimensional jasmine-like Cu@L-aspartic acid(L-ASP) inorganic–organic hybrid nanoflowers to load palladium-platinum nanoparticles (Pd–Pt NPs) as the signal enhancer in order to quantify intracellular speckle-type POZ domain protein. Scanning electron microscope, fourier transform infrared, energy dispersive spectrometer, X-ray photoelectron spectroscopy analysis was used to characterize the newly synthesized materials. The newly formed Cu@L-Asp/Pd-PtNPs can catalyze the decomposition of hydrogen peroxide and exhibit excellent catalytic performance. When different concentration of speckle-type POZ domain protein is captured by speckle-type POZ domain protein antibody linked to the surface of Cu@L-Asp/Pd–Pt NPs, the current signal decreases with the increase concentration of speckle-type POZ domain protein. After optimization, the speckle-type POZ domain protein immunosensor exhibited a good linear response over a concentration range from 0.1–1 ng mL −1 with a low detection limit of 19 fg mL −1 . The proposed sensor demonstrates good stability within 28 days, acceptable reproducibility (RSD = 0.52%) and selectivity to the speckle-type POZ domain protein in the presence of possible interfering substances and has potential application for detecting other intracellular macromolecular substances.
研究领域:
分析化学
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生物化学
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纳米技术
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生物传感器
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DOI
PubMed
高影响因子
FOOD AND AGRICULTURAL IMMUNOLOGY
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2019
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IF 2.398
Xiaoling Wu,Steven Suryoprabowo,Hua Kuang,Liqiang Liu
Aminophylline (AMP), a bronchodilator drug, is a modified form of theophylline (the pharmacological active ingredient). AMP is often given to treat respiratory diseases, including bronchial asthma, blocked emphysema, panting bronchitis, and cardiogenic asthma. In this study, we developed a rapid and sensitive method to determine AMP concentration in mouse serum. A sensitive monoclonal antibody against AMP was produced by immunizing BALB/c mice with a well-characterized AMP2-keyhole limpet hemocyanin and coating antigen (hapten-AMP1-OVA). The coating antigen and goat anti-mouse IgG antibody were sprayed onto a nitrocellulose membrane representing the test and control lines, respectively. Under optimized conditions, the cut-off limits of the test strip were 50 ng/mL in 0.01 M phosphate buffered saline (pH 7.4) and 250 ng/mL in serum. The results were obtained within 10 min and revealed that this immunochromatographic strip test is a sensitive, rapid, and simple tool for the detection of AMP in serum.
研究领域:
药理学
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分析化学
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免疫学
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DOI
高影响因子
ANALYTICA CHIMICA ACTA
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2026
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IF 6.1
Haoyuan Deng,Shan Li,Chunfei Bao,Daoyuan Zhao,Yubin Ding
Background Although sensor arrays are powerful for discriminating glycosaminoglycans, the construction of a sensor array is usually cost and labour inefficient. With the purpose to acquire a high dimensional response data using only a limited number of dyes, the rational assembly of fluorescent dye molecules may provide an alternative approach. We envision that co-assembling different dyes within a supramolecular structure can trigger multiple photophysical processes, which should produce high dimensional optical signals. Results A supramolecular AIEgen-porphyrin co-assembly is synthesized by assembling a negatively charged AIEgen ( TPE ) and meso-tetra(4-carboxyphenyl)porphine ( TCPP ) on the surface of a cationic polymer saying poly(diallyldimethylammonium chloride) ( PDDA ). With the co-assembly strategy, the aggregation-induced emission of TPE , the aggregation-caused quenching characteristic of TCPP , and especially, the Förster Resonance Energy Transfer efficiency from TPE to TCPP can be manipulated by a dynamic dye assembly approach. A sensor array is thus readily constructed by varying the loading ratio of TPE and TCPP on the surface of PDDA . Significance The sensor array is determined to be powerful for pattern recognition of various glycosaminoglycans even in 100% serum media through competitive compaction or removal of the aggregated TPE and TCPP dyes on the PDDA surface. It can be successfully applied for accurate and reliable detecting trace GAG analogues in Hep samples and identifying unknown GAG samples with an accuracy of 96.88%.
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产品关联
DOI
高影响因子
Gels
·
2026
·Vol. 12
·期 7
·630
·
IF 6.4
Yuan Li,Ziyu Chen,Shiyu Zhu,Yan Wei,Zhen Geng,Jianping Huang,Mengmeng Li
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss of articular cartilage and an associated decline in its intrinsic mechanoelectrical signaling. Current osteoarthritis treatments relieve symptoms but fail to prevent cartilage degeneration or restore its native biophysical microenvironment. Here, we present an ultrasound-activated, mussel-inspired bio-adhesive hydrogel that addresses these challenges by recreating the cartilage’s piezoelectric cues in situ while achieving stable intra-articular retention under synovial conditions. The hydrogel, denoted SFHD-BT@PDA, consists of a silk fibroin (SF) matrix integrated with dopamine-functionalized hyaluronic acid (HADA) and embedded barium titanate nanoparticles coated with polydopamine (BT@PDA). This multi-level design imparts strong interfacial adhesion to wet cartilage (via catechol-mediated bonding to collagen) and piezoelectric sensitivity to external ultrasound. Under ultrasound stimulation, SFHD-BT@PDA generates localized electrical microcurrents that recruit endogenous MSCs via electrotaxis and subsequently promote their chondrogenic differentiation. In vitro, ultrasound-triggered electrical cues upregulated chondrogenic markers (SOX9, collagen II, aggrecan) in MSCs and activated TGF-β signaling, demonstrating restoration of the pro-anabolic bioelectric microenvironment. In a murine DMM model, the adhesive hydrogel exhibited prolonged retention on cartilage surfaces and, with ultrasound, induced robust cartilage regeneration and OA reversal. Treated joints showed preserved proteoglycan and Type II collagen content, inhibited osteophyte formation, and protection of subchondral bone microarchitecture. In summary, this mussel-inspired piezoelectric hydrogel provides an electromechanical stimulation platform that effectively couples physical cues with bio-adhesion to regenerate cartilage.
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产品关联
DOI
PubMed
高影响因子
Advanced Materials Interfaces
·
2026
·
IF 4.5
Yan Xue,Kai Zheng,Yang Liao,Jing Cao,Xupeng Yuan,Fusong Yuan,Yuxin Leng
Cracks in the tooth enamel may lead to cracked tooth syndrome, posing a potential threat to overall health. Hydroxyapatite (HAP) is the principal component of tooth enamel. In this paper, the repair of initial crack on the surface of HAP are demonstrated using an ultraviolet picosecond laser. The influences of laser processing parameters on the widths of dendritic cracks after laser melting repair were investigated. Although the laser repair results in the formation of dendritic cracks, the width of dendritic crack is submicron-scale. The localized temperature rise of HAP during laser repair is 3.5 ± 0.2 °C, which could effectively avoid the dental pulp damage in the clinical application. Moreover, the average hardness of HAP specimens significantly increases after laser repair (from 188.3 ± 37.2 HV to 501.9 ± 86.1 HV). With an optimized set of laser parameters, the proposed method has potential for rapid repair of early cracked teeth.
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产品关联
DOI
高影响因子
NATURE BIOTECHNOLOGY
·
2026
·
IF 44.5
Yao Lang,Wang Zixuan,Chen Jialu,Sun Wen,Wang Kefan,Xiao Yunqi,Zhang Hanhan,Li Wenzheng,Wang Yifan,Zhao Lulu,Dai Xinyi,Qian Lu,Zhang Panke,Huang Shuo
Simultaneous characterization of proteins, RNAs and glycans with a nanopore remains a substantial challenge. To advance toward this goal, we introduce a multifunctional adaptor, maleimido-C2-formylphenylboronic acid (maleimido-C2-FPBA), into the Mycobacterium smegmatis porin A (MspA) nanopore at the pore constriction site. Here we demonstrate that the engineered nanopore, MspA-FPBA, enables the simultaneous identification of a diverse set of analytes, including 21 proteinogenic amino acids, three post-translationally modified (PTM) amino acids, four canonical nucleoside monophosphates (NMPs), three epigenetically modified NMPs, four monosaccharides and five peptides. Combined with machine learning, this sensor achieves an overall accuracy of 98.7%. Furthermore, it generates predictable event signatures for specific analyte types, enabling the machine learning model to identify analytes without strictly relying on prearchived event features, as demonstrated by the nanopore analysis of yeast cell extract. Lastly, we apply MspA-FPBA for compositional analysis of G2 glycopeptides. Future integration of hydrolase with MspA-FPBA may further improve MspA-FPBA utility as a single system to identify diverse biomolecules.
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DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Yang Wendong,Liu Pei,Wang Linfeng,Jiang Hua,Zhang Shuangbin,Luo Bin,Long Xue,Zeng Yilin,Cai Xuan,Zhang Yifan,Gan Zuoxuan,Ke Huaiyu,Guo Jinhua,Duan Jiangjiang
Iron-chromium redox flow batteries are promising for long-duration energy storage owing to their safety, low cost, and environmental compatibility, but are limited by sluggish chromium(II/III) kinetics and parasitic hydrogen evolution in chromium-based negolytes. Here we re-engineer iron-chromium redox chemistry through chelation-driven molecular design using the strong-field ligand 2,2-Bis(hydroxymethyl)−2,2’,2”-nitrilotriethanol. The ligand reshapes the electronic configurations of iron and chromium centres and tunes their redox potentials, enabling an alkaline iron-chromium redox flow battery with rapid kinetics and suppressed hydrogen evolution. It stabilizes an octahedral hexacoordinate chromium chelate and unlocks an unconventional chromium(III/IV) couple at +0.34 V versus the standard hydrogen electrode, circumventing the Jahn-Teller effects associated with chromium(II/III). Paired with an iron-chelate negolyte based on the same ligand, the cell operates at 1.15 V within the aqueous stability window and remains stable over 500 cycles, achieving 99.0% coulombic efficiency and 75.8% energy efficiency at 100 mA cm −2 (80% of state-of-charge). Together with a projected raw-material cost of $17.02 kWh −1 and theoretical capacity of 68.07 Ah L −1 based on posolyte volume, this work establishes a scalable, cost-effective strategy for grid-scale energy storage.
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DOI
高影响因子
Cell Chemical Biology
·
2026
·
IF 9
Qingxuan Chen,Ancheng Shen,Xinyi Shi,Tailiang Lin,Qinghua Wang,Zhen Wang,Xuekui Yu,Buyong Ma,Chunyong Ding,Ao Zhang
Overactive stimulator of interferon gene (STING) signaling drives inflammatory and autoimmune diseases, making STING inhibition a promising therapeutic strategy. However, the complex binding mechanisms and limited structural diversity hinder the development of STING inhibitors. In this study, we identified a small-molecule STING inhibitor, Y-320, via cell-based screening. It binds STING with nanomolar affinity and potently inhibits STING-mediated interferon signaling in human and mouse cells. Mechanistically, Y-320 blocks the Golgi translocation and phosphorylation of STING, preventing interferon regulatory factor 3 (IRF3) recruitment. Notably, Y-320 allosterically targets the non-canonical transmembrane domain (TMD) pocket without competing with the endogenous agonist 2′3′-cGAMP by engaging residues Y46 and W119 in the transmembrane helices 2 and 4. Importantly, Y-320 alleviated cisplatin-induced acute kidney injury in mice in a STING-dependent manner. This work not only reveals an additional mechanism underlying the regulatory complexity of STING but also provides a TMD-targeted allosteric STING inhibitor with demonstrated efficacy in both in vitro and in vivo models.
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Xiu Zhao,Hongyuan Guo,Zhuo Shi,Xiayu Song,Xuedong Jia,Xiaoyang Fu,Xuan Yu,Yingchun Zhu,Suozhu Wu
The AuNPs-poly(PBA)-poly(Arg)-based electrochemical sensor was developed. • It exhibited a wide detection range (1.00 pM–10.00 μM) for nitrite. • It displayed an ultra-low limit of detection (0.17 pM). • This sensor showed rapid response, high selectivity, and excellent reproducibility. Excessive intake of nitrite (NO 2 − ) poses a serious threat to human health, so it is significantly important to develop rapid and sensitive detection methods for NO 2 − . In this study, an electrochemical sensor was constructed based on a glassy carbon electrode modified with a composite material consisting of gold nanoparticles-poly(phenylboronic acid)-poly(arginine) (AuNPs-poly(PBA)-poly(Arg)), which was constructed via a one-step in-situ electrochemical co-deposition strategy. The detection of NO 2 − was achieved using an iodine/iodide (I 2 /I − ) probe system. Under the optimal conditions, the sensor exhibited a wide linear detection range for NO 2 − from 1.00 pM to 10.00 μM with a limit of detection as low as 0.17 pM. Moreover, the applicability of the developed sensor was successfully demonstrated by determining NO 2 − levels in beef and surface water samples, yielding satisfactory recovery rates between 89.70% and 107.33%. This study provided a novel and effective approach for monitoring NO 2 − in food and environmental samples. Download: Download high-res image (66KB) Download: Download full-size image
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ADVANCED MATERIALS
·
2026
·
IF 29.1
Guoqing Chen,Yunhao Hu,Zhouquan Sun,Yujie Lin,Shuhan Wang,Guoping Zeng,Xin Zhong,Yangyang Fan,Kerui Li,Yaogang Li,Qinghong Zhang,Chengyi Hou,Hongzhi Wang
Moisture-electric generators (MEGs) offer a promising route for clean energy harvesting. However, most existing MEGs suffer from low current densities due to limited ion concentration and migration rates, while often lack of capability for direct integration of wearable systems. Here, a moisture-electric yarn (MEY) featuring high current density and continuous power generation is designed. An ion pump strategy is introduced to facilitate the establishment of ion concentration gradients and enhance ion migration rates, enhancing electrical output. The MEY continuously generates ∼1 V and a high current density of 5.7 mA cm −3 at 25 °C and 60% RH, outperforming most reported MEGs. A scalable continuous fabrication process enables single-batch production of hundreds of meters of yarn. Owing to its yarn structure, the output current increases with length, reaching 4.3 mA for a 1 m yarn (∼0.1 g). Harvesting atmospheric and body moisture, a 2 m MEY can sustainably power LED strips. This lightweight and sewable yarn provides a safe and eco-friendly auxiliary power source for wearable electronics and real-time positioning applications.
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PubMed
高影响因子
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