ACS Nano
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2019
·
IF 13.903
Hao Ren,Xiaoli Sun,Chengfeng Du,Jin Zhao,Daobin Liu,Wei Fang,Sonal Kumar,Rodney Chua,Shize Meng,Pinit Kidkhunthod,Li Song,Shuiqing Li,Srinivasan Madhavi,Qingyu Yan
Electrocatalysts are one of the most important parts for oxygen evolution reaction (OER) to overcome the sluggish kinetics. Herein, amorphous Fe–Ni–P–B–O (FNPBO) nanocages as efficient OER catalysts are synthesized by a simple low-cost and scalable method at room temperature. The samples are chemically stable, in clear contrast to reported unstable or even pyrophoric boride samples. The Fe/Ni ratio of the FNPBO nanocages can be continuously adjusted to optimize the OER catalytic performance. The FNPBO nanocages composed of multicomponent elements can weaken the metal–metal bonds, thus rearranging the electron density around the catalytic metal atom centers and reducing the energy barrier for intermediate formation. Hence the optimized FNPBO (Fe6.4Ni16.1P12.9B4.3O60.2) catalyst shows superior intrinsic electrocatalytic activity for OER. The low overpotential to afford the current density of 10 mA cm–2 (236 mV), the small Tafel slope (39 mV dec–1), and the high specific current density (26.44 mA cm–2) at a given overpotential of 300 mV make a sharp contrast to state-of-the-art RuO2 (327 mV, 136 mV dec–1, and 0.028 mA cm–2, respectively).
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LIFE SCIENCES
·
2019
·
IF 3.448
Enxia Zhang,Jiasi Liu,Lei Shi,Xin Guo,Ze Liang,Jiaxin Zuo,Hong Xu,Huaxin Wang,Xiaohong Shu,Shanshan Huang,Shubiao Zhang,Xiaohui Kang,Yuhong Zhen
Aims To investigate the effect of 7- O -geranylquercetin (GQ), a derivative of quercetin (Q), on reversing drug resistance in breast cancer MCF-7/ADR cells and reveal the mechanisms related to P-glycoprotein (P-gp). Main methods Cell viability was determined by MTT assay. Accumulation of adriamycin (ADR) in cells was determined by confocal fluorescence microscope and microplate reader while that of rhodamine (Rh) was measured by flow cytometry. Expression levels of P-gp and MDR1 gene in cells were detected by western blot and Real-Time PCR, respectively. Molecular docking of GQ and Q with P-gp was conducted using AutoDock program. Xenograft model was established by inoculating MCF-7/ADR cells in BALB/c-nude mice. Tumor bearing mice were administered with ADR via tail vein injection and/or GQ (Q) by gavage. Expression levels of P-gp in tissues were detected by western blot and immunohistochemistry. Key findings GQ could reverse drug resistance of MCF-7/ADR cells to ADR. GQ inhibited the efflux of ADR by down-regulating the expression of P-gp protein and its encoding gene MDR1 in MCF-7/ADR cells. Molecular modeling showed that GQ matched with P-gp better than Q. GQ enhanced the antitumor effects of ADR and decreased the expression of P-gp in mice and its activities were higher than that of Q. GQ could reverse drug resistance of MCF-7/ADR cells by down-regulating the expression of P-gp in vitro and in vivo. Significances The reversal effect of GQ on P-gp-mediated drug resistance indicates its potential as a reversal agent for drug resistance in cancer chemotherapy.
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高影响因子
Frontiers in Chemistry
·
2022
·
IF 5.545
Li Yongfeng,Liao Qianyan,Ling Weizhao,Ye Fan,Liu Fangfang,Zhang Xipeng,He Jiajun,Cheng Gao
Exploring high-efficiency and stable monolithic structured catalysts is vital for catalytic combustion of volatile organic compounds. Herein, we prepared a series of Pd/δ-MnO2 nanoflower arrays monolithic integrated catalysts (0.01–0.07 wt% theoretical Pd loading) via the hydrothermal growth of δ-MnO2 nanoflowers onto the honeycomb cordierite, which subsequently served as the carrier for loading the Pd nanoparticles (NPs) through the electroless plating route. Moreover, we characterized the resulting monolithic integrated catalysts in detail and evaluated their catalytic activities for toluene combustion, in comparison to the controlled samples including only Pd NPs loading and the δ-MnO2 nanoflower arrays. Amongst all the monolithic samples, the Pd/δ-MnO2 nanoflower arrays monolithic catalyst with 0.05 wt% theoretical Pd loading delivered the best catalytic performance, reaching 90% toluene conversion at 221°C at a gas hourly space velocity (GHSV) of 10,000 h−1. Moreover, this sample displayed superior catalytic activity for o-xylene combustion under a GHSV of 10,000 h−1. The monolithic sample with optimal catalytic activity also displayed excellent catalytic stability after 30 h constant reaction at 210 and 221°C.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2022
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IF 5.999
Qingqing Li,Xinyu Fan,Xiaohan Pan,Ying Yu,Lingyan Jian,Yu Zhang,Tian Yin,Haibing He,Xing Tang,Jian Jin,Jingxin Gou
The intramuscular administration of long-acting injectable microparticles elicits a local macrophage uptake resulting in decreased bioavailability. Herein, we developed a ginkgolide B (GB) loaded Solid/Oil/Water (S/O/W) solid lipid microparticles (SLMs) which were modified by hydroxyethyl starch (HES) or poly(ethylene glycol) (PEG) with different surface densities to investigate the influence of surface properties on the cellular uptake and systemic drug exposure. The spherical SLMs with a mean particle size of 10 µm were prepared by melt emulsification and post-insertion method, showing controlled release profile with less than 10 % of GB released in first 2 h. HES-SLMs resulted in lowest degree of RAW264.7 macrophage uptake in vitro and a higher systemic drug exposure in rats than PEG coating SLMs, indicting the capability of thick HES layer of SLMs in evading cellular uptake and sustained GB release. Overall, HES modified SLMs possess a great potential as intramuscular injected drug delivery system to improved bioavailability.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2022
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IF 4.831
Zhishun Jie,Jia Liu,Ye Ying,Haifeng Yang
High plasma homocysteine (Hcy) levels may indicate cardiovascular disease. However, sensitive and selective determination of Hcy remains a major challenge. Herein, we present a sensing strategy for Hcy by surface enhanced Raman scattering (SERS) method along with a specific reaction of o-phthalaldehyde (OPA) and Hcy. The obtained adduct 2-(1-carboxyl-3-thiopropyl)-1-isoindolinone (Hcy-OPA) can be directly detected by SERS using gold nanoparticles (Au NPs) as the substrate. The developed SERS method displays superior sensitivity (low detection limit of 2.50 × 10 −12 mol L −1 ) with a broad linear range (5.00 × 10 −10 −5.00 × 10 −6 mol L −1 ). As a proof of real application, it can be used to detect Hcy in bovine serum samples with a concentration as low as 5.00 × 10 −9 mol L −1 , which is free from the interference of the other amino acids and glutathione.
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MOLECULAR PHARMACEUTICS
·
2023
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IF 4.9
Bingyi Lin,Siyuan Chai,Qijun Zhang,Yuejie Lu,Jiahao Hu,Jie Zhang,Yong-Zhong Du,Liming Wu
O-linked-N-acetylglucosaminylation (O-GlcNAcylation) plays a key role in hepatocellular carcinoma (HCC) development, and the inhibition of O-GlcNAcylation has therapeutic potential. To decrease the systemic adverse events and increase targeting, we used sialic acid (SA)-decorated liposomes loaded with OSMI-1, an inhibitor of the O-GlcNAcylation, to further improve the anti-HCC effect. Fifty pairs of HCC tissue samples and the cancer genome atlas database were used to analyze the expression of O-GlcNAc transferase (OGT) and its effects on prognosis and immune cell infiltration. OSMI-1 cells were treated with SA and liposomes. Western blotting, immunofluorescence, cell proliferation assay, flow cytometry, enzyme-linked immunosorbent assay, immunohistochemistry, and tumorigenicity assays were used to investigate the antitumor effect of SA-modified OSMI-1 liposomes in vitro and in vivo. OGT was highly expressed in HCC tissues, negatively correlated with the degree of tumor infiltration of CD8+ and CD4+T cells and prognosis, and positively correlated with the degree of Treg cell infiltration. SA-modified OSMI-1 liposome (OSMI-1-SAL) was synthesized with stable hydrodynamic size distribution. Both in vitro and in vivo, OSMI-1-SAL exhibited satisfactory biosafety and rapid uptake by HCC cells. Compared to free OSMI-1, OSMI-1-SAL had a stronger capacity for suppressing the proliferation and promoting the apoptosis of HCC cells. Moreover, OSMI-1-SAL effectively inhibited tumor initiation and development in mice. OSMI-1-SAL also promoted the release of damage-associated molecular patterns, including anticalreticulin, high-mobility-group protein B1, and adenosine triphosphate, from HCC cells and further promoted the activation and proliferation of the CD8+ and CD4+T cells. In conclusion, the OSMI-1-SAL synthesized in this study can target HCC cells, inhibit tumor proliferation, induce tumor immunogenic cell death, enhance tumor immunogenicity, and promote antitumor immune responses, which has the potential for clinical application in the future.
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Polymers
·
2023
·Vol. 15
·期 19
·4011
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IF 5
Huan-Jun Lu,Jian-Ke Cen,Yu Ren,Mei-Xian Li
Nanoparticle delivery of functional molecules or vaccines is an effective method for the treatment of many diseases. This study aims to design ginsenoside Rh2-conjugated O-carboxymethyl chitosan (O-CMC/Rh2) as a drug delivery system and explore its anti-nociceptive effects. O-CMC/Rh2 was synthesized with an esterification reaction, and its chemical composition and morphology were evaluated using proton nuclear magnetic resonance (1H NMR), the attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, and scanning electron microscopy (SEM). In addition, the in vitro cumulative release of Rh2 from the O-CMC/Rh2 was also evaluated under different pH conditions. The results showed that the ginsenoside Rh2 was successfully conjugated to the O-CMC matrix and exhibited a highly porous structure after conjugation, facilitating the release of Rh2 from O-CMC. Complete Freund’s adjuvant (CFA) and burn injury-induced pain models were used to evaluate the anti-nociceptive effects of O-CMC/Rh2 on inflammatory pain. O-CMC/Rh2 reduced CFA-induced pain hypersensitivity in a dose-dependent manner and had a longer analgesic effect than Rh2. In addition, O-CMC/Rh2 also relieved the chronic pain induced by bury injury. These results indicated that O-CMC/Rh2 could be useful in reducing inflammatory pain, thus possessing a potential medicinal application in pain therapy.Keywords:O-carboxymethyl chitosan;ginsenoside Rh2;anti-nociception;inflammatory pain
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2018
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IF 1.454
Xinyue Wang,Xinyue Lu,Lili Wen,Zongning Yin
Water-in-oil-in-water (W/O/W) double emulsion can be prepared by incomplete phase inversion method using both medium chain triglycerides (MCT) and isopropyl myristate (IPM) as oil phase, Span 85-Tween 80 (HLB values of 2.5-3.0) as mixed emulsifiers. The preparation method was simple, and the final double emulsions were proved of good microstructure and particle size distribution. Owning to the addition of Tween 80 to Span 85, interfacial tension, interfacial viscosity and modulus decreased, which contributed to the phase inversion. Furthermore, formation of reverse micelles under high-speed dispersion may be a hypothesis to explain the incomplete phase inversion phenomenon.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Zehao Chen,Ting Zhao,Qing Tan,Jihao Zuo,Shouping Xu,Yunjun Nong,Xiufang Wen,Pihui Pi
The crude oil spillage and large-scale industrial release of oily effluents has led to significant ecological degradation and resource wastage. Traditional superwetting materials encounter intractable challenges for treating surfactant-stabilized oil–water emulsions, including trade-off effect of permeation flux and separation efficiency, and low emulsion processing life. These issues considerably impede advancements in oil–water separation industry. In order to enhance the demulsification durability of materials while ensuring high separation efficiency and flux, this work doped perfluorooctanoic acid (PFOA) onto the modified sponge surface with superhydrophilic charged surface, and a unique in-air superhydrophilic-oleophobic sponge was prepared. This special surface allows rapid water phase permeation yet offers remarkably more stable oleophobicity compared with traditional underwater oleophobic materials when processing a large amount of emulsions. The intrinsic oleophobicity endows the sponge outstanding fouling resistance and greatly increases the one-cycle emulsion treatment amount up to 1695 L·m −2 . Moreover, the sponge's inherent long permeation channels and surface charge maintain a high separation efficiency of over 97 %. The large pores of the sponges and superhydrophilic surface provide a high permeation flux exceeding 40,000 L·m −2 ·h −1 . The sponge with high separation efficiency, flux, and capacity marks a significant advancement, offering a promising strategy for superwetting material applications in oil-in-water emulsion separation fields.
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RSC Advances
·
2023
·Vol. 13
·期 29
·20314-20320
·
IF 3.9
Han Chen,Yuanming Li,Zanyun Ying,Yinfeng Xia,Juping You
Microbial fuel cells (MFCs) are widely acknowledged to be a promising eco-friendly abatement technology of pollutants, and are capable of generating electricity. However, the poor mass transfer and reaction rate in MFCs significantly decrease their treatment capacity for contaminants, especially hydrophobic substances. The present work developed a novel MFC integrated with an airlift (ALR) reactor using a polypyrrole modified anode to promote the bioaccessibility of gaseous o-xylene and attachment of microorganisms. The results indicated that the established ALR-MFC system showed excellent elimination capability, with removal efficiency exceeding 84% even at high o-xylene concentration (1600 mg m−3). The maximum output voltage of 0.549 V and power density of 13.16 mW m−2 obtained by the Monod-type model were approximately twice and sixfold higher than that of a conventional MFC, respectively. According to the microbial community analysis, the superior performances of the ALR-MFC in terms of o-xylene removal and power generation were mainly ascribed to the enrichment of degrader (i.e. Shinella) and electrochemical active bacteria (i.e. Proteiniphilum). Moreover, the electricity generation of the ALR-MFC did not decrease at a high O2 concentration, as O2 was conducive to o-xylene degradation and electron release. The supplication of an external carbon source such as sodium acetate (NaAc) was conducive to increasing output voltage and coulombic efficiency. The electrochemical analysis revealed that released electrons can be transmitted with the action of NADH dehydrogenase to OmcZ, OmcS, and OmcA outer membrane proteins via a direct or indirect pathway, and ended up transferring to the anode directly.
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Materials Research Express
·
2019
·Vol. 6
·期 9
·095601
·
IF 1.449
Hao Xu,Xiang-Hui Yan,Ziwei Meng,Tong Xue,Dong Li,Guoli Fang,Hongfang Shen
Nitrogen-doped mesoporous carbon/poly-o-phenylenediamine composites (denoted as N-MC/PoPD) were successfully synthesized by sacrificial hard template method followed by in situ oxidation polymerization initiated by FeCl3. It is revealed that the resultant N-MC/PoPD composites still remained original graphitization structure and narrow pore size distributions (centered at ∼3.8 nm) but suffered visibly monotonical decrease in specific surface area after oPD was increasingly polymerized onto N-MC with an increase of the mass ratio of PoPD to N-MC from 1:1 to 5:1. As supercapacitor electrode measured by galvanostatic charge-discharge in 6 mol L−1 KOH, a volcano curve was found when plotting specific capacitance of the N-MC/PoPD versus the mass ratio of N-MC to oPD; the N-MC/PoPD(2:1) with moderate surface area and the highest electrochemical conductivity delivered the highest specific capacitance of 229 F g−1 at a current density of 1 A g−1, which is twice of that obtained on the single N-MC with the maximum surface area. The remarkable enhancement in specific capacitance could be ascribed to the synergistic effect between two components of N-MC and PoPD.
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Results in Physics
·
2019
·
IF 3.042
Yang Zhou,Xiaoyuan Liu,Ke Wang,Jing Li,Xinglai Zhang,Xin Jin,Xinyue Tang,Xiuhui Zhu,Ruishi Zhang,Xin Jiang,Baodan Liu
Series of “Hopcalite” catalysts for low-temperature CO oxidation are prepared through a facile ultra-sonic spray pyrolysis approach. It has been found that the spray pyrolysis temperature and Cu/Mn atomic ratio in initial precursors show significant impacts on the catalytic activity of Cu-Mn-O catalysts. The catalyst synthesized at 550 °C with Cu/Mn = 1/2 in precursor (Cu1Mn2-550) shows the highest catalytic activity towards CO oxidation (T 100 = 63 °C; E a = 17.04 KJ mol −1 ), owing to the formation of CuMn 2 O 4 phase with poor crystallinity. The synergistic effect of Cu and Mn species in spinel Cu-Mn-O phases attributes to the evaluated catalytic activity compared with those of pure oxides of copper or manganese towards CO oxidation. The results reveal that Cu1Mn2-550 not only provides more defects and vacancies to create more active sites, but also generates more highly active Cu (II) to promote CO oxidation. On the contrary, the decreasing amount of Cu (II) and the higher degree of crystallinity resulting from higher synthesis temperature lead to the deterioration of catalytic activity. Moreover, the phase transformation among the Cu x Mn 3-x O 4 spinels also shows significant effect on CO conversion rate. Finally, the formation mechanism of Cu-Mn-O catalysts and related CO oxidation process are discussed based on series of characterizations.
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