MOLECULAR NEUROBIOLOGY
·
2025
·Vol. 63
·期 1
·335
·
IF 4.3
Pan Gaowei,Liu Xiaoling,Zhang Xiaoyue,Gao Hao,Xu Ting,Li Kemin,Wang Lei,Ji Shangrong,Li Ting,Zhang Shengxiang
Monomeric C-reactive protein (mCRP) is a key acute phase reactant involved in inflammatory responses. Cerebral ischemia triggers persistent neuroinflammation. However, the effects of mCRP on global cerebral ischemia are poorly understood. In present study, mCRP was intracerebroventricularly injected to brain, and a bilateral common carotid artery ligation (BCAL) model was established in CX3CR1 GFP/+ mice. Behavioral tests were employed to evaluate spontaneous activity, rotarod performance (latency to fall), and forelimb grasping strength in mice. Nissl and Fluoro-Jade C (FJ-C) staining were used to assess neuronal injury. Skeletonization analysis and CD16/32, CD206 staining were used to assess microglial activation. RT-qPCR was applied to evaluate the changes of inflammatory factors and complement system. Primary cultured microglia and oxygen–glucose deprivation (OGD) model were used to verify the effects of mCRP on microglia in vitro . Results showed that mCRP treatment exacerbated behavioral performance post-ischemia. Nissl staining showed that mCRP caused a significant decrease in neuronal density. Additionally, FJ-C staining indicated an increase in degenerative cells after mCRP treatment. Immunofluorescence analysis revealed an increase in CD16/32 and CD206-positive microglia, and skeletonization analysis showed increased de-ramification of microglia following mCRP administration. RT-qPCR results further demonstrated that mCRP treatment upregulated the expression of pro-inflammatory and anti-inflammatory factors, as well as complement system components, in both brain tissue and primary cultured microglia following ischemia or OGD. These findings suggest that mCRP significantly enhances microglial activation, increases the level of inflammatory response, exacerbates neuronal loss and degenerative damage, and impairs behavioral performance after ischemia.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2024
·
IF 5.8
Zesheng Li,Fangyu Gan,Juncheng Han,Qingrong Yao,Lichun Cheng,Jiang Wang,Jianqiu Deng,Zhao Lu,Qianxin Long,Yan Zhong,Huaiying Zhou,Guanghui Rao
Y 2 O 3 has emerged as a promising material for electromagnetic wave (EMW) absorption due to its excellent dielectric properties . However, the inherent insulating nature and single loss mechanism limit its absorption performance. Research on the microstructure modulation and component regulation of Y 2 O 3 -based absorbers remains relatively unexplored. In this work, Y 2 O 3 /C composites with flower-like architectures were synthesized for the first time via a metal-organic framework (MOFs) templating method. The effects of pyrolysis temperature on the microstructure, phase composition, and EMW absorption performance of the Y 2 O 3 /C composites were systematically investigated. At a pyrolysis temperature of 800 °C, the flower-like Y 2 O 3 /C microsphere exhibited optimal EMW absorption performance. The minimum reflection loss (RL) of pristine Y 2 O 3 was only −4.75 dB, while the Y 2 O 3 /C composite achieved a minimum RL of −51.77 dB and a maximum effective absorption bandwidth of 4.32 GHz. Moreover, by simply adjusting the matching thickness, the optimal sample exhibited strong absorption (RL < −30 dB) over a wide frequency range of 4–18 GHz. The incorporation of carbon effectively neutralized the insulating nature of Y 2 O 3 , thereby optimizing the impedance matching . The synergistic effects of multiple loss mechanisms, including polarization loss, resistance loss, and interfacial polarization, facilitated substantial EMW attenuation . This study provides a promising strategy for the design and fabrication of high-performance rare-earth oxide EMW absorbers with tunable morphologies and properties.
研究领域:
材料科学
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电磁材料
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纳米技术
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复合材料
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DOI
高影响因子
BMC Chemistry
·
2019
·Vol. 13
·期 1
·1-15
·
IF 0
Guo J.,Ma Yu L.,Yu Jia Y.,Gao Yu J.,Ma Ning X.,Wu Xiao Y.
Herein, 2-(2-methoxyphenoxy)-1-phenylethanol (β- O -4), 2-methoxyphenyl anisole (α- O -4) and 4-phenoxyphenol (4- O -5) were selected as typical lignin model compounds. Given the effectiveness of traditional acid–base catalysts for lignin depolymerisation, a novel Ni/CaO–H-ZSM-5(60) catalyst was prepared to investigate the difficulty level of C–O bond of three model compounds cleavage in ethanol. It was observed that Ni/CaO–H-ZSM-5(60) had prominent performance on the C–O bond cleavage at very mild conditions (140 °C, 1 MPa H 2 ). Among them, the C–O bond of α- O -4 and β- O -4 could be completely cleaved within 60 min. Although the C–O bond of 4- O -5 had high bond energy, 41.2% of conversion was occurred in 60 min. The introduction of CaO could regulate the acidity of H-ZSM-5 to enhance the ability to break C–O bonds. Moreover, the possible pathways of C–O ether bonds in three lignin model compounds cleavage were proposed in order to selectively obtain target products from the raw lignin degradation.
研究领域:
化学工程
·
催化科学
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DOI
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Wei Zhao,Xunhui Xiong,Yingbang Yao,Bo Liang,Ye Fan,Shengguo Lu,Tao Tao
The construction of high capacity cathode materials consisting of two active components, LiFe x Mn 1-x PO 4 and Li 3 V 2 (PO 4 ) 3 , is rarely reported. Herein, 5LiFe 0.9 Mn 0.1 PO 4 ∙4Li 3 V 2 (PO 4 ) 3 /C (LFMVP/C) composites are synthesized by a simple two-step process, including ball milling and heat-treatment. The electrochemical reactivity of the composites with lithium is evaluated. The cathode assembled with LFMVP/C shows better electrochemical performance than that of the single active component (LiFePO 4 , LiMnPO 4, or Li 3 V 2 (PO 4 ) 3 ) during charging and discharging in the potential range of 2.4 and 4.8 V. It delivers the specific capacities of 195, 173, and 158 mAh∙g −1 at 0.1C, 0.5C, and 2C, and retains 88% of the initial discharge capacity after 100 cycles at 0.1 C. Compared with the single active component (LiFePO 4 , LiMnPO 4, or Li 3 V 2 (PO 4 ) 3 ), the lithium-ion diffusion coefficient of the composite composed of two active components (LFMVP/C) is higher.
研究领域:
材料科学
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电化学
·
能源存储
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Yuzhe Liu,Qi Li,Yuhan Liang,Junhao Liang,Wenliang Feng,Bin Wu,XuLei Sui,Zhenbo Wang
The inherently low active site accessibility of single-atom Fe-N-C catalysts severely compromises their catalytic activity relative to Pt-based catalysts, thereby hindering their practical implementation in critical applications. This work systematically investigates the synergistic effects of physical confinement and chemical induced growth strategy on optimizing active site accessibility of Fe-N-C catalysts for oxygen reduction reaction. Through a physical confinement strategy, the catalyst particle size is successfully reduced from the micrometer scale to the nanometer scale. Subsequently, by employing chemical-induced growth, the particle size is precisely controlled within the range of 623 nm to 421 nm, simultaneously establishing an optimal balance between the catalyst particle size threshold (420 nm) and the ordered macroporous framework. This approach maximized the accessibility of active sites and significantly enhanced the catalytic activity of the Fe-N-C catalyst. The optimized catalyst (OM-Fe-NC-4) exhibits outstanding performance, achieving a remarkable half-wave potential of 0.888 V, surpassing both commercial Pt/C and most state-of-the-art Fe-N-C catalysts. Additionally, it demonstrates excellent four-electron selectivity and delivers a kinetic current density of 14.7 mA cm −2 at 0.85 V in acidic medium. This dual-dimensional modulation strategy offers a paradigm for enhancing the accessibility of active sites for non-precious metal catalysts.
研究领域:
材料科学
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催化化学
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能源科学
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产品关联
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
Wei Zeng,Yao Tian,Xuehua Dong,Ling Huang,Hongmei Zeng,Zhien Lin,Guohong Zou
Birefringent crystals are extensively utilized across diverse optical applications due to their unique property of splitting incident light into dual refracted rays, thereby modulating and controlling light polarization. The pursuit of promoting the birefringence of such crystals to facilitate device miniaturization has recently emerged as a prominent area of focus. In this investigation, we introduce two molybdenyl iodates, namely, C(NH2)3MoO3(IO3) and Rb2MoO2(I2O6)(IO3)2, conceived through a “cation–anion synergetic interaction” strategy. Each compound exhibits a one-dimensional chain structure. Despite processing similar wide band gaps (3.33 and 3.22 eV), these materials display a variance in their birefringence (Δn = 0.426 and 0.261 @546 nm). Notably, C(NH2)3MoO3(IO3) showcases the highest birefringence among all hitherto reported molybdenyl iodates, signifying its potential as a high-performance birefringent crystal. Theoretical analyses indicate that the C(NH2)3+ cation, acting as a birefringence-active unit, significantly bolsters the birefringence of molybdate iodates. Moreover, the presence of extensive hydrogen-bonding interactions between C(NH2)3+ cations and iodates influences the orientation of the highly anisotropic iodates, thereby further enhancing the birefringence of C(NH2)3MoO3(IO3). This research paves the way for the future exploration of organic–inorganic hybrid molybdenyl iodates exhibiting exceptional optical performance.
研究领域:
光学材料
·
晶体学
·
材料科学
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DOI
高影响因子
ANTICANCER RESEARCH
·
2024
·Vol. 44
·期 7
·2861-2870
·
IF 1.6
YINA ZHANG,XIAOCEN NIU,YUANHE WANG,SHUTING BAO,PEIYUE JIANG,XIAORUI DONG
Background/Aim: Glutamine metabolism is crucial in cell proliferation, aging, and apoptosis across various cancer types. Existing research indicates that Sirtuin 4 (SIRT4), primarily located in mitochondria, modulates this process. This study aimed to clarify the regulatory relationship between SIRT4 and glutamine metabolism in cervical cancer. Materials and Methods: SIRT4 mRNA levels and their clinical correlation to cervical cancer were analyzed using the UALCAN database. Immunohistochemistry (IHC) was performed to assess SIRT4 protein expression in tissue samples from cervical cancer patients. Transient transfection was employed to create Hela and Siha cell lines with overexpressed SIRT4, mitogen-activated extracellular signal-regulated kinase (MEK), and glutaminase 1 (GLS1). The impact on cellular functions was studied using MTT, soft agar, transwell, and western blotting assays. Glutamate and ATP levels were also measured to evaluate metabolic changes. Results: Low levels of SIRT4 mRNA in cervical cancer tissues correlated with tumor metastasis and poor survival rates. Overexpression of SIRT4 led to suppressed cell proliferation, colony growth, and motility, along with significant down-regulation of GLS expression, a key contributor to glutamine metabolism. Additionally, SIRT4 overexpression resulted in the inactivation of the MEK/ERK/c-myc signaling pathway, while overexpression of MEK reversed these effects. Notably, the inhibitory effects of SIRT4 on cell proliferation, colony formation, migration, and invasion in Hela and Siha cells were significantly attenuated following GLS1 overexpression. Conclusion: SIRT4 acts as an anti-cancer agent in cervical cancer by inhibiting glutamine metabolism through the MEK/ERK/c-myc signaling pathway, providing a novel sight for cervical cancer therapy.
研究领域:
肿瘤学
·
分子生物学
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细胞生物学
·
癌症代谢
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DOI
PubMed
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2017
·
IF 4.849
Xiaoxia Wang,Na Li,Zhongfeng Li,Honghua Rao
A dehydrogenative C(sp2)–N bond-forming strategy via copper-catalyzed intramolecular C–H/N–H coupling has been developed, which systematically unraveled the feasibility and practicality for benzoimdazo[1,2-a]indole formations through oxidative anilidic N–H activation. The merit of this strategy is illustrated by the broad tolerance of functionalities, as well as the utilization of extremely cheap copper catalysis to realize potentially useful indole-fused tetracycles in a step- and atom-economical manner.
研究领域:
有机化学
·
药物化学
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DOI
PubMed
高影响因子
CARBON
·
2022
·
IF 11.307
Dangcheng Su,Yuanhua Xiao,Yingliang Liu,Shengang Xu,Shaoming Fang,Shaokui Cao,Xuezhao Wang
2D MXenes (transition metal carbides, Ti 3 C 2 T x ) with large surface area and metallic conductivity are widely used as supporters in catalysts. Unfortunately, the single MXene sheets would deteriorate in the presence of oxygen and water, which is almost the same as the environment of oxygen reduction reaction (ORR). Herein, an “armor” was constructed to encapsulate the oxidizable MXene by a confined in-situ oxidative polymerization strategy, employing the electrostatic interaction between the exfoliated MXene sheets (negatively charged) and oxidant (Fe 3+ , positively charged). The ultra-dispersed binary Fe 3 N and Co sits coupled with the large surface area MXene supporter synergy to endow more exposed active sites, meanwhile, the density functional theory (DFT) studies reveal that a moderate binding strength between the intermediates and the binary active sites was effectively modulated to enhance the ORR performance. The synthesized Fe 3 N/Co–N–C@MXene exhibits an impressive half-wave potential (E 1/2 , 0.871V) and a lower Tafel slope of 52.56 mV dec −1 than that of Pt–C-20% (74.89 mV dec −1 ). The Fe 3 N/Co–N–C@MXene based ZAB exhibits a four times higher peak power density (189.16 mW cm −2 ) than the Pt–C-20% based ZABs and superior cycle stability within 320 h. Furthermore, the assembled flexible ZABs shows high flexibility and stability in different bending scenarios.
研究领域:
材料科学
·
电化学
·
纳米催化
·
能源存储与转换
·
功能材料
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Tao Tang,Chengcai Li,Wenyu He,Wei Hong,Hailin Zhu,Guojin Liu,Yuan Yu,Caihong Lei
In this paper, the ZIF-8/ZnO mixture was sintered at high temperature to prepare C-ZnO composite nano-particles with excellent photocatalytic degradation ability under ultraviolet light , and then blended with PVDF to fabricate PVDF composite membrane with capabilities of photocatalytic degradation of methylene blue(MB) via solution phase conversion. The results show that the photocatalytic performance of the prepared C-ZnO composite particles was the best when the ZIF-8/ZnO mass ratio was 1:2, and the photocatalytic degradation efficiency of the PVDF composite film prepared was as high as 95.02% when the composite particle content was 15%. The photocatalytic activity of C-ZnO composite material benefits from the synergy between the two. Moreover, the efficiency of photodegradation of MB remained above 90% after the composite membrane was subjected to five cycles of experiments, which solved the problem that the traditional photocatalyst was difficult to recycle. In addition, it is found that O 2 - plays a major role in the photocatalytic degradation of MB through free radical capture experiments. All in all, the PVDF composite membrane containing C-ZnO composite particles has a foreseeable potential in the field of photocatalytic printing and dyeing wastewater in the future.
研究领域:
环境科学
·
材料科学
·
化学工程
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Peiyuan Mao,Yong Wang,Pandeng Xiao,Wen Zhang,Shun Rao,Zhi Wang
Herein, we demonstrate the reasonable design and preparation of yolk-heteroshell Sn@N-doped C@MoS 2 nanospheres as anode materials in sodium-ion battery. Through an effective multi-step strategy, Sn nanoparticles are encapsulated in N-doped C nanocage surrounded by ultra-thin MoS 2 nanosheets to form Sn@N-doped C@MoS 2 nanospheres. In this novel structure, Sn nanoparticles with high theoretical capacity improve the space utilization inside the heteroshell; the N-doped carbon nanocage as the skeleton not only inhibits the mutual accumulation of Sn and MoS 2 , but also improves conductivity; the outer MoS 2 ultra-thin sheets can consolidate C@MoS 2 heteroshell, provide numerous active sites and favor the fast diffusion of Na + /e - . Notably, the combination of carbon nanocage and MoS 2 sheets in the yolk-heteroshell structure can effectually buffer the volume expansion of Sn nanoyolks and reinforce C@MoS 2 heteroshell while reducing the carbon content. Therefore, the yolk-heteroshell structure plays a crucial role in enhanced reversible capacity and cyclic stability of Sn@N-doped C@MoS 2 nanospheres, which activates their sodium storage potential. The yolk-heteroshell Sn@N-doped C@MoS 2 nanospheres exhibit high reversible capacity of 488.4 mAh g −1 at 0.1 A g −1 after 300 cycles and long-cycle stability of 350.6 mAh g −1 at 0.5 A g −1 after 500 cycles. Moreover, their full cell delivers a stable reversible discharge capacity of about 80.1 mAh g −1 after 30 cycles at 0.5 C. This work provides a feasible yolk-heteroshell strategy for Sn-based composite nanomaterials .
研究领域:
材料科学
·
电化学
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DOI
高影响因子
CHINESE JOURNAL OF CATALYSIS
·
2018
·
IF 3.525
Hualin Jiang,Jun Liu,Menglin Li,Lei Tian,Gongsheng Ding,Pinghua Chen,Xubiao Luo
Lattice-doping and surface decoration are prospective routes to improve the visible-light photocatalytic ability of TiO 2 , but the two techniques are difficult to combine into one preparation process because they are usually conducted under different conditions, which limits the efficiency of TiO 2 modification. In this study, TiO 2 was successfully modified by simultaneous lattice-doping and surface decoration, and the visible-light photocatalytic capacity was largely improved. Upon comparing the method reported here with previous ones, the most significant difference is that Fe(II)-phenanthroline was first used as the co-precursor of the introduced elements of C, N, and Fe. These three elements were simultaneously introduced to TiO 2 at high levels by this co-precursor method. The as-synthesized photocatalysts were systemically investigated and analyzed by several characterization methods such as XRD , FT-IR, XPS , Raman spectroscopy , EPR , UV-Vis DRS, photoluminescence spectra, photocurrent , electrochemical impedance spectra, TEM, and HRTEM . The photocatalytic degradation of 4-NP under visible-light irradiation was used to evaluate the photocatalytic activity of the photocatalysts. Based on the experimental data, a probable mechanism for the photocatalytic degradation by the photocatalysts is proposed. This is a novel method of using one source to simultaneously introduce metal and non-metal elements to TiO 2 at high levels, which may provide a new way to prepare highly effective TiO 2 photocatalysts.
研究领域:
材料科学
·
环境化学
·
纳米技术
·
光催化
·
无机合成
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）